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华南理工大学学报（自然科学版） 2016年第8期44卷 123-130页

作者：王爱丽董宝田武鸿源北京交通大学交通运输学院北京100044 中国铁路总公司信息技术中心北京100038

在目标尺寸和颜色发生变化时,传统均值漂移法因目标模型单一和核窗口大小方向固定而导致目标丢失.为此,文中提出一种基于多特征概率分布的均值漂移行人跟踪算法,首先利用目标的颜色、轮廓和运动特征构建目标模型,得到颜色、边缘和运动... 详细信息

在目标尺寸和颜色发生变化时,传统均值漂移法因目标模型单一和核窗口大小方向固定而导致目标丢失.为此,文中提出一种基于多特征概率分布的均值漂移行人跟踪算法,首先利用目标的颜色、轮廓和运动特征构建目标模型,得到颜色、边缘和运动直方图分布;然后将颜色和边缘的直方图反向投影生成二维概率密度分布,利用运动信息修正颜色和边缘概率分布;并根据各特征所占权重,运用自适应融合法得到目标特征关联概率分布;最后利用关联概率密度的零阶矩值调整下一帧跟踪窗口尺寸,结合均值漂移跟踪框架,实现常态下目标跟踪.实验结果表明,该算法提取的目标特征具有较强的准确性,能实现复杂交通场景下的行人跟踪.

关键词：行人跟踪均值漂移直方图分布多特征融合关联概率分布

应用“跨零-能量”法估算海洋波浪再生能资源

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海洋与湖沼 2017年第5期48卷 926-931页

作者：尤再进尹宝树石洪源鲁东大学港口与海岸研究中心烟台264025 Coastal Research Centre University of Queensland 中国科学院海洋环流与波动重点实验室青岛266071 中国科学院海洋研究所青岛266071 青岛海洋科学与技术国家实验室青岛266237 中国科学院大学北京100049

海洋波浪能是一种可持续和零污染的再生能源,随着自然能源日渐匮乏和全球气候变化,人类对波浪能的开发利用显得尤其重要。本文应用"跨零—能量"波浪分析的新方法,首次推导了不规则波浪的波能流垂向分布及其理论计算公式。本文研究发现,... 详细信息

海洋波浪能是一种可持续和零污染的再生能源,随着自然能源日渐匮乏和全球气候变化,人类对波浪能的开发利用显得尤其重要。本文应用"跨零—能量"波浪分析的新方法,首次推导了不规则波浪的波能流垂向分布及其理论计算公式。本文研究发现,浅水波能流具有均匀的垂向分布,深水波能流集中于海表层的水体中,过渡区波能流的垂向分布介于浅水和深水波能的分布之间。研究还发现,目前海洋波能流的估算方法和现今波浪发电装置的波能采集深度缺少相关性,过高估算了海洋波浪的可发电资源。

关键词：波浪能波能流规则波不规则波浪

一种新的子宫内膜腺上皮细胞和基质细胞的分离纯化及培养方法的探讨

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中国医科大学学报 2007年第5期36卷 608-610页

作者：鲍远红王秀霞中国医科大学附属盛京医院生殖中心辽宁沈阳110004

目的:建立一种简捷的分离纯化培养子宫内膜腺上皮细胞和基质细胞的方法。方法:选择子宫全切育龄妇女的新鲜子宫内膜组织,经单酶消化、二次筛网过滤及贴壁纯化技术分离纯化培养人子宫内膜腺上皮细胞和基质细胞,光镜及免疫细胞化学染色鉴... 详细信息

目的:建立一种简捷的分离纯化培养子宫内膜腺上皮细胞和基质细胞的方法。方法:选择子宫全切育龄妇女的新鲜子宫内膜组织,经单酶消化、二次筛网过滤及贴壁纯化技术分离纯化培养人子宫内膜腺上皮细胞和基质细胞,光镜及免疫细胞化学染色鉴定细胞纯度。结果:腺上皮细胞漩涡状生长,细胞呈蝌蚪形或类圆型,细胞角蛋白19免疫组化染色阳性,纯度可达92%。基质细胞呈平行状生长,细胞呈梭形或多角形。波形蛋白免疫组化染色阳性,纯度达95%以上。每例子宫肌瘤切除标本可获得(10～25)×106原代基质细胞和(4～6)×106原代腺上皮细胞。结论:该培养方法可获得高产量的纯化的子宫内膜腺上皮细胞和基质细胞。

关键词：子宫内膜上皮细胞基质细胞细胞培养

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高职高专学生英语听力障碍分析及应试策略

武汉职业技术学院学报 2007年第6期6卷 82-84页

作者：包宏元武汉职业技术学院外语系湖北武汉430074

文章对高职高专学生在听力方面存在的问题进行分析,指出了中国学生在英语听力中存在的主要障碍;分析了问题产生的原因;提出了改进听力训练的有效途径和基本方法。文章对听力考试提出了应试的策略和技巧,以帮助学生提高听力的能力。

关键词：英语听力障碍分析应试策略

光折变聚合物PVK∶5CB∶C_(60)中生色团动态取向的研究

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物理学报 2002年第4期51卷 796-804页

作者：袁保红姜永远孙秀冬裴延波王健周忠祥哈尔滨工业大学应用物理系哈尔滨150001

考虑到聚合物基体对生色团的取向的阻尼作用 ,以及外电场对生色团的极化作用 ,在已有的生色团气体取向模型基础上 ,建立了非气体取向模型 .并利用数值计算方法求解了这一非气体取向模型方程 .讨论了外加电场、温度对生色团取向的动态过... 详细信息

考虑到聚合物基体对生色团的取向的阻尼作用 ,以及外电场对生色团的极化作用 ,在已有的生色团气体取向模型基础上 ,建立了非气体取向模型 .并利用数值计算方法求解了这一非气体取向模型方程 .讨论了外加电场、温度对生色团取向的动态过程和稳态分布的影响 ,比较了两模型的计算结果 .采用椭圆偏振法 ,测量了光折变聚合物PVK∶5CB∶C60 中的生色团 5CB在聚合物基体PVK中动态取向过程 .给出了生色团的稳态和动态取向参量随外加电场和温度的变化关系 .理论与实验的比较。

关键词：光折变聚合物生色团非气体取向模型动态取向 PVK:5CB:C60

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期68卷 46-95页

作者： Zhong-Liang Gong hong-Jie Zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-Jiang Yao yuan-yuan Zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry

Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao yuan Lingqi Yu Xudong Zhuang Dongjing Wen Jin He Jingmei hong Jiayu Xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying hong Ximin yuan Weicheng Kong Pengcheng Xia yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment