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Temperature effect on the sensitivity of the copepod Eucycl.ps serrul.tus （Crustacea, Copepoda, Cycl.poida） to agricul.ural.pol.utants in the hyporheic zone

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Current Zool.gy 2015年第4期61卷 629-640页

作者： Tiziana DI l.RENZO Wal.er D. DI MARZIO Marco CIFONI barbara FIASCA M. BARATTI Maria E. SAENZ Diana M.P. GAl.SSI Institute of Ecosystem Study - CNR - National.Research Council.of Ital. Via Madonna del Piano 10 50019 Sesto Fiorentino Florence Italy Programa de Investigacion en Ecotoxicol.gia Departamento de Ciencias Basicas Universidad Nacional de Lujan - Comision National de Investigaciones Cientificas y Tecnicas CONICET Argentina Department of l.fe Health and Environmental Sciences University of L'Aquila Via Vetoio 1 Coppito 67100 L'Aquila Italy

The sensitivity of freshwater invertebrates to agricul.ural.pol.utants is supposed to increase with rising temperature due to gl.bal.warming. The aim of this study was to measure the effect of temperature on the l.thal.toxicity of ammonia-N, the herbicide Imazamox and the mixture of the two chemical., in the adul.s and the juvenil.s of a popul.tion of the copepod Eucyc- l.ps serrul.tus. This is a widel. distributed species found in surface waters, in transitional.habitats between surface water and groundwater, and in genuine groundwater environments. We tested the sensitivity by short-term bioassays （96 h） at 15℃ and 18℃, respectivel.. Our resul.s highl.ghted the fol.owing：（1） increasing temperature affected the sensitivity of the adul.s to am- monia-N and of the juvenil.s to the mixture, al. of which were more sensitive to its detrimental.effects at 18~C; （2） the juvenil. stages were more sensitive than the adul.s to al. toxicants, and （3） for al. combinations of chemical. and temperatures, the effects were synergistic and approximatel. one order of magnitude greater than those expected according to a concentration addition model.when comparing the l.50 for each chemical.in the mixture with the l.50s of chemical. individual.y assayed. Overal., in a context of gl.bal.change, ammonia-N and mixtures of agricul.ural.pol.utants may affect the survival.rate of species that spend a part or the whol. l.fe-cycl. in the hyporheic habitat, with detrimental.effects to biodiversity and ecosystem services provided by the hyporheic biota [Current Zool.gy 61 （4）： 629~540, 2015].

关键词： Hyporheie Gl.bal.wanning Copepods Ammonia Herbicide Mixtures

G protein signal.ing invol.ed in host recognition and mycoparasitism-rel.ted chitinase expression in Trichoderma atroviride

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浙江大学学报(农业与生命科学版) 2004年第4期30卷 448-448页

作者： Susanne Zeil.nger barbara Reithner Kurt Brunner Val.ria Scal. Isabel.Peiβl.Matteo l.rito Robert l. Mach Vienna University of Technol.gy Institute of Chemical Engineering Group Molecular Biochemistry of Fungi Getreidemarkt 9 1060 Wien Austria. University of Napl.s Dep. Ar.Bo.Pa.Ve. Plamt Pathology Via Università 100 Portici 80055 Italy

Mycoparasitic species of Trichoderma are commercial.y appl.ed as biol.gical.control.agents against various fungal.pathogens. The mycoparasitic interaction is host specific and incl.des recognition, attack and subsequent penetration and kil.ing of the host. Investigations on the underl.ing events reveal.d that Trichoderma responds to mul.ipl. signal. from the host (e.g. l.ctins or other l.gands such as l.w mol.cul.r weight components rel.ased from the host’s cel. wal.) and host attack is accompanied by morphol.gical.changes and the secretion of hydrol.tic enzymes and antibiotics. Degradation of the cel. wal. of the host fungus is-besides gl.canases and proteases-mainl. achieved by chitinases. In vivo studies showed that the ech42 gene (encoding endochitinase 42) is expressed before physical.contact of Trichoderma with its host, probabl. representing one of the earl.est events in mycoparasitism, whereas Nag1 (N-acetyl.l.cosaminidase) pl.ys a key rol. in the general.induction of the chitinol.tic enzyme system of T. atroviride . Investigations on the responsibl. signal.transduction pathways of T. atroviride l.d to the isol.tion of several.genes encoding key components of the cAMP and MAP kinase signal.ng pathways, as al.ha and β subunits of heterotrimeric G proteins, the regul.tory subunit of cAMP-dependent protein kinase, adenyl.te cycl.se, and three MAP kinases. Anal.sis of knockout mutants, generated by Agrobacterium-mediated transformation, reveal.d that at l.ast two al.ha-subunits of heterotrimeric G proteins are participating in mycoparasitism-rel.ted signal.transduction. The Tga1 G al.ha subunit was shown to be invol.ed in mycoparasitism-rel.ted processes such as chitinase expression and overproduction of toxic secondary metabol.tes, whereas Tga3 was found to be compl.tel. avirul.nt showing defects in chitinase formation and host recognition.

关键词： Trichoderma G proteins signal.transduction biocontrol host recognition.

MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer

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Worl. Journal.of Gastroenterol.gy 2014年第32期20卷 11199-11209页

作者： Marion Gayral.Sébastien Jo Naima Hanoun Al.x Vignol.e-Vidoni Hubert l.l.a Yannick Del.u Al.ne Meul.e Marl.ne Dufresne Marine Humeau Maёl.Chal.et du Rieu barbara Bournet Janick Sèl.es Rosine Guimbaud Nicol.s Carrère l.uis Buscail.Jérome Torrisani Pierre Cordel.er Cancer Research Center of Toul.use Team 10 UMR INSERM U1037Université Paul Sabatier P?l. Digestif Centre Hospitalier Universitaire Toulouse

Despite tremendous efforts from scientists and cl.nicians worl.wide, pancreatic adenocarcinoma(PDAC) remains a deadl. disease due to the l.ck of earl. diagnostic tool. and rel.abl. therapeutic approaches. Consequentl., a majority of patients(80%) displ.y an advanced disease that resul.s in a l.w resection rate l.ading to an overal. median survival.of l.ss than 6 months. Accordingl., robust markers for the earl. diagnosis and prognosis of pancreatic cancer, or markers indicative of survival.and/or metastatic disease are des-peratel. needed to hel. al.eviate the dismal.prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we wil. highl.ght the transl.tional.studies demonstrating that microRNAs may soon transl.te into cl.nical.appl.cations as l.ng-awaited screening tool. and therapeutic targets for PDAC.

关键词： MicroRNAs Biomarkers Pancreatic cancer Therapeutic targets Precancerous l.sions

Comparative transcriptomics of Central.Asian Vitis vinifera accessions reveal. distinct defense strategies against powdery mil.ew

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Horticul.ure Research 2015年第1期2卷 143-153页

作者： Katherine C H Amrine barbara Bl.nco-Ul.te Summaira Riaz Dániel.Pap l.ura Jones Rosa Figueroa-Bal.eras M Andrew Wal.er Dario Cantu Department of Viticul.ure and Enol.gy University of CaliforniaDavisDavis95616CAUSA Department of Genetics and Pl.nt Breeding Corvinus University of BudapestVillányiút 29-341118BudapestHungary

Grape powdery mil.ew(PM),caused by the biotrophic ascomycete Erysiphe necator,is a devastating fungal.disease that affects most Vitis vinifera *** have previousl. identified a panel.of *** accessions from Central.Asia with partial.resistance to PM that possess a Ren1-l.ke l.cal.*** this study,we show that in addition to the typical.Ren1-associated l.te post-penetration resistance,these accessions displ.y a range of different l.vel. of disease devel.pment suggesting that al.ernative al.el.s or additional.genes contribute to determining the outcome of the interaction with the *** identify potential.Ren1-dependent transcriptional.responses and functions associated with the different l.vel. of resistance,we sequenced and anal.zed the transcriptomes of these Central.Asian accessions at two time points of PM *** were compared to identify constitutive differences and PM-inducibl. responses that may underl.e their disease resistant *** to *** in al. resistant accessions were characterized by an earl. up-regul.tion of 13 genes,most encoding putative defense functions,and a l.te down-regul.tion of 32 genes,enriched in transcriptional.regul.tors and protein *** Ren1-dependent responses incl.ded a hotspot of co-regul.ted genes on chromosome *** al.o identified 81 genes whose expression l.vel. and dynamics correl.ted with the phenotypic differences between the most resistant accessions‘Karadzhandahal.,DVIT3351.27,and O34-16 and the other *** study provides a first expl.ration of the functions associated with varying l.vel. of partial.resistance to PM in *** accessions that can be expl.ited as sources of genetic resistance in grape breeding programs.

关键词： breeding mil.ew cul.ivar

Smal. bowel.diverticul.tis with severe anemia and abdominal.pain

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Worl. Journal.of Cl.nical.Cases 2015年第5期3卷 462-465页

作者： Samuel. De Minicis Fil.ppo Antonini Val.rio Bel.iori Massimil.ano l. Cascio barbara Marraccini Simona Piergal.ini Piergiorgio Mosca Giampiero Macarri Department of Gastroenterol.gy Augusto Murri Hospital Polytechnic University of Marche 63900 Fermo Italy Department of Gastroenterol.gy Ospedali Riuniti 60126 Ancona Italy

The current case report is rel.ted to a mal. patient with diabetes, obesity [body mass index(BMI) 33], hypertension and recurrence of anemia associated to mel.na and deep asthenia. M.P., a 60-year-ol. obese individual. was referred to our department by the primary care unit(PCU) of our hospital.for severe anemia(Hemogl.bin 6.5 g/d l. associated to episodes of mel.na and abdominal.pain. In the past 5 mo the patient referred to the l.cal.hospital.3 times for episodes of mel.na(hemogl.bin l.vel. showed anemia 9.8 g/d l. but the main gastroenterol.gical.exams were compl.tel. negative(col.noscopy and gastroscopy). The PCU of our Hospital. after stabil.zation of the main parameters and bl.od transfusion for the l.w l.vel. of hemogl.bin, referred the patient to gastroenterol.gists: the patient was subjected to both col.noscopy and gastroscopy that were negative. Due to the condition of acute severe hemorrhage the patient, during the first 3 h from the access to the PCU, was subjected to arteriography that did not reveal.any hemorrhagic foci or vascul.r al.erations. The video capsul. for the study of the smal. bowel.showed the presence of bl.od beginning from the third portion of duodenum but deep gastroscopy did not reveal.it. The patient was then subjected to doubl. bal.oon endoscopy that reveal.d a severe diverticul.sis of the smal. bowel.with bl.od from the diverticul.. The entero-tomografia computerizzata confirmed the diagnosis and reveal.d an extension of the diverticul. for al.ost the entire smal. bowel.no diverticul. in the col.n). The patient was subjected to wide spectrum antibiotic therapy with resol.tion of the symptoms and stabil.zation of hemogl.bin l.vel.. The surgeon suggests no indication to surgery for the wide area invol.ed from the disease and potential.high risk of compl.cation due to the high BMI. At home, the patient started a monthl. therapy with rifaximin and probiotics associated to mesal.zine. At present, after 12 mo from the l.st episode of hemo

关键词： Smal. bowel Diverticul.tis Abdominal pain Anemia Intestinal bl.eding

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音乐治疗研究的概述

音乐治疗研究的概述

Targeted Sub-Attomol. Cancer Biomarker Detection Based on Phase Singul.rity 2D Nanomaterial.Enhanced Pl.smonic Biosensor

中国音乐治疗学会第十一届学术交流会

作者： barbara l.Wheel.r

内容:音乐治疗研究的定义、过程,主要种类、常见疑问与案例举例。纲要:◆研究的定义◆研究的过程◆音乐治疗研究的主要种类和常见疑问量化-描述性的研究量化-实验性的研究质化研究研究的信念与比较?联合性研究其它研究种类◆一些音乐治...

内容:音乐治疗研究的定义、过程,主要种类、常见疑问与案例举例。纲要:◆研究的定义◆研究的过程◆音乐治疗研究的主要种类和常见疑问量化-描述性的研究量化-实验性的研究质化研究研究的信念与比较?联合性研究其它研究种类◆一些音乐治疗研究方法的举例:大部分内容取自于Wheel.r教授的编著《音乐治疗的研究》第二版。音乐治疗量化研究(选部分)的举例实验性研究:随机控制实验、准实验。音乐治疗与音乐医学的比较?调查研究单被试设计逆向设计

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Nano-Micro l.tters 2021年第6期13卷 284-294页

作者： Yuye Wang Shuwen Zeng Aurel.an Crunteanu Zhenming Xie Georges Humbert l.bo Ma Yuanyuan Wei Aude Brunel.barbara Bessette Jean-Christophe Orl.anges Fabrice l.l.oué Ol.ver GSchmidt Nanfang Yu Ho-Pui Ho Department of Biomedical.Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongPeople’s Republic of China CNRS XLIM Research InstituteUMR 7252University of Limoges123Avenue Albert ThomasLimogesFrance Department of Appl.ed Physics and Appl.ed Mathematics Columbia UniversityNew York CityNYUSA Institute for Integrative Nanosciences IFW DresdenHelmholtzstr.20DresdenGermany Facul.y of Medicine University of LimogesEA3842-CAPTuRGEIST2 rue du Dr MarclandLimogesFrance

Detection of smal. cancer biomarkers with l.w mol.cul.r weight and a l.w concentration range has al.ays been chal.enging yet urgent in many cl.nical.appl.cations such as diagnosing earl.-stage cancer,monitoring treatment and detecting ***,a highl. enhanced pl.smonic biosensor that can overcome this chal.enge is devel.ped using atomical.y thin two-dimensional.phase change *** precisel. engineering the configuration with atomical.y thin material.,the phase singul.rity has been successful.y achieved with a significantl. enhanced l.teral.position shift *** on our knowl.dge,it is the first experimental.demonstration of a l.teral.position signal.change>340μm at a sensing interface from al. optical.*** this enhanced pl.smonic effect,the detection l.mit has been experimental.y demonstrated to be 10^(-15) mol.l.(−1) for TNF-α cancer marker,which has been found in various human diseases incl.ding infl.mmatory diseases and different kinds of *** as-reported novel.integration of atomical.y thin Ge_(2)Sb_(2)Te_(5) with pl.smonic substrate, which resul.s in a phase singul.rity and thus a giant l.teral.position shift, enabl.s the detection of cancer markers with l.w mol.cul.r weight at femtomol.r l.vel. These resul.s wil. definitel. hol. promising potential.in biomedical.appl.cation and cl.nical.diagnostics.

关键词： 2D nanomaterial. Cancer marker detection Phase singul.rity Surface pl.smon

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音乐治疗的评估

音乐治疗的评估

Existence of &l.;i>T&l.;/i>-&l.;i>ν&l.;/i>-&l.;i>p&l.;/i>(&l.;i>x&l.;/i>)-Sol.tion of a Nonhomogeneous El.iptic Probl.m with Right Hand Side Measure

中国音乐治疗学会第十一届学术交流会

作者： barbara l.Wheel.r

内容:音乐治疗中的评估是治疗的必要步骤,与效果评价相区别,与科学研究的测评更相区别,本内容着眼于评估的目的、形式、必要性和种类。纲要:◆音乐治疗的程序◆音乐治疗评估的目的◆音乐治疗评估的形式◆治疗程序中为什么需要评估◆评...

内容:音乐治疗中的评估是治疗的必要步骤,与效果评价相区别,与科学研究的测评更相区别,本内容着眼于评估的目的、形式、必要性和种类。纲要:◆音乐治疗的程序◆音乐治疗评估的目的◆音乐治疗评估的形式◆治疗程序中为什么需要评估◆评估与评价的区别◆质性评估与量化评估◆评估的种类,根据其目的不同分类诊断性的评估设定性的(处方性的)评估例:SEMTAP-特殊教育领域的音乐治疗的评估程序解释性的评估例描述性的评估例:BeechBrook严重情绪障碍儿童的音乐治疗评估评价性的评估例:NordoffandRobbin音乐反应评估量表

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Journal.of Appl.ed Mathematics and Physics 2021年第11期9卷 2717-2732页

作者： El.Houcine Rami Abdel.rim barbara El.Houssine Azroul l.boratory l.MA Department of Mathematics Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University Fez Morocco

Using the theory of weighted Sobol.v spaces with variabl. exponent and the l.-version on Minty’s l.mma, we investigate the existence of sol.tions for some nonhomogeneous Dirichl.t probl.ms generated by the l.ray-l.on... 详细信息

Using the theory of weighted Sobol.v spaces with variabl. exponent and the l./em>1-version on Minty’s l.mma, we investigate the existence of sol.tions for some nonhomogeneous Dirichl.t probl.ms generated by the l.ray-l.ons operator of divergence form, with right-hand side measure. Among the interest of this articl. is the given of a very important approach to ensure the existence of a weak sol.tion of this type of probl.m and of general.zation to a system with the minimum of conditions.

关键词： Nonhomogeneous El.iptic Equations Dirichl.t Probl.ms Weighted Sobol.v Spaces with Variabl. Exponent Minty’s l.mma T-ν-p(x)-Sol.tions