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*** stem cells repair retinal vascular damage in retinopathy of prematurity mouse model

Annals of Eye Science 2018年第1期 434-434页

作者： baraa noueihed Jose Carlos Rivera Sylvain Chemtob Department of Pharmacology McGill UniversityMontréalQCCanada Research Center Hôpital Maisonneuve-Rosemont Universitéde MontréalMontréalQCCanada Research Center CHU Sainte-Justine Universitéde MontréalMontréalQCCanada Department of Pharmacology Universitéde MontréalMontréalQCCanada Department of Ophthalmology Universitéde MontréalMontréalQCCanada Department of Pediatrics Universitéde MontréalMontréalQCCanada

Background:Retinopathy of prematurity is a leading cause of visual impairment and blindness in *** of premature babies to the hyperoxic extrauterine environment leads to vaso-obliteration(VO),followed by ischemia,and subsequently pathological intravitreal neovascularization(NV)in the immature *** treatments target only aberrant intravitreal vessel growth without repopulating the avascular regions of the ***,there is a dire need of new therapies that arrest pathological NV and promote normal retinal *** stem cells(MSCs)have shown the ability to migrate to the damaged tissue in different animal models and enhance ***,therefore,investigated whether MSCs can promote vascular repair in a mouse model of ***:Oxygen-induced retinopathy(OIR)model was used *** day 7(P7)mice were subjected to 75%O2 until P12 to induce VO followed by 5 days of room air leading to *** bone-derived MSCs were isolated from adult C57BL/6 mice and cultured either in hypoxia(5%O2)or normoxia(21%O2).Conditioned media(CM)was collected 24 hours later and injected intravitreally in P12 OIR retinas to assess vascular *** determine possible factors involved in MSC-induced revascularization,gene expression analysis was performed on P17 OIR *** vitro,we investigated the effect of MSC-CM on microglial polarization using quantitative PCR and flow ***:Hypoxic MSC-CM significantly(P<0.01)decreased both VO and NV areas in comparison to the normoxic *** of IGF-1 and VEGF were significantly high in MSC-injected OIR ***,gene expression levels of pro-inflammatory cytokines(IL-1β,TNFα)dropped whereas levels of anti-inflammatory cytokines(IL-10,IL-4)*** of pro-inflammatory M1 microglia with MSC-CM decreased the gene expression of IL-1βand TNFα,and iNOS(M1 marker)at the transcript and protein ***:In this study,we demonstrated that MSCs

关键词： Optokinetics visual evoked potentials Nogo-A 11C7

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AB035. Lactate receptor GPR81 modulates epigenetic modification in the subretina

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Annals of Eye Science 2018年第1期 441-441页

作者： Xiaojuan Yang Raphael Rouget Tang Zhu Christiane Quiniou Shasha Lv Suna Jung Francois Duhamel Houda Tahiri Samy Omri baraa noueihed Xin Hou JoséCarlos Rivera Mathieu Nadeau-Vallée Pierre Lachapelle Sylvain Chemtob Department of Pharmacology McGill UniversityMontréalQCCanada Department of Pharmacology Universitéde MontréalMontréalQCCanada Research Center CHU Sainte-Justine Universitéde MontréalMontréalQCCanada Department of Ophthalmology and Neurology-Neurosurgery Montréal Children’s Hospital-Research InstituteMcGill UniversityMontréalQCCanada Research Center Hôpital Maisonneuve-Rosemont Universitéde MontréalMontréalQCCanada Department of Ophthalmology Universitéde MontréalMontréalQCCanada Department of Pediatrics Universitéde MontréalMontréalQCCanada

Background:Retinal pigment epithelium(RPE)is vital for the homeostasis of the subretina including photoreceptors and ***,our previous results suggested that the recently discovered lactate receptor GPR81 is abundantly expressed in *** date,only one previous study has shown that activating GPR81 could enhance DNA repair by activating ***,we investigated whether GPR81 exhibits epigenetic modification in the subretina by using GPR81−/−***:GPR81−/−mice and wide type littermates were generated on a background of C57BL/6J *** thicknesses of their choroid were evaluated by ***,Q-PCR,western blot and choroid sprout assay were *** vitro,primary retinal pigment epithelium(pRPE)cells were isolated from mice,and cultured for ***:The thickness of choroid was reduced in GPR81−/−mice compared to GPR81+/+mice,suggesting that GPR81 is important for the integrity of *** the choroid sprout assay,lactate treated RPE/choroid complex showed a significant increase in angiogenesis compared to controls while lactate treated KO RPE/choroid complex showed no difference compared to their *** Q-PCR,most of the genes screened elevated their expression in GPR81−/−mice compared to WT mice,suggesting epigenetic modification may exist,which were confirmed by histone acetylation and HDACs activity ***:Taking together,the lactate receptor GPR81 in RPE is very important for maintaining homeostasis of the *** novel discovery sheds new light on the relationship between metabolism and epigenetic modification.

关键词： Subretina GPR81 epigenetic modification

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Improved Transient Search Optimization with Machine Learning Based Behavior Recognition on Body Sensor Data

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Computers, Materials & Continua 2023年第5期75卷 4593-4609页

作者： baraa Wasfi Salim Bzar Khidir Hussan Zainab Salih Ageed Subhi R.M.Zeebaree ITM Department Technical College of AdministrationDuhok Polytechnic UniversityDuhokIraq Information System Engineering Department Erbil Technical Engineering CollegeErbil Polytechnic UniversityErbilIraq Computer Science Department College of ScienceNawroz UniversityDuhokIraq Energy Eng.Department Technical College of EngineeringDuhok Polytechnic UniversityDuhokIraq

Recently,human healthcare from body sensor data has gained considerable interest from a wide variety of human-computer communication and pattern analysis research owing to their real-time applications namely smart healthcare *** though there are various forms of utilizing distributed sensors to monitor the behavior of people and vital signs,physical human action recognition(HAR)through body sensors gives useful information about the lifestyle and functionality of an *** article concentrates on the design of an Improved Transient Search Optimization with Machine Learning based BehaviorRecognition(ITSOMLBR)technique using body sensor *** presented ITSOML-BR technique collects data from different body sensors namely electrocardiography(ECG),accelerometer,and *** addition,the ITSOML-BR technique extract features like variance,mean,skewness,and standard ***,the presented ITSOML-BR technique executes a micro neural network(MNN)which can be employed for long term healthcare monitoring and ***,the parameters related to the MNN model are optimally selected via the ITSO *** experimental result analysis of the ITSOML-BR technique is tested on the MHEALTH *** comprehensive comparison study reported a higher result for the ITSOMLBR approach over other existing approaches with maximum accuracy of 99.60%.

关键词： Behavior recognition transient search optimization machine learning healthcare sensors wearables

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Three-Dimensional Structural Comparison of Mandibular Functional Units in Adult Patients with Different Sagittal Skeletal Patterns：A Cone-beam Computed Tomography Study Based on the Functional Matrix Theory

Three-Dimensional Structural Comparison of Mandibular Functi...

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作者： baraa M. O. DARAQEL 重庆医科大学

学位级别：硕士

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Getting Fuel from Sucrose (Table Sugar)

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Journal of Sustainable Bioenergy Systems 2021年第4期11卷 272-284页

作者： Al-baraa Akram Department of Pharmaceutical Biotechnology De Montfort University Leicester City United Kingdom

This idea is based mainly on the most important biochemical process, which is the process of bioremediation, it is based on the use of anaerobic fermentation yeast/Saccharomyces cerevisiae in the conversion of sugar to alcohol and then oxidizing it to get food vinegar followed by some reactions of neutralization and heating using catalysts and increasing pressure to get water gas, or what it is called natural gas. This method produces three liters of natural gas using one liter of sugar solution. The main result of this process is getting 3 folds of natural gas from 1 liter of sugar in addition that the source of biofuel is agricultural so it is free from the organic impurities that are always present with fossil fuels would be obtained and the biofuel obtained does not cause air pollution. Glucose is fermented under anaerobic conditions to avoid the formation of bread yeast.

关键词： Anaerobic Respiration Biogas Saccharomyses ceviseae Methane Natural Gas Gravimetrical Oven Renewable Energy Sugar Cane Sugar Beet

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Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation

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Cellular & Molecular Immunology 2024年第8期21卷 842-855页

作者： Yunhui Niu Marjolein Heddes baraa Altaha Michael Birkner Karin Kleigrewe Chen Meng Dirk Haller Silke Kiessling ZIEL-Institute for Food&Health Technical University of Munich85354FreisingGermany Chair of Nutrition and Immunology School of Life SciencesTechnical University of MunichGregor-Mendel-Str.285354FreisingGermany Bavarian Center for Biomolecular Mass Spectrometry Technical University of MunichGregor-Mendel-Str.485354FreisingGermany Faculty of Health and Medical Sciences University of SurreyStag Hill CampusGU27XPGuildfordUK

The expression of clock genes has been observed to be impaired in biopsies from patients with inflammatory bowel disease(IBD).Disruption of circadian rhythms,which occurs in shift workers,has been linked to an increased risk of gastrointestinal diseases,including *** peripheral circadian clock in intestinal epithelial cells(IECs)was previously shown to balance gastrointestinal homeostasis by regulating the ***,we demonstrated that the intestinal clock is disrupted in an IBD-relevant mouse model(IL-10−/−).A lack of the intestinal clock gene(Bmal1)in intestinal epithelial cells(IECs)in a chemically and a novel genetically induced colitis model(DSS,Bmal1IEC−/−xIL-10−/−)promoted colitis and dramatically reduced survival ***-free Bmal1IEC−/−mice colonized with disease-associated microbiota from IL-10−/−mice exhibited increased inflammatory responses,highlighting the importance of the local intestinal clock for microbiota-induced IBD *** the intestinal clock directly by timed restricted feeding(RF)in IL-10−/−mice restored intestinal clock functions,including immune cell recruitment and microbial rhythmicity;improved inflammatory responses;dramatically enhanced survival rates and rescued the histopathological *** contrast,RF failed to improve IBD symptoms in Bmal1IEC−/−xIL-10−/−mice,demonstrating the significance of the intestinal clock in determining the beneficial effect of ***,we provide evidence that intestinal clock dysfunction triggers host immune imbalance and promotes the development and progression of IBD-like *** intestinal clock function by RF modulates the pathogenesis of IBD and thus could become a novel strategy to ameliorate symptoms in IBD patients.

关键词： Intestinal circadian clock Gastrointestinal inflammation IBD Restricted feeding Microbiota

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Hamstring autograft utilization in reconstructing anterior cruciate ligament:Review of harvesting techniques,graft preparation,and different fixation methods

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World Journal of Orthopedics 2022年第10期13卷 876-890页

作者： Waleed Albishi baraa Baltow Nora Albusayes Ameer A Sayed Hamza M Alrabai Department of Orthopedic Surgery College of MedicineKing Saud UniversityRiyadh 11362Saudi Arabia Department of Orthopedic Surgery AlHada Armed Forces HospitalMinistry of DefenseAlHada 26792Saudi Arabia Department of Orthopedic Surgery King Fahad Armed Forces HospitalMinistry of DefenseJeddah 23311Saudi Arabia

Rupture of the anterior cruciate ligament(ACL)is a common orthopedic *** graft options are available for the reconstruction of ruptured *** the hamstring muscle as an autograft was first described in 1934,and it remains a commonly harvested graft for ACL *** autografts can be harvested using the traditional anteromedial approach or the newer posteromedial *** isolated semitendinosus tendon can be used or combined with the gracilis *** are numerous methods for graft fixation,such as intra-tunnel or extra-tunnel *** comprehensive review discusses the different hamstring muscle harvesting techniques and graft preparation options and fixation *** provides a comprehensive overview for choosing the optimal surgical technique when treating patients.

关键词： Anterior cruciate ligament Anterior cruciate ligament reconstruction Graft fixation Hamstring autograft Infrapatellar nerve injury Patient reported outcomes

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Hepatitis D virus and liver transplantation: Indications and outcomes

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World Journal of Hepatology 2021年第3期13卷 291-299页

作者： Haris Muhammad Aniqa Tehreem Muhammad baraa Hammami Peng-Sheng Ting Ramzan Idilman Ahmet Gurakar Department ofInternal Medicine Greater Baltimore Medical CenterTowsonMD 21204United States Department of Internal Medicine Sinai Hospital BaltimoreMD 21204United States Division of Gastroenterology and Hepatology Johns Hopkins University School of MedicineBaltimoreMA 21205United States Department of Gastroenterology Ankara University School of MedicineAnkara 06690Turkey

Hepatitis D virus(HDV)is a dependent virus that relies on hepatitis B virus for its replication and *** hepatitis D is a severe form of viral hepatitis that can result in end stage liver ***,pegylated interferon alpha is the only approved therapy for chronic HDV infection and is associated with significant side *** transplantation(LT)is the only treatment option for patients with end-stage liver disease,hepatocellular carcinoma,or fulminant hepatitis due to coinfection with *** LT for HDV and hepatitis B virus coinfection is uncommon in the United States,most data on the long-term impact of LT on HDV are from international *** this review,we discuss the indications and results of LT with treatment options in HDV patients.

关键词： Hepatitis delta virus Liver transplant Hepatitis B immunoglobins Hepatocellular carcinoma

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Identification Transgenic DNA of Transformed Arabidopsis Using PCR and Southern Blot

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Advances in Bioscience and Biotechnology 2022年第3期13卷 134-144页

作者： Al-baraa Akram Glen McCann Triaziana Sgamma Department of Pharmaceutical Biotechnology De Montfort University Leicester UK

For identification of transgenic DNA of Arabidopsis plant material, the followed methods are transformation and growing of seeds after bleaching them for sterilization should be performed then using polymerase chain reaction (PCR) for amplification the gene before making gel electrophoresis to be ready for southern blot analysis, this method is possible because the length of the given primers, there are slightly modifications in the methods as ligating PCR technique developed for amplification of the unknown DNA after extracting it to determine its transgenicity. The methods were specific and reproducible for many different plants from transgenic and non-transgenic cell lines. Furthermore, the number of products of PCR result can be considered as a good estimation of transgenic DNA, during comparison to southern blot analysis, the results obtained by the PCR give information about DNA of Arabidopsis, applications of the approach to Arabidopsis plants after transformation with an Agrobacterium-mediated transformation will be described.

关键词： Arabidopsis Southern Blot Polymerase Chain Reaction Agrobacterium Primeres

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Transcutaneous dorsal penile nerve stimulation for the treatment of premature ejaculation:A novel technique

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Asian Journal of Urology 2022年第3期9卷 337-339页

作者： Mohamad Moussa Mohamad Abou Chakra baraa Dabboucy Youssef Fares Athanasios Dellis Athanasios Papatsoris Chairman of Urology Department Lebanese UniversityBeirutLebanon Department of Urology Lebanese UniversityBeirutLebanon Department of Neurosurgery Faculty of MedicineLebanese UniversityBeirutLebanon Department of Neurosurgery Neuroscience Research CenterFaculty of Medical SciencesLebanese UniversityBeirutLebanon Department of Urology/General Surgery Areteion HospitalAthensGreece nd Department of Urology School of MedicineSismanoglio HospitalNational and Kapodistrian University of AthensAthensGreece

Dear editor,Premature ejaculation(PE)is a common male sexual *** occurs in 4%e39%of men across studies in community samples[1].It is impossible to establish accurately the real prevalence of PE because it lacks a widely accepted ***,PE is frequently a self-reported,self-rated complaint,making it difficult to appreciate its real *** addition,the fact that in some couples PE is diagnosed based on distress rather than as an objective symptom complicates the matter even further[2].Oral dapoxetine has been recommended as first-choice therapy for *** using this drug,side effects were uncommon,dose-dependent,including nausea,diarrhea,headache,and dizziness[1].Although since the early 1930s,many drugs have been used to treat PE such as topical local anesthetics and selective serotonin reuptake inhibitors.

关键词： epidemiology drugs diarrhea

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