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Majorana fermions induced fast-and slow-light in a hybrid semiconducting nanowire/superconductor device

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Chinese Physics B 2022年第2期31卷 598-605页

作者： Hua-Jun Chen Peng-Jie Zhu Yong-Lei Chen bao-Cheng hou School of Mechanics and Photoelectric Physics Anhui University of Science and TechnologyHuainan 232001China

We investigate theoretically Rabi-like splitting and Fano resonance in absorption spectra of quantum dots(QDs)based on a hybrid QD-semiconducting nanowire/superconductor(SNW/SC)device mediated by Majorana fermions(MFs).Under the condition of pump on-resonance and off-resonance,the absorption spectrum experiences the conversion from Fano resonance to Rabi-like splitting in different parametric *** addition,the Fano resonances are accompanied by the rapid normal phase dispersion,which will indicate the coherent optical *** results indicate that the group velocity index is tunable with controlling the interaction between the QD and MFs,which can reach the conversion between the fast-and *** resonance will be another method to detect MFs and our research may indicate prospective applications in quantum information processing based on the hybrid QD-SNW/SC devices.

关键词： majorana fermions Fano resonance slow and fast light hybrid semiconducting/superconductor device

AN ARTIFICIAL BOUNDARY CONDITION FOR THE INCOMPRESSIBLE VISCOUS FLOWS IN A NO-SLIP CHANNEL

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Journal of Computational Mathematics 1995年第1期13卷 51-63页

作者： Han hou-de bao Wei-zhu(Department of Applied Mathematics, Tsinghua University, Beijing, China) 清华大学应用数学系北京

The numerical simulation of the steady incompressible viscous flows in a no-slip channel is considered. A discrete artificial boundary condition on a given segmental artificial boundary is designed by the method of lines. Then the original problem is reduced to a boundary value problem of Navier-Stokes equations on a bounded domain. The numerical examples show that this artificial boundary condition is very effective and more accurate than Dirichlet and Neumann boundary conditions used in engineering literature.

关键词： Boundary conditions Viscous flow Eigenvalues Approximation Navier Stokes equation Polynomials Ordinary differential equations

Transcutaneous Electrical Acupoint Stimulation Combined with Warm Acupuncture for Breast Cancer Related Upper Limb Lymphedema:A Retrospective Cohort Study

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Chinese Journal of Integrative Medicine 2023年第6期29卷 534-539页

作者： LU Chao LI Guang-liang DENG De-hou bao Wen-long WANG Yan ZHANG Ai-qin Department of Traditional Chinese Medicine the Cancer Hospital of University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Hangzhou(310022)China Institute of Basic Medicine and Cancer Chinese Academy of SciencesHangzhou(310022)China Department of Breast Medical Oncology the Cancer Hospital of University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Hangzhou(310022)China

Objective To observe the clinical efficacy of transcutaneous electrical acupoint stimulation(TEAS)combined with warm acupuncture in treating breast cancer associated with upper limb lymphedema(BCRL).Methods This was a retrospective cohort study using a paired control ***-two BCRL patients were assigned to the control group(27 cases)and the treatment group(25 cases).The patients in the control group were treated with lymphedema comprehensive detumescence treatment(CDT)for 4 weeks,including systematic therapy composed of manual lymphatic drainage,compression bandage,skincare,and functional *** patients in the treatment group were treated with TEAS combined with warm acupuncture based on the control group *** treatment lasted for 30 min and was applied twice a week for 4 *** arm circumference(AC)of different positions of the affected limb and the degree of swelling of the affected limb were evaluated before the first treatment and after the last *** clinical efficacy was evaluated according to the degree of edema before and after *** adverse events during treatment were *** The patients’AC and the swelling feeling of the affected limb in the treatment group and the control group were both reduced compared with those before *** with the control group,AC of the wrist joint transverse stria,the midpoint between the wrist joint transverse stria and the elbow joint transverse stria in the treatment group were significantly reduced(P<0.05).The decrease in AC diameter at the midpoint between the elbow joint transverse stria and the axillary transverse stria was the most significant(P<0.01).The swelling degree of the affected limbs in the treatment group was significantly lower than before treatment,and was significantly lower compared with the control group after treatment(P<0.01).The total effective rate was 72%in the treatment group,significantly higher than that in the control group(55.56%,P<0

关键词： transcutaneous electrical acupoint stimulation warm acupuncture breast cancer related upper limb lymphedema comprehensive detumescence treatment clinical efficacy

Reproductive outcomes of intracytoplasmic sperm injection using testicular sperm and ejaculated sperm in patients with AZFc microdeletions:a systematic review and meta-analysis

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Asian Journal of Andrology 2021年第5期23卷 495-500页

作者： Yu Zhou cun-Can Deng Wu-Jiang Liu Huang Liu hou-Bin Zheng Yun-Ge Tang Xin-Zong Zhang Jun-Hong Deng Department of Urology The First Affiliated HospitalJinan UniversityGuangzhou 510630China NHC Key Laboratory of Male Reproduction and Genetics Family Planning Research Institute of Guangdong ProvinceGuangzhou 510600China Digestive Diseases Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China Department of Andrology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China

Studies have explored the assisted reproductive technology(ART)outcomes of Y-chromosome azoospermia factor c(AZFc)microdeletions,but the effect of sperm source on intracytoplasmic sperm injection(ICSI)remains *** determine the ART results of ICSI using testicular sperm and ejaculated sperm from males with AZFc microdeletions,we searched Embase,Web of Science,and PubMed to conduct a systematic review and *** first meta-analysis results for 106 cycles in five studies showed no significant differences in the live birth rate between the testicular sperm group and the ejaculated sperm group(risk ratio:0.97,95%confidence interval[CI]:0.73-1.28,P=0.82).The second meta-analysis of 106 cycles in five studies showed no difference in the abortion rate between the testicular sperm group and ejaculated sperm group(risk ratio:1.06,95%Cl:0.54-2.06,P=0.87).The third meta-analysis of 386 cycles in seven studies showed no significant difference in clinical pregnancy rates between the testicular sperm group and the ejaculated sperm group(risk ratio:1.24,95%Cl:0.66-2.34,P=0.50).Inevitable heterogeneity weakened our ***,our results indicated that testicular sperm and ejaculated sperm yield similar ART outcomes,representing a meaningful result for clinical *** properly designed studies are needed to further confirm our conclusions.

关键词： assisted reproductive technology azoospermia factor c microdeletions ejaculated sperm live birth rate testicular sperm

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基于反向最近邻的密度估计聚类算法

计算机工程与应用 2025年第01期61卷 165-173页

作者：许梅梅侯新民中国科学技术大学大数据学院中国科学技术大学数学科学学院中国科学技术大学中国科学院吴文俊数学重点实验室合肥国家实验室

基于相互最近邻的密度峰聚类算法（DenMune）通过相互最近邻计算数据点的局部密度，是一种有效的聚类手段。但该算法存在构建聚类骨架不合理的问题，在分配弱点时采用硬投票策略，易产生错误。因此提出一种新的基于反向最近邻的密度估... 详细信息

基于相互最近邻的密度峰聚类算法（DenMune）通过相互最近邻计算数据点的局部密度，是一种有效的聚类手段。但该算法存在构建聚类骨架不合理的问题，在分配弱点时采用硬投票策略，易产生错误。因此提出一种新的基于反向最近邻的密度估计聚类算法（RNN-DEC）。该算法引入反向最近邻来计算数据点的局部密度，将数据点分成强点、弱点和噪声点。使用强点构建聚类算法的骨架，通过软投票的方式将弱点分配到与其相似度最高的簇中去。提出了一种基于反向最近邻的簇融合算法，将相似度高的子簇融合，得到最终的聚类结果。实验结果表明，在一些合成数据集和UCI真实数据集上，相比较于其他经典算法，该算法具有更好的聚类效果。

关键词：反向最近邻局部密度密度聚类算法子簇融合

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Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第7期13卷 555-566页

作者： bao-le ZHANG Ye LI Jian-hua DING Fu-lu DONG Yan-jun hou bao-chun JIANG Fang-xiong SHI Yin-xue XU College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China

We cloned the complete coding sequences of porcine Gpr3, Gpr6, and Gpr12 genes. Further, on the basis of their high levels of sequence similarity, these genes are identified as a subfamily of G protein-coupled receptors. These putative protein sequences also showed high sequence identity with other mammalian orthologs, including several highly conserved motifs. A wide expression of the Gpr3 gene in pigs was observed through tissue distribution analysis by reverse transcriptase-polymerase chain reaction （RT-PCR） and real-time PCR, specially in the brain, pituitary, fat, liver and oocyte, where its strong expression was observed. The Gpr3 gene was found to be located on chromosome 6 and a single exon coded for the entire open reading frame. Expression of porcine Gpr3 in HEK293 cells resulted in constitutive activation of adenylate cyclase （AC） similar in amplitude to that produced by fully stimulated Gs coupled receptors. Moreover, sphingosine 1-phosphate （S1P） could increase AC activation via the constitutively active Gpr3 receptor. When a Gpr3-green fluorescent protein （GFP） construct was expressed in HEK293 cells, GFP-labeled Gpr3 protein was shown to be localized in the plasmalemma and subcellular membranes. After S1P treatment, agonist-mediated internalization could be visualized by confocal microscopy. In short, our findings suggest the porcine Gpr3, Gpr6, and Gpr12 genes as a subfamily of G protein-coupled receptors, and porcine Gpr3 was a constitutively active G protein-coupled receptor. Constitutive activation of AG and agonist-mediated internalization of Gpr3 receptor could be modulated by the S1 P, suggesting that S1P might act as an activator for porcine Gpr3 receptor.

关键词： G protein-coupled receptor Constitutive activity Sphingosine 1-phosphate Receptor internalization Porcine Gpr3 Molecular cloning

Highly [010]-oriented self-assembled LiCoPO4/C nanoflakes as high-performance cathode for lithium ion batteries

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Nano Research 2018年第5期11卷 2424-2435页

作者： Yan hou Kun Chang bao Li Hongwei Tang Zhenyu Wang Jianli Zou Huimin Yuan Zhouguang Lu Zhaorong Chang Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals School of Chemistry and Chemical Engineering Henan Normal University Xinxiang 453007 China National Institute for Materials Science (NIMS) 1-1 Namiki Tsukuba Ibaraki 305-0044 Japan Department of Materials Science & Engineering Southern University of Science and Technology Shenzhen 518055 China

In this artide, highly [010]-oriented self-assembled LiCoPO4/C nanoflakes were prepared through simple and facile solution-phase strategies at low temperature and ambient pressure. The formation of 5-hydroxylmethylfurfural and levoglucosan via the dehydration of glucose during the reaction played a key role in mediating the morphology and structure of the resulting products. LiCoPO4 highly oriented along the （010）-facets exposed Li^＋ ion transport channels, facilitating ultrafast lithium ion transportation. In turn, the unique assembled mesoporous structure and the flake-like morphology of the prepared products benefit lithium ion batteries constructed using two-dimensional （2D） LiCoPO4/C nanoflakes self- assembles as cathodes and commercial Li4Ti5O12 as anodes. The tested batteries provide high capacities of 154.6 mA·h·g^-1 at 0.1 C （based on the LiCoPO4 weight of 1 C = 167 mA·h·g^-1） and stable cycling with 93.1% capacity retention after 100 cycles, which is outstanding compared to other recently developed LiCoPO4 cathodes.

关键词： lithium ion battery lithium cobalt phosphate two-dimensional (2D) nanoflakes (010) oriented assembly solution-phase synthesis

The role of water in methane adsorption and diffusion within nanoporous silica investigated by hyperpolarized 129Xe and 1H PFG NMR spectroscopy

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Nano Research 2018年第1期11卷 360-369页

作者： Yuanli Hu Mingrun Li Guangjin hou Shutao Xu Ke Gong Xianchun Liu Xiuwen Han Xiulian Pan Xinhe bao State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences 457 Zhongshan Road Dalian 116023 China National Engineering Laboratory for Methanol to Olefins Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences 457 Zhongshan Road Dalian 116023 China University of Chinese Academy of Sciences Beijing 100049 China

Understanding the properties and behavior of water molecules in restricted geometries, such as the nanopores of rocks, is of interest for shale gas exploitation. We present herein ex situ and in situ nuclear magnetic resonance （NMR） studies on the effects of water on the adsorption and diffusion of methane in nanopores. Silica materials with one-dimensional pores of ZSM-22, MCM-41, and SBA-15, with pore sizes ranging from 0.5 to 6 nm, were chosen as models. Hyperpolarized （HP） 129Xe NMR results show that water adsorption does not affect the pore sizes of ZSM-22 and MCM-41 but reduces that of SBA-15. The presence of water suppresses methane adsorption; this suppression effect is stronger in smaller pores. The self-diffusion coefficients of methane within ZSM-22 and MCM-41 are not significantly influenced by the presence of water, as measured by ~H pulsed field gradient （PFG） NMR. However, within SBA-15, which has a pore size of 6 nm, the diffusion coefficient of methane increases as the amount of water adsorption increases, peaks, and then decreases to a constant value with further water adsorption. These experiments reveal the effects of the pore size and the presence of water on methane adsorption and diffusion in constrained spaces, which could have important implications for flow simulations of methane in shales.

关键词： water adsorption nanopores diffusion hyperpolarized 129Xe nuclear magnetic resonance

Kinome-wide polypharmacology profiling of small molecules by multi-task graph isomorphism network approach

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Acta Pharmaceutica Sinica B 2023年第1期13卷 54-67页

作者： Lingjie bao Zhe Wang Zhenxing Wu Hao Luo Jiahui Yu Yu Kang Dongsheng Cao Tingjun hou Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China State Key Lab of CAD&CG Zhejiang UniversityHangzhou 310058China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China

Prediction of the interactions between small molecules and their targets play important roles in various applications of drug development,such as lead discovery,drug repurposing and elucidation of potential drug side ***,a variety of machine learning-based models have been developed to predict these *** this study,a model called auxiliary multi-task graph isomorphism network with uncertainty weighting(AMGU)was developed to predict the inhibitory activities of small molecules against 204 different kinases based on the multi-task Graph Isomorphism Network(MT-GIN)with the auxiliary learning and uncertainty weighting *** calculation results illustrate that the AMGU model outperformed the descriptor-based models and state-of-the-art graph neural networks(GNN)models on the internal test ***,it also exhibited much better performance on two external test sets,suggesting that the AMGU model has enhanced generalizability due to its great transfer learning ***,a naÏve model-agnostic interpretable method for GNN called edges masking was devised to explain the underlying predictive mechanisms,and the consistency of the interpretability results for 5typical epidermal growth factor receptor(EGFR)inhibitors with their structure-activity relationships could be ***,a free online web server called KIP was developed to predict the kinomewide polypharmacology effects of small molecules(http://***/kip).

关键词： Kinome-wide polypharmacology Machine learning Kinases Graph neural networks Artificial intelligence