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Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma

World Journal of Gastroenterology 2015年第42期21卷 12157-12170页

作者： Amy P Chiu barbara r tschida Lilian H Lo Branden S Moriarity Dewi K rowlands David A Largaespada Vincent W Keng Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Masonic Cancer Center Department of PediatricsCenter for Genome Engineering University of Minnesota Laboratory Animal Services Centre The Chinese University of Hong Kong Sha Tin New Territories

The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia.

关键词： Hepatocellular carcinoma Hepatitis B virus Transpo

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