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DEL RBC transfusion should be avoided in particular blood recipient in East Asia due to allosensitization and ineffectiveness

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第11期13卷 913-918页

作者： Chao-peng SHAO bao-yan wang Shi-hui YE Wen-li ZHANG Hua XU Nai-bao ZHUANG Xiao-ying WU Heng-gui XU Shenzhen Blood Center Shenzhen 518035 China Department of Blood Transfusion the First Affiliated Hospital of Medical College Xi 'an Jiaotong University Xi 'an 710060 China Shaanxi Blood Center Xi 'an 710061 China College of Laboratory Medicine Dalian Medical University Dalian 116044 China

Previously, both primary and secondary anti-D alloimmunizations induced by "Asian type" DEL (RHD1227A allele) were observed in two incidents. We investigated how often these alloimmunization events occur. The transfusions of any D-negative patients were investigated in the First Affiliated Hospital of Xi'an Jiaotong University Medical College, China, during the entire 2009. The antigens of D, C, c, E, and e were routinely serotyped. The "Asian type" DEL variant was genotyped and the RHD heterozygote was determined through two published methods. The changes in anti-D levels were monitored by the indirect antiglobulin test (IAT) and flow cytometry. Thirty D-negative transfused patients were included in the study. We focused on 11 recipients who were transfused with packed red blood cells (RBCs) from DEL donors at least one time. Of those 11 recipients, seven were anti-D negative before transfusion and four were anti-D positive (one patient with an autoantibody). One of the seven pre-transfusion anti-D negative patients produced a primary-response anti-D after being transfused with 400 ml of DEL blood twice. All four pre-transfusion antibody positive patients were not observed hemoglobin (Hb) levels increased, as expected after transfusions. Two patients had an increase in anti-D from 1:8 to 1:64 by IAT, which was also shown by flow cytometry. None of the patients experienced an acute hemolytic episode. Our data indicated that the primary anti-D induced by DEL transfusion or the secondary anti-D elevated by DEL in a truly D-negative patient might not be unusual. We suggest that a truly D-negative childbearing-aged woman should avoid DEL transfusion to protect her from primary anti-D allosensitization. In addition, anti-D positive recipients should also avoid DEL red cell transfusion due to the delayed hemolytic transfusion reaction (DHTR).

关键词： Rh blood group DEL Allo-anti-D Transfusion Pregnancy Delayed hemolytic transfusion reaction

CIDNP Study of Photoinduced [2+2] Cycloadditions (the Paterno- Bühi Coupling) of Arylacetylenes and Quinone

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Chinese Chemical Letters 2003年第3期 270-273页

作者： Xin yan wang, bao Zhen yan*, Ting wang Department of Applied Chemistry, Beijing University of Chemical Technology, Beijing 100029

CIDNP techniques were applied to study the mechanism of photocycloadditions of 2-chloro-5-methoxybenzoquinone 1 with arylacetylenes 2-5 in benzene-d6 and acetonitrile-d6 respectively.

关键词： Paterno-B點hi reaction 1 4-biradicals photo-CIDNP arylacetylenes quinones.

Stress increases MHC-I expression in dopaminergic neurons and induces autoimmune activation in Parkinson’s disease

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Neural Regeneration Research 2021年第12期16卷 2521-2527页

作者： bao-yan wang Yong-Yi Ye Chen Qian Hong-Bo Zhang Heng-Xu Mao Long-Ping Yao Xiang Sun Guo-Hui Lu Shi-Zhong Zhang The National Key Clinical Specialty The Engineering Technology Research Center of Education Ministry of ChinaGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationDepartment of NeurosurgeryZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Neurosurgery the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina

The expression of major histocompatibility complex class I(MHC-I),a key antigen-presenting protein,can be induced in dopaminergic neurons in the substantia nigra,thus indicating its possible involvement in the occurrence and development of Parkinson’s ***,it remains unclear whether oxidative stress induces Parkinson’s disease through the MHC-I *** the present study,polymerase chain reaction and western blot assays were used to determine the expression of MHC-I in 1-methyl-4-phenylpyridinium(MPP+)-treated SH-SY5Y cells and a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced Parkinson’s disease mouse *** findings revealed that MHC-I was expressed in both *** detect whether the expression of MHC-I was able to trigger the infiltration of cytotoxic T cells,immunofluorescence staining was used to detect cytotoxic cluster of differentiation 8(CD8)+T cell infiltration in the substantia nigra of MPTP-treated *** results indicated that the presentation of MHC-I in dopaminergic neurons was indeed accompanied by an increase in the number of CD8+T ***,in MPTP-induced Parkinson’s disease model mice,the genetic knockdown of endogenous MHC-I,which was caused by injecting specific adenovirus into the substantia nigra,led to a significant reduction in CD8+T cell infiltration and alleviated dopaminergic neuronal *** further investigate the molecular mechanisms of oxidative stress-induced MHC-I presentation,the expression of PTEN-induced kinase 1(PINK1)was silenced in MPP+-treated SH-SY5Y cells using specific small interfering RNA(siRNA),and there was more presentation of MHC-I in these cells compared with control siRNA-treated *** together,MPP+-/MPTP-induced oxidative stress can trigger MHC-I presentation and autoimmune activation,thus rendering dopaminergic neurons susceptible to immune cells and *** may be one of the mechanisms of oxidative stress-induced Parkinson’s disease,and implies the potential

关键词： antigen presentation autoimmune CD8+T cell dopaminergic neuron major histocompatibility complex class I mitochondria neuroinflammation oxidative stress Parkinson’s disease PINK1

Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie wang Wei wang Xuheng Chen Junfang bao Qiuyue Hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

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注意控制与短时记忆的知觉组织

心理学报 2003年第3期35卷 285-290页

作者：包燕王甦北京大学心理系北京100871

考察了短时记忆中的知觉组织是否受双作业时指导语引导的注意策略控制。各有 2 4名北京大学本科生参加了自由回忆和顺序回忆实验。实验任务有 2种 :记忆和声音监控。声音监控或者安排在记忆编码阶段 ,或者安排在记忆提取阶段。双作业时... 详细信息

考察了短时记忆中的知觉组织是否受双作业时指导语引导的注意策略控制。各有 2 4名北京大学本科生参加了自由回忆和顺序回忆实验。实验任务有 2种 :记忆和声音监控。声音监控或者安排在记忆编码阶段 ,或者安排在记忆提取阶段。双作业时的指导语类型有 3种 ,分别强调记忆、声音监控或两种作业同样重要。记忆项目表分 2种 :不分组和知觉分组。研究发现 :自由回忆中的知觉组织仅受编码阶段的指导语影响 ;顺序回忆中的知觉组织仅受提取阶段的指导语影响。作者设想 ,短时记忆中的知觉组织在编码和提取阶段都受注意控制 ,但记忆类型不同。

关键词：短时记忆知觉组织双作业指导语注意控制

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三氧化硫法合成对氯苯磺酸

辽宁化工 1998年第5期 47-48页

作者： wang Qinbao bao yanfen yan Haicheng wang Qingquan

比较了氯苯磺化制备对氯苯磺酸的磺化剂，研究了磺化能力强的三氯化硫磺化工艺，探讨了各种因素对磺化转化率的关系，确定了适宜的合成工艺。

关键词：磺化三氧化硫氯苯对氯苯磺酸

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng wang Guo-Cui Mao Hui-Lin Jiang bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

Silk damping in scalar-induced gravitational waves: a novel probe for new physics

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 79-85页

作者： yan-Heng Yu Sai wang Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences School of Physics University of Chinese Academy of Sciences

Silk damping is well known in the study of cosmic microwave background（CMB） and accounts for suppression of the angular power spectrum of CMB on large angular multipoles. In this article, we study the effect of Silk damping on the scalar-induced gravitational waves（SIGWs）. Resulting from the dissipation of cosmic fluid, the Silk damping notably suppresses the energydensity spectrum of SIGWs on scales comparable to a diffusion scale at the decoupling time of weakly-interacting particles. The effect offers a novel observable for probing the underlying particle interaction, especially for those mediated by heavy gauge bosons beyond the standard model of particles. We anticipate that pulsar timing arrays are sensitive to gauge bosons with mass ～10～3-10～4 GeV, while space-and ground-based interferometers to those with mass ～10～7-1012GeV, leading to essential complements to on-going and future experiments of high-energy physics.

关键词： scalar-induced gravitational waves Silk damping new physics

High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun wang Shuai wang yan Li Libo Chen Handong Jiao Zhijing Yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Lithium manganese iron phosphate High energy density Lithium-ion batteries Reaction mechanism Tap density