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TCP-1,a novel peptide to diagnose early colon cancer

Chinese Chemical Letters 2024年第3期35卷 226-233页

作者： Hang Yu baoying wen Min Huang Ru Feng Libin Pan Manyi Xu Hao Lin Lin Cong Sen Zhang Yan Li Chi-Hin Cho Chongjing Zhang Xiaoguang Chen Yan Wang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesBeijing 100050China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina

A nine cyclic peptide(TCP-1)showed excellent specificity for colon ***-1 binds with human tumor tissues at early stages and mice tumor with diameters of 1-4 mm,suggesting that TCP-1 may be used for early diagnosis of colon *** mechanism of the targeted binding of TCP-1 to colon cancer was also studied using immunoprecipitation,LC-MS and *** screening and identifying of the possible binding target proteins of TCP-1,keratin,typeⅡcytoskeletal 5 was speculated to be the specific binding target protein of TCP-1 in human tumor *** studies were conducted to investigate the target-mediated drug disposition of the new tumor-specific peptide by LC-MS/*** tissue distribution study showed that TCP-1 was found only in colon tumors(the target site)in tumor mice did not bind to any other *** TCP-1 to tumor markedly increased its removal rate from blood circulation but mildly extended its staying time in *** tumor mice,a lower AUC of TCP-1(reduced by almost 35%)and 2-fold higher clearance were found compared to that of normal *** proposed metabolic pathway of TCP-1 in the kidney was also determined using LC-MS^(n)-*** high specificity and low toxicity of the peptide may be caused by its extremely tight binding to the *** applications for future clinical use,including MRI and PET/CT were also explored,and this research may promote the development of colon cancer diagnostic technology research and provide new ideas and technical routes for tumor diagnostic technology.

关键词： Colon cancer TCP-1 Peptide Cytokeratin 5 Pharmacokinetics/pharmacodynamics(PK/PD)

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试论第二语言语音教学的原则和方法

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天津师范大学学报（社会科学版） 2023年第1期 14-20页

作者：石锋温宝莹南开大学文学院天津300071 南开大学汉语言文化学院

有声语言是人类语言的基本存在形式,无论是研究一种语言还是学习一种语言,首先就要研究和学习这种语言的语音。语言习得包括母语习得和二语习得,二者的共同点是两种习得都是依靠两种本能:模仿学习,概率匹配,并且受到语言关键期的制约;... 详细信息

有声语言是人类语言的基本存在形式,无论是研究一种语言还是学习一种语言,首先就要研究和学习这种语言的语音。语言习得包括母语习得和二语习得,二者的共同点是两种习得都是依靠两种本能:模仿学习,概率匹配,并且受到语言关键期的制约;不同点主要在于有无语言迁移的影响。语言教学和语言习得关系紧密,二语教学和二语习得同样密不可分。二语语音教学要解决三个主要问题:第一个是教什么人?第二个是教什么?第三个是怎么教?二语语音教学有三个主要原则:最简优先,精讲多练,语流为本。

关键词：第二语言语言习得语音教学教学原则最简优先

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Thermodynamic theory of flotation for a complex multiphase solid -liquid system and high-entropy flotation

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1177-1197页

作者： Shuming wen State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Land Resource EngineeringKunming University of Science and TechnologyKunming 650093China

The flotation of complex solid–liquid multiphase systems involve interactions among multiple components,the core problem facing flotation ***,the combined use of multicomponent flotation reagents to improve mineral flotation has become an important issue in studies on the efficient use of refractory mineral ***,studying the flotation of complex solid–liquid systems is extremely difficult,and no systematic theory has been developed to *** addition,the physical mechanism associated with combining reagents to improve the flotation effect has not been unified,which limits the development of flotation theory and the progress of flotation *** this study,we applied theoretical thermodynamics to a solid–liquid flotation system and used changes in the entropy and Gibbs free energy of the reagents adsorbed on the mineral surface to establish thermodynamic equilibrium equations that de-scribe interactions among various material components while also introducing adsorption equilibrium constants for the flotation reagents adsorbed on the mineral *** homogenization effect on the mineral surface in pulp solution was determined using the chemical potentials of the material components of the various mineral surfaces required to maintain *** flotation effect can be improved through synergy among multicomponent flotation reagents;its physical essence is the thermodynamic law that as the number of compon-ents of flotation reagents on the mineral surface increases,the surface adsorption entropy change increases,and the Gibbs free energy change of adsorption *** to the results obtained using flotation thermodynamics theory,we established high-entropy flotation theory and a technical method in which increasing the types of flotation reagents adsorbed on the mineral surface,increasing the adsorption entropy change of the flotation reagents,decreasing the Gibbs free energy change,and improving the adsorption efficiency

关键词： multicomponent flotation reagent adsorption entropy change equations of thermodynamic equilibrium adsorption equilibri-um constant high-entropy flotation

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Goal-Oriented Control Systems(GOCS):From HOW to WHAT

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 816-819页

作者： wen-Hua Chen the Department of Aeronautical and Automotive Engineering Loughborough UniversityLeicestershireLE113TUU.K.

Brief:New control theory is required to underpin safe design and deployment of future highly automated systems to deal with uncertain environments and complicated tasks,enabled by AI and other advanced ***-Oriented Control Systems offer potential to transform the control system design from currently instructing a control system how to perform a task to specifying what is to be achieved.

关键词： automated instru system

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Observation of gapless corner modes of photonic crystal slabs in synthetic translation dimensions

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Photonics Research 2024年第3期12卷 444-455页

作者： wen-JIN ZHANG HAO-CHANG MO wen-JIE CHEN XIAO-DONG CHEN JIAN-wen DONG School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China

Second-order topological photonic crystals support localized corner modes that deviate from the conventional bulk-edge ***,the frequency shift of corner modes spanning the photonic band gap has not been experimentally ***,we observe the gapless corner modes of photonic crystal slabs within a parameter space by considering translation as an additional synthetic *** corner modes,protected by topological pumping in synthetic translation dimensions,are found to exist independently of the specific corner *** gapless corner modes are experimentally imaged via the near-field scanning measurement and validated numerically by full-wave *** propose a topological rainbow with gradient translation,demonstrating the ability to extract and separate specific frequency components of light into different spatial *** work contributes to the advancement of topological photonics and provides valuable insights into the exploration of gapless corner modes in synthetic dimensions.

关键词： translation dimensions corner

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Isotopic insights on quantitative assessments of interaction of eco-hydrological processes in multi-scale karst watersheds

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International Soil and Water Conservation Research 2024年第1期12卷 156-170页

作者： Zhuo Hao Yang Gao Qingwen Zhang wen wen Agricultural Clean Watershed Research Group Institute of Environment and Sustainable Development in AgricultureCAASBeijing100081China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing100101China School of Humanities and Social Sciences Beijing Institute of TechnologyBeijing100081China

The dynamics of hydrological processes and the storage mechanisms of karst water resources are the most important issues in karst *** impact of environmental changes on water quantity,and the evaluation and quantification of eco-hydrological processes remain poorly *** this study,high-frequency continuous monitoring in multi-scale karst watersheds in Southwest China combined the approaches of water isotopes and the hybrid single-particle lagrangian integrated trajectory(HYSPLIT)model to identify the recharge mechanisms between atmospheric vapor,rainfall,surface water,and groundwater,and to reveal the interaction of eco-hydrological *** dominant moisture sources in Puding(PD)County were the Indian Ocean(43-69%)and local moisture(24-33%).Theδ^(18)O and deuterium excess(d-excess)values showed a positive correlation indicating that secondary or sub-cloud evaporation was prominent in the wet *** water line-conditioned excess(lc-excess)indicated that karst water interacted with recent precipitation,groundwater,and evaporation across *** to its specific hydrogeological structure,surface water and rainwater have a higher contribution rate to groundwater *** Chenqi stream replenished the Houzhai River mainly in the form of groundwater,with percentages ranging from 38.1 to 93.5%in the wet season,and 47.8-80.1%in the dry *** the Houzhai outlet,surface water and groundwater interconverted frequently with a percentage of 45.6-49.1%.We believe this is the first systematic study to quantify the supply relationship between water vapor transport,rainfall,surface water and groundwater in the Chinese karst zone,making a significant move forward in the field of karst hydrological processes and improving the efficiency of water resource evaluation and management.

关键词： Stable isotope Moisture sources Water cycle Karst watersheds

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Weakly Approximate Diagonalization of Homomorphisms into Finite von Neumann Algebras

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数学学报（英文版） 2024年第9期40卷 2187-2194页

作者： wen Hua QIAN Jun Hao SHEN wen Ming WU School of Mathematical Sciences Chongqing Normal UniversityChongqing 401331P.R.China Department of Mathematics and Statistics University of New HampshireDurhamNH 03824USA

Let A be a unital C*-algebra and B a unital C*-algebra with a faithful trace τ.Let n be a positive *** give the definition of weakly approximate diagonalization(with respect to τ)of a unital homomorphism φ:A →Mn(B).We give an equivalent characterization of McDuff Ⅱ1 *** show that,if A is a unital nuclear C*-algebra and B is a type Ⅱ1 factor with faithful trace τ,then every unital*-homomorphism φ:A → Mn(B)is weakly approximately *** B is a unital simple infinite dimensional separable nuclear C*-algebra,then any finitely many elements in Mn(B)can be simultaneously weakly approximately diagonalized while the elements in the diagonals can be required to be the same.

关键词： hyperfinite McDuff factors nuclear Weakly approximately diagonalizable

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句中“连NP都VP”句式的韵律焦点分析及研究

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中国语音学报 2022年第2期 87-99页

作者：温宝莹东韡妍南开大学汉语言文化学院南开大学周恩来政府管理学院

“连”字句是汉语特殊句式之一。本文运用韵律格局的思想,针对“连NP都VP”结构位于句中位置的“连”字句进行实验分析,对10位汉语母语发音人的发音从音高、音长、音强三方面考察韵律焦点分布模式。实验结果表明:“连”字句中“连”字结... 详细信息

“连”字句是汉语特殊句式之一。本文运用韵律格局的思想,针对“连NP都VP”结构位于句中位置的“连”字句进行实验分析,对10位汉语母语发音人的发音从音高、音长、音强三方面考察韵律焦点分布模式。实验结果表明:“连”字句中“连”字结构(连NP)为韵律焦点,表现为音高调域大幅扩展、音长显著加长、音强显著增强,表现出较强的对比性。“连”字参与焦点表现,为焦点标记词,对焦点前的成分影响较小。“都”字参与焦点表现较为有限,在音高、音长、音强三方面均无显著表现。韵律三要素在焦点后位置表现不同步,音高和音强表现较为一致,而音长的独立性较强。

关键词： “连”字句焦点对比性

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A combined Liouville integrable hierarchy associated with a fourth-order matrix spectral problem

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Communications in Theoretical Physics 2024年第07期76卷 3-10页

作者： wen-Xiu Ma Department of Mathematics Zhejiang Normal University Department of Mathematics King Abdulaziz University Department of Mathematics and Statistics University of South Florida Tampa Material Science Innovation and Modelling Department of Mathematical Sciences North-West University Mafikeng Campus

This paper aims to propose a fourth-order matrix spectral problem involving four potentials and generate an associated Liouville integrable hierarchy via the zero curvature formulation. A bi-Hamiltonian formulation is furnished by applying the trace identity and a recursion operator is explicitly worked out, which exhibits the Liouville integrability of each model in the resulting hierarchy. Two specific examples, consisting of novel generalized combined nonlinear Schr?dinger equations and modified Korteweg–de Vries equations, are given.

关键词： Hamiltonian structure integrable hierarchy Lax pair matrix spectral problem zero curvature equation

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Geochemical identification of a source rock affected by migrated hydrocarbons and its geological significance:Fengcheng Formation,southern Mahu Sag,Junggar Basin,NW China

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Petroleum Science 2024年第1期21卷 100-114页

作者： wen-Long Dang Gang Gao Xin-Cai You Ke-Ting Fan Jun Wu De-wen Lei wen-Jun He Yong Tang State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum(Beijing)Beijing102249China School of GeoSciences China University of Petroleum(Beijing)Beijing102249China Exploration&Development Institute Xinjiang Oil Field CompanyKaramay834000XinjiangChina

The Fengcheng Formation is a crucial source rock and the primary reservoir for oil accumulation in the Mahu *** oils are distributed throughout the Fengcheng Formation,ranging from the edge to the interior of the sag in the southern Mahu *** crude oils originate from in-situ source rocks in shallowly buried areas and the inner deep *** migration,the crude oil from the inner deep sag affects the source rocks close to carrier beds,leading to changes in the organic geochemical characteristics of the source *** changes might alter source rock evaluations and oil-source *** on data such as total organic carbon(TOC),Rock-Eval pyrolysis of source rocks,and gas chromatography-mass spectrometry(GC-MS)of the saturated fraction,and considering the geological characteristics of the study area,we define the identification characteristics of source rock affected by migrated hydrocarbons and establish the various patterns of influence that migrated hydrocarbons have on the source rock of the Fengcheng Formation in the southern Mahu *** source rocks of the Fengcheng Formation are mostly fair to good,containing mainly Type II organic matter and being thermally mature enough to generate *** rocks affected by migrated hydrocarbons exhibit relatively high hydrocarbon contents(S1/TOC>110 mg HC/g TOC,Extract/TOC>30%,HC:hydrocarbon),relatively low Rock-Eval Tmax values,and relatively high tricyclic terpane contents with a descending and mountain-shaped ***,biomarker composition parameters indicate a higher thermal maturity than in-situ source *** a comparison of the extract biomarker fingerprints of adjacent reservoirs and mudstones in different boreholes,three types of influence patterns of migrated hydrocarbons are identified:the edge-influence of thin sandstone-thick mudstone,the mixed-influence of sandstone-mudstone interbedded,and the full-influence of thick sandstone-thin *** finding reminds

关键词： Organic geochemistry Source rock Influence of migrated hydrocarbons Fengcheng Formation Southern Mahu Sag

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