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Genome-wide Expansion and Expression Divergence of the Basic Leucine Zipper Transcription Factors in Higher Plants with an Emphasis on Sorghum

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Journal of Integrative Plant Biology 2011年第3期53卷 212-231页

作者： Jizhou Wang Junxia Zhou Baolan Zhang Jeevanandam Vanitha Srinivasan Ramachandran Shu-Ye Jiang Institute of Botany and Temasek Life Sciences Laboratory Joint Research & Development Laboratory Institute of Botany the Chinese Academy of Sciences Beijing 100093 China Temasek Life Sciences Laboratory 1 Research Link the National University of Singapore Singapore 117604 Singapore

Plant bZIP transcription factors play crucial roles in multiple biological processes. However, little is known about the sorghum bZIP gene family although the sorghum genome has been completely sequenced. In this study, we have carried out a genome-wide identification and characterization of this gene family in sorghum. Our data show that the genome encodes at least 92 bZIP transcription factors. These bZIP genes have been expanded mainly by segmental duplication. Such an expansion mechanism has also been observed in rice, arabidopsis and many other plant organisms, suggesting a common expansion mode of this gene family in plants. Further investigation shows that most of the bZIP members have been present in the most recent common ancestor of sorghum and rice and the major expansion would occur before the sorghum-rice split era. Although these bZlP genes have been duplicated with a long history, they exhibited limited functional divergence as shown by nonsynonymous substitutions （Ka）lsynonymous substitutions （Ks） analyses. Their retention was mainly due to the high percentages of expression divergence. Our data also showed that this gene family might play a role in multiple developmental stages and tissues and might be regarded as important regulators of various abiotic stresses and sugar signaling.

关键词： LEUCINE zippers TRANSCRIPTION factors SORGHUM GENETICS PLANT genomes PLANT gene expression DIVERGENCE (Biology) CARRIER proteins

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Natural Variation in the Promoter of GSE5 Contributes to Grain Size Diversity in Rice

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Molecular Plant 2017年第5期10卷 685-694页

作者： Penggen Duan Jinsong Xu Dali Zeng Baolan Zhang Mufan Geng Guozheng zhang Ke Huang Luojiang Huang Ran Xu Song Ge Qian Qian Yunhai Li State Key Laboratory of Plant Cell and Chromosome Engineering CAS Centre for Excellence in Molecular Plant Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 P. R. China State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences Beijing 100093 P. R. China University of Chinese Academy of Sciences Beijing 100039 P. R. China These authors contributed equally to this article

The utilization of natural genetic variation greatly contributes to improvement of important agronomic traits in crops. Understanding the genetic basis for natural variation of grain size can help breeders develop high- yield rice varieties. In this study, we identify a previously unrecognized gene, named GSE5, in the qSW5/ GW5 locus controlling rice grain size by combining the genome-wide association study with functional analyses. GSE5 encodes a plasma membrane-associated protein with ｜Q domains, which interacts with the rice calmodulin protein, OsCaMl-1. We found that loss of GSE5 function caused wide and heavy grains, while overexpression of GSE5 resulted in narrow grains. We showed that GSE5 regulates grain size predominantly by influencing cell proliferation in spikelet hulls. Three major haplotypes of GSE5 （GSE5, GSE5DELl＋IN1, and GSESDEL~ in cultivated rice were identified based on the deletion/insertion type in its pro- moter region. We demonstrated that a 950-bp deletion （DELl） in indica varieties carrying the GSE5DELl＋IN1 haplotype and a 1212-bp deletion （DEL2） in japonica varieties carrying the GSE5DEL2 haplotype associated with decreased expression of GSE5, resulting in wide grains. Further analyses indicate that wild rice acces- sions contain all three haplotypes of GSE5, suggesting that the GSE5 haplotypes present in cultivated rice are likely to have originated from different wild rice accessions during rice domestication. Taken together, our results indicate that the previously unrecognized GSE5 gene in the qSW5/GW5 locus, which is widely utilized by rice breeders, controls grain size, and reveal that natural variation in the promoter region of GSE5 contributes to grain size diversity in rice.

关键词： rice natural variation GSE5 grain size cell proliferation

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The GW2-WG1-OsbZIP47 pathway controls grain size and weight in rice

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Molecular Plant 2021年第8期14卷 1266-1280页

作者： Jianqin Hao Dekai Wang Yingbao Wu Ke Huang Penggen Duan Na Li Ran Xu Dali Zeng Guojun Dong Baolan Zhang Limin zhang Dirk Inze Qian Qian Yunhai Li State Key Laboratory of Plant Cell and Chromosome Engineering CAS Centre for Excellence in Molecular Plant BiologyInstitute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China Ghent University Department of Plant Biotechnology and Bioinformatics9052 GhentBelgium VIB Center for Plant Systems Biology 9052 GhentBelgium University of Chinese Academy of Sciences Beijing 100039China

Regulation of seed size is a key strategy for improving crop yield and is also a basic biological question.However,the molecular mechanisms by which plants determine their seed size remain elusive.Here,we report that the GW2-WG1-OsbZIP47 regulatory module controls grain width and weight in rice.WG1,which encodes a glutaredoxin protein,promotes grain growth by increasing cell proliferation.Interestingly,WG1 interacts with the transcription factor OsbZIP47 and represses its transcriptional activity by associating with the transcriptional co-repressor ASP1,indicating that WG1 may act as an adaptor protein to recruit the transcriptional co-repressor.In contrary,OsbZIP47 restricts grain growth by decreasing cell proliferation.Further studies reveal that the E3 ubiquitin ligase GW2 ubiquitinates WG1 and targets it for degradation.Genetic analyses confirm that GW2,WG1,and OsbZIP47 function in a comm on pathway to control grain growth.Taken together,ourfindi ngs reveal a genetic and molecular framework for the control of grain size and weight by the GW2-WG1-OsbZIP47 regulatory module,providing new targets for improving seed size and weight in crops.

关键词： rice WG1 GW2 OsbZIP47 grain size and weight cell proliferation

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Control of Grain Size and Weight by the OsMKKK10-OsM KK4-OsMAPK6 Signaling Pathway in Rice

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Molecular Plant 2018年第6期11卷 860-873页

作者： Ran Xu Penggen Duan Haiyue Yu Zhengkui Zhou Baolan Zhang Ruci Wang Jing Li Guozheng zhang Shangshang Zhuang Jia Lyu Na Li Tuanyao Chai Zhixi Tian Shanguo Yao Yunhai Li State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China CAS Centre for Excellence in Molecular Plant Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Plant Genomics National Centre for Plant Gene Research (Beijing) Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100039 China

Grain size is one of the key agronomic traits that determine grain yield in crops. However, the mechanisms underlying grain size control in crops remain elusive. Here we demonstrate that the OsMKKK10-OsMKK4- OsMAPK6 signaling pathway positively regulates grain size and weight in rice. In rice, loss of OsMKKKIO function results in small and light grains, short panicles, and semi-dwarf plants, while overexpression of constitutively active OsMKKK10 （CA-OsMKKK10） results in large and heavy grains, long panicles, and tall plants. OsMKKK10 interacts with and phosphorylates OsMKK4. We identified an OsMKK4 gain-of-func- tion mutant （large11-1D）that produces large and heavy grains. OsMKK4A227T encoded by the large11-1D allele has stronger kinase activity than OsMKK4. Plants overexpressing a constitutively active form of OsMKK4 （OsMKK4oDD） also produce large grains. Further biochemical and genetic analyses revealed that OsMKKK10, OsMKK4, and OsMAPK6 function in a common pathway to control grain size. Taken together, our study establishes an important genetic and molecular framework for OsMKKK10-OsMKK4- OsMAPK6 cascade-mediated control of grain size and weight in rice.

关键词： Oryza sativa grain size MAPK signaling cell proliferation

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Core fungal species strengthen microbial cooperation in a food-waste composting process

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Environmental Science and Ecotechnology 2022年第4期12卷 18-25页

作者： Yuxiang Zhao Jingjie Cai Pan zhang Weizhen Qin Yicheng Lou Zishu Liu baolan Hu Department of Environmental Engineering Zhejiang UniversityHangzhouChina State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbinChina Zhejiang Province Key Laboratory for Water Pollution Control and Environmental Safety HangzhouChina Key Laboratory of Environment Remediation and Ecological Health Ministry of EducationCollege of Environmental Resource SciencesZhejiang UniversityHangzhouChina

In ecosystem engineering research,the contribution of microbial cooperation to ecosystem function has been emphasized.Fungi are one of the predominant decomposers in composting,but thus far,less attention has been given to fungal than to bacterial cooperation.Therefore,network and cohesion analyses were combined to reveal the correlation between fungal cooperation and organic matter(OM)degradation in ten composting piles.Positive cohesion,reflecting the cooperation degree,was positively linked to the degradation rate of OM.From the community perspective,core species(i.e.,Candida tropicalis,Issatchenkia orientails,Kazachstania exigua,and Dipodascus australiensis)with high occurrence frequency and abundance were the key in regulating positive cohesion.These species were highly relevant to functional genera associated with OM degradation in both fungal and bacterial domains.Therefore,focusing on these core fungal species might be an appropriate strategy for targeted regulation of functional microbes and promotion of degradation rates.

关键词： Composting Fungi Core species Microbial cooperation

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免疫检查点抑制剂在驱动基因阳性晚期非小细胞肺癌中的应用进展

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中国肺癌杂志 2021年第3期24卷 188-195页

作者：张同梅(综述) 李宝兰(审校) 首都医科大学附属北京胸科医院综合科北京市结核病胸部肿瘤研究所北京101149

随着肿瘤精准医学的发展,驱动基因阳性非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受靶向治疗极大地改善了生存和预后,但不管是哪代靶向药物均不可避免的会经历耐药,患者会面临无靶可用的局面。免疫检查点抑制剂因其特有的... 详细信息

随着肿瘤精准医学的发展,驱动基因阳性非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受靶向治疗极大地改善了生存和预后,但不管是哪代靶向药物均不可避免的会经历耐药,患者会面临无靶可用的局面。免疫检查点抑制剂因其特有的长拖尾效应,能给部分晚期NSCLC患者带来长生存。越来越多的研究显示免疫治疗同样可为部分驱动基因阳性NSCLC患者带来获益,但免疫治疗介入的时机、治疗方案的选择以及预测生物标记物等问题仍不十分明确,值得进一步探讨。

关键词：肺肿瘤驱动基因免疫检查点抑制剂预测

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儿童肥胖与代谢综合征的关联性研究综述

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广东微量元素科学 2017年第3期24卷 12-15页

作者：张宝兰天津市滨海新区大港中塘镇社区卫生服务中心天津300270

近年来,我国儿童肥胖发病率有明显上升趋势,对儿童健康成长造成严重威胁。儿童肥胖与代谢综合征(MS)之间是否存在一定联系,就此方面的研究进展进行综述。

关键词：儿童肥胖代谢综合征关联性体质量指数身体健康

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某地区学龄前儿童膳食营养状况调查分析

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广东微量元素科学 2017年第2期24卷 27-29页

作者：张宝兰天津市滨海新区大港中塘镇社区卫生服务中心天津300270

目的探究某地区学龄前儿童的膳食营养状况。方法采用整群抽样方法抽取某地区学龄前儿童500人,通过称质量记帐法进行3 d的膳食调查。结果 1某地区学龄前儿童膳食结构不甚合理,蔬菜类、水果类、鱼虾类、牛奶以及豆类的摄入量明显低于推荐... 详细信息

目的探究某地区学龄前儿童的膳食营养状况。方法采用整群抽样方法抽取某地区学龄前儿童500人,通过称质量记帐法进行3 d的膳食调查。结果 1某地区学龄前儿童膳食结构不甚合理,蔬菜类、水果类、鱼虾类、牛奶以及豆类的摄入量明显低于推荐量。2某地区学龄前儿童蛋白质、能量摄入量接近膳食营养素推荐摄入量(RNI),但是维生素A、维生素C、钙的摄入量均低于RNI。结论应针对性调整某地区学龄前儿童膳食结构,适当增加蔬菜类、水果类、鱼虾类、牛奶以及豆类食物的摄入量。

关键词：学龄前儿童膳食营养调查

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Genetic regulation of seed size in plants

Genetic regulation of seed size in plants

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2018全国植物生物学大会

作者： Na Li Ran Xu PenggenDuan Haiyue Yu Tian Xia Liangliang Chen Baolan Zhang Yunhai Li Institute of Genetics and Developmental Biology Chinese Academy of Sciences

Seed size is one of the most important yield traits in plants.In angiosperms,a mature seed consists of the embryo,the endosperm and the seed coat,which develop from the zygote,the fertilized central cell and the maternal integument.Thus,the characteristic size of plant seeds is coordinately determined by maternal and zygotic tissues.However,the genetic and molecular mechanisms that set the final size of seeds are largely unknown.We are focusing on understanding how plants determine their final seed size in rice and Arabidopsis.We have recently identified several pathways of seed size control in rice and Arabidopsis.The emerging genetic and molecular mechanisms ofseed size control in plants will be discussed.

关键词： Rice Arabidopsis seed size control

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经羊膜干细胞疗法:产前治疗多种先天性疾病的新策略

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中国组织工程研究 2023年第24期27卷 3892-3900页

作者：成曦孙宝兰谢园园张玉泉南通大学附属医院妇产科南通大学医学院江苏省南通市226001 南通大学附属医院检验科江苏省南通市226001

背景:产前诊断的进步使得多种先天性疾病的产前管理和治疗成为可能,经羊膜干细胞疗法作为一种产前治疗先天性异常的新策略应运而生。目的:文章对应用经羊膜干细胞疗法产前治疗多种先天性疾病的研究结果进行综述。方法:通过计算机检索中... 详细信息

背景:产前诊断的进步使得多种先天性疾病的产前管理和治疗成为可能,经羊膜干细胞疗法作为一种产前治疗先天性异常的新策略应运而生。目的:文章对应用经羊膜干细胞疗法产前治疗多种先天性疾病的研究结果进行综述。方法:通过计算机检索中国知网、维普、万方和PubMed数据库发表的文献,检索时间从各数据库建库至2022-08-01,中文检索词为“经羊膜干细胞疗法”“经羊膜”“羊膜腔内”“干细胞”或“经羊膜干细胞疗法”,英文检索词为“Transamniotic stem cell therapy”“Transamniotic”“intra-amniotic”“stem cells”或“TRASCET”。最终共纳入61篇经羊膜干细胞疗法相关的文献进行综述。结果与结论:(1)经羊膜干细胞疗法通过充分放大生理或病理条件下存在于羊水中干细胞的生物学功能用于产前胎儿异常治疗。(2)羊膜腔内输注的特定干细胞不仅可以直接播散至暴露于羊水的缺陷,而且还可以血行转运至胎盘、羊膜、绒毛膜、脐带、胎儿骨髓、脾脏、髋骨和脑等部位。(3)羊膜腔内输注间充质干细胞可明显促进组织修复和/或显著改善与主要先天性异常相关的不良影响,例如经羊膜干细胞疗法可以通过形成新生皮肤诱导部分或完全覆盖实验性脊柱裂;经羊膜干细胞疗法还可以缓解与腹裂相关的肠道损伤;同时,经羊膜干细胞疗法还能影响实验性先天性膈疝肺发育,显著降低肺小动脉壁厚度;经羊膜干细胞疗法可以逆转大鼠宫内生长受限的不良影响,包括显著改善胎盘效率以及提高胎儿体质量。(4)经羊膜干细胞疗法在先天性脊柱裂、腹裂、先天性膈疝和宫内生长受限这些先天性疾病模型中展现出良好的治疗潜能,但迄今为止尚无经羊膜干细胞疗法的临床报道,临床转化前需要在大型动物中进一步验证经羊膜干细胞疗法的有效性和安全性。(5)尽管经羊膜干细胞疗法目前仍处于起步阶段,但其在产前治疗胎儿先天性疾病方面展现出的潜能值得进一步研究。

关键词：经羊膜干细胞疗法产前治疗先天性疾病出生缺陷羊水干细胞胎盘干细胞综述

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