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Heinrich layer in Antarctic marine sediments and its significance to global changes

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Chinese Science Bulletin 1998年第21期43卷 1830-1834页

作者： Hongrning Hou Youlang Luo Honghan Zheng baogui wang Xianzan Tang Chinese Acad Sci S China Sea Inst Oceanol Guangzhou 510301 Peoples R China Chinese Acad Sci Guangzhou Inst Geochem Guangzhou 510640 Peoples R China

Results of grain size analysis and rock magnetic measurements of core NP95-1 from Prydz Bay, Antarctica revealed two series of ice-rafted detritus layers, which correspond to cold climatic events, Younger Dryas and Heinrich event 1, occurring at about 11.7-10.3 and 14.3-13.6 kaB.P. respectively. Studies also show that the sequence of paleoclimatic changes in Antarctica can be correlated with that in other parts of the world, and that the millennial climate of the earth could change synchronously and globally. In addition, magnetic fabric analysis also shows a close relationship between paleoclimatic change and ocean circulation re-assemblage.

关键词： Antarctica Heinrich layer global change ice-rafted detritus marine sediments

Elevated preoperative plasma D-dimer dose not adversely affect survival of gastric cancer after gastrectomy with curative intent: A propensity score analysis

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Chinese Journal of Cancer Research 2018年第2期30卷 254-262页

作者： Yuexiang Liang Donglei He Liangliang Wu Xuewei Ding Xiaona wang baogui wang Rupeng Zhang Han Liang Department of Gastrointestinal Oncology the First Affiliated Hospital of Hainan Medical College Department of Gastric Cancer Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center of Cancer Tianjin's Clinical Research Cancer for Cancer Key Laboratory of Cancer Prevention and Therapy

Objective： Elevated plasma D-dimer has been reported to be associated with advanced tumor stage and poor survival in several types of malignancies. The purpose of this study was to assess the potential impact of preoperative plasma D-dimer level（PDL） on overall survival（OS） of gastric cancer（GC） patients undergoing curative surgery by applying propensity score ***： A total of 1,025 curatively resected GC patients in Tianjin Medical University Cancer Institute ＆Hospital were enrolled. Patients were categorized into two groups based on preoperative PDL： the elevated group（EG） and the normal group（NG）. To overcome bias due to the different distribution of covariates for the two groups, a one-to-one match was applied using propensity score analysis, after matching, prognostic factors were ***： In analysis for the whole study series, patients in the EG were more likely to have a larger proportion of tumor size ≥5 cm（67.5% vs. 55.8%, P=0.006）, elder mean age（64.0±10.8 years vs. 60.5±11.6 years, P〈0.001） and advanced tumor（T）, node（N）, and TNM stage. Patients with elevated PDL demonstrated a significantly lower 5-year OS than those with normal PDL（27.0% vs. 42.6%, P〈0.001）, however, the PDL was not an independent prognostic factor for OS in multivariate analysis [hazard ratio： 1.13, 95% confidence interval（95% CI）： 0.92–1.39,P=0.236]. After matching, 163 patients in the EG and 163 patients in the NG had the same characteristics. The 5-year OS rate for patients in the EG was 27.0% compared with 25.8% for those in the NG（P=0.809, log-rank）.Conclusions： The poor prognosis of GC patients with elevated preoperative PDL was due to the advanced tumor stage and elder age rather than the elevated D-dimer itself.

关键词： Gastric carcinoma D-dimer prognosis

Relations between sedimentary sequence and paleoclimatic changes during last 200 ka in the southern South China Sea

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Chinese Science Bulletin 2000年第14期45卷 1334-1340页

作者： Muhong Chen Xia Tu Fan Zheng Wen Yan Xianzan Tang Jun Lu baogui wang Miao’an Lu Chinese Acad Sci S China Sea Inst Oceanol Open Lab Marginal Sea Geol & Paleoenvironm Guangzhou 510301 Peoples R China

Core NS-93-5 was taken from the mild slope terrace of the southern South China Sea (SCS), which has preserved the steadiness depositional record of the normal marine environment since late Quaternary. Sedimentary sequence and oxygen isotopic stratigraphy of high resolution in the near 200 ka of the southern SCS has been established. By the comparative analysis with GISP2’s ice core, the depositional record of D/O’s events 1-21 and Heinrich’s events H1-H6 in the southern SCS that reflected the quick climate change in short time scale since the last interglacial stage is revealed, which indicates that in the last 200 ka in the southern SCS and the Arctic area there was tele-connection of paleoclimate and the unstability of the Western Pacific Warm Pool. This note shows that the sedimentary layers order of this sea area classified by color identification and by oxygen isotope stratum has the very good corresponding relation. The color feature of sediment changes along with the climate and the former

关键词： southern South China Sea sedimentary sequence quick climate change D/O and Heinrich events Toba’s volcanic record.

High Efficiency Hypocrellin Production by a Novel Mutant Isolated from Shiraia bambusicola

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Asian Agricultural Research 2019年第2期11卷 94-99页

作者： Wen DU baogui wang Shandong Provincial Engineering and Technology Research Center for Wild Plant Resources Development and Application of Yellow River Delta Binzhou University Shandong Key Laboratory of Eco-environmental Science for the Yellow River Delta Binzhou University School of Biological and Environmental Engineering Binzhou University

The fungus Shiraia bambusicola GZ19 M1 is biotechnologically important due to its ability to biosynthesis the pigment *** showed that ethyl methane sulfonate( EMS) was effective mutagenic agent for strain and potentially produced large numbers of random mutations broadly and uniformly over the whole genome to generate unique strains. Wild-type cultures of S. bambusicola GZ19 were subjected to EMS( 80 mM) induction targeted at approximately 20% spores' survival. When surviving spores were selected in sufficient numbers and cultured on PDA medium for 7 d at 26℃,five novel mutagenized S. bambusicola strains were obtained. A mutant GZ19 M1 that exhibited an activity of more than two times over the wild strain was obtained. Also,batch experiments were carried out to achieve the suitable conditions for hypocrellin. Glucose and rice extract were the most favorable carbon and nitrogen sources for hypocrellin production by submerged culture of S. bambusicola GZ19 M1,and initial glucose and rice extract concentrations were at 35 and 250 g/L,respectively. The optimal surfactant were found to be 0. 008 V/V Tween 80,it was added into cultivation medium at 24 h. Hypocrellin concentration reached 498. 89 mg/L under optimal nutritional conditions,an increment of about 8. 70 times of hypocrellins production was observed compared with that of in non-optimized medium by the wild strain.

关键词： Hypocrellin Shiraia bambusicola Mutagenesis Tween 80 Rice extract

Development of quantum dot-based immunochromatographic strip by double labeling PCR products for detection of Vibrio parahemolyticus in food

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Development of quantum dot-based immunochromatographic strip...

第十二届全国营养科学大会

作者： wang baogui 南昌大学

目的 Vibrio parahemolyticus is an important pathogen which can cause food-borne *** this study,a rapid,sensitive and simple quantum dot immunity test strip was developed in order to detect bacteria.方法 Genomic DNA wa...

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机器人手术系统在腹部肿瘤外科手术中的应用

中国肿瘤临床 2011年第16期38卷 988-990页

作者：王宝贵梁寒天津医科大学附属肿瘤医院胃部肿瘤科天津市肿瘤防治重点实验室天津市300060

微创手术已成为外科医疗水平的象征,传统腹腔腔镜手术已广泛应用于临床,但其在腹部肿瘤外科中的应用受到一定限制,主要原因在于腹部肿瘤外科手术所必须的区域淋巴结清扫以及消化道重建等复杂操作在传统腹腔镜下完成相当困难随着通讯技... 详细信息

微创手术已成为外科医疗水平的象征,传统腹腔腔镜手术已广泛应用于临床,但其在腹部肿瘤外科中的应用受到一定限制,主要原因在于腹部肿瘤外科手术所必须的区域淋巴结清扫以及消化道重建等复杂操作在传统腹腔镜下完成相当困难随着通讯技术、医用内窥镜技术和机器人技术的不断发展,机器人手术系统成功应用到临床医疗。该系统具有微创、高清3D视野、操作准确稳定以及可远程控制等优势,镜下手眼协调能力大大增强,并可通过计算机滤除手部震颤,加之机械手的灵活性,可以更加容易的在镜下完成各种复杂、精细的手术操作(如缝合、打结等),使得全腹腔镜下完成复杂手术成为可能目前机器人手术系统已用于临床10余年,在心脏外科、泌尿外科、妇科以及腹部外科等各个领域获得成功。本文对机器人手术系统作简单介绍并回顾近年来其在腹部肿瘤外科领域中的应用成果。

关键词：机器人手术系统胃癌结直肠癌胰腺癌肝癌

Influence of Perioperative Blood Transfusion on Prognosis in Patients with Colon Cancer

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The Chinese-German Journal of Clinical Oncology 2006年第4期5卷 261-267页

作者： LIANG Han wang Xiaona wang baogui PAN Yuan LIU Ning wang Dianchang HAO Xishan Department of Gastrointestinal Oncological Surgery Tianjin Cancer Hospital Tianjin Medical University Tianjin 300060 China

Objective： To explore the influence of perioperative blood transfusion on the postoperative survival of patients with colon cancer. Methods： Univariate and multivariate retrospective analyses were performed on the survival in a total of 723 colon cancer patients which were treated surgically during a period of 10 years. Results： Kaplan-Meier estimates showed that more than 800 mL perioperative blood transfusion was the survival predictor. Blood transfusion influenced significantly the prognosis of patients 40 years old and younger, those undergoing helicoloectomy left side, those with papillary adenocarcinoma, those with big tumors （diameter ≥ 8 cm）, those with stage Ⅰ tumors, those with lymphatic node metastases and those without liver metastases. In multivariate analysis only the tumor location, radicality of operation, lymphatic invasion, liver metastasis, depth of tumor invasion and TNM stage retained their significance. Conclusion： Perioperative blood transfusion is some extent. The indication of blood transfusion the prognostic factor for patients with colon cancer to must be restricted strictly, specially in patients younger than 40 years old, with right side lesion, papillary adenocarcinoma, big tumors （diameter ≥8 cm）, stage Ⅰ tumors and lymphatic node metastases or without liver metastases. But perioperative blood transfusion may not be deleterious for patients with staging Ⅳ disease and with distant metastases.

关键词： cancer colon surgery blood transfusion prognosis

Positive impact of adding No.14v lymph node to D2 dissection on survival for distal gastric cancer patients after surgery with curative intent

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Chinese Journal of Cancer Research 2015年第6期27卷 580-587页

作者： Yuexiang Liang Liangliang Wu Xiaona wang Xuewei Ding Hongmin Liu Bin Li baogui wang Yuan Pan Rupeng Zhang Ning Liu Han Liang Department of Gastric Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center of CancerKey Laboratory of Cancer Prevention and Therapy Department of Abdominal Cancer Hainan Province Cancer Hospital

Background： D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer （GC）, while the necessity of No.14v lymph node （14v） dissection for distal GC is still controversial. Methods： A total of 920 distal GC patients receiving at least a D2 lymph node dissection in Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital were enrolled in this study, of whom, 243 patients also had the 14v dissected. Other 677 patients without 14v dissection were used for comparison. Results： Forty-five （18.5%） patients had 14v metastasis. There was no significant difference in 3-year overall survival （OS） rate between patients with and without 14v dissection. Following stratified analysis, in TNM stages I, II, IIIa and IV, 14v dissection did not affect 3-year OS; in contrast, patients with 14v dissection had a significant higher 3-year OS than those without in TNM stages IIIb and IIIc. In multivariate analysis, 14v dissection was found to be an independent prognostic factor for GC patients with TNM stage IIIb/IIIc disease [hazard ratio （HR）, 1.568; 95% confidence interval （CI）： 1.186-2.072; P=0.002]. GC patients with 14v dissection had a significant lower locoregional, especially lymph node, recurrence rate than those without 14v dissection （11.7 % vs. 21.1%, P=0.035）. Conclusions： Adding 14v to D2 lymphadenectomy may be associated with improved 3-year OS for distal GC staged TNM IIIb/IIIc.

关键词： Gastric carcinoma No. 14v lymph node metastasis dissection prognosis

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脉冲气流发生器流场的优化实验研究

爆炸与冲击 2016年第1期36卷 31-37页

作者：任保祥陶钢周杰王坚王保贵南京理工大学能源与动力工程学院江苏南京210094 北京跟踪与通信技术研究所北京100094

为了分析脉冲气流发生器在不同喷嘴结构下的脉冲气流特征及其流场的变化规律,利用高速摄影技术,通过控制闪光光源,得到不同喷嘴结构产生的冲击波及脉冲气流流场的实验图像及其影响。采用多项式拟合的方法获得冲击波超压值、速度随距离... 详细信息

为了分析脉冲气流发生器在不同喷嘴结构下的脉冲气流特征及其流场的变化规律,利用高速摄影技术,通过控制闪光光源,得到不同喷嘴结构产生的冲击波及脉冲气流流场的实验图像及其影响。采用多项式拟合的方法获得冲击波超压值、速度随距离变化的衰减规律;通过图像处理技术,获取脉冲气流的有效数据,采用一阶指数衰减方程拟合出脉冲气流位移、速度随时间的变化规律。该实验方法及数据处理技术可以认知不同结构脉冲气流发生器产生的冲击波、脉冲气流的相关参数。

关键词：流体力学涡环图像处理脉冲气流发生器冲击波