检索结果-南通市图书馆

Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第1期19卷 100-115页

作者： Jianjian Chu Weicong Zhang Yan Liu baofeng Gong Wenbo Ji Tong Yin Chao gao Danqi Liangwen Mengqi Hao Cuimin Chen Jianhua Zhuang Jie gao You Yin Department of Neurology Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical UniversityShanghaiChina School of Pharmacy University College LondonLondonUK Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineClinical Pharmacy Innovation InstituteShanghai Jiao Tong University School of MedicineShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina

The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease *** re,there is an urgent need for new effective *** underlying pathogenic factors of Alzheimer's disease are not clear,but neuroinflammation can link various hypotheses of Alzheimer's disease;hence,targeting neuroinflammation may be a new hope for Alzheimer's disease *** inflammation can restore neuronal function,promote neuro regeneration,reduce the pathological burden of Alzheimer's disease,and improve or even reverse symptoms of Alzheimer's *** review focuses on the relationship between inflammation and various pathological hypotheses of Alzheimer's disease;reports the mechanisms and characteristics of small-molecule drugs(e.g.,nonsteroidal anti-inflammatory drugs,neurosteroids,and plant extracts);macromolecule drugs(e.g.,peptides,proteins,and gene therapeutics);and nanocarriers(e.g.,lipid-based nanoparticles,polymeric nanoparticles,nanoemulsions,and inorganic nanoparticles)in the treatment of Alzheimer's *** review also makes recommendations for the prospective development of anti-inflammatory strategies based on nanocarriers for the treatment of Alzheimer's disease.

关键词： Alzheimer's disease anti-inflammation blood-brain barrier drug delivery microglia nanoparticles neuroinflammation plant extracts

Advances in Molecular Regulatory Mechanisms of Fruit Trees under Low Temperature Stress

在线全文

学校读者我要写书评

暂无评论

Plant Diseases and Pests 2024年第3期15卷 46-48页

作者： Huan LIU Lijuan gao Minghui JI Longfei LI Jintao XU baofeng HAO Changli Institute of Pomology Hebei Academy of Agriculture and Forestry SciencesChangli 066600China

The most recent research findings on the tolerance of fruit trees to cold stress are reviewed from a molecular perspective,including the perception and transduction of low temperature calcium signaling,CBF-dependent molecular regulatory mechanisms,non-CBF-dependent molecular regulatory mechanisms,and so *** objective is to provide a reference basis for further improving the cold resistance of fruit trees and cultivating new varieties of hardy plants.

关键词： Low temperature stress Fruit trees Growth and development Molecular mechanism Research progress

Evaluation of Cold Resistance and Semi-lethal Low Temperature(LT_(50))of Nine Pear Cultivars

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Agricultural Research 2024年第6期16卷 45-47页

作者： Huan LIU Lijuan gao Jintao XU Minghui JI Longfei LI baofeng HAO Changli Institute of Pomology Hebei Academy of Agriculture and Forestry SciencesChangli 066600China

[Objectives]To evaluate the cold resistance and semi-lethal temperature of pear cultivars,and provide a theoretical basis for the regional extension and breeding of cold-resistant pear cultivars.[Methods]Nine pear cultivars were used to study the changes in relative conductivity and cell injury rate of pear branches under low temperature stress,and the semi-lethal temperature(LT_(50))of pear branches was analyzed by fitting Logistic equation.[Results]The relative conductivity and cell injury rate of pear branches took on the trend of slow increase,rapid increase,and slow increase the decrease of treatment *** LC_(50) of the nine pear cultivars were as follows:Nanguo pear-33.9℃,Wanyu-32.3℃,Red D Anjou-31.8℃,Jinfeng-31.3℃,Wujiuxiang-29.2℃,20 th Century Pear-29.1℃,Hanxiang-35.1℃,Yuluxiang-27.9℃ and Korla Fragrant Pear-29.2℃.[Conclusions]The semi-lethal temperature could reflect the cold resistance of pear trees,and Wanxiang had better cold *** evaluation of cold resistance and semi-lethal temperature of pear cultivars can provide theoretical basis for regional extension and breeding of cold-resistant pear cultivars.

关键词： Pear Cold resistance Semi-lethal temperature (LT_(50)) Low temperature

A Light and Simplified Branch Bending Method for Young Pear Trees

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Diseases and Pests 2024年第2期15卷 19-21页

作者： Jintao XU Longfei LI Minghui JI Huan LIU Lijuan gao baofeng HAO Changli Institute of Pomology Hebei Academy of Agriculture and Forestry SciencesChangli 066600China

Aiming at high cost and low efficiency of conventional branch bending method in the modern intensive planting and labor-saving cultivation mode of young pear trees,this paper provides a new branch bending method with wide source of raw materials,cheap price and simple operation,which is also suitable for the management of low-age branches in the process of high grafting and upgrading of traditional big trees.

关键词： Pear tree Light and simplified Branch bending Method

A method for Improving the Efficiency of Pear Tree Crossbreeding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Agricultural Biotechnology 2024年第2期13卷 25-26,42页

作者： Jintao XU Longfei LI Minghui JI Huan LIU Lijuan gao Yong GUO Yingjie WANG baofeng HAO Changli Institute of Pomology Hebei Academy of Agriculture and Forestry SciencesChangli 066600China

In view of the short blooming period of pear tree crossbreeding and the complexity of pollination process, a method that can improve the efficiency of crossbreeding of pear trees was provided. Meanwhile, this method can also be applied to the study of pollen xenia effect, pollination tree selection and pure pollen collection in pear tree cultivation.

关键词： Pear tree Cross breeding Efficiency Method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

飞机环控系统在线检测设备设计

现代工业经济和信息化 2016年第4期6卷 36-37页

作者：沈文和王岩高宝峰 91395部队北京100642

介绍了检测设备采用stm32嵌入式主控设备完成对某型飞机环控系统的在线检测,分析了检测设备采用I2C总线控制5个数字电位器模拟环境温度变化时电阻阻值的变化,并检测相应执行机构电机电流及电动活门全开、全闭的工作时间等数值是否符合... 详细信息

介绍了检测设备采用stm32嵌入式主控设备完成对某型飞机环控系统的在线检测,分析了检测设备采用I2C总线控制5个数字电位器模拟环境温度变化时电阻阻值的变化,并检测相应执行机构电机电流及电动活门全开、全闭的工作时间等数值是否符合相应的规程,从而检测出系统的故障。

关键词：嵌入式在线检测数字电位器电机电流

2006-2020年天津市职业中毒发病特征分析

在线全文

学校读者我要写书评

暂无评论

环境与职业医学 2024年第6期41卷 668-672页

作者：高雅王欣曾强刘保峰白羽天津市疾病预防控制中心职业健康所天津300011

[背景]目前,职业中毒已经成为我国除尘肺病之外危害劳动者健康最严重的职业病之一,影响范围广,社会经济损失较重。[目的]分析2006—2020年天津市职业中毒发病特点和规律,为制定有效的干预措施和防治策略提供科学依据。[方法]通过中国疾... 详细信息

[背景]目前,职业中毒已经成为我国除尘肺病之外危害劳动者健康最严重的职业病之一,影响范围广,社会经济损失较重。[目的]分析2006—2020年天津市职业中毒发病特点和规律,为制定有效的干预措施和防治策略提供科学依据。[方法]通过中国疾病预防控制信息系统子系统“职业病及健康危害因素监测信息系统”收集2006年1月1日至2020年12月31日期间,天津市各职业病诊断机构诊断并通过该系统报告的急、慢性职业中毒病例。数据内容包括病例基本情况、职业史、疾病特征、用人单位信息等。采用Excel 2016建立数据库,计数资料使用频数、构成比进行统计描述。[结果]2006—2020年天津市累计报告职业性化学中毒共234例,其中急性职业中毒49例(20.94%),慢性职业中毒185例(79.06%)。急性职业中毒病例数呈先上升后下降趋势,慢性职业中毒病例数整体呈下降趋势。急性职业中毒主要集中发生于环城四区(22例,44.90%),慢性职业中毒主要集中发生于滨海新区(90例,48.65%)。男性病例明显多于女性,发病年龄集中于45~55岁。急性职业中毒病例较集中于工龄不足5年组(22例,44.90%),以窒息性气体中毒为主,高发行业为化学原料和化学制品制造业。慢性职业中毒病例较集中于工龄5~14年之间(70例,37.84%),以有机溶剂中毒为主,高发行业亦为化学原料和化学制品制造业。[结论]天津市对于职业中毒的防治应根据本市急、慢性职业中毒毒物种类、地区经济差异、行业类别和劳动者分布等特点,分层次、有重点地开展精准职业病防治及卫生监测与管理。

关键词：职业中毒发病特征流行病学研究化工行业防治策略

橡胶素基因家族4个成员在橡胶树染色体上的定位

在线全文

学校读者我要写书评

暂无评论

热带生物学报 2016年第3期7卷 318-324页

作者：彭宝丰王英高和琼庄南生海南大学农学院/海南省热带生物资源可持续利用重点实验室海口570228 中国热带农业科学院橡胶研究所海南儋州571737

笔者以巴西橡胶树‘热研7-33-97’品种为材料,利用原位PCR技术对巴西橡胶树的4个橡胶素基因(Hev1.1,Hev1.2,Hev2.1,Hev2.2)在染色体的位置进行了物理定位分析,并利用荧光原位杂交技术对原位PCR结果进行了验证。结果表明:Hev1.1,Hev1.2,H... 详细信息

笔者以巴西橡胶树‘热研7-33-97’品种为材料,利用原位PCR技术对巴西橡胶树的4个橡胶素基因(Hev1.1,Hev1.2,Hev2.1,Hev2.2)在染色体的位置进行了物理定位分析,并利用荧光原位杂交技术对原位PCR结果进行了验证。结果表明:Hev1.1,Hev1.2,Hev2.1,Hev2.2基因分别位于巴西橡胶树第8号染色体长臂、第7号染色体长臂、第6号染色体短臂和第12号染色体长臂上;信号距着丝粒平均百分距分别为10.88,31.51,63.81和67.92。

关键词：巴西橡胶树橡胶素基因(Hev1.1,Hev1.2,Hev2.1,Hev2.2) 原位PCR 荧光原位杂交

组织芯片检测β-连环蛋白、c-erbB2在胃腺癌中的表达及其临床意义

在线全文

学校读者我要写书评

暂无评论

胃肠病学 2009年第11期14卷 661-664页

作者：史冬涛陈卫昌张宝峰胡莺郜恒骏苏州大学附属第一医院消化科 215006 生物芯片上海国家工程研究中心上海芯超生物科技有限公司

背景:近年来组织芯片已越来越多地应用于恶性肿瘤的相关研究,但用于胃癌研究的报道较少。目的:探讨胃腺癌、癌旁组织和外周正常黏膜组织中β-连环蛋白和c-erbB2的表达及其临床意义。方法:取102例胃腺癌、97例癌旁组织和98例外周正常黏... 详细信息

背景:近年来组织芯片已越来越多地应用于恶性肿瘤的相关研究,但用于胃癌研究的报道较少。目的:探讨胃腺癌、癌旁组织和外周正常黏膜组织中β-连环蛋白和c-erbB2的表达及其临床意义。方法:取102例胃腺癌、97例癌旁组织和98例外周正常黏膜组织分别制成含282点、156点和156点的3块组织芯片。以免疫组化法检测组织芯片中β-连环蛋白和c-erbB2的表达,并分析其与胃腺癌临床病理特征的关系。结果:胃腺癌组织中β-连环蛋白和c-erbB2阳性表达率显著高于癌旁组织和外周正常黏膜组织(57.0%对22.1%和7.3%,P=0.000;29.0%对5.3%和0%,P=0.000)。β-连环蛋白和c-erbB2异常表达与胃腺癌的分化程度(P=0.027,P=0.001)和浸润深度(P=0.033,P=0.011)有关,与其他临床病理特征无关。胃腺癌中β-连环蛋白表达与c-erbB2表达呈明显正相关(P<0.05)。结论:c-erbB2异常表达可能导致靶基因β-连环蛋白异常表达,从而在胃腺癌的发生、发展中起重要作用。

关键词：组织阵列分析胃肿瘤 β连环素 c—erbB2