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牛膝提取物含药血清对Aβ_(1-42)诱导的神经元氧化应激和凋亡的调控机制研究

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湖南中医药大学学报 2024年第8期44卷 1366-1372页

作者：马宝君叶涵斌孟高强叶子南通市第一人民医院神经外科江苏南通226001

目的探讨牛膝提取物含药血清对β淀粉样蛋白_(1-42)(amyloidβ-protein_(1-42),Aβ_(1-42))诱导的神经元氧化应激和凋亡的影响及作用机制。方法体外培养大鼠海马神经元,分为对照组,模型组(Aβ_(1-42)诱导神经元),牛膝低、中、高剂量组(1... 详细信息

目的探讨牛膝提取物含药血清对β淀粉样蛋白_(1-42)(amyloidβ-protein_(1-42),Aβ_(1-42))诱导的神经元氧化应激和凋亡的影响及作用机制。方法体外培养大鼠海马神经元,分为对照组,模型组(Aβ_(1-42)诱导神经元),牛膝低、中、高剂量组(15、30、45μg/mL的牛膝提取物含药血清作用于Aβ_(1-42)诱导的神经元),si-ZBTB20-AS1组[Aβ_(1-42)诱导转染锌指和BTB结构域蛋白20的反义RNA小干扰RNA的神经元]和si-NC组(Aβ_(1-42)诱导转染乱序无意义阴性序列的神经元)。ELISA法检测超氧化物歧化酶(superoxide dismutase,SOD)和丙二醛(malondialdehyde,MDA)含量,CCK-8法检测细胞存活率,流式细胞术检测细胞凋亡率,RT-qPCR法检测ZBTB20-AS1表达水平,Western blot法检测细胞增殖抗原Ki67和胱天蛋白酶-3(cysteine aspartic acid specific protease-3,Caspase-3)表达水平。结果与对照组比较,模型组SOD含量、细胞存活率、Ki67蛋白表达均降低(P<0.05),MDA含量、细胞凋亡率、BTB20-AS1表达、Caspase-3蛋白表达均升高(P<0.05)。与模型组比较,牛膝中、高剂量组SOD含量、细胞存活率、Ki67蛋白表达均升高(P<0.05),MDA含量、细胞凋亡率、BTB20-AS1表达、Caspase-3蛋白表达均降低(P<0.05)。与si-NC组比较,si-ZBTB20-AS1组SOD含量、细胞存活率、Ki67蛋白表达均升高(P<0.05),MDA含量、细胞凋亡率、BTB20-AS1表达、Caspase-3蛋白表达均降低(P<0.05)。结论牛膝提取物含药血清可能通过下调ZBTB20-AS1表达抑制Aβ_(1-42)诱导的海马神经元氧化应激和凋亡。

关键词：牛膝提取物 β淀粉样蛋白_(1-42) 海马神经元氧化应激凋亡

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信息管理与信息系统一流专业建设改革与创新

信息系统学报 2024年第1期 156-159页

作者：许伟程絮森马宝君左美云中国人民大学信息学院北京100872 脑机协同信息行为教育部和上海市重点实验室上海外国语大学国际工商管理学院上海201620

本文基于第十届中国系统工程学会信息系统工程专业委员会中主题为“信息管理与信息系统一流专业建设与评估”的第八届院长/系主任论坛特邀专家分享与讨论内容,回顾了信息管理与信息系统一流专业建设中的经验措施和面临的挑战,提出了新... 详细信息

本文基于第十届中国系统工程学会信息系统工程专业委员会中主题为“信息管理与信息系统一流专业建设与评估”的第八届院长/系主任论坛特邀专家分享与讨论内容,回顾了信息管理与信息系统一流专业建设中的经验措施和面临的挑战,提出了新时代背景下信息管理与信息系统专业改革创新的实施路径,最后结合研讨内容总结了该专业未来发展的建议。

关键词：信息管理与信息系统专业建设专业改革创新发展

Study on the ore-forming and ore-controlling structure of the Mujicun Cu (Mo) ore deposit, Hebei Province, China

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Chinese Journal Of Geochemistry 2012年第1期31卷 1-14页

作者： NIU Shuyin ma Guoxi CHEN Zhikuan WANG Baode CHEN Lijing SUN Aiqun ma Xiaofeng ZHANG Jianzhen ma baojun CHEN Chao LU Hongpeng Shijiazhuang University of Economics Shijiazhuang 050031China Baoding Geo-Engineering Investigation Institute of Hebei Province Baoding 071051China College of Earth Science and Natural Resources China University of Geosciences(Beijing)BeOing 100029China

The Mujicun Cu (Mo) ore deposit at Laiyuan, Hebei Province, is a currently proven large-sized Cu (Mo) polymetallic ore deposit and it is located in the second-ordered fault depression basin of the ditachment belt on the hanging-wall on the western side at the juncture of the Laiyuan dumbell-shaped complex in the northern part of the Fuping mantle-branch structure. Metallogenesis is controlled by diorite porphyrite in intrusive relation with the fault depression basin and other relevant fault structure systems and intenstive wall-rock alteration zones. This study, in conjunction with the most recent exploration data, analyzed the geological background of metallogenesis of this deposit, summaried the geological characteristics of typical ore deposits, determined the alteration zonation of the deposit, investigated regional metallogenesis and the genesis of typical ore deposits, discussed the regional ore-forming and ore-controlling structures, and generalized the regional ore-controlling model and metallogenic model of the deposit. It is considered that the Mujicun porphry Cu (Mo) deposit, the Tieling, Futuyu, Xiaoligou and other skarn-type Fe-Cu deposits and the He'ergou hydrothermal-type Pb-Zn-Ag deposit jointly constitute a three-in-one polymetallic orefield, with the characteristics of typical metallogenic series.

关键词：多金属矿床控矿构造成矿控制河北省铜矿钼中国断裂构造系统

Metallogenic characteristics of the region of Northwest Hebei and analysis of ore prospecting potential in its peripheries

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Chinese Journal Of Geochemistry 2011年第1期30卷 1-13页

作者： SUN Aiqun NIU Shuyin WANG Baode HAN Yuchou WEI Minhui ma baojun ZHAO Zhiyuan XIA Dong College of Resources Shijiazhuang Univerity of Economics Shijiazhuang 050031 China Department of Land and Natural Resources of Hebei Province Shijiazhuang 050081 China

The region of Northwest Hebei is an area where Au-Ag polymetallic ore depsits are concentrated in Hebei Province. There were divided the Au ore-concentrated region with the magmatic-metamorphic diamictite zone as the center and the perpheral cover-strata zone and Ag-polymetallic metallogenic zone along the line of Xuanhua-Songli-Chicheng. Research on mantle branch structure indicates that Au-Ag polymetallic ore-forming materials come mainly from the deep interior of the Earth. The ore-forming materials tend to migrate upwards through the multi-stage evolution of mantle plume, and are concentrated as ores in the favourable tectonic expansion zone of a mantle branch structure. As viewed in plane, from the center to the periphery and as viewed in space, from the lower part to the upper part there exists Au-Ag-Pb-Zn zonation, as evidenced by drilling data from a number of mines. So, there is still great potential for ore prospecting in the region of Northwest Hebei.

关键词：成矿地质特征冀西北地区找矿潜力银多金属矿多金属成矿带地球深部成矿物质多级演化

Analysis of the ore-controlling role of Guojiadian mantle branch structure,Northwest Shandong Peninsula,China

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Chinese Journal Of Geochemistry 2012年第4期31卷 414-423页

作者： NIU Shuyin Sun Aiqun ZHANG Jianzhen ma baojun WANG Baode CHEN Chao ZHANG Fuxiang LIU Cheng ZHANG Xiaofei College of Resources Shijiazhuang University of Economics Shijiazhuang 050031 China College of Earth Science and Resources China University ofGeosciences Beifing 100083 China

Metallogenesis in the gold ore-concentrated zone of Northwest Shandong Peninsula is closely related to deep *** region in the eastern part of North China entered into the stage of mantle plume evolution during the Yanshanian movement,following the long-time stage of stable platform evolution during Paleozoic *** that time,the ore-concentrated zone of Northwest Shandong Peninsula just entered into the development-evolution stage of the Laiyang sub-mantle plume and the Guojiadian mantle branch structure in its *** core-mantle-source gold was present in the gas-liquid form,and it migrated through mantle plume→sub-mantle plume→mantle branch structure→favorable tectonic expansion zone to the favorable loci of the mantle branch structure,where gold was deposited as ores,thereafter constituting a series of large-to medium-sized gold deposits distributed around the Guojiadian mantle branch *** study also dealt with the Jiaojia fault as the main detachment(fault altered rock) belt on the northwestern margin of the mantle branch structure and also presented a basic cognition about the fact that the Sanshandao fault as the listric fault on the hanging wall of the detachment ***,on this basis,this study also pointed out the orientation for further ore prospecting in this region.

关键词：分支结构山东半岛地幔柱中国北方西北部控矿作用演化阶段焦家断裂带

Timing of mineralization at the Shihu gold deposit in the middle segment of the Taihang Mountain, China

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Acta Geochimica 2018年第1期37卷 80-89页

作者： Chao Chen Shuyin Niu Fang Wang Fuxiang Zhang Qinglian Zhang baojun ma Aiqun Sun Jianzhen Zhang Yaqi Cao Xiaoqing Zhang Hebei GEO University Shijiazhuang 050031 China

The Shihu gold deposit, located in the middlesouth section of the core of the Fuping mantle branch structure, is hosted in the Archean Fuping Group and adjacent to the quartz diorite porphyrite. The gold deposit is the only large gold deposit with reserves of more than 30 tons gold discovered in western Hebei Province so far. In order to constrain the timing of mineralization of this ore deposit, this paper focuses on the isotopic dating of zircon and pyrite. Zircons in gold-bearing quartz veins are magmatic in origin and no hydrothermal zircon has been found in such quartz veins, indicating that zircons were derived from the wall rocks. U–Pb ages of zircons fall mainly in the two domains: 2492 ± 82 and 136 ± 4 ma, respectively,indicative of the contribution of the Fuping-Group TTG gneiss and Yanshanian igneous rocks, respectively. The Re–Os isotopic compositions of pyrites in the gold-bearing quartz veins yield an isochron age of 127 ± 31 ma. Combined with other dating results, we suggest that the main metallogenic age of the Shihu gold deposit is 120–127 ma.

关键词： mantle branch structure Shihu gold deposit Zircon U–Pb dating Pyrite Re–Os dating Gold-bearing quartz vein

Study on the Metallogenetism of Sub-mantle Plume and mantle Branches in the Gold Mineralization Concentration Area of Northwest Jiaodong Peninsula

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Acta Geologica Sinica(English Edition) 2014年第5期88卷 1409-1420页

作者： NIU Shuyin CHENG Guangsuo ZHANG Jianzhen SUN Aiqun ma baojun ZHANG Fuxiang WANG Baode XU Meng WU Jichun ZHAO Rongxin WANG Shanfei Key Laboratory of Gold Mineralization Processes and Resource Utilization Subordinated to the Ministry of Land and Resources Shijiazhuang University of Economics Shandong Gold Group Co. Ltd.

The northwest of Jiaodong peninsula is characterized by its greatest gold concentration area, enormous gold reserves and limited time interval （115±5ma） of gold mineralization in China. Studies show that the east area of north China began its mantle plume evolution since the Yanshanian movement, and the Laiyang sub-mantle plume and its surrounding mantle branches such as those in Guojiadian, Aishan and Panshidian were formed in the mineralization concentration area of northwestern Jiaodong peninsula. With the development of mantle plume →sub-mantle plume → mantle branch→ favorable expending structures, the deep-derived hydrothermal fluid moved up to the favorable places, such as brittle-ductile or ductile-brittle shearing zones, the internal and external contact zones of intrusions, dense fracturing zones and the contact zones between dikes and countryrocks, and concentrated into deposits. Then the gold mineralization concentration zones that are centralized on mantle branches were formed. This study takes Guojiadian mantle branch as an example to discuss their metallogenetism and conclude the metallogenetic mode.

关键词： sub-mantle plume mantle branch ore-controlling structure metallogenetism,metallogenetic mode northwest Jiaodong peninsula

惠民凹陷江家店油田低序级断层精细解释及控藏作用

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石油地质与工程 2024年第1期38卷 57-62页

作者：李柄毅曹爱锋马宝军牛子凡李庆安甄鑫河北地质大学河北石家庄050000 中国石化胜利油田分公司勘探开发研究院山东东营257015 中国石化河南油田分公司采油一厂河南南阳474780 中国石化河南油田分公司采油二厂河南南阳473400

江家店油田地质构造复杂,内部断层十分发育,预示着其依旧有较大的油气勘探潜力。由于该区发育众多断距较小的低序级断层,且目前对低序级断层的识别和勘探研究程度较低,因此,需要对低序级断层的构造精细解释及其控藏作用进行研究。该区... 详细信息

江家店油田地质构造复杂,内部断层十分发育,预示着其依旧有较大的油气勘探潜力。由于该区发育众多断距较小的低序级断层,且目前对低序级断层的识别和勘探研究程度较低,因此,需要对低序级断层的构造精细解释及其控藏作用进行研究。该区发育北东-南西向、近东西向以及南北向三组低序级断层,在二级、三级断层附近,低序级断层与主干断层以斜交式分布,远离二级、三级断层,低序级断层呈现不同方向分布。利用相干体切片方法能够识别出江家店油田低序级断层,通过对低序级断层的构造精细解释,进而分析该区成藏模式,主要有构造控制的层状油藏和构造-岩性油藏,此外有少量透镜体岩性油藏。低序级断层的精细解释及其控藏作用的研究对油气的勘探开发具有重要意义。

关键词：江家店油田低序级断层构造解释控藏作用

Analysis of the ore-controlling structure of the Shihu gold deposit, Hebei Province and deep-seated ore-prospecting prediction

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Chinese Journal Of Geochemistry 2009年第4期28卷 386-396页

作者： NIU Shuyin WANG Baode SUN Aiqun CHEN Chao WANG Zili ma baojun WANG Wenxue JIANG Xiaoping ZHAO Yongli GAO Yincang LIU Huabin QIU Jianping College of Resources Shijiazhuang University of Economics Shijiazhuang 050031 China Shijiazhuang Integrated Geological Party Shijiazhuang 050081 China Shihu Gold Mine Shijiazhuang 050506 China

Under the guidance of the theory of mantle-branch structure-associated metallogenesis and on the basis of the geological characteristics, analysis of the ore-forming and ore-controlling structures, the geochemical characteristics of metallogenesis, the source of ore-forming materials, changes in the physical and chemical conditions of metallogenesis, changes in the vertical width of ore veins, and changes in gold grade of the Shihu gold deposit, the mechanism of its metallogenesis was discussed and the rules of vertical variation of ore veins were summarized in this study. It is pointed out that the orebodies under exploitation at present time should be in the middle and upper portions of gold veins in the Shihu gold mining district. Particularly on the basis of the characteristics of mantle-branch structure-associated metallogenesis, it is indicated that metallogenesis is controlled mainly by such ore-forming conditions as temperature and pressure. Deep-seated ore-forming fluids are characterized mainly by injection and precipitation. So the vein bodies in the adjacent metallogenic structures are of obvious comparability, and there would be great prospects for ore search both at depth and in the periphery of the Shihu gold deposit. Therefore, ore prospecting should be strengthened both at depth and in the peripheries.

关键词：分支结构找矿预测金矿脉控矿河北省成矿理论地球化学特征成矿物质来源