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Frontiers of Electrical and Electronic Engineering in China 2011年第2期6卷 353-362页

作者： Lubin WANG Hui SHEN baojuan li Dewen HU College of Mechatronics and Automation National University of Defense TechnologyChangsha 410073China

Several meta-analyses were recently conducted in attempts to identify the core brain regions exhibiting pathological changes in schizophrenia,which could potentially act as disease *** on the findings of these meta-analyses,we developed a multivariate pattern analysis method to classify schizophrenic patients and healthy controls using structural magnetic resonance imaging(sMRI)*** component analysis(ICA)was used to decompose gray matter density images into a set of spatially independent *** multiple regression of a region of interest(ROI)mask with each of the components was then performed to determine pathological patterns,in which the voxels were taken as features for *** dimensionality reduction using principal component analysis(PCA),a nonlinear support vector machine(SVM)classifier was trained to discriminate schizophrenic patients from healthy *** performance of the classifier was tested using a 10-fold cross-validation *** results showed that two distinct spatial patterns displayed discriminative power for schizophrenia,which mainly included the prefrontal cortex(PFC)and subcortical regions *** was found that simultaneous usage of these two patterns improved the classification performance compared to using either of them ***,the two pathological patterns constitute a prefronto-subcortical network,suggesting that schizophrenia involves abnormalities in networks of brain regions.

关键词： schizophrenia discriminative analysis gray matter network independent component analysis(ICA) support vector machine(SVM)

石榴花水提物调节AHR/BNIP3改善糖尿病小鼠肝脏胰岛素信号

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食品工业科技 2024年第7期45卷 320-327页

作者：叶雨萌荣雨李包娟周克春张䶮之新疆医科大学药学院新疆乌鲁木齐830000

目的:探讨石榴花水提物(pomegranate flower water extract,PFW)对2型糖尿病小鼠肝脏胰岛素信号传导的影响及机制。方法:将C57BL/6J随机分为正常组、模型组、二甲双胍组(Met)、石榴花水提物低剂量组(PFWL)和石榴花水提物高剂量组(PFWH)... 详细信息

目的:探讨石榴花水提物(pomegranate flower water extract,PFW)对2型糖尿病小鼠肝脏胰岛素信号传导的影响及机制。方法:将C57BL/6J随机分为正常组、模型组、二甲双胍组(Met)、石榴花水提物低剂量组(PFWL)和石榴花水提物高剂量组(PFWH)。连续给药11周后,称小鼠体质量,检测空腹血糖(FBG)、胰岛素(INS)、甘油三酯(TG)和总胆固醇(TC)的含量,计算胰岛素抵抗指数(HOMA-IR);苏木素-伊红(HE)染色观察肝组织病理变化;Western blot法检测肝组织中胰岛素受体底物1(IRS1)、p-IRS1(Ser307)、蛋白激酶B(AKT)、p-AKT(Ser473)、糖原合成酶激酶-3β(Gsk3β)、p-Gsk3β(S9)、芳香烃受体(AhR)、磷脂酰乙醇胺N-甲基转移酶(PEMT)、Bcl-2/腺病毒E1B-19kDa相互作用蛋白3(BNIP3)蛋白表达。结果:与模型组比较,PFWH组FBG、INS、HOMA-IR、TG和TC含量极显著降低(P<0.01);PFWH组小鼠肝细胞内脂肪滴明显减少;PFWH组极显著升高肝脏中IRS1、p-AKT(Ser473)/AKT、p-Gsk3β(S9)/Gsk3β、BNIP3蛋白表达(P<0.01),极显著降低p-IRS1(Ser307)/IRS1、AHR、PEMT蛋白表达(P<0.01)。结论:PFW可能通过调节AHR/BNIP3抑制肝脏脂质沉积,改善p-IRS1(Ser307)/p-AKT(Ser473)/p-GSK3β(S9)胰岛素信号通路转导。

关键词：石榴花水取物胰岛素信号通路芳香烃受体 Bcl-2/腺病毒E1B-19kDa相互作用蛋白3 磷脂酰乙醇胺N-甲基转移酶

One-step growth of ultrathin CoSe_(2)nanobelts on N-doped MXene nanosheets for dendrite-inhibited and kinetic-accelerated lithium-sulfur chemistry

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Science Bulletin 2024年第13期69卷 2059-2070页

作者： Chuanliang Wei Zhengran Wang Peng Wang Xinlu Zhang Xuguang An Jinkui Feng baojuan Xi Shenglin Xiong School of Chemistry and Chemical Engineering School of Materials Science and EngineeringShandong UniversityJinan 250100China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

The practical application of lithium–sulfur(li–S)batteries is inhibited by the shuttle effect of lithium polysulfides(liPSs)and slow polysulfide redox kinetics on the S cathode as well as the uncontrollable growth of dendrites on the li metal ***,both cathode and anode sides must be considered when modifying liS ***,two-dimensional(2D)ultrathin CoSe_(2)nanobelts are in situ grown on 2D N-doped MXene nanosheets(CoSe_(2)@N-MXene)via one-step solvothermal process for the first *** to its unique 2D/2D structure,CoSe_(2)@N-MXene can be processed to crumpled nanosheets by freeze-drying and flexible and freestanding films by vacuum *** crumpled CoSe_(2)@NMXene nanosheets with abundant active sites and inner spaces can act as S hosts to accelerate polysulfide redox kinetics and suppress the shuttle effect of liPSs owing to their strong adsorption ability and catalytic conversion effect with ***,the CoSe_(2)@N-MXene film(CoSe_(2)@NMF)can act as a current collector to promote uniform li deposition because it contains lithiophilic CoSe_(2)and N *** the systematic effect of CoSe_(2)@N-MXene on S cathode and li metal anode,the electrochemical and safety performance of li–S batteries are ***_(2)@NMF also shows excellent storage performances in flexible energy storage devices.

关键词： Ultrathin CoSe_(2)nanobelts N-doped MXene nanosheets In situ growth Flexible MXene-based films li-S batteries

Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia

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Neuroscience Bulletin 2017年第3期33卷 281-291页

作者： baojuan li Long-Biao Cui Yi-Bin Xi Karl J.Friston Fan Guo Hua-Ning Wang lin-Chuan Zhang Yuan-Han Bai Qing-Rong Tan Hong Yin Hongbing Lu School of Biomedical Engineering Fourth Military Medical UniversityXi'an 710032China Department of Radiology Xijing HospitalFourth Military Medical UniversityXi'an 710032China Wellcome Trust Center for Nettroimaging Institute ofNeurologyUniversity College LondonLondon WC1N 3BGUK Department of Psychiatry Xijing HospitalFourth Military Medical UniversityXi'an 710032China

Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations（AVHs） in schizophrenia（SZ） remains unclear. In this study, we used stochastic dynamic causal modeling（s DCM） to quantify connections among the left dorsolateral prefrontal cortex（inner speech monitoring）, auditory cortex（auditory processing）, hippocampus（memory retrieval）, thalamus（information filtering）, and Broca＇s area（language production） in 17 first-episode drug-na？¨ve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance ***, we performed receiver operating characteristic（ROC） analysis and correlation analysis between image measures and symptoms. s DCM revealed an increasedsensitivity of auditory cortex to its thalamic afferents and a decrease in hippocampal sensitivity to auditory inputs in SZ patients with AVHs. The area under the ROC curve showed the diagnostic value of these two connections to distinguish SZ patients with AVHs from those without AVHs. Furthermore, we found a positive correlation between the strength of the connectivity from Broca＇s area to the auditory cortex and the severity of AVHs. These findings demonstrate, for the first time, augmented AVHspecific excitatory afferents from the thalamus to the auditory cortex in SZ patients, resulting in auditory perception without external auditory stimuli. Our results provide insights into the neural mechanisms underlying AVHs in SZ. This thalamic-auditory cortical-hippocampal dysconnectivity may also serve as a diagnostic biomarker of AVHs in SZ and a therapeutic target based on direct in vivo evidence.

关键词： Effective connectivity Stochastic dynamic causal modeling Auditory verbal hallucinations Schizophrenia

Rational design of F,N-rich artificial interphase via chemical prelithiation initiation strategy enabling high coulombic efficiency and stable micro-sized SiO anodes

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Journal of Energy Chemistry 2024年第5期92卷 224-232页

作者： Quanyan Man Hengtao Shen Chuanliang Wei baojuan Xi Shenglin Xiong Jinkui Feng Key Laboratory for liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061ShandongChina School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100ShandongChina

Silicon monoxide(SiO)is regarded as a potential candidate for anode materials of lithium-ion batteries(liBs).Unfortunately,the application of SiO is limited by poor initial Coulombic efficiency(ICE)and unsteady solid electrolyte interface(SEI),which induce low energy,short cycling life,and poor rate *** address these drawbacks of SiO,we achieve in-situ construction of robust and fast-ion conducting F,N-rich SEI layer on prelithiated micro-sized SiO(P-μSiO)via the simple and continuous treatment ofμSiO in mild lithium 4,4′-dimethylbiphenyl solution and nonflammable hexafluorocyclotriphosphazene *** prelithiation eliminates irreversible capacity through pre-forming inactive lithium ***,the symbiotic F,N-rich SEI with good mechanical stability and fast li^(+)permeability is conductive to relieve volume expansion ofμSiO and boost the li+diffusion ***,the P-μSiO realizes an impressive electrochemical performance with an elevated ICE of 99.57%and a capacity retention of 90.67%after 350 ***,the full cell with P-μSiO anode and commercial liFePO_(4) cathode displays an ICE of 92.03%and a high reversible capacity of 144.97 mA h g^(-1).This work offers a general construction strategy of robust and ionically conductive SEI for advanced liBs.

关键词： Chemical prelithiation Silicon monoxide SEI lithium-ion batteries Interphase engineering

Performance optimization of chalcogenide catalytic materials in lithium-sulfur batteries:Structural and electronic engineering

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Chinese Chemical Letters 2024年第7期35卷 147-166页

作者： Jianmei Han Peng Wang Hua Zhang Ning Song Xuguang An baojuan Xi Shenglin Xiong College of Chemistry and Chemical Engineering Taishan UniversityTai'an 271021China Key Laboratory of Colloid and Interface Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShandong UniversityJi'nan 250100China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

lithium-sulfur batteries(LSBs)boasting remarkable energy density have garnered significant attention within academic and industrial ***,the progression of LSBs remains constrained by the languid redox kinetics intrinsic to sulfur and the pronounced shuttle effect induced by lithium polysulfides(li PSs),which seriously affecting the energy density,cycling life and rate *** conceptualization and implementation of catalytic materials stand acknowledged as a propitious stratagem for orchestrating kinetic modulation,particularly in excavating the conversion of liPSs and has evolved into a focal point for *** them,chalcogenide catalytic materials(CCMs)have shown satisfactory catalytic effects ascribe to the unique physicochemical properties,and have been extensively developed in recent *** the lack of systematic summary regarding the development of CCMs and corresponding performance optimization strategies,herein,we initiate a comprehensive review regarding the recent progress of CCMs for effective collaborative immobilization and accelerated transformation kinetics of li *** that,the modulation strategies to improve the catalytic activity of CCMs are summarized,including structural engineering(morphology engineering,surface/interface engineering,crystal engineering)and electronic engineering(doping and vacancy,etc.).Finally,the application prospect of CCMs in LSBs is clarified,and some enlightenment is provided for the reasonable design of CCMs serving practical LSBs.

关键词： lithium-sulfur batteries Chalcogenide Catalytic materials lithium polysulfides Structural engineering Electronic engineering

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基于地震沉积学的复杂曲流带沉积相研究

中国石油大学学报（自然科学版） 2018年第6期42卷 30-39页

作者：刘海林承焰董春梅栗宝鹃李佳中国石油大学(华东)地球科学与技术学院山东青岛266580 山东省油藏地质重点实验室山东青岛266580 中海石油能源发展安全环保分公司天津300450

为了揭示孔店油田河流相砂体展布特征及复杂连通关系,运用地震沉积学方法综合井资料和90°相位地层切片对孔店油田Ng23砂层的河流沉积砂体平面展布进行精细刻画,并且结合动态资料分析油气开采中储层内部结构对流体运动的控制作用。研究... 详细信息

为了揭示孔店油田河流相砂体展布特征及复杂连通关系,运用地震沉积学方法综合井资料和90°相位地层切片对孔店油田Ng23砂层的河流沉积砂体平面展布进行精细刻画,并且结合动态资料分析油气开采中储层内部结构对流体运动的控制作用。研究认为将孔店油田的三维地震数据进行90°相位转化可以获得更好的测井岩性标定,地层切片分析结果表明孔店油田Ng23砂层为复杂曲流带沉积,内部发育点坝、河道、泥质河道和泛滥平原,复杂曲流带是由多期河道沉积拼接、叠置组合形成,其内部结构对储层内部流体的运动有明显的控制作用,是调整开发措施、提高油田采收率的目标区域。

关键词： 90°相位地层切片复杂曲流带沉积特征

黄骅坳陷孔店地区馆陶组地震沉积特征及沉积演化模式

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中国矿业大学学报 2018年第3期47卷 549-561页

作者：刘海林承焰张宪国栗宝鹃中国石油大学(华东)地球科学与技术学院山东青岛266580 中海石油能源发展安全环保分公司天津300450

为了揭示黄骅坳陷孔店地区馆陶组沉积演化规律,本文以井和地震资料划分出的沉积层序及体系域为等时地层单元对相应的地震资料进行90°相位转化及地层切片处理,结合单井相分析结果刻画并解释沉积体系的平面展布特征并建立了孔店地区河流... 详细信息

为了揭示黄骅坳陷孔店地区馆陶组沉积演化规律,本文以井和地震资料划分出的沉积层序及体系域为等时地层单元对相应的地震资料进行90°相位转化及地层切片处理,结合单井相分析结果刻画并解释沉积体系的平面展布特征并建立了孔店地区河流沉积体系演化模式.认为馆陶组为一完整三级层序,可划分为低位、水侵和高位3个体系域,低位和高位体系域发育辫状河沉积,水侵体系域发育曲流河体系,馆陶组经历了辫状河-曲流河-辫状河的演化过程.研究结果表明:辫状沉积体系中厚层砂体垂向频繁叠置,厚度可达70m,平面上大面积展布,泛滥平原沉积发育较差,地层含砂率大于70%;曲流河道及边滩砂体呈孤立状被厚层泛滥平原泥岩包裹,平面上曲流河沉积分布于大面积泛滥平原内,泛滥平原泥岩占比为48.5%.可容空间和古气候控制了基准面变化进而控制了河流沉积体系展布模式,可容空间相对较低,气候相对潮湿时,发育大范围辫状河沉积体系,基准面迅速上升时期,可容空间迅速增加且气候相对干燥,更有利于曲流河的发育.

关键词：沉积特征层序地层地层切片沉积模式黄骅坳陷

甘肃省甘南藏族自治州藏族僧侣高血压流行病学调查

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中华心血管病杂志 2015年第12期43卷 1088-1091页

作者：李星辉谢萍乔燕马玉安李宝鹃甘肃省人民医院心血管内科兰州730000 兰州市城关区人民医院内科甘肃省甘南州疾病预防控制中心甘肃省甘南州人民医院内科

目的调查甘肃省甘南藏族自治州藏族僧侣的高血压患病率、知晓率、治疗率和控制率,并分析高血压的危险因素.方法 2014年3至6月,采用整群抽样方法入选甘肃省甘南藏族自治州18岁及以上藏族僧侣984名.对研究对象进行问卷调查及血压测量,采... 详细信息

目的调查甘肃省甘南藏族自治州藏族僧侣的高血压患病率、知晓率、治疗率和控制率,并分析高血压的危险因素.方法 2014年3至6月,采用整群抽样方法入选甘肃省甘南藏族自治州18岁及以上藏族僧侣984名.对研究对象进行问卷调查及血压测量,采用多因素非条件logistic回归分析高血压的危险因素.结果甘肃省甘南藏族自治州藏族僧侣的高血压患病率为19.3％（190/984）,标化患病率为21.7％.其中,18 ～39、40～59和≥60岁3个年龄段僧侣的患病率分别为16.3％（82/502）、21.0％（60/286）和24.5％（48/196）,标化患病率分别为17.8％、22.1％和26.6％.知晓率、治疗率和控制率分别为9.5％（18/984）、4.2％（8/984）、1.6％（3/984）.多因素logistic回归分析显示,年龄、体质指数、高血压家族史均是高血压的危险因素（P＜0.01或0.05）.结论甘肃省甘南藏族自治州18岁及以上藏族僧侣高血压患病率、知晓率、治疗率和控制率均较低;年龄、体质指数和高血压家族史是高血压的危险因素.

关键词：高血压患病率藏族

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高温光子晶体光纤温度传感器

光学技术 2017年第6期43卷 538-541页

作者：高红春江毅李宝娟李晓玮北京理工大学光电学院北京100081 北京首钢股份有限公司河北迁安064400 北京理工大学激光微纳制造研究所北京100081

针对大于500℃的高温环境,提出了一种可用于高温温度测量的高温光子晶体光纤(PCF)温度传感器。在光子晶体光纤末端熔接一段纯石英无芯光纤构成外腔式光纤法珀腔(EFPI)结构。纯石英无芯光纤在高温下的热膨胀和热光效应使得EFPI的光学腔... 详细信息

针对大于500℃的高温环境,提出了一种可用于高温温度测量的高温光子晶体光纤(PCF)温度传感器。在光子晶体光纤末端熔接一段纯石英无芯光纤构成外腔式光纤法珀腔(EFPI)结构。纯石英无芯光纤在高温下的热膨胀和热光效应使得EFPI的光学腔长发生变化。结合光纤白光干涉测量技术,通过测量EFPI的腔长得到被测温度。在不同温度环境下,对腔长为175μm的EFPI光纤温度传感器进行连续测量。测量结果显示,设计的高温光纤温度传感器在27~1100℃范围内,腔长-温度三阶拟合精度达到99.95%,腔长-温度灵敏度为(0.851+0.0023T-0.000000957T2)nm/℃,其中在1100℃时,温度测量分辨率为0.225℃。

关键词：外腔式法珀腔(EFPI) 光子晶体光纤(PCF) 光纤白光干涉测量