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World Journal of Gastroenterology 2014年第43期20卷 16191-16196页

作者： barbara braden Christoph F Dietrich Translational Gastroenterology Unit Oxford University Hospitals NHS TrustOxford OX3 9DUUnited Kingdom Med.Klinik 2 Caritas HospitalUhlandstr.797980 Bad MergentheimGermany

In the last decades,the treatment of pancreatic pseudocysts and necrosis occurring in the clinical context of acute and chronic pancreatitis has shifted towards minimally invasive endoscopic *** procedures can be avoided in many cases by using endoscopically placed,Endoscopic ultrasonography-guided techniques and *** ultrasound enables the placement of transmural plastic and metal stents or nasocystic tubes for the drainage of peripancreatic fluid *** development of selfexpanding metal stents and exchange free delivering systems have simplified the drainage of pancreatic fluid *** review will discuss available therapeutic techniques and new developments.

关键词： Pancreatic pseudocyst Walled-off necrosis Endoscopic ultrasonography-guided drainage Self-expanding metal stent Acute pancreatitis

Sonographic signs of neutropenic enterocolitis

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World Journal of Gastroenterology 2006年第9期12卷 1397-1402页

作者： Christoph F Dietrich Stella Hermann Stefan Klein barbara braden Department of Internal Medicine Cari-tas Hospital Bad Mergentheim Bad MergentheimGermany Medical Department University Hospital Frankfurt/MainGermany

AIM： To investigate the sonographic features at time of diagnosis and follow-up in patients with neutropenic enterocolitis. METHODS： The sonographic findings in 14 patients with neutropenic enterocolitis were described and evaluated regarding symptoms and clinical outcome. RESULTS： In all patients with neutropenic enterocolitis, the ileocoecal region was involved with wall thickening 〉10 mm. A transmural inflammatory pattern, hypervascularity of the thickened bowel wall and free abdominal fluid were the common findings. The sonographically revealed thickness of the bowel wall was associated with lethal outcome （P〈0.03）. In the 11 surviving patients, the improvement of clinical symptoms was accompanied by progressive reduction of intestinal wall thickness. CONCLUSION： High-end sonography of the bowel is a helpful tool for diagnosis, assessment of prognosis and follow-up of patients with neutropenic enterocolitis. The ultrasonographically revealed bowel thickness reflects the severity and the course of the disease, and seems to be predictive for the clinical outcome.

关键词： Neutropenia Bowel wall thickness Ultrasonography

Intraductal papillary mucinous neoplasm in chronic calcifying pancreatitis:Egg or hen?

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World Journal of Gastroenterology 2009年第10期15卷 1273-1275页

作者： Evangelos Kalaitzakis barbara braden Palak Trivedi Yalda Sharifi Roger Chapman Department of Gastroenterology John Radcliffe HospitalOxford OX3 9DUUnited Kingdom Section of Gastroenterology and Hepatology Department of Internal MedicineSahlgrenska University Hospital41345 GothenburgSweden

Intraductal papillary mucinous neoplasm(IPMN)is an increasingly reported *** pancreatic calcification is generally thought to be a sign of chronic pancreatitis,but it may occur simultaneously with IPMN leading to diagnostic *** report a case of a patient initially diagnosed with chronic calcifying pancreatitis who was later shown to have a malignant *** case illustrates potential pitfalls in the diagnosis of IPMN in the case of extensive pancreatic calcification as well as clues that may lead the clinician to suspecting the *** possible mechanisms of the relation between pancreatic calcification and IPMN are also reviewed.

关键词： Intraductal papillary mucinous neoplasm Endoscopic ultrasound Calcifying pancreatitis Carcinoembryonic antigen Endoscopic retrogradecholangiopancreatography

Tunneled biopsy is an underutilised,simple,safe and efficient method for tissue acquisition from subepithelial tumours

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World Journal of Clinical Cases 2021年第21期9卷 5822-5829页

作者： Andreas Koutsoumpas Ruwan Perera Adele Melton Jonathan Kuker Tilak Ghosh barbara braden Translational Gastroenterology Unit Oxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom Senior School Magdalen College SchoolOxford OX40DZUnited Kingdom Translational Gastroenterology Unit Oxford University Hospital NHS Foundation TrustOxford OX39DUUnited Kingdom

BACKGROUND Tissue acquisition from subepithelial lesions is often attempted by endoscopic ultrasound(EUS)-sampling as conventional endoscopic biopsy usually fails to reach deeper layers of the gastrointestinal *** To investigate the utilisation,safety and diagnostic yield of an intensified“biteon-bite”tunnel biopsy *** In this retrospective cohort study,all patients presenting with subepithelial masses in the upper gastrointestinal tract from March 2013 to July 2019 were *** were analysed for size and location of the subepithelial mass,use of intensified tunnel biopsy protocol(more than 10 double bite-on-bite biopsies)or superficial conventional biopsies,histology and imaging results,occurrence of readmission and adverse events after *** Two hundred and twenty-nine patients with subepithelial lesions were *** conventional biopsies were taken in 117 patients and were diagnostic only in one lipoma(0.9%).Tunnel biopsies taken in 112/229(48.9%)patients were significantly more likely to provide histological diagnosis(53.6%;P<0.001).For lesions≥10mm the diagnostic yield of tunnel biopsies further increased to 41/67(61.2%).No immediate or delayed complications were *** 8 of the 51 endoscopists(15.7%)regularly attempted tunnel *** Tunnel biopsy is a simple,safe and efficient but underutilised diagnostic modality for tissue acquisition in subepithelial *** should be routinely attempted at the initial endoscopy.

关键词： Gastrointestinal stromal tumour Fine needle biopsy Lipoma Immunohistology Neuroendocrine tumours Fine needle biopsy

Addition of senna improves quality of colonoscopy preparation with magnesium citrate

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World Journal of Gastroenterology 2009年第14期15卷 1759-1763页

作者： Stergios Vradelis Evangelos Kalaitzakis Yalda Sharifi Otto Buchel Satish Keshav Roger W Chapman barbara braden Department of Gastroenterology John Radcliffe Hospital Oxford OX3 9DU United Kingdom Section of Gastroenterology and Hepatology Department of Internal Medicine Sahlgrenska University Hospital 41345 Gothenburg Sweden

AIM: To prospectively investigate the effectiveness and patient’s tolerance of two low-cost bowel cleansing preparation protocols based on magnesium citrate only or the combination of magnesium citrate and senna. METHODS: A total of 342 patients who were referred for colonoscopy underwent a colon cleansing protocol with magnesium citrate alone (n = 160) or magnesium citrate and senna granules (n = 182). The colonoscopist rated the overall efficacy of colon cleansing using an established score on a 4-point scale. Patients were questioned before undergoing colonoscopy for side effects and symptoms during bowel preparation. RESULTS: The percentage of procedures rescheduled because ofinsufficient colon cleansing was 7% in the magnesium citrate group and 4% in the magnesium citrate/senna group (P = 0.44). Adequate visualization of the colonic mucosa was rated superior under the citramag/senna regimen (P = 0.004). Both regimens were well tolerated, and did not significantly differ in the occurrence of nausea, bloating or ***, abdominal cramps were observed more often under the senna protocol (29.2%) compared to the magnesium citrate only protocol (9.9%, P < 0.0003). CONCLUSION: The addition of senna to the bowel preparation protocol with magnesium citrate significantly improves the cleansing outcome.

关键词： Colonoscopy Bowel preparation Senna Magnesium citrate Polyp

Repeat endoscopic retrograde cholangiopancreaticography after failed initial precut sphincterotomy for biliary cannulation

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World Journal of Gastroenterology 2014年第36期20卷 13153-13158页

作者： Michael Pavlides Ashley Barnabas Nilesh Fernandopulle Adam A Bailey Jane Collier Jane Phillips-Hughes Anthony Ellis Roger Chapman barbara braden Translational Gastroenterology Unit Oxford University Hospitals Oxford OX3 9DU United Kingdom Department of Radiology Oxford Uni-versity Hospitals Oxford OX3 9DU United Kingdom

AIM: To investigate the outcome of repeating endoscopic retrograde cholangiopancreaticography (ERCP) after initially failed precut sphincterotomy to achieve biliary cannulation.

关键词： Mortality Post-endoscopic retrograde cholangio-pancreaticography pancreatitis Precut sphincterotomy Endoscopic retrograde cholangio-pancreaticography Choledocholithiasis

Endoscopic ultrasound-guided drainage of pancreatic walled-off necrosis using self-expanding metal stents without fluoroscopy

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World Journal of Gastrointestinal Endoscopy 2018年第5期10卷 93-98页

作者： barbara braden Andreas Koutsoumpas Michael A Silva Zahir Soonawalla Christoph F Dietrich Translational Gastroenterology Unit Oxford University Hospitals Hepatobiliary Surgery Oxford University Hospitals Caritas Krankenhaus Bad Mergentheim

AIM To investigate whether endoscopic ultrasound(EUS)-guided insertion of fully covered self-expandable metal stents in walled-off pancreatic necrosis(WOPN) is feasible without *** Patients with symptomatic pancreatic WOPN undergoing EUS-guided transmural drainage using self-expandable and fully covered self expanding metal stents(FCSEMS) were included. The EUS visibility of each step involved in the transmural stent insertion was assessed by theoperators as "visible" or "not visible":(1) Access to the cyst by needle or cystotome;(2) insertion of a guide wire;(3) introducing of the diathermy and delivery system;(4) opening of the distal flange; and(5) slow withdrawal of the delivery system until contact of distal flange to cavity wall. Technical success was defined as correct positioning of the FCSEMS without the need of *** In total, 27 consecutive patients with symptomatic WOPN referred for EUS-guided drainage were included. In 2 patients large traversing arteries within the cavity were detected by color Doppler, therefore the insertion of FCSEMS was not attempted. In all other patients(92.6%) EUS-guided transgastric stent insertion was technically successful without fluoroscopy. All steps of the procedure could be clearly visualized by EUS. Nine patients required endoscopic necrosectomy through the FCSEMS. Adverse events were two readmissions with fever and one self-limiting bleeding; there was no procedure-related mortality. CONCLUSION The good endosonographic visibility of the FCSEMS delivery system throughout the procedure allows safe EUS-guided insertion without fluoroscopy making it available as bedside intervention for critically ill patients.

关键词： Necrotizing pancreatitis Peripancreatic fluid collection Therapeutic endoscopic ultrasound Transmural drainage Acute pancreatitis

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合理的检查诊断幽门螺旋杆菌感染

英国医学杂志中文版 2012年第4期15卷 248-251页

作者： barbara braden 张月宁(译) 不详首都医科大学附属北京佑安医院消化内科

本文探讨如何检测幽门螺旋杆菌感染及何时判断治疗是否有效。一名32岁的护士，间断上腹不适5个月余，空腹时尤甚。患者否认体重减轻、反复呕吐、吞咽困难、发热以及排便习惯改变等，亦没有证据表明存在消化道出血。患者无用药史，包括... 详细信息

本文探讨如何检测幽门螺旋杆菌感染及何时判断治疗是否有效。一名32岁的护士，间断上腹不适5个月余，空腹时尤甚。患者否认体重减轻、反复呕吐、吞咽困难、发热以及排便习惯改变等，亦没有证据表明存在消化道出血。患者无用药史，包括非甾体类抗炎药等非处方药物。患者无吸烟史，每周饮酒约4个单位（译者注：125ml、浓度为8％的酒为1个单位）。腹部检查提示上腹轻压痛。

关键词：幽门螺旋杆菌感染检查诊断间断上腹不适非甾体类抗炎药消化道出血非处方药物体重减轻反复呕吐

Heterogeneous patterning of blood-brain barrier and adaptive myelination as renewing key in gray and white matter

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Neural Regeneration Research 2024年第3期19卷 481-482页

作者： barbara Pavan Department of Neuroscience and Rehabilitation University of Ferraravia L BorsariFerraraItalyCenter for Translational Neurophysiology of Speech and Communication(CTNSC)Italian Institute of Technology(IIT)via Fossato di MortaraFerraraItaly

Background:Development and homeostasis of the brain are enabled through the precise control of the cell microenvironment by the blood-brain barrier(BBB),which interfaces between the brain parenchyma and the lumen of blood microvessels,and by the blood-cerebrospinal fluid barrier,which separates the cerebrospinal fluid from the blood vessels of the choroid plexus(Villabona-Rueda et al.,2019).Here,the focus will be on the BBB,the impairment of which is considered the earliest common denominator in neurovascular diseases.

关键词： homeostasis blood

Ultrasonographic imaging of inflammatory bowel disease in pediatric patients

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World Journal of Gastroenterology 2015年第17期21卷 5231-5241页

作者： Liliana Chiorean Dagmar Schreiber-Dietrich barbara braden Xin-Wu Cui Reiner Buchhorn Jian-Min Chang Christoph F Dietrich Sino-German Research Center of Ultrasound in Medicine the First Affiliated Hospital of Zhengzhou University Department of Ultrasonography "Octavian Fodor" Institute of Gastroenterology and Hepatology400162 Cluj-NapocaRomania Medical Department 2 Caritas-KrankenhausD-97980 Bad MergentheimGermany Translational Gastroenterology Unit Oxford University HospitalsOX3 9DU OxfordUnited Kingdom Department of Pediatrics Caritas-KrankenhausD-97980 Bad MergentheimGermany

Inflammatory bowel disease(IBD) is one of the most common chronic gastrointestinal diseases in pediatric *** the optimal imaging modality for the assessment of gastrointestinal disease in pediatric patients can be *** invasiveness and patient acceptance,the radiation exposure and the quality performance of the diagnostic test need to be *** reviewing the literature regarding imaging in inflammatory bowel disease the value of ultrasound in the clinical management of pediatric patients is *** ultrasound is a useful,noninvasive method for the initial diagnosis of IBD in children;it also provides guidance for therapeutic decisions and helps to characterize and predict the course of the disease in individual *** techniques including color Doppler imaging and contrast-enhanced ultrasound are promising imaging tools to determine disease activity and *** studies between different imaging methods are needed.

关键词： Ultrasonography Guidelines Complication Intestine Pediatrics