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Aldehyde dehydrogenase 2 preserves mitochondrial morphology and attenuates hypoxia/reoxygenationinduced cardiomyocyte injury

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World Journal of Emergency Medicine 2020年第4期11卷 246-254页

作者： Rui Zhang Meng-yang Xue bao-shan liu Wen-jun Wang Xin-hui Fan Bo-yuan Zheng Qiu-huan Yuan Feng Xu Jia-li Wang Yu-guo Chen Department of Emergency Medicine and Chest Pain Center Qilu HospitalShandong UniversityJinanChina shandong Provincal Clinical Research Center for Emergency and Critical Care Medicine of shandong Province Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu HospitalShandong UniversityJinanChina Key Laboratory of Emergency and Critical Care Medicine of shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceQilu HospitalShandong UniversityJinanChina The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical Sciencesthe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu HospitalShandong UniversityJinanChina

BACKGROUND:Disturbance of mitochondrial fi ssion and fusion(termed mitochondrial dynamics)is one of the leading causes of ischemia/reperfusion(I/R)-induced myocardial *** studies showed that mitochondrial aldehyde dehydrogenase 2(ALDH2)conferred cardioprotective effect against myocardial I/R injury and suppressed I/R-induced excessive mitophagy in ***,whether ALDH2 participates in the regulation of mitochondrial dynamics during myocardial I/R injury remains ***:In the present study,we investigated the effect of ALDH2 on mitochondrial dynamics and the underlying mechanisms using the H9c2 cells exposed to hypoxia/reoxygenation(H/R)as an in vitro model of myocardial I/R ***:Cardiomyocyte apoptosis was significantly increased after oxygen-glucose deprivation and reoxygenation(OGD/R),and ALDH2 activation largely decreased the cardiomyocyte ***,we found that both ALDH2 activation and overexpression significantly inhibited the increased mitochondrial fission after OGD/***,we found that ALDH2 dominantly suppressed dynamin-related protein 1(Drp1)phosphorylation(Ser616)and adenosine monophosphate-activated protein kinase(AMPK)phosphorylation(Thr172)but not interfered with the expression levels of mitochondrial shaping ***:We demonstrate the protective effect of ALDH2 against cardiomyocyte H/R injury with a novel mechanism on mitochondrial fission/fusion.

关键词： Myocardial hypoxia/reoxygenation injury Aldehyde dehydrogenase 2 Mitochondrial fi ssion/fusion Mitochondrial dynamics Dynamin-related protein 1

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Extraction and Characterization of Humic Acids and Humin Fractions from a Black Soil of China

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Pedosphere 2005年第1期15卷 1-8页

作者： XING bao-shan, liu Ju-Dong, liu Xiao-Bing and HAN Xiao-ZengNortheast Institute of Geography and Agro-ecology, Chinese Academy of Sciences, Harbin 150040 (China). Department of Plant, Soil and Insect Sciences, University of Massachusetts, MA 01003 (USA) Northeast Institute of Geography and Agro-ecology Chinese Academy of Sciences Harbin 150040 （China）. Department of Plant Soil and Insect Sciences University of Massachusetts MA 01003 （USA）

Twenty-three progressive extractions were performed to study individual humic acids (HAs) and humin fractions from a typical black soil (Mollisol) in Heilongjiang Province, China using elemental analysis and spectroscopic techniques. After 23 HA extractions the residue was separated into high and low organic carbon humin fractions. HA yield was the highest for the first extraction and then gradually decreased with further extractions. Organic carbon (OC) of the humin fractions accounted for 58% of total OC even after 23 successive HA extractions. In addition, the atomic C/H ratio decreased during the course of extraction while C/O increased; the E4/E6 ratio from the UV analysis decreased with further extraction while E2/E3 increased; the band assigned to aliphatic carbon (2930 cm-1) in the diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) spectra gradually increased with progressive extraction; the calculated ratio of the sum of aromatic carbon peak heights to that of aliphatic carbon

关键词： elemental composition humic acid humin soil organic matter spectroscopic analysis

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Research and exploration progress on lithium deposits in China

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China Geology 2020年第1期3卷 137-152页

作者： Deng-hong Wang Hong-zhang Dai shan-bao liu Cheng-hui Wang Yang Yu Jing-jing Dai Li-jun liu Yue-qing Yang Sheng-chao Ma Ministry of Natural Resources Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China Sichuan Institute of Geology&Mineral Resources Bureau of Geology and Mineral Exploration&Development of Sichuan ProvinceChengdu 610000China

Since 2012,some advances have been made through the resource investigation,metallogenesis research,and comprehensive utilizing of lithium deposits in ***,the progress of lithium exploration has been made in Sichuan,Xinjiang,Qinghai and Jiangxi provinces(autonomous region).Li deposits are not only found within the pegmatite rocks but also within the granitic rocks and sedimentary ***,the methods of geological survey,geochemical and geophysical exploration,remote sensing technology and even drilling technology have been improved,which can be delineating orebodies ***,the mechanisms of Li mineralization were summarized by analyzing the relationship between the Li contents and kinds of geological *** on practice,a new understanding of"multi-cycle,deep circulation,integration of internal and external"metallogenic mechanism or"MDIE"metallogenic mechanism for short has been put forwarded further in this paper,and the"five levels+basement"exploration model has been successfully expanded to guide the prospecting work both in the Jiajika and Keeryin pegmatite ore fields in western Sichuan ***,new progress has been made in the aspect of amblygonite deposits of granite-type and hydrothermal type in the Mufushan-Jiuling ore district,which points out a new direction for prospecting new types of lithium deposits in China.

关键词： Lithium deposits Amblygonite "MDIE"metallogenic mechanism "Five levels+basement"exploration model Mineral exploration engineering China

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Geology and mineralization of the Duobaoshan supergiant porphyry Cu-Au-Mo-Ag deposit(2.36 Mt)in Heilongjiang Province,China:A review

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China Geology 2023年第1期6卷 100-136页

作者： Sen Zhang Nan Ju Guo-bin Zhang Yuan-dong Zhao Yun-sheng Ren bao-shan liu Hui Wang Rong-rong Guo Qun Yang Zhen-ming Sun Feng-ming Xu Ke-yong Wang Yu-jie Hao Cores and Samples Centre of Natural Resources China Geological SurveyMinistry of Natural ResourcesLangfang 065200China Shenyang Center China Geological SurveyMinistry of Natural Resources(Northeast Geological S&T Innovation Center)Shenyang 110034China Mining College Liaoning Technical UniversityFuxin 123000China Mudanjiang Natural Resources Survey Center China Geological SurveyMinistry of Natural ResourcesMudanjiang 157021China Institute of Disaster Prevention Langfang 065200China College of Earth Sciences Jilin UniversityChangchun 130000China School of Earth Science and Resources Chang’an UniversityXi’an 710000China School of Resources and Civil Engineering Northeastern UniversityShenyang 110031China School of Prospecting&Surveying Engineering Changchun Institute of TechnologyChangchun 130000China

The reserves of the Duobaoshan porphyry Cu-Au-Mo-Ag deposit(also referred to as the Duobaoshan porphyry Cu deposit)ranks first among the copper deposits in China and 33rd among the porphyry copper deposits in the *** has proven resources of copper(Cu),molybdenum(Mo),gold(Au),and silver(Ag)of 2.28×10^(6)t,80×10^(3)t,73 t,and 1046 t,*** major characteristics of the Duobaoshan porphyry Cu deposit are as *** is located in a zone sandwiched by the Siberian,North China,and paleo-Pacific plates in an island arc tectonic setting and was formed by the Paleozoic mineralization and the Mesozoic mineralization induced by superposition and *** metallogenic porphyries are the Middle Hercynian granodiorite *** alterations of surrounding rocks are distributed in a ring *** silicified porphyries at the center,the alteration zones of K-feldspar,biotite,sericite,and propylite occur from inside to *** deposit is composed of 215 ore bodies(including 14 major ore bodies)in four mineralized *** body No.X in the No.3 mineralized zone has the largest resource reserves,accounting for more than 78%of the total reserves of the *** ore components include Cu,Mo,Au,Ag,Se,and Ga,which have an average content of 0.46%,0.015%,0.16 g/t,1.22 g/t,0.0003%,and 0.001%-0.003%,*** ore minerals of this deposit primarily include pyrite,chalcopyrite,bornite,and molybdenite,followed by magnetite,hematite,rutile,gelenite,and *** ore-forming fluids of this deposit were magmatic water in the early metallogenic stage and then the mixture of meteoric water and magmatic water at the late metallogenic *** ore-forming fluids experienced three *** ore-forming fluids of stageⅠhad a hydrochemical type of H_(2)O-CO_(2)-Na Cl,an ore-forming temperature of 375-650℃,and ore-forming pressure of 110-160 *** ore-forming fluids of stageⅡhad a hydrochemical type of H_(2)O-CO_(2)-Na Cl,an ore-forming temperatur

关键词： Cu-Au-Mo-Ag deposit Porphyry Mineralization Mineralization model Mineral exploration engineering Prospecting modle Duobaoshan Heilongjiang China

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Mechanism study of the effect of Ningxue Shengban decoction on regulating the ratio of Treg/Th17 cells and downstream inflammatory factors in immune thrombocytopenia model mice

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Integrative Medicine Discovery 2023年第36期7卷 1-7页

作者： Ai-Di Wang Hong-Lei Guo Dong-Jie Xie Xiang-Yu Zuo Lin Ma bao-shan liu Department of Chinese Medicine Tianjin Medical University General HospitalTianjin 300052China Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Oncology the First Affiliated Hospital of Henan University of Science and TechnologyHenan 471003China College of Traditional Chinese Medicine Health Service Shanxi Datong UniversityShanxi 037009China

Background:To explore the role and mechanism of T cell imbalance in the process of immune thrombocytopenic purpura(ITP)and the efficacy of the Ningxue Shengban decoction in treating this ***:Passive immune ITP mouse model was established by injecting CD41 monoclonal antibody into BALB/c *** mice were divided into different groups for intervention and drug administration for 9 *** therapeutic effects(blood cell count,bone marrow morphology)were *** changes in the number and proportion of regulatory T/Th17 cells in each group,as well as the expression of key transcription proteins and genes(Foxp3,RORγt)in mouse spleen,and the secretion of related inflammatory factors(interleukin-17,TGF-β,interleukin-21,interleukin-10)in serum were ***:Ningxue Shengban decoction significantly increased the peripheral blood platelet count in ITP mice,improved bone marrow morphology,restored the imbalance of regulatory T/Th17 ratio,and exerted a positive regulatory effect on target proteins and downstream inflammatory factor ***:Ningxue Shengban decoction may exert its therapeutic effect in treating ITP by regulating T cells and exerting immune regulatory function.

关键词： immune thrombocytopenic purpura immunologic balance traditional Chinese medicine Ningxue Shengban decoction

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Anlotinib in combination with Envolizumab plus Etoposide for the treatment of EX-SCLC:a case report

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Clinical Research Communications 2024年第1期7卷 29-33页

作者： Hong-Lei Guo Hong Wang Yan-Qi Song Xin-Long Song Ai-Di Wang bao-shan liu Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Chinese Medicine Tianjin Medical University General HospitalTianjin 300052China

Background:Small cell lung cancer(SCLC)is an aggressive malignant tumor with strong immunosuppressive effects,characterized by rapid doubling time and poor ***,effective therapeutic options are urgently needed for Extensive-stage small-cell lung *** description:In the present case,a combination therapy of anlotinib,envolizumab,and etoposide was administered to treat an 80-year-old female patient with extensive-stage SCLC accompanied by mediastinal lymph node and bone *** two cycles of treatment,the tumor lesions in the right lungs decreased from 5.04*3.44 cm to 1.65*1.42 *** of now,no significant mass is seen there and no serious adverse reactions in this *** September 2023,she has survived for 18 months with no disease ***:Research shows that Alectinib,in combination with evolocumab plus etoposide,could be an original,viable therapeutic option for the treatment option of patients with extensive-stage SCLC.

关键词： Extensive-stage Small Cell Lung Cancer anti-angiogenesis PD-1 inhibitors Combined treatment case report

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The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying Wu shan Ye Xiangyi liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

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异时性多原发结直肠癌临床特点分析31例

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世界华人消化杂志 2009年第6期17卷 627-631页

作者：郑阳春燕锦刘宝善刘超徐琳四川省肿瘤医院腹部外科四川省成都市610041

目的:探讨异时性多原发结直肠癌的临床特点,为临床诊治提供参考.方法:回顾性总结31例异时性多原发结直肠癌的临床资料,分析肿瘤发生、分布及治疗与预后.结果:31例患者,平均5.1年出现次发癌,平均3.8年后3例出现第3癌,平均3.5年后2例再发... 详细信息

目的:探讨异时性多原发结直肠癌的临床特点,为临床诊治提供参考.方法:回顾性总结31例异时性多原发结直肠癌的临床资料,分析肿瘤发生、分布及治疗与预后.结果:31例患者,平均5.1年出现次发癌,平均3.8年后3例出现第3癌,平均3.5年后2例再发第4癌.45.2%的患者合并存在腺瘤.59.5%的首发癌位于直肠、乙状结肠;大部分次发癌的分化程度、病理分期好于首发癌或与之相同;首发癌术后平均存活8.3年,5年生存率84.8%.结论:大多数异时性多原发结直肠癌的首发癌位于直肠及乙状结肠.合并存在腺瘤是发生该病的危险因素,根治术后应进行定期复查.

关键词：结直肠癌多原发癌异时性临床特点

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Sorption of Organic Compounds in Soil Organic Matter

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Journal of Northeast Agricultural University(English Edition) 2001年第1期8卷 72-80页

作者： XING bao-shan,liu Xiao-bing, SONG Chun-yu ( Heilongjiang Institute of Agricultural Modernization,Academia Sinica,Harbin, Heilongjiang 150040,P R C) ( Department of Plant and Soil Seinces, University of Massachussetts, Amherst, USA) Heilongjiang Institute of Agricultural Modernization Academia Sinica Department of Plant and Soil Seinces University of Massachussetts Heilongjiang Institute of Agricultural Modernization Academia Sinica

Soil organic matter(SOM)is the predominant component for sorption of hydrophobic organic compouds in soil and sorption by SOM ultimately affects chemical fate and availability in soil,and the degree of remedia- tion success of contaminated soils. This paper summarizes the latest development on sorption of organic com- pounds in soil (natural) organic matter,addresses four sorption mechanisms: surface adsorption,solid - phase Partitioning,dual-mode sorption,and fixed-pore sorption model,and presents future research directions as well.

关键词： Sorption Soil organic matter Sorption mechanism Organic compounds

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玉竹组织培养技术研究

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人参研究 2017年第3期29卷 21-24页

作者：包京姗刘春博杨世海吉林农业大学长春130118 吉林省经济管理干部学院长春130012

以玉竹的叶片、根状茎为外植体,采用不同种类、不同浓度的植物生长调剂进行组织培养。结果表明:玉竹的根状茎用0.2%升汞消毒15min最为合适,根状茎诱导愈伤组织最适培养基为MS+2.0 mg/L 6-BA+2.0mg/L 2,4-D,诱导率为81%。MS+3.0mg/L 6-BA... 详细信息

以玉竹的叶片、根状茎为外植体,采用不同种类、不同浓度的植物生长调剂进行组织培养。结果表明:玉竹的根状茎用0.2%升汞消毒15min最为合适,根状茎诱导愈伤组织最适培养基为MS+2.0 mg/L 6-BA+2.0mg/L 2,4-D,诱导率为81%。MS+3.0mg/L 6-BA+0.5mg/L NAA的培养基上诱导不定芽最高,达到87%。MS+2.0mg/L6-BA+0.2mg/LNAA的培养基上诱导不定根最高,达到95%。

关键词：玉竹组织培养根状茎诱导率

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