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IL-13/IL-13RA2 signaling promotes colorectal cancer stem cell tumorigenesis by inducing ubiquitinated degradation of p53

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Genes & Diseases 2024年第1期11卷 495-508页

作者： baoyu he Jing Liang Qianqian Qin Yuqin Zhang Shuo Shi Jinghe Cao Zhixin Zhang Qingli Bie Rou Zhao Li Wei Baogui Zhang Bin Zhang Department of Laboratory Medicine Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Postdoctoral Mobile Station of Shandong University of Traditional Chinese Medicine JinanShandong 250355China Department of Reproductive Medicine Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Department of Gastrointestinal Surgery Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Institute of Forensic Medicine and Laboratory Medicine Jining Medical UniversityJiningShandong 272067China

Cancer stem cells(CSCs)are considered tumor-initiating cells and the main drivers of disease *** these rare cancer cells,however,remains challenging with respect to therapeutic ***,we report the up-regulation of IL-13RA2 expression in colorectal cancer(CRC)tissues and spheroid *** expression of IL-13RA2 was positively correlated with canonical stemness markers in *** further demonstrated that the level of IL-13 was up-regulated in the serum of CRC ***,recombinant IL-13(rIL13)stimulation promoted the sphere formation,proliferation,and migration of CRC cells in vitro and enhanced tumorigenesis in *** phenotype could be reversed by knocking down ***,IL-13 activated autophagy by inducing LC3I/LC3II transformation in CRC-CSCs,which was crucial for the biological functions of *** further demonstrated that IL-13RA2 acted as a modular link of the E3 ligase UBE3C and the substrate p53 protein,enhancing the interaction of UBE3C and p53,thereby inducing the K48-linked ubiquitination of *** conclusion,the IL-13/IL-13RA2 signaling cascade promotes CRC-CSC self-renewal and tumorigenesis by inducing p53 ubiquitination,adding an important layer to the connection between IL-13 and p53,which can be translated into novel targeted therapies.

关键词： Autophagy Colorectal cancer stem cells IL-13/IL-13RA2 signaling p53

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中共早期特派制度、特派巡行制度和巡视制度关系辨析

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广东党史与文献研究 2024年第2期 42-53页

作者：贺宝玉张莉梅赣南师范大学中国共产党革命精神与文化资源研究中心赣南师范大学教务处

特派制度、特派巡行制度和巡视制度是中共早期在不同历史阶段形成的三种主要的党内监督制度。长期以来,学术界认为特派制度就是巡视制度,特派员等同于巡视员,反之亦然;对于特派巡行制度则简单地认为是由特派制度向巡视制度转变的过渡性... 详细信息

特派制度、特派巡行制度和巡视制度是中共早期在不同历史阶段形成的三种主要的党内监督制度。长期以来,学术界认为特派制度就是巡视制度,特派员等同于巡视员,反之亦然;对于特派巡行制度则简单地认为是由特派制度向巡视制度转变的过渡性制度。本文通过梳理特派制度、特派巡行制度和巡视制度三者形成的原因与背景,辨析其中的区别与联系,以厘清学术界对此问题的模糊认识。

关键词：特派制度特派巡行制度巡视制度中国共产党

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Targeting p85β nuclear translocation for the tumors with PIK3CA helical domain mutations

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Genes & Diseases 2022年第6期9卷 1391-1393页

作者： baoyu he Yujun Hao State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200032PR China Department of Laboratory Medicine Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272029PR China

Phosphatidylinositol 3-kinases(PI3Ks)play key roles in ***3CA,which encodes PI3K complex catalytic subunit p110a,is one of the most frequently mutated oncogenes in human cancers.1 So,targeting p110a holds great promis... 详细信息

关键词： PIK3CA helical domain mutation p85β EZH2 USP7

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Optimization-based mode selection scheme for OAM millimeter wave system in the off-axis misalignment case

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Digital Communications and Networks 2024年第1期10卷 101-108页

作者： Haie Dou Lei Wang Bin Kang baoyu Zheng Key Lab of Broadband Wireless Communication and Sensor Network Technology(Nanjing University of Posts and Telecommunications) Ministry of EducationNanjing210003China School of Internet of Things Nanjing University of Posts and TelecommunicationsNanjing210003China

Millimeter-wave transmission combined with Orbital Angular Momentum(OAM)has the advantage of reducing the loss of beam power and increasing the system ***,to fulfill this advantage,the antennas at the transmitter and receiver must be parallel and coaxial;otherwise,the accuracy of mode detection at the receiver can be seriously *** this paper,we design an OAM millimeter-wave communication system for overcoming the above ***,the first contribution is that the power distribution between different OAM modes and the capacity of the system with different mode sets are analytically derived for performance *** second contribution lies in that a novel mode selection scheme is proposed to reduce the total interference between different *** results show that system performance is less affected by the offset when the mode set with smaller modes or larger intervals is selected.

关键词： Orbital angular momentum Millimeter wave Off-axis misalignment Mode selection Capacity

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Production of linear alkylbenzene over Ce containing Beta zeolites

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Chinese Journal of Chemical Engineering 2024年第3期67卷 220-227页

作者： Shiqi Zhang Shengzhi Gan baoyu Liu Jinxiang Dong School of Chemical Engineering and Light Industry Guangdong Provincial Key Laboratory of Plant Resources BiorefineryGuangzhou Key Laboratory of Clean Transportation Energy ChemistryGuangdong University of TechnologyGuangzhou 510006China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Ce-encapsulated Beta zeolite was synthesized by a one-pot hydrothermal method with citric acid complexing Ce in the absence of Na *** citric acid can effectively prevent the deposition of Ce species during the hydrothermal synthesis of zeolites,leading to uniform distribution of Ce cluster in the framework of Beta ***,the sodium-free synthesis system resulted that the Brønsted acid sites were mainly located on the straight channels and external surface of Beta zeolites,improving the utilization of Brønsted acid *** addition,Ce encapsulated Beta zeolites showed enhanced activity and robust stability in the alkylation of benzene with 1-dodecene based on the synergistic effect between Ce species and Brønsted acid sites,which pave the way for its practical application in the production of alkylbenzene.

关键词： Beta zeolites Catalysis Alkylation Long-chain olefins

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关于农村集体经济组织与村民委员会关系的思考

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法律适用 2023年第1期2023卷 95-105页

作者：何宝玉全国人大农业与农村委员会办公室

在土地集体所有基础上建立的农村集体经济组织制度,与村民自治组织制度相交织,构成我国农村治理的基本框架,为中国特色农业农村现代化提供基本制度支撑。农村改革以来,有些地方存在农村集体经济组织不健全、运行机制不顺畅、监督制度不... 详细信息

在土地集体所有基础上建立的农村集体经济组织制度,与村民自治组织制度相交织,构成我国农村治理的基本框架,为中国特色农业农村现代化提供基本制度支撑。农村改革以来,有些地方存在农村集体经济组织不健全、运行机制不顺畅、监督制度不完善等问题,由村民委员会代行集体经济组织的职能也面临财产所有权与管理权不对应等矛盾。新形势下发展壮大新型集体经济,促进农民农村共同富裕,需要充分发挥农村集体经济组织的作用,有关法律法规和农村集体产权制度改革成果,为农村集体经济组织的分设提供了法律和实践基础。当前迫切需要在健全农村集体经济组织的基础上,深入研究如何理顺农村集体经济组织与村民委员会的关系,为制定农村集体经济组织法和修改村民委员会组织法提供参考。

关键词：农村集体经济组织村民委员会分设必要性与可行性理顺关系

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Fabrication of surface passivated two-dimensional MFI zeolite for alkylation between toluene with methanol

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 115-124页

作者： Zhenyuan Zou Shengzhi Gan Ting Pu Xingxing Zeng Yi Huang baoyu Liu School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China School of Engineering Institute for Materials&Processesthe University of EdinburghEdinburgh EH93FBUnited Kingdom

The fabrication of suitable MFI zeolites to effectively produce para-xylene through the alkylation between toluene and methanol is highly ***,the two-dimensional pillared MFI zeolite was modified by silicalite-1,and its morphology and structure were systematically investigated by tuning the concentration of Si species during the secondary crystallization *** MFI zeolites were characterized by X-ray diffraction,transmission electron microscopy,pyridine-infrared and N_(2) adsorption-desorption *** characterization results showed that the external Brønsted acid sites of surface passivated P-MFI-x samples have been successfully ***,the P-MFI-23 showed long lifetime and high selectivity of para-xylene(about 35%)based on the cooperation between opened interlamellar structure and passivated silicalite-1 *** was found that the accumulated hard coke in the interior of MFI zeolites not only blocked the channels of zeolites but also covered the acidic sites,resulting in the deactivation of ***,the highest selectivity of para-xylene(about 48%)can be achieved for P-MFI-30 under harsh reaction condition,which also exhibited excellent regeneration property in the alkylation reaction between toluene and *** strategy described in present research may open a window for the design of other advanced materials.

关键词： alkylation MFI nanosheets catalysis

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Flexible interdigitated layered framework with multiple accessible active sites for high-performance CH_(3)I capture

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Science China Chemistry 2024年第5期67卷 1569-1577页

作者： Bo Tai baoyu Li Linwei he Zhonglin Ma Shujing Lin Mingxing Zhang Junchang Chen Fuqi Wu Long Chen Xing Dai Fuyin Ma Zhifang Chai Shuao Wang State Key Laboratory of Radiation Medicine and Protection School for Radiological and interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China

The development of adsorbent materials for effective capture of radioactive iodomethane(CH_(3)I) from the off-gas of used nuclear fuel reprocessing, remains a significant and challenging line of research because currently state-of-art adsorbents still suffer from low binding affinity with CH_(3)I. here, we proposed a brand-new adsorption topological structure by developing a 2D interdigitated layered framework, named SCU-20, featuring slide-like channel with multiple active sites for CH_(3)I capture. The responsive rotating-adaptive aperture of SCU-20 enables the optimal utilization of all active sites within the pore for highly selective recognition and capture of CH_(3)I. A record-breaking CH_(3)I uptake capacity of 1.84 g/g was achieved under static sorption conditions with saturated CH_(3)I vapor. Both experimental and theoretical findings demonstrated that the exceptional uptake of SCU-20 towards CH_(3)I can be attributed to the confined physical electrostatic adsorption of F sites, coupled with the chemical nitrogen methylation reaction with uncoordinated N atoms of pyrazine. Moreover, dynamic CH_(3)I uptake capacity potentially allows for the capture of CH_(3)I in simulated real-world off gas reprocessing conditions. This study highlights the potential of SCU-20 as a promising candidate for efficient capture of iodine species and contributes to the development of effective solutions for radioactive iodine remediation.

关键词： 2D interdigitated layered framework iodomethane dual-sites electrostatic interaction physisorption and chemisorption

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Simulation Analysis of Deformation Control for Magnetic Soft Medical Robots

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 794-796页

作者： Jingxi Wang baoyu Liu Edmond Q.Wu Jin Ma Ping Li Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineeringthe School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China IEEE the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China the Department of Aerospace Medicine Air Force Medical UniversityXi’an 710032China

Dear Editor,This letter presents a biocompatible cross-shaped magnetic soft robot and investigates its deformation mode control strategy through COMSOL modeling and *** soft robots offer novel avenues for precise trea... 详细信息

关键词： robot simulation COMSOL

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Synergy of heterogeneous Co/Ni dual atoms enabling selective C-O bond scission of lignin coupling with in-situ N-functionalization

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Journal of Energy Chemistry 2024年第5期92卷 16-25页

作者： baoyu Wang Jinshu Huang Hongguo Wu Ximing Yan Yuhe Liao Hu Li National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide&Agricultural BioengineeringMinistry of EducationState-Local Joint Laboratory for Comprehensive Utilization of BiomassCollege of Pharmacy&Center for R&D of Fine ChemicalsGuizhou UniversityGuiyang 550025GuizhouChina Guangxi Key Laboratory of Green Chemical Materials and Safety Technology Beibu Gulf UniversityQinzhou 535011GuangxiChina Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640GuangdongChina

Selective cleavage of Csp^(2)-OCH_(3)bond in lignin without breaking other types of C-O bonds followed by N-functionalization is fascinating for on-purpose valorization of ***,a Co/Ni-based dual-atom catalyst CoNiDA@NC prepared by in-situ evaporation and acid-etching of metal species from tailor-made metal–organic frameworks was efficient for reductive upgrading of various lignin-derived phenols to cyclohexanols(88.5%–99.9%yields),which had ca.4 times higher reaction rate than the single-atom catalyst and was superior to state-of-the-art heterogeneous *** synergistic catalysis of Co/Ni dual atoms facilitated both hydrogen dissociation and hydrogenolysis steps,and could optimize adsorption configuration of lignin-derived methoxylated phenols to further favor the Csp^(2)-OCH_(3)cleavage,as elaborated by theoretical ***,the CoNi_(DA)@NC catalyst was highly recyclable,and exhibited excellent demethoxylation performance(77.1%yield)in real lignin monomer *** in-situ cascade conversion processes assisted by dual-atom catalysis,various high-value N-containing chemicals,including caprolactams and cyclohexylamines,could be produced from lignin.

关键词： Biomass conversion heterogeneous catalysis Lignin Dual-atom catalyst Selective C-ocleavage

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