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Channel Correlation Based User Grouping Algorithm for Nonlinear Precoding Satellite Communication System

China Communications 2024年第1期21卷 200-214页

作者： Ke Wang baorui Feng Jingui Zhao Wenliang Lin Zhongliang Deng Dongdong Wang Yi Cen Genan Wu School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China School of Information Engineering Minzu University of ChinaBeijing 100081China Institute of Spacecraft Application System Engineering China Academy of Space TechnologyBeijing 100094China Academy for Network and Communications of CETC Science and Technology on Communication Networks LaboratoryShijiazhuang 050081China

Low Earth Orbit(LEO)multibeam satellites will be widely used in the next generation of satellite communication systems,whose inter-beam interference will inevitably limit the performance of the whole *** precoding such as Tomlinson-Harashima precoding(THP)algorithm has been proved to be a promising technology to solve this problem,which has smaller noise amplification effect compared with linear ***,the similarity of different user channels(defined as channel correlation)will degrade the performance of THP *** this paper,we qualitatively analyze the inter-beam interference in the whole process of LEO satellite over a specific coverage area,and the impact of channel correlation on Signal-to-Noise Ratio(SNR)of receivers when THP is *** user grouping algorithm is proposed based on the analysis of channel correlation,which could decrease the number of users with high channel correlation in each precoding group,thus improve the performance of ***,our algorithm is designed under the premise of co-frequency deployment and orthogonal frequency division multiplexing(OFDM),which leads to more users under severe inter-beam interference compared to the existing research on geostationary orbit satellites broadcasting *** results show that the proposed user grouping algorithm possesses higher channel capacity and better bit error rate(BER)performance in high SNR conditions relative to existing works.

关键词： channel correlation inter-beam interference multibeam satellite Tomlinson-Harashima precoding user grouping

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Mycobacterium smegmatis enhances shikonin-induced immunogenic cell death—an efficient in situ tumor vaccine strategy

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Journal of Biomedical Research 2024年第4期38卷 369-381页

作者： Zhaoye Qian Zhe Zhang Lanqi Cen Yaohua Ke Jie Shao Manman Tian baorui Liu Department of Oncology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingJiangsu 210008China Department of Oncology the Affiliated Huai'an No.1 People's HospitalNanjing Medical UniversityHuai'anJiangsu 223000China Center of Clinical Oncology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221000China Department of Oncology China Pharmaceutical University Nanjing Drum Tower HospitalNanjingJiangsu 210008China The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu 210008China Department of Oncology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu 210008China

Tumor vaccines are a promising avenue in cancer *** the progress in targeting specific immune epitopes,tumor cells lacking these epitopes can evade the ***,we aimed to construct an efficient in situ tumor vaccine called Vac-SM,utilizing shikonin(SKN)to induce immunogenic cell death(ICD)and Mycobacterium smegmatis as an immune adjuvant to enhance in situ tumor vaccine *** showed a dose-dependent and time-dependent cytotoxic effect on the tumor cell line and induced ICD in tumor cells as evidenced by the CCK-8 assay and the detection of the expression of relevant indicators,*** with the control group,the in situ Vac-SM injection in mouse subcutaneous metastatic tumors significantly inhibited tumor growth and distant tumor metastasis,while also improving survival *** smegmatis effectively induced maturation and activation of bone marrow-derived dendritic cells(DCs),and in vivo tumor-draining lymph nodes showed an increased maturation of DCs and a higher proportion of effector memory T-cell subsets with the Vac-SM treatment,based on flow cytometry analysis ***,the Vac-SM vaccine effectively induces ICD,improves antigen presentation by DCs,activates a specific systemic antitumor T-cell immune response,exhibits a favorable safety profile,and holds the promise for clinical translation for local tumor immunotherapy.

关键词： Mycobacterium smegmatis shikonin immunogenic cell death tumor vaccines immunogenicity cytotoxicity

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A novel nomogram for predicting the prognosis of hepatocellular carcinoma patients following immune checkpoint inhibitors treatment beyond progression:a single center study based on Chinese population

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 771-787页

作者： Chao Chen Xiaoyuan Chu Hong Liu Mingzhen Zhou Zhan Shi Anfeng Si Ying Zhao Xiufeng Liu Jie Shen baorui Liu Comprehensive Cancer Center Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingChina Department of Oncology Jinling HospitalNanjing Medical UniversityNanjingChina Department of Cardiothoracic Surgery Nanjing Hospital Affiliated to Nanjing University of Chinese MedicineNanjingChina Department of Surgical Oncology of PLA Cancer Center Jinling HospitalNanjing Medical UniversityNanjingChina Department of Radiology Jinling HospitalNanjing Medical UniversityNanjingChina

Background:Hepatocellular carcinoma(HCC)persists as a dominant cause of cancer-related mortality globally,with a notably rapid escalation in mortality *** advent of immunotherapy,particularly immune checkpoint inhibitors(ICIs),has ushered in a new era in the management of liver cancer,albeit with unresolved challenges in the context of treatment beyond progression(TBP)and stratified prognosis in diverse *** study aimed to develop and validate a novel nomogram model to identify factors that predict the benefit of continued immunotherapy for hepatocellular carcinoma patients following disease progression in clinical ***:This study retrospectively analyzed the efficacy of ICIs in TBP,focusing on the Chinese population with advanced liver cancer.A nomogram was constructed based on four independent risk factors identified through Cox multivariate analysis,aiming to predict patient prognosis post-ICI *** model was validated through receiver operating characteristic(ROC)curve analysis and categorized patients into high-,intermediate-,and low-risk groups,with further validation using calibration plots and decision curve analysis(DCA).Results:The low-risk group demonstrated significantly enhanced overall survival(OS)compared to the high-risk group,with the nomogram predictions aligning closely with actual outcomes for 6-and 9-month *** model exhibited commendable predictive accuracy,achieving a C-index exceeding 0.7 in both training and validation *** DCA underscored the clinical utility of the nomogram-based prognostic model,further substantiated by the area under the ROC curve(AUC).Conclusions:The developed nomogram presents a potentially valuable tool for predicting the prognosis of HCC patients undergoing ICI therapy beyond progression,particularly within the Chinese ***,the study is constrained by its retrospective,single-center nature and necessitates further validation through large-scale,multicente

关键词： Hepatocellular carcinoma(HCC) immune checkpoint inhibitors(ICIs) novel nomogram

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Role of the Alleviating Aβ Toxicity in the Anti-AD Effect of Brown Wolfberry

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Food Science and Human Wellness 2024年

作者： Miaosi Zhang Rui Liu Ran Yang Jilite Wang Xiaozhi Liu baorui Li Ye Zhang Hao Wang State Key Laboratory of Food Nutrition and Safety， Tianjin University of Science and Technology (TUST) Department of Agriculture， Hetao College Tianjin Key Laboratory of Epigenetic for Organ Development of Preterm Infants， Tianjin Fifth Central Hospital High Altitude Characteristic Medical Research Institute， Huangnan Tibetan Autonomous Prefecture People's Hospital Institute of Food & Nutrition Science and Technology， Shandong Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing Technology of Shandong Province/Key Laboratory of Novel Food Resources Processing， Ministry of Agriculture and Rural Affairs/Shandong Engineering Research Center of Food for Special Medical Purpose

Wolfberry (Lycium barbarum L.) is a medicinal herb with anti-aging and neuroprotective effects. The purpose of this study was to explore the enhanced neuroprotective effects of wolfberry water extract (RW)， and brown wolfberry water extract (BBW). The reduced percentage of reducing sugar in BBW was shown to be 62.8%， 64.3%， 39.8%， and 11.6% for glucose， fructose， maltose， and lactose compared to those of RW， as well as free amino acids. And the contents of total phenols and total flavonoids were increased by 62.0% and 33.1%. Melanoidins (1% ± 0.05%) were first isolated from BBW. RW and BBW increased anti-stress abilities (oxidative stress: 2..2. vs 35.7%， and heat stress: 10.9% vs 19.1%) while decreasing the ROS levels in vivo. RW and BBW reduced the rate of paralysis and odor cognitive deficits. At the same time， RW and BBW reduced the number of fluorescent spots of Aβ::GFP. The RW and BBW activated autophagy by upregulating the gene levels (bec-1， lgg-1， lgg-2. unc-51， vps-34， atg-5， atg-18， and sqst-1). Additionally， BBW promoted the nuclear-cytoplasmic ratio of DAF-16::GFP and fluorescence intensity of SOD-3::GFP by 39.4 fold and 1.16 fold. This study laid a new insight for exploring the Maillard reaction in improving the anti-AD activity of wolfberry.

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First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2960-2969页

作者： Huizi Sha Fan Tong Jiayao Ni Yi Sun Yahui Zhu Liang Qi Xiaoqin Li Wei Li Yan Yang Qing Gu Xing Zhang Xiaoxuan Wang Chan Zhu Dongsheng Chen baorui Liu Juan Du The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingChina The Comprehensive Cancer Center Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Department of Oncology The Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Oncology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina National Institute of Healthcare Data Science at Nanjing University NanjingChina State Key Laboratory of Neurology and Oncology Drug Development Jiangsu Simcere Diagnostics Co.Ltd.Nanjing Simcere Medical Laboratory Science Co.Ltd.NanjingChina

Metastatic pancreatic cancer(mPC)has a dismal ***,we conducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease control rate(DCR),while secondary endpoints encompassed progression-free survival(PFS),overall survival(OS),and *** 66 patients analysed for efficacy,the best response,indicated by the ORR,was recorded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,*** 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(2./66).In prespecified exploratory analysis,patients with altered SWI/SNF complex had a poorer ***,low serum CA72. level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell scores at baseline were potential predicative biomarkers for more favourable *** conclusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for *** biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-combo regimen.

关键词： CA72. prospective centre

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中国哲学中“自然”概念的内涵及衍化

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上海交通大学学报（哲学社会科学版） 2024年第2期32卷 11-23页

作者：张雅迪杜保瑞上海交通大学马克思主义学院上海200240 上海交通大学人文学院上海200240

“自然”是中国古典哲学中的重要概念,研究“自然”对深入理解自然界、自然科学、社会科学有重要裨益。从造字法、词法、语法角度理解“自然”的来源和本意,可明晰其在先秦时的主要内涵,揭示出老子使用“自然”的语境,把握“自然”的哲... 详细信息

“自然”是中国古典哲学中的重要概念,研究“自然”对深入理解自然界、自然科学、社会科学有重要裨益。从造字法、词法、语法角度理解“自然”的来源和本意,可明晰其在先秦时的主要内涵,揭示出老子使用“自然”的语境,把握“自然”的哲学意蕴。道家综合、辩证地讨论了“道”与“自然”、人之自然与物之自然、宇宙生成论与本体论,且影响到两汉、魏晋,直至清代。“自然”内涵的重要衍变发生于魏晋,既深化又窄化了“自然”的内涵。道家与儒释的交融中,“自然”概念产生流变,在“人”与“物”之间摇摆。随着时代发展,“自然”概念逐渐窄化和形而下化,最终尘埃落定为现代社会中的语义——既是哲学概念又是日常用语。

关键词：自然内涵衍化

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高温热管技术在空间核能热能转换系统中的应用及展望

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清华大学学报（自然科学版） 2024年第10期64卷 1818-1838页

作者：李欣袁达忠陈民杜宝瑞中国科学院工程热物理研究所北京100190 中国科学院大学北京100049 清华大学航天航空学院北京100084

随着未来空间多元化任务的需求提升,空间核电源中核能热能转换系统的空间受限、长距离无动力循环、无重力环境等极限传热难题凸显。高温热管具有传热热流密度大、工作温度高、传热温差小、自适应能力强等优点,可作为空间核电源核能热能... 详细信息

随着未来空间多元化任务的需求提升,空间核电源中核能热能转换系统的空间受限、长距离无动力循环、无重力环境等极限传热难题凸显。高温热管具有传热热流密度大、工作温度高、传热温差小、自适应能力强等优点,可作为空间核电源核能热能转换系统的关键核心器件,应用前景广阔。该文分析了当前空间核电源核能热能转换系统存在的极限传热难题,讨论了高温热管技术应用于空间核能热能转换系统的优势和挑战,从高温热管内工质流动传热机理、高温热管的冷态启动、稳态传热、传热极限和寿命失效以及异形高温热管设计和研制等方面进行了综述,总结了高温热管技术在空间核能热能转换系统中的研究现状和最新应用进展,并给出合理建议。适应极限传热的高温热管工质流动和传热机制、异形高温热管的研制和热力结构耦合传热实验验证、空间核能热能转换与用能之间的匹配和优化是后续研究的重点方向。

关键词：高温热管空间核电源核能热能中间转换系统极限传热

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间皮素靶向药物用于肿瘤免疫治疗的机遇与挑战

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中国肿瘤生物治疗杂志 2024年第9期31卷 841-848页

作者：王颖刘宝瑞南京大学医学院附属鼓楼医院肿瘤中心暨南京大学临床肿瘤研究所江苏南京210008

肿瘤免疫治疗是一种新兴且发展前景广阔的治疗模式。间皮素是一种细胞表面膜蛋白,通过糖基化磷脂酰肌醇锚定在细胞膜上。间皮素在多种恶性实体肿瘤及血液恶性肿瘤中呈高表达,在少数正常组织的间皮细胞中呈低表达,是一个有潜力的肿瘤免... 详细信息

肿瘤免疫治疗是一种新兴且发展前景广阔的治疗模式。间皮素是一种细胞表面膜蛋白,通过糖基化磷脂酰肌醇锚定在细胞膜上。间皮素在多种恶性实体肿瘤及血液恶性肿瘤中呈高表达,在少数正常组织的间皮细胞中呈低表达,是一个有潜力的肿瘤免疫治疗靶点。间皮素的高表达与患者不良预后密切相关,可溶性间皮素已成为多种肿瘤的诊断性生物标志物。应用抗体药物偶联物和CAR-T细胞治疗等免疫治疗策略,针对间皮素阳性实体瘤进行转化研究并取得了初步进展。本文对间皮素的结构、体内分布、生物学功能、肿瘤细胞内信号传导机制及其作用、基于核素的靶向成像与治疗策略、抗体偶联药物和CAR-T细胞的治疗策略,以及面临的挑战进行系统阐述,为进一步探索以间皮素为靶点的免疫治疗提供新思路。

关键词：间皮素肿瘤免疫治疗靶向治疗

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基于关键点亲和场与支持向量机的人体姿态识别

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计算机应用与软件 2024年第1期41卷 126-132页

作者：闫新庆张保锐华北水利水电大学信息工程学院河南郑州450046

针对传统动作姿态识别仍需物理数据采集设备或深度体感设备进行手工提取特征的问题,提出一种基于关键点亲和场与支持向量机的人体姿态识别方法。以关键点亲和场为核心进行关节点检测,获取各种姿态下的18个关节点坐标信息,使用标准化后... 详细信息

针对传统动作姿态识别仍需物理数据采集设备或深度体感设备进行手工提取特征的问题,提出一种基于关键点亲和场与支持向量机的人体姿态识别方法。以关键点亲和场为核心进行关节点检测,获取各种姿态下的18个关节点坐标信息,使用标准化后的坐标数据对支持向量机模型加以训练,选择不同的高斯核函数进行对比。实现在没有人体深度信息和无穿戴设备的情况下,只使用普通RGB图片便可对人体姿态进行分类识别的效果。实验表明它在KTH数据集、Weizmann数据集中的识别效果良好;在自采集数据集中与带有传感器的方法相比,缩减操作步骤的同时准确率提高了7百分点。另外,还在保持关节点检测不变的情况下,使用随机森林、KNN算法进行姿态分类对比,实验结果证明该方法优于后两者。

关键词：姿态识别关键点亲和场 SVM 随机森林 KNN算法

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计及时空响应特性的电力系统灵活性资源配置优化模型

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电力建设 2024年第8期45卷 51-61页

作者：聂保瑞鞠立伟杨慧齐鑫瞿斌华北电力大学经济与管理学院北京市102206

随着我国能源结构逐步低碳转型,风、光等新能源的并网比例将不断扩大,为满足未来新能源装机容量规划的同时保证电力系统的安全可靠运行,在电力系统中需要具备相应调节能力的灵活性资源。为此,提出一种计及时空响应特性的多类型灵活性资... 详细信息

随着我国能源结构逐步低碳转型,风、光等新能源的并网比例将不断扩大,为满足未来新能源装机容量规划的同时保证电力系统的安全可靠运行,在电力系统中需要具备相应调节能力的灵活性资源。为此,提出一种计及时空响应特性的多类型灵活性资源配置优化模型。首先,建立基于空间响应特性和时间响应特性的灵活性评价模型,并构造灵活性平均缺额和灵活性覆盖指数的灵活性评价指标,分别用于电力系统灵活性不足节点筛选和各节点的灵活性充裕性分析。然后,分析多类型灵活性资源的调节特性,建立多类型调节能力模型。最后,考虑时间灵活性评价指标约束,构建灵活性资源两阶段配置优化模型,基于灵活性资源与新能源波动特性的多尺度匹配特性,指导各灵活性不足节点的灵活性资源配置,并以IEEE 9节点系统验证了所提灵活性资源配置方法的有效性和适用性。

关键词：灵活性资源时空响应特性灵活性评价灵活性不足节点优化配置

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