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Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate

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Asian Journal of Andrology 2010年第2期12卷 227-233页

作者： Gideon Sartorius Carolyn Fennell Sasa Spasevska Leo Turner Ann J. conway David J. Handelsman Andrology Department Concord Hospital ＆ ANZA C Research Institute Sydney NSW 2139 Australia

Pain following depot intramuscular （IM） injection of oil vehicle-based drugs has been little studied. This study aimed to determine prospectively the prevalence,determinants,severity and functional consequences of pain during the week after IM injection of 1 000 mg testosterone undecanoate （TU） in a 4-mL castor oil vehicle. Androgendeficient men receiving regular T replacement therapy at an academic andrology clinic were recruited to report pain scores using a coloured visual linear analogue scale at seven times over the first day and daily for a week after a deep IM gluteal injection. The time course and covariables influencing pain scores were analysed by mixed model analysis of variance （ANOVA）. Following 168 injections in 125 men,pain was reported by 80% of men,peaking immediately after injection,reaching only moderate severity,lasting 1-2 days and returning to baseline by day *** pain required little analgesic use and produced minimal interference in daily activities. The time course of pain scores was reproducible in the 43 men who underwent two consecutive injections. Pain was more severe in men who had an earlier painful injection,but less severe in older and more obese men. There were negligible differences in post-injection pain experience between experienced nurses administering injections. Deep IM gluteal injection of depot TU in 4-mL castor oil is well tolerated and post-injection pain is influenced by earlier painful injection experience,as well as age and obesity.

关键词： ageing intramuscular injection obesity pain testosterone

A Delphi Approach to the Selection of Good Agricultural Practices （GAPs） for resilience Enhancement for Dry Land Farmers in North-Western Nigeria

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Journal of Food Science and Engineering 2017年第8期7卷 383-395页

作者： Nugun Patrick Jellason richard N. Baines John S. conway royal Agricultural University Stroud Road Cirencester GL 7 6JS Gloucestershire England National Biotechnology Development Agency Lugbe Umar Musa Yar 'Adua Road Abuja 900107 Nigeria

An earlier baseline study （Jellason et al. in preparation） has identified some of the key challenges faced by farmers and from that, appropriate Good Agricultural Practices （GAPs） have been selected for the environment the farmers find themselves in and based on a review of available literature. Farmer action plans for enhancing smallholder resilience, GHGs emission mitigation and food security for these dry lands were developed. Expert opinions on the applicability of the selected GAPs to inform farmer co-learning and to validate the suitability of these practices in a dry land context were sought through the Delphi study. Experts were also invited to offer suggestions for improvement of the training action plan. Two rounds of a modified Delphi survey were carried out with experts from diverse backgrounds and locations across the globe to solicit their opinion. results show that experts＇ agreement was reached on most of the action plan items. The results and opinions obtained from the survey were reviewed and adapted into the action plan leading to the development of GAPs for the co-learning exercise.

关键词： Delphi technique good agricultural practices mitigation resilience dry lands food security

全球14个城市的体力活动与城市环境的关系:一项横断面研究

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城市规划学刊 2018年第5期 118-119页

作者：潘洁燕 SALLIS J F CErIN E conway T L

缺乏体力活动是一种全球性流行病,每年因其对多种非传染性疾病的影响而导致500多万人死亡。本文开展了一项针对成年人的国际性研究,旨在记录城市环境要素与客观测量的体力活动之间的相关关系。本文的分析是基于"国际体力活动与环境网络"... 详细信息

缺乏体力活动是一种全球性流行病,每年因其对多种非传染性疾病的影响而导致500多万人死亡。本文开展了一项针对成年人的国际性研究,旨在记录城市环境要素与客观测量的体力活动之间的相关关系。本文的分析是基于"国际体力活动与环境网络"(International Physical Activity and Environment Network,IPEN)针对成年人的研究。参与者包括6 822名年龄在18-66岁的成年人。通过

关键词：体力活动公共交通环境变量

Changes in peripheral perfusion index within 72h of life in a cohort of very low birth weight infants

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Chinese Medical Journal 2022年第10期135卷 1252-1254页

作者： Xiaojing Hu conway Niu ruyi Zheng Li Zhang Hongyan Chen Yun Cao Guoying Huang Neonatal Congenital Heart Disease Screening Office Children's Hospital of Fudan UniversityShanghai 201102China Department of Neonatology King Edward Memorial HospitalSubiacoPerthWestern Australia 6008Australia Department of Neonatology Children's Hospital of Fudan UniversityShanghai 201102China Department of Clinical Epidemiology and Clinical Trial Unit Children's Hospital of Fudan UniversityShanghai 201102China Shanghai Key Laboratory of Birth Defects Shanghai 201102China

To the Editor:The latest generation of pulse oximeters are equipped with technology allowing for monitoring of the peripheral perfusion index(PI),the percentage of the amount of light absorbed by pulsatile tissue(variable arterial blood flow)over non-pulsatile tissue(venous blood,muscle,and other tissues)at a wavelength of 940 nm as a signal.

关键词： index equipped weight

Neutrophil kinetics and function after major trauma:A systematic review

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World Journal of Critical Care Medicine 2021年第5期10卷 260-277页

作者： Liam DB Finlay Andrew conway Morris Adam M Deane Alexander JT Wood Melbourne Medical School University of MelbourneMelbourne 3052VictoriaAustralia Department of Medicine University of CambridgeCambridge 01223United Kingdom Centre for Integrated Critical Care University of MelbourneParkville 3052VictoriaAustralia Intensive Care Unit Royal Melbourne HospitalParkville 3052VictoriaAustralia

BACKGrOUND Immune dysfunction following major traumatic injury is complex and strongly associated with significant morbidity and mortality through the development of multiple organ dysfunction syndrome(MODS),persistent inflammation,immunosuppression,and catabolism syndrome and *** are thought to be a pivotal mediator in the development of immune *** To provide a review with a systematic approach of the recent literature describing neutrophil kinetics and functional changes after major trauma in humans and discuss hypotheses as to the mechanisms of the observed neutrophil dysfunction in this *** Medline,Embase and PubMed were searched on January 15,*** were screened by two reviewers and those included had their reference list hand searched for additional papers of *** criteria were adults>18 years old,with an injury severity score>12 requiring admission to an intensive care *** that analysed major trauma patients as a subgroup were *** Of 107 papers screened,48 were included in the *** were heterogeneous and most studies had a moderate to significant risk of bias owing to their observational nature and small sample *** findings included a persistently elevated neutrophil count,stereotyped alterations in cell-surface markers of activation,and the elaboration of heterogeneous and immunosuppressive populations of cells in the *** of these changes correlate with clinical outcomes such as MODS and secondary *** phenotype remains a promising avenue for the development of predictive markers for immune *** Understanding of neutrophil phenotypes after traumatic injury is expanding.A greater emphasis on incorporating functional and clinically significant markers,greater uniformity in study design and assessment of extravasated neutrophils may facilitate risk stratification in patients affected by major trauma.

关键词： Neutrophils Multiple trauma Immunophenotypes Inflammation Systemic inflammatory response syndrome Intensive care units

Advanced concepts in knee arthrodesis

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World Journal of Orthopedics 2015年第2期6卷 202-210页

作者： Jennifer H Wood Janet D conway Department of Orthopaedics University of Maryland School of Medicine University of Maryland Medical System International Center for Limb Lengthening Rubin Institute for Advanced OrthopedicsSinai Hospital of Baltimore

The aim is to describe advanced strategies that can beused to diagnose and treat complications after knee arthrodesis and to describe temporary knee arthrodesis to treat infected knee arthroplasty. Potential difficult complications include nonunited knee arthrodesis, limb length discrepancy after knee arthrodesis, and united but infected knee arthrodesis. If a nonunited knee arthrodesis shows evidence of implant loosening or failure, then bone grafting the nonunion site as well as exchange intramedullary nailing and/or supplemental plate fixation are recommended. If symptomatic limb length discrepancy cannot be satisfactorily treated with a shoe lift, then the patient should undergo tibial lengthening over nail with a monolateral fixator or exchange nailing with a femoral internal lengthening device. If a united knee arthrodesis is infected, the nail must be removed. Then the surgeon has the option of replacing it with a long, antibiotic cement-coated nail. The authors also describe temporary knee arthrodesis for infected knee arthroplasty in patients who have the potential to undergo insertion of a new implant. The procedure has two goals: eradication of infection and stabilization of the knee. A temporary knee fusion can be accomplished by inserting both an antibiotic cement-coated knee fusion nail and a static antibiotic cement-coated spacer. These advanced techniques can be helpful when treating difficult complications after knee arthrodesis and treating cases of infected knee arthroplasty.

关键词： arthroplasty Knee arthrodesis Nonunion Limb salvage Limb length inequality Infection Osteomyelitis Bone lengthening External fixator

An Output Feedback Controller for Store-Operated Calcium Entry and Extracellular Calcium Sensing in Yeast Cells

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An Output Feedback Controller for Store-Operated Calcium Ent...

2010 Chinese Control and Decision Conference

作者： Weijiu Liu~1,Fusheng Tang~2 1.Department of Mathematics,University of Central arkansas,201 Donaghey Avenue,conway,ar 72035,USA. 2.Department of Biology,University of arkansas at Little rock,2801 S.University Ave.,Little rock,ar 72204-1099,USA.

＜正＞Store-operated calcium entry（SOCE）and extracellular calcium sensing are two important feedback control mechanisms of calcium ion uptake into yeast cells observed in *** this work,we design output feedback controllers for these two *** the control model,we simulate the experimental observations on these two mechanisms and on high-affinity calcium ion influx system in pmrl mutants.

关键词： Yeast store-operated calcium entry extracellular calcium sensing output feedback controller

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蓄电池开发一瞥

新能源 1991年第4期13卷 55-57页

作者： conway,A 黄新

WESTINGHOUSE AP1000 CONTAINMENT DESIGN

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WESTINGHOUSE AP1000 CONTAINMENT DESIGN