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Journal of Materials Science & Technology 2020年第10期42卷 162-175页

作者： Mariana X.Milagre Uyime Donatus Naga V.Mogili Rejane Maria PSilva barbara victoria gde viveiros Victor F.Pereira Renato A.Antunes Caruline S.CMachado Joao Victor S.Araujo Isolda Costa Instituto de Pesquisas Energeticas e Nucleares IPEN/CNENAv.Prof.Lineu Prestes2242Sao PauloBrazil Laboratorio Nacional de Nanotecnologia LNNano/CNPENRua Giuseppe Maximo Scolfaro10.000Polo II deAlta Tecnologia de CampinasBrazil Centro de Engenharia Modelagem e Ciencias Sociais AplicadasUFABCAv.dos Estados 5001Santo AndreBrazil

Scanning electrochemical microscopy(SECM)and scanning vibrating electrode technique(SVET)were used to investigate the electrochemical behaviour of the top surface of the 2098-T351 alloy welded by friction stir welding(FSW).The SVET technique was efficient in identifying the cathodic and anodic weld *** welding joint(WJ),which comprises the thermomechanically affected zone(TMAZ)and the stir zone(SZ),was cathodic relative to the heated affected zone(HAZ)and the base metal(BM).The reactivities of the welding joint at the advancing side(AS)and the retreating side(RS)were analyzed and compared using SECM technique in the competition mode by monitoring the dissolved oxygen as a redox mediator in 0.005 mol L^-1 NaCl *** RS was more electrochemically active than the AS,and these results were correlated with the microstructural features of the welded alloy.

关键词： Aluminum alloys Friction stir welding Localized corrosion

Local renin angiotensin system and sperm DNA fragmentation

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Asian Journal of Andrology 2022年第2期24卷 139-146页

作者： María victoria Aparicio Prieto María victoria Rodríguez Gallego Asier Valdivia Palacín Yosu Franco Iriarte Gotzone Hervás barbara Enrique Echevarría Orella Luis Casis Saenz Human Reproduction Unit Cruces University HospitalBarakaldo 48903Spain Human Reproduction Unit San Pedro HospitalLogroño 26006Spain Department of Physiology Faculty of Medicine and NursingUniversity of the Basque Country(UPV/EHU)Leioa 48940Spain Human Reproduction Unit Ruber International HospitalMadrid 28034Spain

The renin angiotensin system(RAS)appears to influence male fertility at multiple *** this work,we analyzed the relationship between the RAS and DNA *** male volunteers were divided into two groups(25 each):control(DNA fragmentation≤20%)and pathological(DNA fragmentation>20%)*** of five peptidases controlling RAS were measured fluorometrically:prolyl endopeptidase(which converts angiotensin[A]I and A II to A 1–7),neutral endopeptidase(NEP/CD10:A I to A 1–7),aminopeptidase N(APN/CD13:A III to A IV),aminopeptidase A(A II to A III)and aminopeptidase B(A III to A IV).Angiotensin-converting enzyme(A I to A II),APN/CD13 and NEP/CD10 were also assessed by semiquantitative cytometry and quantitative flow cytometry assays,as were the receptors of all RAS components:A II receptor type 1(AT1R),A II receptor type 2(AT2R),A IV receptor(AT4R or insulin-regulated aminopeptidase[IRAP]),(pro)renin receptor(PRR)and A 1–7 receptor or Mas receptor(MasR)None of the enzymes that regulate levels of RAS components,except for APN/CD13(decrease in fragmented cells),showed significant differences between both *** of RAS receptors revealed no significant differences in immunolabeling patterns between normozoospermic and fragmented *** of AT1R(94.3%normozoospermic vs 84.1%fragmented),AT4R(96.2%vs 95.3%)and MasR(97.4%vs 87.2%)was similar between the ***2R(87.4%normozoospermic vs 63.1%fragmented)and PRR(96.4%vs 48.2%)were higher in non-fragmented *** findings suggest that fragmented DNA spermatozoa have a lower capacity to respond to bioactive RAS peptides.

关键词： DNA fragmentation local renin angiotensin system sperm fertility

Nucleation of recrystallization in magnesium alloy grains of varied orientation and the impacts on texture evolution

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Journal of Magnesium and Alloys 2022年第11期10卷 3041-3053页

作者： victoria M.Miller Jian-Feng Nie Tresa M.Pollock Department of Materials Science and Engineering University of FloridaGainesvilleFL 32611USA Department of Materials Science and Engineering Monash UniversityVictoria 3800Australia Materials Department University of California Santa BarbaraSanta BarbaraCA 93106-5050USA

Selection of appropriate thermomechanical processing parameters is crucial for control of the crystallographic texture and grain size distribution in wrought magnesium alloys, which in turn dictate their mechanical properties. In this work, the recrystallization behavior of binary Mg-Zn alloys are examined after warm rolling as a function of alloy content and heat treatment temperature. The Avrami exponent increased with increasing heat treatment temperature up to the Mg Zn solvus, while the strength of the recrystallization texture *** the Avrami exponent nor the qualitative trends in texture evolution were sensitive to the Zn alloying content in the examined *** and transmission electron microscopy observations revealed that the changes in texture and recrystallization kinetics could be attributed to differences in the nucleation behavior of basal and off-basal orientations.

关键词： Magnesium alloys Recrystallization Dislocation substructure Texture

利用位置测量的单点和两点差分跟踪起始算法的比较研究(英文)

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自动化学报 2008年第3期34卷 258-265页

作者： MALLICK Mahendra LA SCALA barbara 1048 Highland Drive Del Mar CA 92014USA Melbourne Systems Laboratory Department of Electrical and Electronic EngineeringUniversity of MelbourneVictoria3010Australia

我们考虑初始化当时，与将近经常的速度移动的一个目标的追踪的过滤器的问题位置 -- 仅仅(1D,2D， or3D ) 大小是可得到的。Kalman 过滤器为如此的一个问题是最佳的，这被知道，如果它正确地被初始化。我们比较一单个点并且著名二点的... 详细信息

我们考虑初始化当时，与将近经常的速度移动的一个目标的追踪的过滤器的问题位置 -- 仅仅(1D,2D， or3D ) 大小是可得到的。Kalman 过滤器为如此的一个问题是最佳的，这被知道，如果它正确地被初始化。我们比较一单个点并且著名二点的差别轨道初始化算法。我们经分解表演如果过程噪音接近零，过去常初始化速度变化的一个目标的最大的速度接近无穷，那么，单个点的算法归结为二点的差别算法。我们出现的现在的数字结果单个点的算法在均方差意义比二点的差别算法更好一致地表现。我们也介绍支持这一般来说是真的 conjecture 的分析结果。

关键词：位置测量跟踪开始算法卡尔曼滤波器无偏估计值最小均方差

Use of a neoprene binding to reduce giant omphaloceles followed by delayed closure

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World Journal of Pediatric Surgery 2021年第4期4卷 21-43页

作者： barbara Lelj-Garolla Lorena Campbell Jaideep Kanungo Naomi Yoshida Department of Paediatrics The University of British Columbia Faculty of MedicineVancouverBritish ColumbiaCanada Department of Paediatrics Victoria General HospitalVictoriaBritish ColumbiaCanada Department of General Surgery The University of British Columbia Faculty of MedicineVancouverBritish ColumbiaCanada Department of General Surgery Victoria General HospitalVictoriaBritish ColumbiaCanada

Omphaloceles occur in about 1 in 5000 births and are the second most common congenital abdominal wall defects.1 Repair remains a surgeon’s preference with early closure only attempted for small-to medium omphalo-celes,while delayed closure is used for giant omphaloceles.2-4 In recent years,novel tech-niques that aim at reducing the disproportion between the abdominal cavity and the volume of the extra-abdominal viscera have been described to manage giant omphaloceles.

关键词： closure halo les

Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn's disease

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World Journal of Gastroenterology 2017年第27期23卷 4958-4967页

作者： Uri Netz Jane victoria Carter Maurice Robert Eichenberger Gerald Wayne Dryden Jianmin Pan Shesh Nath Rai Susan Galandiuk Price Institute of Surgical Research the Hiram C.Polk Jr.MD Department of SurgeryUniversity of Louisville School of Medicine Department of Surgery A Soroka University Medical Center Faculty of Health Sciences Ben-Gurion University of the Negev Department of Medicine Division of GastroenterologyHepatology and Nutrition University of Louisville School of Medicine Louisville Department of Bioinformatics and Biostatistics University of Louisville School of Public Health and Information Sciences

To investigate genetic factors that might help define which Crohn’s disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODSThis was a prospective cohort study. Patients were recruited from a university digestive disease practice database. We included CD patients who received anti-TNF therapy, had available medical records (with information on treatment duration and efficacy) and who consented to participation. Patients with allergic reactions were excluded. Patients were grouped as ever-responders or non-responders. Genomic DNA was extracted from peripheral blood, and 7 single nucleotide polymorphisms (SNPs) were assessed. The main outcome measure (following exposure to the drug) was response to therapy. The patient genotypes were assessed as the predictors of outcome. Possible confounders and effect modifiers included age, gender, race, and socioeconomic status disease, as well as disease characteristics (such as Montreal criteria). RESULTS121 patients were included. Twenty-one were non-responders, and 100 were ever-responders. Fas ligand SNP (rs763110) genotype frequencies, TNF gene -308 SNP (rs1800629) genotype frequencies, and their combination, were significantly different between groups on multivariable analysis controlling for Montreal disease behavior and perianal disease. The odds of a patient with a Fas ligand CC genotype being a non-responder were four-fold higher as compared to a TC or TT genotype (P = 0.009, OR = 4.30, 95%CI: 1.45-12.80). The presence of the A (minor) TNF gene -308 allele correlated with three-fold higher odds of being a non-responder (P = 0.049, OR = 2.88, 95%CI: 1.01-8.22). Patients with the combination of the Fas ligand CC genotype and the TNF -308 A allele had nearly five-fold higher odds of being a non-responder (P = 0.015, OR = 4.76, 95%CI: 1.35-16.77). No difference was seen for the remaining SNPs. CONCLUSIONThe Fas-ligand SNP and TNF gene -308 SNP are associated with anti-TNF treatment

关键词： Anti-tumor necrosis factor Fas ligand Antibody Response Crohn’s disease Single nucleotide polymorphisms Genotype Tumor necrosis factor gene

Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features

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Science Bulletin 2020年第15期65卷 1281-1296,M0004页

作者： Xiangmin Lv Chunbo He Cong Huang Guohua Hua Xingcheng Chen barbara K.Timm victoria M.Maclin Abigail A.Haggerty Shelly K.Aust Denae M.Golden Bhavana J.Dave Yun-An Tseng Li Chen Hongbo Wang Peichao Chen David L.Klinkebiel Adam R.Karpf Jixin Dong Ronny I.Drapkin Bo R.Rueda John S.Davis Cheng Wang Vincent Center for Reproductive Biology Department of Obstetrics and GynecologyMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Olson Center for Women's Health Department of Obstetrics and GynecologyUniversity of Nebraska Medical CenterOmahaNE 68198USA College of Animal Sciences and Veterinary Medicine Huazhong Agricultural UniversityWuhan 470000China Fred&Pamela Buffett Cancer Center University of Nebraska Medical CenterOmahaNE 68198USA Department of Pathology and Microbiology.University of Nebraska Medical Center OmahaNE 68198USA Heartland Center for Reproductive Medicine OmahaNE 68198USA Munroe-Meyer Institute University of Nebraska Medical CenterOmahaNE 68198USA Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China College of Life and Environmental Science Wenzhou UniversityWenzhou 325035China Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNE 68198USA Department of Obstetrics and Gynecology University of PennsylvaniaPhiladelphiaPA 19104USA

Understanding the cell-of-origin of ovarian high grade serous cancer(HGSC)is the prerequisite for efficient prevention and early diagnosis of this most lethal gynecological ***,a mesenchymal type of ovarian HGSC with the poorest prognosis among ovarian cancers was identified by both TCGA and AOCS *** cell-of-origin of this subtype of ovarian cancer is *** pursuing studies to understand the role of the Hippo pathway in ovarian granulosa cell physiology and pathology,we unexpectedly found that the Yes-associated protein 1(YAP1),the major effector of the Hippo signaling pathway,induced dedifferentiation and reprogramming of the ovarian granulosa cells,a unique type of ovarian follicular cells with mesenchymal lineage and high plasticity,leading to the development of high grade ovarian cancer with serous *** research results unveil a potential cell-of-origin for a subtype of HGSC with mesenchymal features.

关键词： Ovarian granulosa cells Cell reprogramming Cell dedifferentiation The Hippo pathway YAP1 oncogene Mesenchymal type of high grade serous cancer

Recent investigations on the distribution of avian hepatitis E virus in Europe

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Recent investigations on the distribution of avian hepatitis...

Protocol for the development and validation of a clinical measurement tool for fear of disease progression and recurrence in cardiac patients

The 15th World Veterinary Poultry Congress

作者： Ivana Bilic barbara Jaskulska Chris Morrow Michael Hess Department for Farm Animals and Herd Management University of Veterinary Medicine Vienna Austria. Department for Farm Animals and Herd Management University of Veterinary Medicine Vienna Austria. Bioproperties RingwoodVictoriaAustralia Department for Farm Animals and Herd Management University of Veterinary Medicine Vienna Austria.

＜正＞Hepatitis E viruses（HEV）are emerging pathogens belonging to a newly recognized family of RNA virus- es（Hepeviridae）.They are non-enveloped,positive-sense,single-stranded RNA viruses with icosahedral sym- ***...

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Chronic Diseases and Translational Medicine 2024年第3期10卷 195-204页

作者： Sarah T.Clarke Michael Le Grande barbara M.Murphy Robert Hester Alun C.Jackson Melbourne School of Psychological Sciences University of MelbourneParkvilleVictoriaAustralia Australian Centre for Heart Health MelbourneVictoriaAustralia Centre on Behavioral Health University of Hong KongPokfulamHong KongChina

Introduction: One in two cardiac patients fear having another heart event or their heart condition getting worse. Research in other chronic illnesses demonstrates that screening for fear of progression and recurrence is vital for adequately addressing such concerns in clinical care. The current project aims to develop and validate a measure for fear of progression and recurrence in cardiac ***: The Fear of Cardiac Recurrence and Progression Scale (FCRP) will be developed through a multistep process. An initial item pool will be generated through a review of the literature and existing measures and consultation with and feedback from key informants. The item pool will be tested in a sample of over 250 adults who have ever had an acute coronary event, undergone cardiac surgery, or a chronic cardiac condition. Exploratory factor analysis will be used to identify the underlying factors, and Rasch analysis will be used to reduce the number of items. A short form version of the FCRP will be developed for use as a brief screening tool, informed by clinical relevance and Rasch psychometric ***: While many cardiac patients experience fears related to the progression or recurrence of their illness, there remains the need for a validated tool with which these concerns can be identified and measured. It is expected that the design and validation of the FCRP will aid identification of cardiac patients suffering from clinically significant levels of fear of progression and recurrence and facilitate the design of tailored psychological interventions to target these fears.

关键词： anxiety cardiac anxiety cardiac recovery cardiac rehabilitation depression fear of progression fear of recurrence psychological measurement psychosocial screening

Accretion in strong field gravity with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field Theory and Particle Physics and Department of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera Department of Physics and Astronomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of Physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of Physics Anhui Normal University Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of Physics and Research Centre for Computational Physics and Data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of Physics Middle East Technical University Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di Padova INFN-TIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion