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Nuclear Science and Techniques 2024年第10期35卷 29-40页

作者： Yuan-Yuan Xue Zu-Jun Wang Wu-Ying Ma Min-Bo Liu bao-ping he Shi-Long Gou State Key Laboratory of Intense Pulsed Irradiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi’an 710024China State Key Laboratory of Artificial Microstructure and Microscopic Physics School of Physics Peking UniversityBeijing 100871China

This study investigates the effects of displacement damage on the dark signal of a pinned photodiode CMOS image sensor(CIS)following irradiation with back-streaming white neutrons from white neutron sources at the China spallation neutron source(CSNS)and Xi'an pulsed reactor(XAPR).The mean dark signal,dark signal non-uniformity(DSNU),dark signal distribution,and hot pixels of the CIS were compared between the CSNS back-n and XAPR neutron *** nonionizing energy loss and energy distribution of primary knock-on atoms in silicon,induced by neutrons,were calculated using the open-source package *** analysis combining experimental and simulation results showed a noticeable proportionality between the increase in the mean dark signal and the displacement damage dose(DDD).Additionally,neutron energies influence DSNU,dark signal distribution,and hot *** neutron energies at the same DDD level may lead to pronounced dark signal non-uniformity and elevated hot pixel values.

关键词： Displacement damage effects CMOS image sensor(CIS) CSNS back-n XAPR neutrons Geant4 Dark signal non-uniformity(DSNU)

Control of gallbladder contractions by cholecystokinin through cholecystokinin-A receptors on gallbladder interstitial cells of cajal

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World Journal of Gastroenterology 2008年第18期14卷 2882-2887页

作者： Dan Xu bao-ping Yu he-Sheng Luo Ling-Dan Chen Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan 430060 Hubei Province China

AIM: To identify the cholecystokinin (CCK)-A receptors (CCK-AR) on the guniea pig gallbladder interstitial cells of cajal (ICC) and to study CCK-8 induced gallbladder muscle strip contractions through the CCK-AR. METHODS: The existence of CCK-AR was examined by immunohistofluorescence on sectioned tissue and cultured cells. In vitro contractile response of guinea pig gallbladder muscle strips and the strips with ICC removed were also studied with CCK-8 receptors added. RESULTS: In tissue sections, intensely CCKAR- immunoreactive interstitial cells were found mainly in the muscular layers. In cultured cell sections, distinctive double staining of C-kit and CCK-AR ICCs were found. When we removed the ICC of the gallbladder, CCK-8 induced muscle strip contraction dose response curve significantly shifted to the right. CONCLUSION: We proved that both the existence of CCK-AR on the guinea pig gallbladder ICC and CCK evoked contraction are mediated through direct action on CCK-AR on the gallbladder ICC.

关键词： Gallbladder Interstitial cells of cajal Cholecystokinin-A receptor C-kit Immunohistofluorescence

CD58 expression of liver tissue in patients with chronic hepatitis B virus infection

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Chinese Medical Journal 2008年第6期121卷 557-560页

作者： WANG ping QI bao-tai CheN ping he Lin-jing LI Jie JI Yu-qiang XIE Ming Department of Pathogenic Microbiology and Immunology Medical School of Xi'an Jiaotong University Xi'an Shaanxi710061 China

Background Several kinds of intercellular adhesion molecules closely relate to hepatitis B. The complex of CD2 and CD58 plays an important role in enhancing the adhesion of T lymphocytes to target cells, hyperplasia and activation of T lymphocytes. In this study, we explored the relationship between the expression of CD58 in liver tissue and chronic hepatitus B infection. Methods We determined the expression of the CD58 molecule on the surface of hepatoc^es by using immunohistochemistry and the levels of serum HBV DNA from patients with HBV infection and from normal controls. The biochemical parameters of hepatic function were analyzed as well. Results CD58 expression in hepatocytes significantly increased with the severity progression of chronic HBV infection. The IOD levels （log10） of CD58 in the control, mild, moderate, and severe chronic HBV infection groups were 0, （7.20±4.64）×10^3, （25.63±7.41）×10^3 and （37.47±11.17）×10^3 respectively （P〈O.05 compared with the control group, respectively） Conclusion CD58 probably increases cell mediated immunity to eliminate hepatitis B virus and leads to damage of hepatocytes.

关键词： hepatitis B, chronic CD58 immunohistochemistry

Analyzing the transient effects of 60Co gamma rays in a CIS by Monte Carlo method

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Nuclear Science and Techniques 2019年第7期30卷 100-106页

作者： Yuan-Yuan Xue Zu-Jun Wang Min-Bo Liu Rui Xu Hao Ning Wen Zhao bao-ping he Zhi-Bin Yao Jiang-Kun Sheng Wu-Ying Ma Guan-Tao Dong The State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear Technology Xi’an 710613 China School of Materials Science and Engineering Xiangtan University Xiangtan 411105 China

The objective of this work is to analyze the transient effects of ^60Co gamma rays in the CMOS image sensor (CIS) using the Monte Carlo method, based on Geant4. The track, energy spectrum, and angle of produced electrons when gamma rays traversed a silicon or silicon dioxide cube were calculated. A simplified model of a 500 × 500 CIS array was established, and the transient effects of gamma rays in the CIS were simulated. The raw images were captured when the CIS was irradiated by gamma rays. The experimental results were compared with the simulation results. The characteristics of the typical events induced by transient effects were analyzed.

关键词： ^60Co gamma rays Transient effects CMOS image sensor (CIS) Geant4

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民族古籍的特点及其开发利用研究

中南民族大学学报（人文社会科学版） 2009年第5期29卷 80-83页

作者：包和平大连民族学院图书馆辽宁大连116600

根据民族古籍历史和现状,探讨了民族古籍的特点,并结合民族古籍管理部门的实际,提出开发利用民族古籍的方法和途径。

关键词：民族古籍特点开发利用

Detection of type Ⅳ collagenase activity in malignant ascites

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World Journal of Gastroenterology 2003年第11期9卷 2592-2595页

作者： Xiao-Min Sun Wei-Guo Dong bao-ping Yu he-Sheng Luo Jie-ping Yu, Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China Department of Gastroenterology Renmin Hospital Wuhan University Wuhan 430060 Hubei Province China

AIM: Type IV collagenase participates in invasion and metastasis of cancer cells. Malignant asdtes is a manifestation of advanced malignant disease that is associated with invasion and metastasis of the peritoneal cavity. Thus, it is reasonable to hypothesize that type IV collagenase is linked to malignant ascites. The purpose of our study was to detect type IV collagenase activity in malignant ascites so as to provide the scientific basis for clinic diagnosis and treatment of malignant ascites. METHODS: Cirrhotic ascites (n=36), tuberculous ascites (n=8) and malignant ascites (n=-23) from patients with gastric cancer (n=6), colon cancer (n=5), ovarian cancer (n=8) and other cancers (n=4), including 2 hepatocellular cancers, 1 pancreatic cancer, 1 primary peritoneal carcinoma were collected by paracentesis. The ascites were made cellfree by centrifugation and stored frozen at -70℃ before determination. Type IV collagenase activity was determined by gelatin zymography. RESULTS: The activity of matrix metalloproteinases-2 and -9 could not be detected in ascites of hepatic cirrhosis and tuberculous peritonitis but could be detected in 20 and 18 out of 23 malignant ascites respectively. The positive rate of type IV collagenase (MMP-2, 87.0% and MMP-9, 78.3%) was higher than that by routine ascites tests (Phermore, the activity of MMP-2 was higher than that of MMP-9 (P=0.022<0.05). CONCLUSION: Type IV collagenase is positive in malignant ascites. Detection of type IV collagenase activity is useful in qualitative diagnosis of ascites. Type IV collagenase may play an important role in malignant ascites formation.

关键词：恶性腹水 IV型胶原酶肿瘤转移恶性肿瘤发病机制

Positive effect of Mo on mechanical properties of a Ni-42W-10Co-xMo medium heavy alloy

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China Foundry 2025年第1期22卷 108-116页

作者： Guo-xin Cao Jian-xin Dong Yong-sheng he he Jiang Fang Hao Zhi-hua Nie Teng-fei Ma bao-quan Fu School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Xi'an Superalloy Technology Co. Ltd.Xi’an 710299China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina

In this study,a novel Ni-W-Co-Mo medium heavy alloy(MHA)was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-x Mo alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypo-eutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0 to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-x Mo alloys is Mo-induced solid solution strengthening and precipitation strengthening.

关键词： medium-heavy alloys Ni-based alloy mechanical properties solid solution strengthening precipitation strengthening

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解读默顿科学规范

内蒙古大学学报（哲学社会科学版） 2008年第1期40卷 110-114页

作者：包和平韩晖内蒙古师范大学法政学院内蒙古呼和浩特010022 中国人民大学哲学院北京100872

20世纪40年代初默顿科学规范提出以后,曾被广泛接受,成为当时社会组织科学活动的理论依据。然而,随着科学自身的发展,科学哲学中相对主义思潮的兴起,人们对科学知识的内容进行更加深入的反思,默顿科学规范受到质疑和挑战。通过重新解读... 详细信息

20世纪40年代初默顿科学规范提出以后,曾被广泛接受,成为当时社会组织科学活动的理论依据。然而,随着科学自身的发展,科学哲学中相对主义思潮的兴起,人们对科学知识的内容进行更加深入的反思,默顿科学规范受到质疑和挑战。通过重新解读文本可以得出,默顿提出科学规范的根本目标就在于从科学制度的层面上确立科学的自主性,实现科学的稳定和发展。默顿科学规范所遇困境的根源是它的认识论基础——逻辑实证主义被解构。

关键词：默顿科学规范科学的自主性科学制度逻辑实证主义相对主义

现代少数民族语言辞书编纂出版特点及其存在的问题

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图书馆理论与实践 2010年第11期 97-100页

作者：包爱梅包和平内蒙古大学图书馆呼和浩特010021 大连民族学院图书馆辽宁大连116600

少数民族语言辞书是我国辞书宝库中的重要组成部分。加强对少数民族语言辞书的研究,总结经验、发现问题、寻求对策,已成为我国当前少数民族语言辞书编纂出版及其理论研究非常迫切而又十分有意义的课题。本文论述了新中国成立以来少数民... 详细信息

少数民族语言辞书是我国辞书宝库中的重要组成部分。加强对少数民族语言辞书的研究,总结经验、发现问题、寻求对策,已成为我国当前少数民族语言辞书编纂出版及其理论研究非常迫切而又十分有意义的课题。本文论述了新中国成立以来少数民族语言辞书的编纂出版特点,并对存在的问题提出了改进意见。

关键词：少数民族语言辞书编纂出版出版特点

Role of VEGF and CD44v6 in differentiating benign from malignant ascites

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World Journal of Gastroenterology 2003年第11期9卷 2596-2600页

作者： Wei-Guo Dong Xiao-Min Sun bao-ping Yu he-Sheng Luo Jie-ping Yu, Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei Province, China Department of Gastroenterology Renmin Hospital Wuhan University Wuhan 430060 Hubei Province China. dongwg@***

AIM: To detect the vascular endothelial growth factor (VEGF)and soluble splice variant 6 of CD44 (sCD44v6) levels in ascites and to explore their role in differentiating benign from malignant ***: Cirrhotic ascites (n=36), tuberculosis ascites (n=8) and malignant ascites (n=23) were collected and studied. Concentrations of soluble VEGF and sCD44v6 in various kinds of ascites (n=67) were measured using a sandwich enzyme-linked immunoadsorbent ***: VEGF and sCD44v6 levels in malignant ascites were 640.74±264.81 pg/ml and 89.22±38.20 ng/ml,respectively, both of which were significantly higher than those in cirrhotic ascites and tuberculous ascites (q=18.98,11.89 and q=8.92, 5.09; Phe levels of VEGF and sCD44v6 in cirrhotic and tuberculous ascites had no significant difference (q=0.48, 0.75; P>0.05).Furthermore, VEGF levels in malignant ascites in patients with ovarian cancer were higher than those with gastric and colon cancer (q=5.03, 6.79; P0.05). Whereas, sCD44v6 levels in malignant ascites from patients with ovadan, gastric and colon cancer had no significant difference (q=0.06, 0.91,0.35;P>0.05, respectirely). In comparison with cirrhotic and tuberculous ascites, when the upper limit of its VEGF mean levels 119.44 pg/ml (70.90±48.54) and sCD44v6 mean levels 63.59 ng/ml (44.42±19.17) was taken as the minimum cutoff limit, the sensitivity and specificity of VEGF and sCD44v6 of this assay to the diagnos is of malignant ascites were 91.3 %, 90.9 % and 73.9 %, 88.7 % ***: Elevated levels of VEGF and sCD44v6 may be useful in differential diagnosis of benign and malignant ascites.

关键词：恶性腹水 VEGF CD44v6 晚期肿瘤肿瘤转移发病机制