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makeTwin:A reference architecture for digital twin software platform

Chinese Journal of Aeronautics 2024年第1期37卷 1-18页

作者： Fei TAO Xuemin SUN Jiangfeng CHENG Yonghuai ZHU Weiran liu Yong WANG Hui XU Tianliang HU Xiaojun liu Tingyu liu Zheng SUN Jun XU Jinsong bao Feng XIANG Xiaohui JIN Digital Twin International Research Center International Research Institute for Multidisciplinary ScienceBeihang UniversityBeijing 100191China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Institute of Advanced Manufacturing and Intelligent Technology Beijing University of TechnologyBeijing 100124China RIAMB(Beijing)Technology Development Co Ltd(R.T.D.)Beijing 100120China School of Mechanical Engineering Shandong UniversityJinan 250061China School of Mechanical Engineering Southeast UniversityNanjing 211189China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China College of Mechanical Engineering Donghua UniversityShanghai 201620China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan 430081China Beijing Aero-top Hi-tech Co LtdBeijing 100176China

Digital twin is currently undergoing a significant transformation from the conceptual and theoretical research phase to the implementation and application ***,a universally adaptable research and development platform for digital twin is critically needed to meet the development ***,a publicly accessible simulation,testing,and validation platform which can support digital twin model building,data processing,algorithm design,configuration,etc.,is urgently required for ***,for developers from the industry,a lowcode development platform that can offer a customizable suite of functions such as model creation,data management,protocol configuration,and visualization is urgently ***,for enterprise users,there is a lack of an application management platform that can be configured and migrated for various application scenarios,functions,and ***,based on the system research of digital twin theories and key technologies by the authors(such as the five-dimension digital twin model,digital twin modeling and digital twin data theory,digital twin standards,and so on),a digital twin software platform reference architecture,namely make Twin,is proposed and designed,as well as its ten core *** workflow of the make Twin and the interaction mechanisms among its core functions are ***,a digital twin application system for a chemical fiber textile shop floor(CFTS)which was developed according to make Twin,is introduced,which validates the proposed reference architecture.

关键词： Digital twin Digital twin software platform Industrial software makeTwin Reference architecture

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Clinical Analysis and Mental Health Survey of Hemophilia Carriers:a Cross-sectional Study

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Current Medical Science 2024年第2期44卷 435-440页

作者： Wen WANG Li-juan JIANG Dong-yan CUI Ai ZHANG Xiong WANG Ai-guo liu qun HU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Hemophilia carriers(HCs),who are heterozygous for mutations in the clotting factor VIII/clotting factor IX gene(F8 or F9),may have a wide range of clotting factor levels,from very low,similar to afflicted males,to the upper limit of normal,and may experience mental health *** purpose of this study was to provide genetic information on mothers of hemophilia patients and to understand the clotting factor activity and phenotype of ***,we aimed to investigate the mental health status of HCs in ***:A total of 127 hemophilia mothers,including 93 hemophilia A(HA)mothers and 34 hemophilia B(HB)mothers,were enrolled in this *** distance PCR,multiplex PCR,and Sanger sequencing were used to analyze mutations in F8 or *** factor activity was detected by a one-stage clotting *** Symptom Checklist 90(SCL-90,China/Mandarin version)was given to HCs at the same time to assess their mental ***:A total of 90.6%of hemophilia mothers were diagnosed genetically as carriers,with inversion in intron 22 and missense mutations being the most common mutation types in HA and HB carriers,*** median clotting factor level in carriers was 0.74 IU/mL(ranging from 0.09 to 1.74 IU/mL)compared with 1.49 IU/mL(ranging from 0.93 to 1.89 IU/mL)in noncarriers,of which 14.3%of HCs had clotting factor levels of 0.40 IU/mL or below.A total of 53.8%(7/13)of HA carriers with low clotting factor levels(less than 0.50 IU/mL)had a history of bleeding,while none of the HB carriers displayed a bleeding *** total mean score and the global severity index of the SCL-90 for surveyed HCs were 171.00(±60.37)and 1.78(±0.59),respectively.A total of 67.7%of the respondents had psychological symptoms,with obsessive-compulsive disorder being the most prevalent and *** pooled estimates of all nine factors were significantly higher than those in the general population(P<0.05).Conclusions:The detection rate of gene mutations

关键词： hemophilia A hemophilia B mutation carrier mental health

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Confined Mn^(2+) enables effective aerobic oxidation catalysis

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Science China Chemistry 2024年第5期67卷 1545-1553页

作者： Desheng Yuan Sicong Ma Xiao Kong Chi Zhang Lin Chen Chengsheng Yang Lihua Wang Zhen liu Lin Ye Yongmei liu Rui Ma Zhi-Pan liu Yifeng Zhu Yong Cao Xinhe bao Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsCollaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200438China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Institute of Advanced Fluorine-Containing Materials Zhejiang Normal UniversityJinhua 321004China State Key Laboratory of Catalysis National Laboratory for Clean EnergyCollaborative Innovation Center of Chemistry for Energy MaterialsDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Effective and mild activation of O_(2) is essential but challenging for aerobic oxidation. In heterogeneous catalysis, high-valence manganese oxide(e.g., +4) is known to be active for the oxidation, whereas divalent MnO is ineffective due to its limited capacity to supply surface oxygen and its thermodynamically unstable structure when binding O_(2) in reaction conditions. Inspired by natural enzymes that rely on divalent Mn^(2+), we discovered that confining Mn^(2+) onto the Mn_(2)O_(3) surface through a dedicated calcination process creates highly active catalysts for the aerobic oxidation of 5-hydroxymethylfurfural, benzyl alcohol, and *** Mn_(2)O_(3)-confined Mn^(2+) is undercoordinated and efficiently mediates O_(2) activation, resulting in 2–3 orders of magnitude higher activity than Mn_(2)O_(3) alone. Through low-temperature infrared spectroscopy, we distinguished low-content Mn^(2+) sites at Mn_(2)O_(3) surface, which are difficult to be differentiated by X-ray photoelectron spectroscopy. The combination of in-situ energydispersive X-ray absorption spectroscopy and X-ray diffraction further provides insights into the formation of the newly identified active Mn^(2+) sites. By optimizing the calcination step, we were able to increase the catalytic activity threefold *** finding offers promising frontiers for exploring active oxidation catalysts by utilizing the confinement of Mn^(2+)and oftenignored calcination skills.

关键词： confinement catalysis manganese oxide aerobic oxidation divalent Mn^(2+) operando spectroscopies

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Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis

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Neural Regeneration Research 2024年第10期19卷 2281-2289页

作者： Wang Liao Jiana Wei Chongxu liu Haoyu Luo Yuting Ruan Yingren Mai qun Yu Zhiyu Cao Jiaxin Xu Dong Zheng Zonghai Sheng Xianju Zhou Jun liu Department of Neurology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Special Medical Service Center Neuroscience CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangdongGuangdong ProvinceChina Department of Rehabilitation The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Disturbances in the microbiota-gut-brain axis may contribute to the development of Alzheimer's disease. Magnesium-L-threonate has recently been found to have protective effects on learning and memory in aged and Alzheimer's disease model mice. However, the effects of magnesium-L-threonate on the gut microbiota in Alzheimer's disease remain unknown. Previously, we reported that magnesium-L-threonate treatment improved cognition and reduced oxidative stress and inflammation in a double-transgenic line of Alzheimer's disease model mice expressing the amyloid-β precursor protein and mutant human presenilin 1(APP/PS1). Here, we performed 16S r RNA amplicon sequencing and liquid chromatography-mass spectrometry to analyze changes in the microbiome and serum metabolome following magnesium-Lthreonate exposure in a similar mouse model. Magnesium-L-threonate modulated the abundance of three genera in the gut microbiota, decreasing Allobaculum and increasing Bifidobacterium and Turicibacter. We also found that differential metabolites in the magnesiumL-threonate-regulated serum were enriched in various pathways associated with neurodegenerative diseases. The western blotting detection on intestinal tight junction proteins(zona occludens 1, occludin, and claudin-5) showed that magnesium-L-threonate repaired the intestinal barrier dysfunction of APP/PS1 mice. These findings suggest that magnesium-L-threonate may reduce the clinical manifestations of Alzheimer's disease through the microbiota-gut-brain axis in model mice, providing an experimental basis for the clinical treatment of Alzheimer's disease.

关键词： Alzheimer's disease APP/PS1 double-transgenic Alzheimer's disease mouse model inflammation intestinal barrier dysfunction magnesium-L-threonate microbiome microbiota-gut-brain axis oxidative stress serum metabolites

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Modification of LiMn_(0.6)Fe_(0.4)PO_(4)lithium-ion battery cathode materials with a fluorine-doped carbon coating

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Particuology 2024年第9期92卷 278-287页

作者： Debao Pan Ziyuan liu Chengping Li Rundong Wan Jinsong Wang Jiangzhao Chen Ding Wang Jinkun liu Yingjie Zhang Jianhong Yi Rui bao Zhengfu Zhang Peng Dong Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China

In this study,glucose and NH4F were utilized as sources of carbon and fluorine,respectively,for the synthesis of LiMn_(0.6)Fe_(0.4)PO_(4)(LMFP)*** nanoscales were subsequently modified with varying levels of fluorine-doped carbon through co-precipitation and mechanical ball milling *** LMFP,incorporating carbon and varying levels of fluoride ions,exhibit higher specific discharge capacities at 0.2 Cand electrochemical characteristics compared to the original LMFP coated solely with *** inclusion of fluorine-doped carbon in the composite material creates numerous pathways for expeditious electron ***,the partial formation of metal fluoride at the interface between the surface of LMFP and the layer of carbon coating doped with fluorine enhances the reduction in the charge-transfer *** modified ferromanganese phosphate cathode material reveals an outstanding discharge capacity displaying a reversible discharge specific capacity value of 131.73 mA h g^(−1)at 10C and 154.6 mA h g^(−1)at 0.2C,due to its unique structure.

关键词： Lithium manganese iron phosphate Anode Electrochemical Fluorine-doped carbon

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Adaptive pandemic management strategies for construction sites:An agent-based modeling approach

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Frontiers of Engineering Management 2024年第2期11卷 288-310页

作者： Chengqian LI Qi FANG Ke CHEN Zhikang bao Zehao JIANG Wenli liu School of Civil Engineering Hunan UniversityChangsha 410082China School of Civil Engineering Central South UniversityChangsha 410004China School of Civil and Hydraulic Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Energy GeoscienceInfrastructureand SocietyHeriot-Watt UniversityEdinburghUK

In the face of sudden pandemics,it becomes crucial for project managers to quickly adapt and make informed decisions that anticipate the consequences of their *** highlights the need for proactive management strategies to enhance epidemic response ***,current research mainly emphasizes the negative impacts of pandemics,often neglecting the development of adaptable management approaches for construction *** study aims to fill this research void by developing strategies tailored to managing pandemics at construction *** agent-based modeling,the study simulates the movement patterns of workers and the consequent spread of an epidemic under different risk scenarios and management *** results indicate that measures such as wearing masks,managing group activities,and enforcing entry controls can significantly reduce epidemic spread on construction sites,with entry controls showing the greatest effectiveness.

关键词： epidemic transmission agent-based modeling safety management management strategy

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Naringin ameliorates H_(2)O_(2)-induced oxidative damage in cells and prolongs the lifespan of female Drosophila melanogaster via the insulin signaling pathway

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Food Science and Human Wellness 2024年第3期13卷 1231-1245页

作者： Xiaomei Du Kexin Wang Xiaoyan Sang Xiangxing Meng Jiao Xie Tianxin Wang Xiaozhi liu qun Huang Nan Zhang Hao Wang State Key Laboratory of Food Nutrition and Safety Tianjin University of Science and TechnologyTianjin 300457China The key Laboratory of Environmental Pollution Monitoring and Disease Control Ministry of EducationGuizhou Medical UniversityGuizhou 550025China Department of neurosurgery the Fifth Central Hospital of TianjinTianjin 300450China Tianjin Key Laboratory of Epigenetics for Organ Department in Preterm Infants the Fifth Central Hospital of TianjinTianjin 300450China

Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological *** this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying *** results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in ***,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde *** also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem ***,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of ***,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.

关键词： Drosophila melanogaster Insulin signaling(IIS)pathway Naringin PC12 cell HepG2 cell

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Pan-African metamorphism and magmatism in the Prydz Belt,East Antarctica:a geochronological perspective

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Advances in Polar Science 2024年第2期35卷 143-156页

作者： bao Hong WANG Wei-(RZ) liu Xinshu ZHAO Yue GONG Tingnan liu Xiaochun CUI Ying TIAN Zuolin Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Key Laboratory of Paleomagnetism and Tectonic Reconstruction Ministry of Natural ResourcesBeijing 100081China China University of Geosciences(Beijing) Beijing 100081China MOE Key Laboratory of Orogenic Belt and Crustal Evolution School of Earth and Space SciencesPeking UniversityBeijing 100871China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China

The Prydz Belt in East Antarctica underwent extensive reworking during the late Neoprotertozoic–early Paleozoic Pan-African orogeny,which is characterized by granulite facies,clockwise P–T paths,and high dT/dP *** study compiles the existing age and composition data of zircon and monazite from metamorphic rocks and links their key characteristics to the metamorphic evolution of the Prydz *** frequency of zircon U–Pb ages starts to increase noticeably from~555 Ma,peaking between 530 Ma and 520 Ma,followed by a dramatic decline after 520 *** Th/U values(>0.1)of zircon are observed from~545 Ma,displaying a noticeable increasing trend in Th/U values before a rapid decline from~520 *** frequency of monazite ages progressively increases from~540 Ma,reaching its peak at 515 Ma,and then rapidly decreases after 490 *** with the crystallization behaviors of zircon and monazite,this study suggests that the systematic changes in Th/U values of zircon after 545 Ma indicate a transition in the thermal regime of the Prydz Belt towards the cooling *** growth of zircon and monazite corresponds to the post-peak cooling process,while the crystallization peak of monazite lags behind that of zircon by~5–15 Ma,which indicates a relatively low cooling *** the granitic intrusions accompanied the entire metamorphic evolution,the majority of them are younger than 520 *** results suggest that the Pan-African event likely peaked at~555–545 Ma and gradually cooled to near-solidus conditions at~520–510 Ma,with a relatively slow average cooling process.

关键词： East Antarctica Prydz Belt Pan-African orogeny zircon monazite U–Pb dating

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Global research trends and prospects of cellular metabolism in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 527-542页

作者： Yan-Chen liu Zhi-Cheng Gong Chao-qun Li Peng Teng Yan-Yan Chen Zhao-Hui Huang Wuxi Cancer Institute Affiliated Hospital of Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Wuxi School of Medicine Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Wuxi Institute of Integrated Chinese and Western Medicine Affiliated Hospital of Jiangnan UniversityWuxi 214062Jiangsu ProvinceChina

BACKGROUND An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer(CRC).However,no work is currently available to synthesize the field through *** To analyze the development in the field of“glucose metabolism”(GM),“amino acid metabolism”(AM),“lipid metabolism”(LM),and“nucleotide metabolism”(NM)in CRC by *** Articles within the abovementioned areas of GM,AM,LM and NM in CRC,which were published from January 1,1991,to December 31,2022,are retrieved from the Web of Science Core Collection and analyzed by CiteSpace 6.2.R4 and VOSviewer *** The field of LM in CRC presented the largest number of annual publications and the fastest increase in the last decade compared with the other three ***,China and the United States were two of the most prominent contri-butors in these four *** addition,Gang Wang,Wei Jia,Maria Notar-nicola,and Cornelia Ulrich ranked first in publication numbers,while Jing-Yuan Fang,Senji Hirasawa,Wei Jia,and Charles Fuchs were the most cited authors on average in these four fields,respectively.“Gut microbiota”and“epithelial-mesenchymal transition”emerged as the newest burst words in GM,“gut microbiota”was the latest outburst word in AM,“metastasis”,“tumor microenvironment”,“fatty acid metabolism”,and“metabolic reprogramming”were the up-to-date outbreaking words in LM,while“epithelial-mesenchymal transition”and“apoptosis”were the most recently occurring words in *** Research in“cellular metabolism in CRC”is all the rage at the moment,and researchers are particularly interested in exploring the mechanism to explain the metabolic alterations in *** metabolic vulnerability appears to be a promising direction in CRC therapy.

关键词： Cellular metabolism Colorectal cancer Glucose metabolism Amino acid metabolism Lipid metabolism Nucleotide metabolism

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Intelligent architecture modeling for multilevel fluvial reservoirs based on architecture interface and elements

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Energy Geoscience 2024年第1期5卷 293-310页

作者： Bo Niu Xiangyang Hu Shuijian Wei Wenbo Zheng Jie Xu Bin liu Zhidong bao Petroleum Exploration&Production Research Institute SinopecBeijing100083China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China

At present,the architecture modeling method of fluvial reservoirs are still *** methods usually use grids to characterize architecture interbeds within the *** to the thin thickness of this type of the interlayers,the number of the model grids must be greatly *** number of grids in the tens of millions often makes an expensive computation;however,upscaling the model will generate a misleading *** above confusion is the major reason that restricts the largescale industrialization of fluvial reservoir architecture models in oilfield development and ***,this paper explores an intelligent architecture modeling method for multilevel fluvial reservoirs based on architecture interface and *** on the superpositional relationship of different architectural elements within the fluvial reservoir,this method uses a combination of multilevel interface constraints and non-uniform grid techniques to build a high-resolution 3D geological model for reservoir *** the grid upscaling technology of heterogeneous architecture elements,different upscaling densities are given to the lateral-accretion bedding and lateral-accretion bodies to simplify the model *** new method greatly reduces the number of model grids while ensuring the accuracy of lateral-accretion bedding models,laying a foundation for large-scale numerical simulation of the subsequent industrialization of the architecture *** method has been validated in A layer of X oilfield with meandering fluvial channel sands as reservoirs and B layer of Y oilfield with braided river sands as *** simulation results show that it has a higher accuracy of production history matching and remaining oil distribution forecast of the targeted sand *** numerical simulation results show that in the actual development process of oilfield,the injected water will not displace oil in a uniform diffusive manner as traditionally assu

关键词： Architecture modeling Interface restriction Architectural element Fluvial deposits Mid-channel bar Point bar

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