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Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration

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Bone Research 2024年第2期12卷 390-406页

作者： Xinshu Zhang Yao Xiao Bo Hu Yanhao li Shaoyang Zhang Jian Tian Shuo Wang Zaijin Tao Xinqi Zeng Ning-Ning liu baojie li Shen liu Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine600 Yishan RdShanghai 200233PR China Section of Spine Surgery Department of OrthopaedicsChangzheng HospitalNaval Medical UniversityShanghai 200003PR China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200241PR China Department of Orthopaedics Wuxi Ninth People’s Hospital Affiliated to Soochow UniversityWuxi 214062PR China State Key Laboratory of Systems Medicine for Cancer Center for Single-Cell OmicsSchool of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China

Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without effective anti-fibrotic therapies,resulting in severe *** are widely recognized as a fibrotic trigger during peritendinous adhesion ***,different clusters of macrophages have various functions and receive multiple regulation,which are both still *** our current study,multi-omics analysis including single-cell RNA sequencing and proteomics was performed on both human and mouse tendon adhesion tissue at different stages after tendon *** transcriptomes of over 74000 human single cells were *** results,we found that SPP1^(+)macrophages,RGCC^(+)endothelial cells,ACKR1^(+)endothelial cells and ADAM12^(+)fibroblasts participated in tendon adhesion ***,despite specific fibrotic clusters in tendon adhesion,FOLR2^(+)macrophages were identified as an antifibrotic cluster by in vitro experiments using human ***,ACKR1 was verified to regulate FOLR2^(+)macrophages migration at the injured peritendinous site by transplantation of bone marrow from Lysm-Cre;R26R^(tdTomato) mice to lethally irradiated Ackr1^(-/-)mice(Ackr1^(-/-)chimeras;deficient in ACKR1)and control mice(WT chimeras).Compared with WT chimeras,the decline of FOLR2^(+)macrophages was also observed,indicating that ACKR1 was specifically involved in FOLR2^(+)macrophages *** together,our study not only characterized the fibrosis microenvironment landscape of tendon adhesion by multi-omics analysis,but also uncovered a novel antifibrotic cluster of macrophages and their *** results provide potential therapeutic targets against human tendon adhesion.

关键词： tendon analysis landscape

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《极客之爱》中的残疾身体与科技伦理

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当代外国文学 2024年第1期45卷 52-58页

作者：张申华李保杰山东大学外国语学院

《极客之爱》借助残疾的人物形象,探讨身体改造之限度与后果,以寓言方式再现后现代社会中人类身体的“反向进化”现象。残疾身体是科技被滥用的结果,自然身体边界受到挑战,表征了身体与科技间的复杂关系。科技对身体的改造之所以走向极... 详细信息

《极客之爱》借助残疾的人物形象,探讨身体改造之限度与后果,以寓言方式再现后现代社会中人类身体的“反向进化”现象。残疾身体是科技被滥用的结果,自然身体边界受到挑战,表征了身体与科技间的复杂关系。科技对身体的改造之所以走向极端,而使身体变得残缺和畸形,离不开资本场域下消费主义的推波助澜。小说借由残疾身体多维度地展示了科技改造身体引发的伦理困境与危机,对科技研究与应用的伦理缺位等问题发出了警示。

关键词：《极客之爱》残疾身体后现代科技伦理

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En-Bloc切除式清创后骨搬运联合锁定钢板治疗股骨髁上Cierny-MaderⅣ型感染性骨缺损的疗效分析

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中华创伤骨科杂志 2024年第7期26卷 597-603页

作者：赵刚罗文明李保杰刘振于平孙学成山东省潍坊市人民医院骨科潍坊261000

目的探讨En-Bloc切除式清创后骨搬运联合锁定钢板(BTLP)分期治疗股骨髁上Cierny-MaderⅣ型感染性骨缺损的疗效。方法回顾性分析2020年1月至2023年1月山东省潍坊市人民医院骨科收治的10例股骨髁上感染性骨缺损患者资料。男8例,女2例;年龄... 详细信息

目的探讨En-Bloc切除式清创后骨搬运联合锁定钢板(BTLP)分期治疗股骨髁上Cierny-MaderⅣ型感染性骨缺损的疗效。方法回顾性分析2020年1月至2023年1月山东省潍坊市人民医院骨科收治的10例股骨髁上感染性骨缺损患者资料。男8例,女2例;年龄(48.5±11.4)岁;Cierny-Mader解剖分型均为Ⅳ型;所有患者一期En-Bloc切除式清创后拆除原有内固定物,缺损处填塞抗生素骨水泥,感染控制后二期行手术取出骨水泥,重新内固定并外固定支架辅助搬运,待搬运骨段会师后,将断端新鲜化和少量植骨,螺钉锁定搬运骨段后拆除外固定支架,等待矿化及会师端的愈合。术后记录患者骨缺损长度、外固定支架带架时间和指数、骨愈合时间、肢体功能活动及并发症发生情况。结果10例患者一期清创后形成(9.1±2.1)cm的骨缺损,所有患者随访时间为(19.8±6.6)个月,外固定支架带架时间为(107.2±25.1)d,带架指数为(11.8±0.5)d/cm。术后无一例患者复发,9例患者于术后8个月内获得骨愈合;1例因会师端愈合欠佳,行二次植骨治疗后骨愈合。所有患者恢复原本生活或体力劳动,无疼痛及再骨折等并发症发生。3例患者出现膝关节不同程度僵硬,但能满足日常生活;1例患者要求行关节松解术,疗效满意。结论En-Bloc切除式清创后BTLP分期治疗股骨髁上Cierny-Mader解剖Ⅳ型感染性骨缺损是一种有效的方法。

关键词：骨髓炎股骨骨折清创术骨缺损助骨搬运

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非酒精性脂肪性肝病患者血尿酸水平与心房颤动的相关性研究

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中国医药 2024年第5期19卷 684-688页

作者：张琪李宝杰周萌刘改珍山西医科大学第二医院心血管内科太原030001

目的探讨非酒精性脂肪性肝病(NAFLD)患者血尿酸水平与心房颤动的相关性。方法回顾性选取2020年1月至2022年12月于山西医科大学第二医院诊断为NAFLD的患者565例,根据是否合并心房颤动将其分为心房颤动组(224例)和非心房颤动组(341例)。分... 详细信息

目的探讨非酒精性脂肪性肝病(NAFLD)患者血尿酸水平与心房颤动的相关性。方法回顾性选取2020年1月至2022年12月于山西医科大学第二医院诊断为NAFLD的患者565例,根据是否合并心房颤动将其分为心房颤动组(224例)和非心房颤动组(341例)。分析2组患者的临床资料。多因素Logistic回归分析用于确定NAFLD患者心房颤动发生的相关因素。使用趋势性检验分析血尿酸水平与心房颤动之间的线性趋势。构建列线图模型预测心房颤动的发生风险,绘制校准曲线来评价列线图的准确性。最后绘制受试者工作特征(ROC)曲线,评估血尿酸和列线图模型对NAFLD患者心房颤动发生的预测价值。结果多因素Logistic回归结果显示,年龄(比值比=1.096,95%置信区间:1.071~1.121,P<0.001)、血肌酐(比值比=1.021,95%置信区间:1.003~1.039,P=0.025)及血尿酸(比值比=1.008,95%置信区间:1.005~1.011,P<0.001)是NAFLD患者心房颤动发生的独立危险因素,高密度脂蛋白(P=0.010)是独立保护因素。心房颤动的风险随着血尿酸水平的升高而增加(趋势性检验P<0.001)。列线图模型预测心房颤动的C指数为0.827(95%置信区间:0.793~0.861),Hosmer-Lemeshow检验和校准图均显示该模型的校准度良好。ROC分析显示列线图模型的曲线下面积为0.827,优于血尿酸的0.683。结论血尿酸水平升高是NAFLD患者心房颤动发生的独立危险因素。

关键词：非酒精性脂肪性肝病心房颤动血尿酸氧化应激

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Development of a deviation package method for low-cost robust optimization in compressor blade design

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Chinese Journal of Aeronautics 2024年第4期37卷 166-180页

作者： Mingzhi li Xianjun YU Dejun MENG Guangfeng AN baojie liU Research Institute of Aero-Engine Beihang UniversityBeijing 100191China National Key Laboratory of Science&Technology on Aero-Engine Aero-Thermodynamics Beihang UniversityBeijing 100191China AECC Shenyang Engine Research Institute Shenyang 110015China

Manufacture variations can greatly increase the performance variability of compressor blades. Current robust design optimization methods have a critical role in reducing the adverse impact of the variations, but can be affected by errors if the assumptions of the deviation models and distribution parameters are inaccurate. A new approach for robust design optimization without the employment of the deviation models is proposed. The deviation package method and the interval estimation method are exploited in this new approach. Simultaneously, a stratified strategy is used to reduce the computational cost and assure the optimization accuracy. The test case employed for this study is a typical transonic compressor blade profile, which resembles most of the manufacture features of modern compressor blades. A set of 96 newly manufactured blades was measured using a coordinate measurement machine to obtain the manufacture variations and produce a deviation package. The optimization results show that the scatter of the aerodynamic performance for the optimal robust design is 20% less than the baseline value. By comparing the optimization results obtained from the deviation package method with those obtained from widely-used methods employing the deviation model, the efficiency and accuracy of the deviation package method are demonstrated. Finally, the physical mechanisms that control the robustness of different designs were further investigated, and some statistical laws of robust design were extracted.

关键词： Manufacture variations Robust design optimization Compressor leading edge Aerodynamics Physical mechanism

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Local Adaptive Gradient Variance Attack for Deep Fake Fingerprint Detection

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Computers, Materials & Continua 2024年第1期78卷 899-914页

作者： Chengsheng Yuan baojie Cui Zhili Zhou Xinting li Qingming Jonathan Wu Engineering Research Center of Digital Forensics Ministry of EducationNanjing University of Information Science and TechnologyNanjing210044China School of Computer Science Nanjing University of Information Science and TechnologyNanjing210044China Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou510006China School of International Relations National University of Defense TechnologyNanjing210039China Department of Electrical and Computer Engineering University of WindsorWindsorN9B 3P4Canada

In recent years,deep learning has been the mainstream technology for fingerprint liveness detection(FLD)tasks because of its remarkable ***,recent studies have shown that these deep fake fingerprint detection(DFFD)models are not resistant to attacks by adversarial examples,which are generated by the introduction of subtle perturbations in the fingerprint image,allowing the model to make fake *** of the existing adversarial example generation methods are based on gradient optimization,which is easy to fall into local optimal,resulting in poor transferability of adversarial *** addition,the perturbation added to the blank area of the fingerprint image is easily perceived by the human eye,leading to poor visual *** response to the above challenges,this paper proposes a novel adversarial attack method based on local adaptive gradient variance for *** ridge texture area within the fingerprint image has been identified and designated as the region for perturbation ***,the images are fed into the targeted white-box model,and the gradient direction is optimized to compute gradient ***,an adaptive parameter search method is proposed using stochastic gradient ascent to explore the parameter values during adversarial example generation,aiming to maximize adversarial attack *** results on two publicly available fingerprint datasets show that ourmethod achieves higher attack transferability and robustness than existing methods,and the perturbation is harder to perceive.

关键词： FLD adversarial attacks adversarial examples gradient optimization transferability

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Mdm2 links genotoxic stress and metabolism to p53

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Protein & Cell 2010年第12期1卷 1063-1072页

作者： Zhongfeng Wang baojie li Bio-X Center Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China

Mouse double minute 2(Mdm2)gene was isolated from a cDNA library derived from transformed mouse 3T3 cells,and was classified as an oncogene as it confers 3T3 and Rat2 cells tumorigenicity when *** encodes a nucleocytoplasmic shuttling ubiquitin E3 ligase,with its main target being tumor suppressor p53,which is mutated in more than 50%of human primary ***2’s oncogenic activity is mainly mediated by p53,which is activated by various stresses,especially genotoxic stress,via Atm(ataxia telangiectasia mutated)and Atr(Atm and Rad3-related).Activated p53 inhibits cell proliferation,induces apoptosis or senescence,and maintains genome ***2 is also a target gene of p53 transcription ***,Mdm2 and p53 form a feedback regulatory *** and internal cues,through multiple signaling pathways,can act on Mdm2 to regulate p53 levels and cell proliferation,death,and *** review will focus on how Mdm2 is regulated under genotoxic stress,and by the Akt1-mTOR-S6K1 pathway that is activated by insulin,growth factors,amino acids,or energy status.

关键词： mouse double minute 2(Mdm2) p53 signal transduction tumorigenesis

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Effect of icosahedral phase formation on the stress corrosion cracking(SCC)behaviors of the as-cast Mg-8%li(in wt.%)based alloys

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Journal of Magnesium and Alloys 2024年第1期12卷 225-236页

作者： Shuo Wang Daokui Xu Dongliang Wang Zhiqiang Zhang baojie Wang Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang110819China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Engineering Research Center of Advanced Materials Preparing Technology Ministry of EducationNortheastern UniversityShenyang110819China School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang110159China Binzhou Institute of Technology BinzhouShandong Province256606China Shandong Key Laboratory of Advanced Aluminium Materials and Technology BinzhouShandong Province256606China

Through exploring the stress corrosion cracking(SCC)behaviors of the as-cast Mg-8%li and Mg-8%li-6%Zn-1.2%Y alloys in a 0.1 M NaCl solution,it revealed that the SCC susceptibility index(I_(SCC))of the Mg-8%li alloy was 47%,whilst the I_(SCC)of the Mg-8%li-6%Zn-1.2%Y alloy was 68%.Surface,cross-sectional and fractography observations indicated that for the Mg-8%li alloy,theα-Mg/β-li interfaces acted as the preferential crack initiation sites and propagation paths during the SCC *** regard to the Mg-8%li-6%Zn-1.2%Y alloy,the crack initiation sites included the I-phase and the interfaces of I-phase/β-li andα-Mg/β-li,and the preferential propagation paths were the I-phase/β-li andα-Mg/β-li ***,the SCC of the two alloys was concerned with hydrogen embrittlement(HE)mechanism.

关键词： Magnesium-lithium alloy Stress corrosion cracking I-phase Fracture analysis

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对氯苯丙氨酸建立失眠模型行为学评价方法的研究

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实验动物科学 2024年第3期41卷 9-13页

作者：曲子涵马海钊张野刘英豪郅晓宇李宝杰张红石长春中医药大学长春130117

目的通过观察对氯苯丙氨酸(PCPA)失眠大鼠模型在造模成功后一周内,各类行为学实验中的学习记忆能力改变,验证PCPA失眠模型稳定性。方法 30只SD大鼠随机均分为空白组和模型组,空白组正常饲养,对模型组大鼠腹腔注射PCPA建立失眠模型,建... 详细信息

目的通过观察对氯苯丙氨酸(PCPA)失眠大鼠模型在造模成功后一周内,各类行为学实验中的学习记忆能力改变,验证PCPA失眠模型稳定性。方法 30只SD大鼠随机均分为空白组和模型组,空白组正常饲养,对模型组大鼠腹腔注射PCPA建立失眠模型,建模后第1周进行Morris水迷宫实验等5项大鼠行为学监测。结果与空白组比较,模型组大鼠睡眠潜伏期显著延长(P<0.01),睡眠持续时间显著缩短(P<0.01);在水迷宫实验中,模型组大鼠寻台时间延长(P<0.01);巴恩斯迷宫实验中,模型组大鼠测试探索期的目标洞口停留总时间显著缩短(P<0.01);避暗实验中,模型组错误次数增多(P<0.05),且潜伏期显著延长(P<0.01);高架十字迷宫实验中,模型组大鼠开臂停留时间显著缩短(P<0.01);旷场实验显示模型组大鼠在中央区域的停留时间、直立次数和运动总距离均低于空白组,其中中央区域的停留时间具有显著差异(P<0.01)。结论 PCPA失眠模型具有较高的可重复性和稳定性,可以作为睡眠和记忆相关研究的基础模型。

关键词： PCPA 失眠模型行为学评价

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Abl1 deletion in gut stem cells suppresses p53 induction and promotes colitis-associated tumor formation

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Journal of Molecular Cell Biology 2020年第9期12卷 738-740页

作者： Guo Yu Jie Fu Ana Romo baojie li Huijuan liu Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China School of Basic Medical Science Xinxiang Medical UniversityXinxiang 453003China Laboratory of Stem Cells and Gene Therapy Instituto Tecnolo´gico de Chascomu´s(INTECH)CONICET-UNSAMChascomu´sBuenos AiresArgentina

Dear Editor,Abl1,when fused with BCR,expresses fusion protein BCR‒ABL that underlies the etiology of chronic myeloid leukemia and is therapeutically targeted by Imatinib Mesylate(Khatri et al.,2016).However,the function of proto-oncogene product Abl1 remains not fully *** non-receptor tyrosine kinase can be activated by growth factors,DNA damage,oxidative stress,and microbial pathogens(Wang,2014).Cell-based studies suggest that Abl1 phosphorylates proteins in DNA damage response(DDR)and other signaling pathways,promoting p53 expression as well as cell cycle arrest and apoptosis(Gonfloni et al.,2009).Abl1 deletion leads to runtedness,osteoporosis,and other developmental defects in ***,it has been reported that Abl1 kinase is activated in many solid tumors and Abl1 is implicated in EphB2-mediated intestinal adenoma growth and colorectal cancer(CRC)invasion and metastasis(Kundu et al.,2015;Sonoshita et al.,2015).However,a recent study showed that Abl1 expression is reduced in most CRC patient samples(Uhlen et al.,2015).Thus,the function of Abl1 in CRC initiation warrants further investigation.

关键词： al. invasion damage

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