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Impairment of Autophagic Flux After Hypobaric Hypoxia Potentiates Oxidative Stress and Cognitive Function Disturbances in Mice

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Neuroscience Bulletin 2024年第1期40卷 35-49页

作者： Shuhui Dai Yuan Feng Chuanhao Lu Hongchen zhang Wenke Ma Wenyu Xie Xiuquan Wu Peng Luo Lei zhang Fei Fei Zhou Fei Xia Li Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi'an 710000China National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'an 710000China Department of Neurosurgery The Central Hospital of BaojiBaoji 721000China Department of Ophthalmology Xijing HospitalFourth Military Medical UniversityXi'an 710000China

Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude *** plays a critical role in ischemic brain injury,but its role in hypo-baric hypoxia(HH)remains *** we used an HH chamber to demonstrate that acute HH exposure impairs autophagic activity in both the early and late stages of the mouse brain,and is partially responsible for HH-induced oxidative stress,neuronal loss,and brain *** autophagic agonist rapamycin only promotes the initiation of *** proteome analysis,a screen showed that protein dynamin2(DNM2)potentially regulates autophagic *** of DNM2 significantly increased the formation of autolysosomes,thus maintaining autophagic flux in combination with ***,the enhancement of autophagic activity attenuated oxidative stress and neurological deficits after HH *** results contribute to evidence supporting the conclusion that DNM2-mediated autophagic flux represents a new therapeutic target in HH-induced brain damage.

关键词： Autophagy-Proteomics Oxidative stress Hypobaric hypoxia-Brain injury

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矩阵集极值的定义及其性质

长春工业大学学报 2019年第3期40卷 238-241页

作者：刘庆怀张宝骥长春工业大学数学与统计学院

在锥序下给出矩阵集极值的S序最优阵与S序有效阵,并讨论了其性质。界定了矩阵集的半负定有效阵与弱半负定有效阵。利用加权方法和矩阵的L0和L1范数分别给出了矩阵集的加权有效阵、L0范数最优阵和L1范数最优阵。

关键词：矩阵优化最优阵有效阵弱有效阵

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汽车节油迫在眉睫

中国工程科学 2013年第10期15卷 10-15页

作者：胡晓春张宝吉蒋福康汪燮卿中国石油化工股份有限公司石油化工科学研究院北京100083

石油是关系到国家安全的重要战略资源,中国是石油资源相对缺乏的国家,节约用油、提高资源利用效率尤为重要。指出了现阶段我国汽车用油存在的问题;分析了汽车节油技术发展趋势和政策措施;提出通过政策措施倡导节约优先、效率为本的观念... 详细信息

石油是关系到国家安全的重要战略资源,中国是石油资源相对缺乏的国家,节约用油、提高资源利用效率尤为重要。指出了现阶段我国汽车用油存在的问题;分析了汽车节油技术发展趋势和政策措施;提出通过政策措施倡导节约优先、效率为本的观念,重点开发和应用各种节油技术,提高油品质量,加快淘汰老旧车型,积极开发替代资源,大力发展公共交通和现代物流是现阶段我国汽车节油减排的有效途径。

关键词：汽车节油燃料经济性替代燃料新能源公共交通政策措施

Low-viscosity oligoether esters(OEEs)as high-efficiency lubricating oils:Insight on their structure‒lubricity relationship

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Friction 2024年第6期12卷 1133-1153页

作者： Hanwen WANG Ying WANG Ping WEN Lin MA Mingjin FAN Rui DONG Chunhua zhang Shaanxi Key Laboratory of Phytochemistry College of Chemistry&Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China Key Laboratory of Shaanxi Province for Development and Application of New Transportation Energy Chang’an UniversityXi’an 710064China

Development of energy-efficient lubricants is a way to reduce energy consumption for transportation,with the tendency to design molecules that are beneficial in reducing the viscosity of synthetic *** esters(OEEs),as a low-viscosity ester base oil,have characteristics such as simple synthesis and excellent lubrication effect;however,the application of OEEs in tribology field has rarely been *** objective of the present study is to investigate the effect of structure on the lubricating performance of OEEs and to develop a predictive model for OEEs based on quantitative structure‒property relationship(QSPR)through a combination of experiment and statistical *** showed that glycol chains contribute positively to lubrication with the ether functional groups increasing the sites of *** to branched-chain OEEs,straight-chain OEEs exhibited reduced wear,which was mainly due to the thicker adsorption film formed by the straight-chain ***,carbon films were detected on lightly worn surfaces,indicating that OEEs underwent oxidation during the friction *** on the results of principal component analysis(PCA)and partial least squares(PLS),it could be found that the predictive models of viscosity‒temperature performance,thermal stability performance,coefficient of friction(COF),and wear volume(WV)performed well and *** them,COF and WV can be best predicted with an R^(2) of about 0.90.

关键词： oligoether esters(OEEs) low-viscosity ester friction wear quantitative structure-property relationship(QSPR)

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基于非线性规划法的最小阻力船型优化设计

武汉理工大学学报（交通科学与工程版） 2010年第2期34卷 358-361页

作者：张宝吉马坤纪卓尚上海海事大学海洋环境与工程学院上海201308 大连理工大学船舶工程系大连116024

为了获得阻力性能优良船型,以兴波阻力理论为基础,利用非线性规划法并结合CAD技术研究最小阻力船型的优化设计.以总阻力为目标函数,总阻力用兴波阻力和平板摩擦阻力之和来表达,设计变量取船型修改函数的参数,在保证必要的排水量为基本... 详细信息

为了获得阻力性能优良船型,以兴波阻力理论为基础,利用非线性规划法并结合CAD技术研究最小阻力船型的优化设计.以总阻力为目标函数,总阻力用兴波阻力和平板摩擦阻力之和来表达,设计变量取船型修改函数的参数,在保证必要的排水量为基本约束条件下,选取Wigley船型为初始船型,分别对船体的首部和全船线型进行优化设计.通过将改良船型的阻力性能、船体线型和基于Michell积分法的优化计算结果相比较,证实了在相同的设计参数和约束条件下,采用Rankine源法进行船型优化结果更可靠.

关键词：非线性规划法 Rankine源法 Michell积分法最小阻力船型优化设计

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骑浪/横甩薄弱性衡准的评估方法

上海海事大学学报 2016年第2期37卷 29-34页

作者：虞驰程胡以怀张宝吉陈彦臻邢辉上海海事大学商船学院上海201306 上海海事大学海洋科学与工程学院上海201306

针对目前国际海事组织(International Maritime Organization,IMO)正在讨论制定的第二代完整稳性衡准草案中的骑浪/横甩这一稳性失效模式,研究第二层薄弱性衡准评估方法.基于波浪理论计算波浪纵荡力,运用Melnikov方法预报骑浪临界值,采... 详细信息

针对目前国际海事组织(International Maritime Organization,IMO)正在讨论制定的第二代完整稳性衡准草案中的骑浪/横甩这一稳性失效模式,研究第二层薄弱性衡准评估方法.基于波浪理论计算波浪纵荡力,运用Melnikov方法预报骑浪临界值,采用数值分析方法求解推力和阻力平衡方程,开发骑浪/横甩第二层薄弱性衡准的计算程序.结果表明,C11集装箱船计算结果与IMO给出的参考值相差3%.该方法可为建立新一代完整稳性的衡准技术框架提供参考.

关键词：完整稳性骑浪横甩波浪理论 Melnikov方法数值分析

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太白山牛皮桦林的定量研究

烟台师范学院学报（自然科学版） 1997年第1期13卷 48-52页

作者：傅志军郭俊理张萍宝鸡文理学院环境经济系烟台师范学院生物系

根据调查资料，分析了太白山牛皮桦林的种类组成、多样性、结构及演替趋势．依据聚类分析法和群落相似系数法将牛皮桦林分为４个类型．排序结果表明。

关键词：牛皮桦林定量研究太白山森林植被

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石灰竖窑结瘤原因分析和预防措施

耐火与石灰 2013年第1期38卷 15-17页

作者：刘俊海张宝吉焦作神华重型机械制造有限公司焦作454100

结合生产实践,对石灰竖窑的结瘤原因进行了分析,介绍了结瘤的防范措施、结瘤的判断方法及处理方法。

关键词：石灰竖窑结瘤石灰石粒度

Two-color emissive AIEgens with anti-Kasha property for dual-organelle imaging and phototherapy

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Science China Chemistry 2024年第5期67卷 1740-1752页

作者： Pu Chen Guogang Shan Qingli Nie Yuting Yan Pengfei zhang Zujin Zhao Hai-Tao Feng Ben Zhong Tang AIE Research Center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China Institute of Functional Material Chemistry and National&Local United Engineering Lab for Power Battery Faculty of ChemistryNortheast Normal UniversityChangchun 130024China College of Chemistry&Materials Science Northwest UniversityXi’an 710127China Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. Herein, two dual-emissive aggregation-induced emission luminogens(AIEgens)with donor-π-acceptor structures were designed and synthesized, namely QT-1 and QF-2. Both two AIEgens exhibited excitation wavelength-dependence defying the Kasha's rule, and could stain lipid droplets(LDs) and mitochondria in blue and red fluorescence, respectively. Moreover, thanks to the near-infrared emission and abundant reactive oxygen species(ROS) generation efficiency of QT-1, it was chosen as a photodynamic therapy agent to selectively kill cancer cells from normal cells. Upon light irradiation, an obvious decrease of mitochondrial membrane potential(MMP) and serious change of mitochondrial shape in cells were observed, which corresponded to the efficient inhibition of tumor growth in vivo. This work afforded a promising strategy for the construction of multicolor emission by tuning anti-Kasha behaviors and expanding their application in dualorganelle targeting-based phototheranostics.

关键词： aggregation-induced emission anti-Kasha luminescence fluorescent probe bioimaging photodynamic therapy

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