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Dominant role of in situ native cartilage niche for determining the cartilage type regenerated by BMSCs

Bioactive Materials 2022年第7期7卷 149-160页

作者： Mengjie Hou Baoxing Tian baoshuai bai Zheng Ci Yu Liu Yixin Zhang Guangdong Zhou Yilin Cao Department of Plastic and Reconstructive Surgery Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Tissue EngineeringShanghaiPR China National Tissue Engineering Center of China ShanghaiPR China Research Institute of Plastic Surgery Wei Fang Medical CollegeWeifangPR China Department of Breast Surgery Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai200336PR China

Tissue-engineered cartilage regeneration by bone marrow stromal cells(BMSCs)is considered an ideal ***,how to regulate BMSCs to regenerate specific types of cartilage remains unclear,which significantly limits its clinical translation and leads to suboptimal clinical ***,we systematically explored the role of native ear and articular cartilage niches on the differentiation fate of BMSCs and the type of regenerated ***,we prepared two types of acellular cartilage sheets(ACSs)and two types of *** green fluorescent protein-labeled BMSCs were seeded on two types of ACSs with or without corresponding types of chondrocytes using a sandwich model and directed or cross-implanted them into native cartilage *** one year of in vivo culture,cell tracking and the results of histological results showed that the native cartilage niches were capable of regulating BMSCs regeneration into specific types of cartilage that were consistent with the cartilage types of the implanted ***,even when the type of niche formed by ACSs or the biomimetic cartilage niche constructed by specific types of ACSs and specific types of chondrocytes did not match with the native cartilage niche,the native cartilage niche continued to determine the type of cartilage regenerated by implanted BMSCs and *** our results provide sufficient evidence for specific types of cartilage regeneration using chondrogenic potential cells,such as mesenchymal stem cells and chondrocytes.

关键词： BMSCs Niche Cartilage type Cartilage regeneration In situ Chondrocytes

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Elastic Fiber‑Reinforced Silk Fibroin Scaffold with A Double‑Crosslinking Network for Human Ear‑Shaped Cartilage Regeneration

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Advanced Fiber Materials 2023年第3期5卷 1008-1024页

作者： Qianyi Wang Xinyue Ran Jian Wang Sinan Wang Peiling Zhang Erji Gao baoshuai bai Junfeng Zhang Guangdong Zhou Dong Lei Department of Plastic and Reconstructive Surgery Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Key Lab of Tissue EngineeringShanghai 200011People’s Republic of China Research Institute of Plastic Surgery Weifang Medical UniversityWeifang 261053People’s Republic of China Department of Cardiology Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011People’s Republic of China

Tissue engineering provides a promising approach for regenerative *** ideal engineered tissue should have the desired structure and functional properties suitable for uniform cell distribution and stable shape fidelity in the full period of in vitro culture and in vivo ***,due to insufficient cell infiltration and inadequate mechanical properties,engineered tissue made from porous scaffolds may have an inconsistent cellular composition and a poor shape retainability,which seriously hinders their further clinical *** this study,silk fibroin was integrated with silk short fibers with a physical and chemical double-crosslinking network to fabricate fiber-reinforced silk fibroin super elastic absorbent sponges(Fr-SF-SEAs).The Fr-SF-SEAs exhibited the desirable synergistic properties of a honeycomb structure,hygroscopicity and elasticity,which allowed them to undergo an unconventional cyclic compression inoculation method to significantly promote cell diffusion and achieve a uniform cell distribution at a ***,the regenerated cartilage of the Fr-SF-SEAs scaffold withstood a dynamic pressure environment after subcutaneous implantation and maintained its precise original structure,ultimately achieving human-scale ear-shaped cartilage ***,the SF-SEAs prepara-tion showed valuable universality in combining chemicals with other bioactive materials or drugs with reactive groups to construct microenvironment bionic *** established novel cell inoculation method is highly versatile and can be readily applied to various *** on the design concept of dual-network Fr-SF-SEAs scaffolds,homogenous and mature cartilage was successfully regenerated with precise and complicated shapes,which hopefully provides a platform strategy for tissue engineering for various cartilage defect repairs.

关键词： Silk fibroin Fiber-reinforced Elastic scaffold Cellular distribution Cartilage regeneration

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Large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels

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Bioactive Materials 2022年第8期7卷 97-109页

作者： Junxiang Hao baoshuai bai Zheng Ci Jincheng Tang Guanhuai Hu Chengxiang Dai Mengyuan Yu Meng Li Wei Zhang Yixin Zhang Wenjie Ren Yujie Hua Guangdong Zhou Research Institute of Plastic Surgery Weifang Medical UniversityWeifangShandongChina Department of Plastic and Reconstructive Surgery Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Tissue EngineeringShanghaiChina National Tissue Engineering Center of China ShanghaiChina Institute of Regenerative Medicine and Orthopedics Institutes of Health Central PlainXinxiang Medical UniversityXinxiangHenanChina Cellular Biomedicine Group Inc.ShanghaiChina

Physiological repair of large-sized bone defects is great challenging in clinic due to a lack of ideal grafts suitable for bone *** bone matrix(DBM)is considered as an ideal bone regeneration scaffold,but low cell seeding efficiency and a poor osteoinductive microenvironment greatly restrict its application in large-sized bone *** address these problems,we proposed a novel strategy of bone regeneration units(BRUs)based on microgels produced by photo-crosslinkable and microfluidic techniques,containing both the osteogenic ingredient DBM and vascular endothelial growth factor(VEGF)for accurate biomimic of an osteoinductive *** physicochemical properties of microgels could be precisely controlled and the microgels effectively promoted adhesion,proliferation,and osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in *** were successfully constructed by seeding BMSCs onto microgels,which achieved reliable bone regeneration in ***,by integrating the advantages of BRUs in bone regeneration and the advantages of DBM scaffolds in 3D morphology and mechanical strength,a BRU-loaded DBM framework successfully regenerated bone tissue with the desired 3D morphology and effectively repaired a large-sized bone defect of rabbit *** current study developed an ideal bone biomimetic microcarrier and provided a novel strategy for bone regeneration and large-sized bone defect repair.

关键词： Microgels Large-sized bone defect repair Bone regeneration units Photo-crosslinking Decalcified bone matrix

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基于改进的DDPG算法的蛇形机器人路径规划方法

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河北科技大学学报 2023年第2期44卷 165-176页

作者：郝崇清任博恒赵庆鹏侯宝帅白彤武晓晶樊劲辉河北科技大学电气工程学院河北石家庄050018 南京邮电大学通信与信息工程学院江苏南京210023

针对蛇形机器人执行路径规划任务时,面对复杂环境传统强化学习算法出现的训练速度慢、容易陷入死区导致收敛速度慢等问题,提出了一种改进的深度确定性策略梯度(deep determin-istic policy gradient,DDPG)算法。首先,在策略-价值(actor-... 详细信息

针对蛇形机器人执行路径规划任务时,面对复杂环境传统强化学习算法出现的训练速度慢、容易陷入死区导致收敛速度慢等问题,提出了一种改进的深度确定性策略梯度(deep determin-istic policy gradient,DDPG)算法。首先,在策略-价值(actor-critic)网络中引入多层长短期记忆(long short-term memory,LSTM)神经网络模型,使其控制经验池中信息的记忆和遗忘程度;其次,通过最优化特征参数将CPG(central pattern generators)网络融入强化学习模型,并设计新型网络状态空间和奖励函数;最后,将改进算法与传统算法分别部署在Webots环境中进行仿真实验。结果表明,相比于传统算法,改进算法整体训练时间平均降低了15%,到达目标点迭代次数平均降低了22%,减少了行驶过程中陷入死区的次数,收敛速度也有明显的提升。因此所提算法可以有效地引导蛇形机器人躲避障碍物,为其在复杂环境下执行路径规划任务提供了新的思路。

关键词：机器人控制蛇形机器人改进的DDPG算法强化学习 CPG网络 Webots三维仿真

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