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Commentary on "Association of daily sitting time and leisure-time physical activity with body fat among ***"

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Journal of sport and Health science 2024年第2期13卷 127-129页

作者： barbara E.Ainsworth school of Exercise and Health Shanghai University of SportShanghai 200438China

In their study,association of daily sitting time and leisure-time physical activity (LTPA) with body fat among ***,Liao et al.^(1) analyzed data from the 2011-2018 National Health and Examination survey to examine associations between h/day sitting,meeting (or not meeting) the *** Activity Guidelines of≥150 min/week of moderate-and vigorous-intensity LTPA,and combinations of sitting time and LTPA on totaland trunk percent body fat (BF%).

关键词： U.s. adult among

Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

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Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： Peter Zorn Jaime Calvo sánchez Tala Alakhras barbara schreier Michael Gekle stefan Hüttelmaier Marcel Köhn Junior Group‘Non-coding RNAs and RBPs in Human Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein Institute of Physiology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Institute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein ***,it remains challenging to identify physiologically relevant and tissue-selective proteins that are generated by alternative ***,we investigated the target spectrum of the splicing factor Rbfox1 in the cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adhesion proteins as alternative splicing targets of *** focused on the alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both as potential Rbfox1 *** analyses suggested that both isoforms are promoted by Rbfox1 due to binding in the *** adhesions play an important role in the cardiac muscle context,since they mainly influence cell shape,cytoskeletal organization,and cell–matrix *** data confirmed that depletion of Rbfox1 changed cardiomyoblast morphology,cytoskeletal organization,and multinuclearity after differentiation,which might be due to changes in alternative splicing of focal adhesion ***,our results indicate that Rbfox1 promotes alternative splicing of focal adhesion genes in cardiac muscle cells,which might contribute to heart disease progression,where downregulation of Rbfox1 is frequently observed.

关键词： Rbfox1 alternative splicing focal adhesion cardiac muscle cells

A systematic literature review and bibliometric analysis of sources and analytical approaches of indoor microplastics

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Emerging Contaminants 2024年第1期10卷 1-16页

作者： Nisarg Mehta barbara Kozielska Department of Air Protection Faculty of Energy and Environmental EngineeringSilesian University of Technology22B Konarskiego St.44-100GliwicePoland

This systematic review and bibliometric analysis offer a comprehensive exploration of microplastics(MPs)in indoor air environments up to *** article provides robust insights into the most recent advancements,source identification,and suitable analytical methodologies for emergent indoor *** systematic review was performed according to PRIsMA *** selection procedure involved searching three prestigious journal databases,Web of science,scopus,and PubMed,with a variety of search queries and stringent inclusion and exclusion *** bibliometric analysis provides a quantitative assessment of the global research output,revealing a notable upsurge in scholarly activity commencing in 2017,potentially catalysed by the heightened awareness of indoor air quality issues amid the COVID-19 *** publication sources,such as“science of the Total Environment”and“Environmental Pollution,”are outlined to shed light on the academic conduits in this *** addition,the analysis reveals a hierarchy of research output,with China at the top of the list,followed by Australia,Iran,and *** research efforts between the United states and China have become a prominent feature of the research landscape as a result of this prolific *** review highlights the need for standardised protocols in the collection,preparation,and examination of indoor MP *** significant role ventilation systems play in the dispersion dynamics of MPs in confined spaces is *** the prospective sources and properties of indoor MPs,this review's findings can raise awareness among architects,interior designers and product designers,as well as researchers.

关键词： Microplastic Indoor dust IAQ Bibliometric analysis PRIsMA

Nonuniform Dependence on the Initial Data for solutions of Conservation Laws

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Communications on Applied Mathematics and Computation 2024年第1期6卷 489-500页

作者： John M.Holmes barbara Lee Keyfitz Department of Mathematics The Ohio State UniversityColumbusOH43210USA

In this paper,we study systems of conservation laws in one space *** prove that for classical solutions in sobolev spaces H^(s),with s>3/2,the data-to-solution map is not uniformly *** results apply to all nonlinear s... 详细信息

关键词： Conservation laws Data-to-solution map Nonuniform dependence

Effect of Processing and Cultivar on Thermo-Chemical Properties of Australian-Grown Hemp Hurd(Cannabis sativa L.)

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Journal of Renewable Materials 2024年第8期12卷 1475-1493页

作者： Johannes Fehrmann Benoit Belleville barbara Ozarska Maya Ismayati Wahyu Dwianto school of Agriculture Food and Ecosystem Sciences(SAFES)Faculty of ScienceThe University of MelbourneMelbourne3121Australia Research Center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)Jakarta16911Indonesia

This study explored the thermo-chemical properties of industrial hemp hurd with different provenances,maturity stages,and retting *** findings were then compared to hemp hurd used in the fabrication of citric acid-bonded ultra-low-density hemp hurd ***-gas chromatography-mass spectrometry(Py-GC/Ms),Fourier-transform infrared spectroscopy(FTIR),and thermogravimetric analysis(TGA)were employed to document the variability of the hurd and comprehend the potential impact on biobased composite *** choice of cultivar,maturity stage,and processing modality significantly influenced the chemical composition,presence of functional groups,and thermal stability of the ***-GC/Ms revealed substantial variations in the lignin-to-carbohydrate(L/C)ratio,along with the absence of fatty acids in certain *** FTIR signals confirmed consistent functional groups,differences in peak intensities were indicative of carbohydrate variations associated with maturity and retting duration,impacting the availability of hydroxyl groups for,i.e.,interparticle bonding in citric acid-based ***,it was observed that shorter retting durations initially enhanced the thermal resistance,but prolonged retting led to accelerated degradation,significantly reducing the hurd’s residual *** findings indicated notable differences among the samples,emphasizing the importance of investigating variables such as provenance/cultivar,maturity,and processing *** assessment is essential to ensure effective agronomic practices that align the raw material characteristics with the specific requirements of intended applications,such as the fabrication of biobased hemp hurd composites.

关键词： Hemp hurd material characterization chemical analysis thermal analysis

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Commentary on

Journal of sport and Health science 2024年第5期13卷 672-673页

作者： barbara E.Ainsworth Zeyun Feng school of Exercise and Health Shanghai University of SportShanghai 200438China

In Volume 13,Issue 1,of the Journal of sport and Health science,Herold et al.1 present a systematic review and classification of digital and home-based physical training interventions aiming to support healthy cognitive *** interventions were reviewed:digital databases(i.e.,YouTube videos and apps),online classes,and technology-based exercise devices(e.g.,exergames).

关键词： cognitive games aging

A novel homozygous missense variant in ARsK causes MPs X,a new subtype of mucopolysaccharidosis

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Genes & Diseases 2024年第3期11卷 87-90页

作者： Miao sun Cornelia K.Kaminsky Philip Deppe Mai-Brittllse Frederic M.Vaz barbara Plecko Torben Lubke Linda M.Randolph Division of Genomic Medicine Department of Pathology and Laboratory MedicineChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Radiology Children's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Chemistry BiochemistryBielefeld UniversityBielefeld 33615Germany Amsterdam UMC Location University of Amsterdam Department of Clinical Chemistry and PediatricsLaboratory Genetic Metabolic DiseasesEmma Children's HospitalMeibergdreef 9Amsterdam 1100 DEthe Netherlands Amsterdam Gastroenterology Endocrinology Metabolism Inborn Errors of MetabolismAmsterdam 1105 BKthe Netherlands Core Facility Metabolomics Amsterdam UMC Location University of AmsterdamAmsterdam 1100DDthe Netherlands Department of Pediatrics Division of General PediatricsMedical Universityof GrazGraz8036Austria Division of Medical Genetics Department of PediatricsChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA

Mucopolysaccharidoses(MPs)are a group of rare inborn errors of metabolism caused by defective lysosomal enzymes which prevent cells from degrading and recycling certain carbohydrates and fats,resulting in the storage of glycosaminoglycans in cells throughout the *** leads to multisystem abnormalities involving bone,connective tissues,brain,blood,spinal cord,skin,and other tissues.

关键词： metabolism doses polys

Ca^(2+) binding to the C_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

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Protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin slitin Jakob Neef shashank s.Chepurwar Regina Célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,Jr. Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann Nicola strenzke barbara Vona Julia Preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory systems Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging Cluster of Excellence(MBExC) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended background in supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see supplementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

A brief history of the Compendium of Physical Activities

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Journal of sport and Health science 2024年第1期13卷 3-5页

作者： barbara E.Ainsworth stephen D.Herrmann David R.Jacobs Jr. Melicia C.Whitt-Glover Catrine Tudor-Locke school of Exercise and Health Shanghai University of SportShanghai 200438China College of Health solutions Arizona State UniversityPhoenixAZ 85003USA Kansas Center for Metabolism and Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA Division of Epidemiology and Community Health University of MinnesotaMinneapolisMN 55455USA Gramercy Research Group KnightdaleNC 27545USA College of Health and Human services University of North Carolina at CharlotteCharlotteNC 28223USA

The Compendium of Physical Activities(Compendium)was developed to address consistent assignment of physical activity(PA)intensity values used in PA epidemiology research of the association between PA and health outcomes.1The known protective effects of PA on incident health outcomes traces to the mid-1900s,with over 50 studies examining coronary heart disease(CHD)as the outcome of interest.

关键词： epidemiology Activities protective