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An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads:Experimental studies and molecular dynamics analysis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2669-2684页

作者： Jamie Anne Lugtu-Pe Xuning Zhang Sako mirzaie Hao Han R.Chang Nour AL-mousawi Kuan Chen Yongqiang Li Anil Kane Daniel bar.Shalom Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company Inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Thermo Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution ***,most new chemical entities exhibit poor water solubility,and hence are exempt from such *** combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,particularly within the dosage ***,we explored the potential of an emerging,non-leachable terpolymer nanoparticle(TPN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid dispersion(CRASD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)*** to conventional pore former,polyvinylpyrrolidone(PVP),TPN-containing membranes exhibited superior structural integrity,less crystal formation at the CRASD bead surface,and greater extent of celecoxib ***-atom molecular dynamics analyses revealed that in the presence of TPN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to *** work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CRASD.

关键词： Controlled release amorphous solid dispersion Poorly soluble drug Internal recrystallization membrane-reservoir coated beads molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer interactions

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Catalysts for the hydrogen evolution reaction in alkaline medium:Configuring a cooperative mechanism at the Ag-Ag_(2)S-moS_(2) interface

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Journal of Energy Chemistry 2022年第11期31卷 481-488,I0013页

作者： Avraham bar.Hen Simon Hettler Ashwin Ramasubramaniam Raul Arenal Ronen bar.Ziv maya bar.Sadan Department of Chemistry Ben-Gurion University of the NegevBeer-Sheva 8410501Israel Department of Chemistry Nuclear Research Center NegevP.O.Box 9001Beer-Sheva 84190Israel Laboratorio de microscopías Avanzadas Universidad de Zaragoza50018 ZaragozaSpain Instituto de Nanociencia y materiales de Aragon CSIC-U.de ZaragozaCalle Pedro Cerbuna 1250009 ZaragozaSpain Department of mechanical and Industrial Engineering University of MassachusettsAmherstMA 01003United States ARAID Foundation 50018 ZaragozaSpain

Designing electrocatalysts for HER in alkaline conditions to overcome the sluggish kinetics associated with the additional water dissociation step is a recognized challenge in promoting the hydrogen *** this end,delicately tuning the atomic-scale structure and surface composition of nanoparticles is a common strategy and,specifically,making use of hybrid structures,can produce synergistic effects that lead to highly active ***,we present a core-shell catalyst of Ag@moS_(2)that shows promising results towards the hydrogen evolution reaction(HER)in both 0.5 m H_(2)SO_(4)and 0.5 m *** this hybrid structure,the moS_(2)shell is strained and defective,and charge transfer occurs between the conductive core and the shell,contributing to the electrocatalytic *** shelling process results in a large fraction of Ag_(2)S in the cores,and adjusting the relative fractions of Ag,Ag_(2)S,and moS_(2)leads to improved catalytic activity and fast charge-transfer *** suggest that the enhancement of alkaline HER is associated with a cooperative effect of the interfaces,where the Ag(Ⅰ)sites in Ag_(2)S drive the water dissociation step,and the formed hydrogen subsequently recombines on the defective moS_(2)*** study demonstrates the benefits of hybrid structures as functional nanomaterials and provides a scheme to activate moS_(2)for HER in alkaline conditions.

关键词： Water splitting Core-shell Catalytic mechanism Electrocatalysis 2D materials

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NUTRITIONFORCHILDANDADOLESCENTATHLETES

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中国运动医学杂志 2000年第4期19卷 443-447页

作者： Oded bar.Or m.D. Children’s Exercise & Nutrition Centre mc master University Hamilton Ontario Canada

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Effect of sodium replacement on the quality characteristics of pastırma(a dry-cured meat product)

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Food Science and Human Wellness 2023年第1期12卷 266-274页

作者： bar.şYalınkılıç Güzin Kaban mükerrem Kaya Department of Gastronomy and Culinary Arts Faculty of Fine Arts and Architectureİstanbul Gedik UniversityKartalIstanbul 34876Turkey Department of Food Engineering Faculty of AgricultureAtatürk UniversityErzurum 25240Turkey

This study aims to investigate the effect of sodium replacement on the quality characteristics of pastı*** this purpose,pastırma production with four different salt mixtures(Ⅰ.100%NaCl;Ⅱ.50%NaCl+50%KCl;Ⅲ.40%NaCl+40%KCl+20%CaCl_(2);Ⅳ.30%NaCl+40%KCl+20%CaCl_(2)+10%mgCl_(2))were carried out using traditional *** use of different salt mixtures for pastırma had no statistically significant effect on the microbial counts and residual nitrite of the final *** a*and b*values were affected by this *** salt mixture containing CaCl_(2) or CaCl_(2)+mgCl_(2) significantly decreased the pH values and sensory *** eighteen volatile compounds were affected by the salt ***^(+),K^(+),Ca^(2+),and mg^(2+)had a certain increase depending on their ratio in the salt *** highest Cathepsin activity in all pastırma samples was observed in Cathepsin B+*** salt mixture with NaCl+KCl+CaCl_(2)+mgCl_(2) increased acid lipase ***,this mixture had no significant effect on neutral lipase activity.

关键词： Pastırma Chloride salts Volatile compounds Cathepsin Lipase

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Effect of sodium replacement on the quality characteristics of past?rma(a dry-cured meat product)

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Food Science and Human Wellness 2023年第1期12卷 266-274页

作者： bar.? Yal?nk?l?? Güzin Kaban mükerrem Kaya Department of Gastronomy and Culinary Arts Faculty of Fine Arts and Architecture ?stanbul Gedik University Department of Food Engineering Faculty of Agriculture Atatürk University

This study aims to investigate the effect of sodium replacement on the quality characteristics of past?rma. For this purpose, past?rma production with four different salt mixtures(Ⅰ. 100% Na Cl; Ⅱ. 50% Na Cl + 50% KCl; Ⅲ. 40% NaCl + 40% KCl + 20% CaCl2; Ⅳ. 30% NaCl + 40% KCl + 20% CaCl2+ 10% mgCl2) were carried out using traditional method. The use of different salt mixtures for past?rma had no statistically significant effect on the microbial counts and residual nitrite of the final product. The a* and b* values were affected by this treatment. The salt mixture containing CaCl2or CaCl2+ mgCl2significantly decreased the p H values and sensory scores. The eighteen volatile compounds were affected by the salt mixtures. Na~+, K~+, Ca2+, and mg2+had a certain increase depending on their ratio in the salt mixtures. The highest Cathepsin activity in all past?rma samples was observed in Cathepsin B + L. The salt mixture with NaCl + KCl + CaCl2+ mg Cl2increased acid lipase activity. However, this mixture had no significant effect on neutral lipase activity.

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Protection against Covid-19 by BNT162b2 Booster across Age Groups

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四川生理科学杂志 2021年第10期43卷 1810-1810页

作者： Yinon m bar.On From the Department of Plant and Environmental Sciences Weizmann Institute of Science Rehovot (Y.M.B.-O. R.M.) Technion-Israel Institute of Technology Haifa (Y.G.) the Department of Statistics and Data Science Hebrew University of Jerusalem (M.M.) and Israel Ministry of Health (O.B. S.A.-P. N.A.) Jerusalem the Biostatistical and Biomathematical Unit Gertner Institute for Epidemiology and Health Policy Research Sheba Medical Center Ramat Gan (L.F. A.H.) and the Sackler Faculty of Medicine Tel Aviv University Tel Aviv (L.F. A.H.) - all in Israel.

Background:After promising initial results from the administration of a third(booster)dose of the BNT162b2 messenger RNA vaccine(Pfizer-BioNTech)to persons 60 years of age or older,the booster campaign in Israel was gradually expanded to persons in younger age groups who had received a second dose at least 5 months ***:We extracted data for the period from July 30 to October 10,2021,from the Israel ministry of Health database regarding 4,696,865 persons 16 years of age or older who had received two doses of BNT162b2 at least 5 months *** the primary analysis,we compared the rates of confirmed coronavirus disease 2019(Covid-19),severe illness,and death among those who had received a booster dose at least 12 days earlier(booster group)with the rates among those who had not received a booster(nonbooster group).In a secondary analysis,we compared the rates in the booster group with the rates among those who had received a booster 3 to 7 days earlier(early postbooster group).We used Poisson regression models to estimate rate ratios after adjusting for possible confounding factors.

关键词： Israel younger founding

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Rapid and robust slope failure appraisal using aerial photogrammetry and 3D slope stability models

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International Journal of mining Science and Technology 2020年第5期30卷 651-658页

作者： Neil bar.michael Kostadinovski michael Tucker Glen Byng Rully Rachmatullah Arturo maldonado markus Pötsch Andreas Gaich Alison mcQuillan Thamer Yacoub BHP PerthWA 6000Australia 3GSm GmbH 8010 GrazStyriaAustria Rocscience Inc. Toronto M5T 1V1Canada

Slope failures are an inevitable aspect of economic pit slope designs in the mining *** open pit guidelines and industry standards accept up to 30%of benches in open pits to collapse provided that they are controlled and that no personnel are at *** ground control measures including real time monitoring systems at TARP(trigger-action-response-plan)protocols are widely utilized to prevent personnel from being exposed to slope failure *** and computing capability are rapidly *** photogrammetry techniques using UAV(unmanned aerial vehicle)enable geotechnical engineers and engineering geologists to work faster and more safely by removing themselves from potential line-of-fire near unstable *** stability modelling software using limit equilibrium(LE)and finite element(FE)methods in three dimensions(3D)is also becoming more accessible,user-friendly and faster to *** key components enable geotechnical engineers to undertake site investigations,develop geotechnical models and assess slope stability faster and in more detail with less exposure to fall of ground hazards in the *** paper describes the rapid and robust process utilized at BHP Limited for appraising a slope failure at an iron ore mine site in the Pilbar. region of Western Australia using a combination of UAV photogrammetry and 3D slope stability models in less than a shift(*** than 12 h).

关键词： Slope stability 3D limit equilibrium analysis Aerial imagery Photogrammetry Open pit mining

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Characterization of AAm/4-Styrenesulfonic Acid Sodium Salt/PEG Hydrogels Crosslinked by PEGDA as Highly Swollen Adsorbents for the Effective Removal of Janus Green B from Aqueous Solutions

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Journal of Encapsulation and Adsorption Sciences 2021年第2期11卷 45-68页

作者： Ömer bar.ş ÜZüm Erdener Karadağ Department of Chemistry Fen-Edebiyat Faculty Ayd&#305n Adnan Menderes University Ayd&#305n Turkey

In this study, it has been investigated that the incorporation of poly(ethylene glycol) and 4-styrenesulfonic acid sodium salt into acrylamide hydrogel during free radical solution polymerization synthesis for novel highly swollen adsorbents and for the effective removal of some potential pollutants from aqueous solutions such as cationic dyes. Poly(ethylene glycol)diacrylate was used as a multifunctional crosslinker. The main purpose of this study was to combine both monomers and a polymer in a new polymeric system. Dye sorption properties of the polymeric hydrogels were investigated by using cationic dye such as Janus Green B. Swelling and sorption studies were carried out at 25°C. For structural characterization, FT-IR analysis and SEM studies were applied. To determine the sorption behaviors of Janus Green B, some sorption parameters such as dye removal capacity, adsorption percentage, and partition coefficient of the polymeric hydrogels were investigated.

关键词： Hydrogel Swelling Composite Acrylamide Dye Sorption

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频移反馈Nd∶YLF激光软阈值实验与模拟计算

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光学学报 1996年第2期16卷 146-149页

作者：梁桂云王瑞丽 m.W.PhilipsJ.R.m.bar 长春光学精密机械学院基础科学系云南师范大学物理系南安普顿大学光电子研究中心

实验和模拟计算均表明：在无注入种子激光的频移反馈Ｎｄ∶ＹＬＦ激光系统中，不存在软阈值，而当注入种子激光时，出现软阈值特性，实验还发现：随着种子激光功率增大，软阈值变得更加明显。

关键词：软阈值频移反馈激光系统种子激光

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Water Sorption Behaviors of Novel Biohybrid Hydrogels as Effective Sorbents in Water-Solvent Binary mixtures

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Journal of Encapsulation and Adsorption Sciences 2020年第3期10卷 43-70页

作者： Erdener Karadağ Belgin Yel Semiha Kundakcı Ömer bar.ş Üzüm Aydın Adnan menderes University Fen-Edebiyat Faculty Chemistry Department Ayd&#305n Turkey

Novel sorbent hydrogels containing acrylamide/sodium vinylsulfonate, carboxymethyl cellulose and zeolite were synthesized with free radical solution polymerization by using ammonium persulfate/N,N,N’,N’-tetramethylethyle-nediamine as redox initiating pair in presence of poly(ethylene glycol) diacrylate as crosslinker. It was to investigate the water uptake properties of series of the novel hydrogels, the semi IPNs and the hybrid/biohybrid composite hydrogel sorbents synthesized in this study. Water uptake studies were performed in water and in water-solvent (acetone, methanol and tetrahydrofuran) binary mixtures at 25°C, gravimetrically. Some swelling and diffusion parameters were calculated and discussed. It has been seen that the lower equilibrium swelling factor values in all solvent compositions in comparison with the equilibrium swelling factor values in water.

关键词： Acrylamide/Sodium Vinylsulfonate Biohybrid Hydrogel Swelling Carboxymethyl Cellulose Zeolite Water-Solvent Binary mixtures

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