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Synthesis and acaricidal activity of strobilurin-pyrimidine derivatives

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Chinese Chemical Letters 2014年第1期25卷 137-140页

作者： bao-shan chai Chang-Ling Liu Hui-Chao Li Shao-Wu Liu Ying Xu Yu-Quan Song Jun-Biao Chang College of Chemistry and Molecular Engineering Zhengzhou University State Key Laboratory of the Discovery and Development of Novel Pesticide Shenyang Research Institute of Chemical Industry Co.Ltd.

Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by 1H NMR, MS and elemental analysis. Preliminary bioassays demonstrated that compounds 7e and 7i exhibited significant control against Tetranychus cinnabarinus （Boisd.） at 0.625 mg L^-1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse. The relationship between structure and acaricidal activity was also studied.

关键词： Strobilurin-pyrimidine Acaricidal activity Intermediate derivatization method Pyriminostrohin

DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice

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Genes & Diseases 2024年第4期11卷 368-380页

作者： Dafei chai Xu Wang Praveen Neeli shan Zhou Xingfang Yu Kanaga Sabapathy Yong Li Department of Medicine Section of Epidemiology and Population SciencesDan L Duncan Comprehensive Cancer CenterBaylor College of MedicineHoustonTX 77030USA Division of Cellular&Molecular Research Humphrey Oei Institute of Cancer ResearchNational Cancer Centre SingaporeSingapore 168583Singapore

tThe tumor suppressor p53 is the most common mutated gene in cancer,with the R175H as the most frequent p53 missense ***,there are currently no approved targeted therapies or immunotherapies against mutant ***,we characterized and inves-tigated a monoclonal antibody(mAb)that recognizes the mutant p53-R175H for its affinity,specificity,and activity against tumor cells in *** then delivered DNA plasmids expres-sing the anti-R175H mAb or a bispecific antibody(BsAb)into mice to evaluate their therapeutic *** results showed that the anti-R175H mAb specifically bound to the p53-R175H an-tigen with a high affinity and recognized the human mutant p53-R175H antigen expressed on HEK293T or MC38 cells,with no cross-reactivity with wild-type *** cultured cells,the anti-R175H mAb showed higher cytotoxicity than the control but did not induce antibody-dependent cellular *** made a recombinant MC38 mouse cell line(MC38-p53-R175H)that overexpressed the human p53-R175H after knocking out the endogenous mutant p53 *** vivo,administration of the anti-R175H mAb plasmid elicited a robust anti-tumor effect against MC38-p53-R175H in *** administration of the anti-R175H BsAb plasmid showed no therapeutic effects,yet potent anti-tumor activity was observed in combination with the anti-PD-1 *** results indicate that targeting specific mutant epitopes using DNA-delivered mAbs or BsAbs presents a form of improved natural immunity derived from tumor-infiltrating B cells and plasma cells against intracellular tumor antigens.

关键词： BsAb Cytotoxicity mAb Mutant p53 PD-1 R175H

A causal convolutional neural network for multi-subject motion modeling and generation

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Computational Visual Media 2024年第1期10卷 45-59页

作者： Shuaiying Hou Congyi Wang Wenlin Zhuang Yu Chen Yangang Wang Hujun bao Jinxiang chai Weiwei Xu State Key Lab of CAD&CG Zhejiang UniversityHangzhou310058China Xmov Shanghai200030China School of Automation Southeast UniversityNanjing210096China

Inspired by the success of WaveNet in multi-subject speech synthesis,we propose a novel neural network based on causal convolutions for multi-subject motion modeling and *** network can capture the intrinsic characteristics of the motion of different subjects,such as the influence of skeleton scale variation on motion ***,after fine-tuning the network using a small motion dataset for a novel skeleton that is not included in the training dataset,it is able to synthesize high-quality motions with a personalized style for the novel *** experimental results demonstrate that our network can model the intrinsic characteristics of motions well and can be applied to various motion modeling and synthesis tasks.

关键词： deep learning optimization motion generation motion denoising motion control

Robust asymmetric Cherenkov radiation in tilted anisotropic medium

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 46-51页

作者： Shuwen Xue Yadong Xu Linkang Han Zhi Ning Chen Qiaoliang bao shan Zhu Huanyang Chen Institute of Electromagnetics and Acoustics and Department of Physics College of Physical Science and TechnologyJiujiang Research InstituteXiamen UniversityXiamen 361005China School of Physical Science and Technology Institute of Theoretical and Applied PhysicsSoochow UniversitySuzhou 215006China Department of Electrical and Computer Engineering National University of SingaporeSingapore 8117583Singapore Institute of Energy Materials Science(IEMS) University of Shanghai for Science and TechnologyShanghai 200093China

Cherenkov radiation(CR)is available for a wide variety of terahertz(THz)radiation sources,but its efficiency is deeply affected by intrinsic *** find that if the tilted angle(α)of anisotropic material and radiation angle(θ)meet the condition ofθ+α=π/2,the intensity of radiation fields for the charged particle bunch(CPB)moving from left to right cannot be influenced by intrinsic losses,which means long-distance radiation can be ***,we observe an asymmetric CR when the CPB moves from the opposite *** addition,we select natural van der Waals(vd W)materialα-MoO3as an example,further confirming that the radiation field can reach the far field and the asymmetric CR radiation can also be *** wonderful properties with long-distance radiation will extend the application of CR to a certain extent for future design and fabrication.

关键词： asymmetric Cherenkov radiation intrinsic losses long-distance radiation

Acetylene/argon mixture plasma to build ultrathin carbon bridge of CF_(x)/C/MnO_(2) for high-rate lithium primary battery

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Rare Metals 2024年第6期43卷 2574-2584页

作者： Da-Wei Zou Xing-Guang Fu Gao-Bang Chen Yi-Fan Liu bao-shan Wu Xian Jian School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 31300lChina

Forming an ultrathin conducting layer on a fluorinated carbon(CFx)surface for reducing severe electrochemical polarization in lithium/fluorinated carbon primary batteries(Li/CF_(x))remains a considerable challenge for achieving batteries with excellent rate ***,CFxwas modified by using acetylene/argon mixture plasma combined with MnO_(2)*** CF_(x)/C/MnO_(2)composite effectively reduced the voltage hysteresis and improved the electrochemical performance of Li/CF_(x).The excellent rate performance of CF_(x)/C/MnO_(2)was due to the high electrochemical activity provided by the atomicscale conductive carbon layer and ultrafine MnO_(2)*** with pristine CF_(x),the charge transfer resistance of the optimized CF_(x)/C/MnO_(2)decreased from 218.5 to 48.2Ω,the discharge rate increased from 2C to 10C,and the power density increased from 3.11 to 13.44 kW·g^(-1),The intrinsic reason for the enhanced rate performance was attributed to the fact that the ultrathin carbon layer acted as a conductive bridge to reduce the voltage hysteresis at the initial stage of the Li/CF_(x)discharge,and the high electrochemical activity of the ultrafine MnO_(2)particles provided a faster lithium-ion diffusion rate.

关键词： C_(2)H_(2)/Ar plasma Fluorinated carbon Lithium primary battery MnO_(2)

Locomotion control of a rigid-soft coupled snake robot in multiple environments

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Biomimetic Intelligence & Robotics 2024年第2期4卷 12-23页

作者： Xuanyi Zhou Yuqiu Zhang Zhiwei Qiu Zhecheng shan Shibo Cai Guanjun bao College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China State Key Laboratory of Chemical Engineering College of Chemicaland Bioogical EngineringZhejiang UniverstyHangzhou 310027China College of Biomedical Science and Engineering South China University of TechnologyGuangzhou 510000China

The versatile motion capability of snake robots offers themselves robust adaptability in varieties of challenging environments where traditional robots may be *** study reports a novel flexible snake robot featuring a rigid-flexible coupling structure and multiple motion *** better understand the robot's behavior,a bending model for the soft actuator is ***,a dynamic model is developed to map the relationship between the input air pressure and joint torque,which is the model base for controlling the robot *** on the wave motion generated by the joint coupling direction function in different planes,multiple motion gait planning methods of the snake-like robot are *** order to evaluate the adaptability and maneuverability of the developed snake robot,extensive experiments were conducted in complex *** results demonstrate the robot's effectiveness in navigating through intricate settings,underscoring its potential for applications in various fields.

关键词： Snake robot Rigid-flexible coupled Soft actuator Motion gait analysis

Supramolecular assembly nanoparticle for trans-epithelial treatment of keratoconus

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Chinese Chemical Letters 2024年第10期35卷 1-3页

作者： Wenlong Li Feishi shan Qingdong bao Qinghua Li Hua Gao Leyong Wang State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyEye Institute of Shandong First Medical UniversityQingdao266071China Eye Hospital of Shandong First Medical UniversityJi'nan 250021China College of Ophthalmology Shandong First Medical UniversityJi'nan 250000China Key Laboratory of Mesoscopic Chemistry of MOE Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyEye Institute of Shandong First Medical UniversityQingdao 266071Chin Eye Hospital of shandong First Medical University Ji'nan 250021China

Keratoconus is a clinically prevalent corneal ectasia,characterized by progressive thinning and conical protrusion of the central cornea[1].With an incidence rate of one in every 400 to 2000 individuals,it stands as a leading cause of blindness among the *** date,there are no pharmacological interventions available for the treatment of *** advanced cases culminating in blindness,corneal transplantation remains the only restorative ***,this surgical procedure carries risks of immune rejection and chronic graft failure.

关键词： corneal treatment graft

Experience of humanistic nursing in hemodialysis nursing for patients with diabetic kidney disease

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World Journal of Diabetes 2024年第2期15卷 186-195页

作者： Xiao-Ying chai Xiao-Yan bao Ying Dai Xing-Xing Dai Yu Zhang Yu-Ling Yang Department of Nephrology The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina Department of Hemodialysis The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina Department of Endocrinology The Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is a prevalent complication of diabetes that often requires hemodialysis for *** the field of nursing,there is a growing recognition of the importance of humanistic care,which focuses on the holistic needs of patients,including their emotional,psychological,and social ***,the application of humanistic nursing in the context of hemodialysis for DKD patients remains relatively *** To explore the experience of humanistic nursing in hemodialysis nursing for DKD *** Ninety-six DKD patients treated with hemodialysis from March 2020 to June 2022 were included in the study and divided into the control cluster(48 cases)and the study cluster(48 cases)according to different nursing methods;the control cluster was given routine nursing and the study cluster was given humanized *** variances of negative emotion mark,blood glucose,renal function,the incidence of complications,life mark and nursing satisfaction before and after nur-sing were contrasted between the two *** No significant difference in negative emotion markers between the two clusters were observed before nursing(P>0.05),and the negative emotion markers of the two clusters decreased after *** Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale markers were lower in the study cluster than the control *** healing rate of patients in the study cluster was significantly higher than the control cluster(97.92%vs 85.42%,P0.05).However,after nursing,blood urea nitrogen and serum creatinine(SCr)levels in the study cluster were lower than those in the control cluster(P<0.05).The incidence rate of complications was significantly lower in the study group compared to the control cluster(6.25%vs 20.83%,P<0.05).There was no significant difference in the life markers between the two clusters be

关键词： Diabetic kidney disease Hemodialysis Humanistic nursing Incidence of complication Effect

Polygonatum Sibiricum Saponin-Lactic acid bacteria combination attenuate hyperglycemia in T2DM mice by modulating amino acid metabolism

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Food Science and Human Wellness 2024年

作者： Jiayuan Luo Mingjie Jia Shuang Liang Yangyang chai Yihong bao Shilong Jiang Key Laboratory of Forest Food Resources Utilization of Heilongjiang Province Colleage of Life Science， Northeast Forestry University Heilongjiang Feihe Dairy Industry

Some researches have shown that the combination of plant extracts and probiotics may be a better way to treat type 2 diabetes mellitus (T2DM) than a single intervention. However， there are still relatively few relevant reports in this aspect. Therefore， this study aims to investigate whether the treatment of polygonatum sibiricum saponin (PSS) and lactic acid bacteria (LAB) combination can better manage T2DM. And the anti-diabetes mechanism of the combination was studied from the perspectives of glucose metabolism， microbiome and metabolome. The results showed that PSS+LAB could better improve FBG level， insulin sensitivity， lipid metabolism disorder， and liver function. Protein analysis showed that PSS+LAB treatment significantly increased the expression of p-PI3K/PI3K， p-AKT/AKT， GLUT2， IRS2， and GSK-3β in the liver of T2DM mice， while inhibiting the expression of FOXO1. This combination positively regulated the composition and abundance of the gut microbiota. Metabolomic analysis showed that the combination treatment exhibited more changes in gut microbiota metabolites compared to PSS treatment alone. The alteration of gut microbiota by LAB+PSS led to significant changes in alanine， aspartate and glucose metabolism pathways. This study may provide a theoretical basis for the combined application of plant extracts and probiotics for the management of T2DM.

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