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Intratumoural microorganism can affect the progression of hepatocellular carcinoma

World Journal of Gastrointestinal Oncology 2024年第10期16卷 4232-4243页

作者： bao-Qun Liu Yi Bai Da-Peng Chen Ya-min Zhang Tian-Ze Wang Jing-Rui Chen Xiang-Yu Liu Bin Zheng Zi-Lin Cui First Central Clinical College Tianjin Medical UniversityTianjin 300070China Department of Hepatobiliary Surgery Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China Tianjin First Central Hospital Clinic Institute School of MedicineNankai UniversityTianjin 300192China School of Medicine Tianjin UniversityTianjin 300072China

BACKGROUND Several recent studies have confirmed that intratumoural microorganisms can affect the occurrence and development of hepatocellular carcinoma(HCC);however,their role in tumor progression remains ***,there is a need for further research on the role of intratumoural microorganisms in *** To investigate the changes in intratumoural microorganisms in HCC and the effect of Propionibacterium on HCC *** HCC and normal liver tissue specimens were subjected to fluorescence in situ hybridization(FISH).After performing 16S rRNA sequencing on HCC and peritumoral tissues to analyze the differences between the two *** was cocultured with HCC cells in *** in cell proliferation and migration capacity were *** expression of NF-κB pathway related proteins in tumor cells was *** orthotopic liver implantation model and the subcutaneous xenograft model were *** tissues and subcutaneous tumors were collected 2 weeks *** FISH demonstrated the presence of microorganisms in HCC and normal liver tissues.16S rRNA sequencing revealed an abundance of Lysobacter,Lachnospiraceae,Pseudomonas,and Lactobacillus in HCC *** distribution and abundance of Propionibacterium showed differences between HCC and peritumoral tissues(P<0.05).In vitro studies demonstrated that Propionibacterium and its metabolite propionic acid(PA)inhibited the proliferation and migration of HCC cells(P<0.05).The expression of the proteins in NF-κB signaling pathway also decreased in HCC cells(P<0.05).CONCLUSION Microorganisms in HCC and normal liver tissues displayed significant *** PA-producing bacterium Propionibacterium in HCC exerts an effect on the NF-κB pathway,thereby affecting the biological behavior of HCC.

关键词： Hepatocellular carcinoma Intratumoural microbiome 16S rRNA sequencing Propionibacterium

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Humanβ-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long noncoding RNA TCONS_00014506

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1465-1478页

作者： Yu-Xin Zhao Yan Cui Xin-Hong Li Wen-Hong Yang Shi-Xiang An Jia-Xian Cui min-Yu Zhang Jing-Kun Lu Xuan Zhang Xiu-Mei Wang Li-Li bao Peng-Wei Zhao Department of Anesthesiology Inner Mongolia Chest HospitalThe Fourth HospitalHohhot 010035Inner Mongolia Autonomous RegionChina College of Humanities and Education Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina Department of Radiotherapy The Affiliated Hospital of Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina School of Basic Medical Science Inner Mongolia Medical UniversityHohhot 010059Inner Mongolia Autonomous RegionChina Department of Medical Oncology The Affiliated Cancer Hospital of Inner Mongolia Medical UniversityHohhot 010050Inner Mongolia Autonomous RegionChina

BACKGROUND Colorectal cancer has a low 5-year survival rate and high ***β-defensin-1(hBD-1)may play an integral function in the innate immune system,contributing to the recognition and destruction of cancer *** non-coding RNAs(lncRNAs)are involved in the process of cell differentiation and *** To investigate the effect of hBD-1 on the mammalian target of rapamycin(mTOR)pathway and autophagy in human colon cancer SW620 *** CCK8 assay was utilized for the detection of cell proliferation and determination of the optimal drug *** formation assay was employed to assess the effect of hBD-1 on SW620 cell *** was used to screen potentially biologically significant lncRNAs related to the mTOR ***,p-mTOR(Ser2448),Beclin1,and LC3II/I expression levels in SW620 cells were assessed through Western blot *** hBD-1 inhibited the proliferative ability of SW620 cells,as evidenced by the reduction in the colony formation capacity of SW620 cells upon exposure to ***-1 decreased the expression of p-mTOR(Ser2448)protein and increased the expression of Beclin1 and LC3II/I ***,bioinformatics analysis identified seven lncRNAs(2 upregulated and 5 downregulated)related to the mTOR *** lncRNA TCONS_00014506 was ultimately *** the inhibition of the lncRNA TCONS_00014506,exposure to hBD-1 inhibited p-mTOR(Ser2448)and promoted Beclin1 and LC3II/I protein *** hBD-1 inhibits the mTOR pathway and promotes autophagy by upregulating the expression of the lncRNA TCONS_00014506 in SW620 cells.

关键词： Colon cancer Humanβ-defensin-1 LncRNA Mammalian target of rapamycin Autophagy

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2024年

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-min Zhang Ai-Jun Ma bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi UniversityJiangmen

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Chinese herbal medicine Ginkgo biloba *** for ischemic stroke:An overview of systematic reviews and meta-analyses

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Journal of Integrative Medicine 2024年第2期22卷 163-179页

作者： Tian-tian Meng Ya-ping You min Li Jian-bo guo Xin-bin Song Jing-yi Ding Xiao-long Xie An-qi Li Shang-jin Li Xiang-jun Yin Peng Wang Zhe Wang bao-liang Wang Qing-yong He Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100032China Department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing 100071China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chinese Medicine the University of Hong KongHong KongChina Graduate School Henan University of Chinese MedicineZhengzhou 450008Henan ProvinceChina Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesZhengzhou 450008Henan ProvinceChina School of Integrated Traditional Chinese and Western Medicine Southwest Medical UniversityHangzhou 310053Zhejiang ProvinceChina School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhu 310053Zhejang ProvinceChina Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450003Henan ProvinceChina

Background:Ginkgo biloba ***(GBLPs)are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke(IS).Recently,several systematic reviews(SRs)and meta-analyses(MAs)of GBLPs for IS have been ***:This overview aims to assess the quality of related SRs and *** strategy:Pub Med,Embase,Cochrane Library,Web of Science,Chinese Biological Medicine,China National Knowledge Infrastructure,Wanfang,and Chinese Science and Technology Journals databases were searched from their inception to December 31,*** criteria:SRs and MAs of randomized controlled trials(RCTs)that explored the efficacy of GBLPs for patients with IS were *** extraction and analysis:Two independent reviewers extracted data and assessed the methodological quality,risk of bias(ROB),reporting quality,and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),***,descriptive analysis and data synthesis were ***:Twenty-nine SRs/MAs involving 119 outcomes were included in this *** overall methodological quality of all SRs/MAs was critically low based on AMSTAR 2,and 28 had a high ROB based on the *** to the PRISMA statement,the reporting items of the included SRs/MAs are relatively *** results based on GRADE showed that of the 119 outcomes,8 were rated as moderate quality,24 as low quality,and 87 as very low *** on the data synthesis,GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function ***:GBLPs can be considered a beneficial supplemental therapy for ***,because of the low quality of the existing eviden

关键词： statement synthesis alone

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安徽巢湖早三叠世短腿巢湖龙的牙齿替换研究

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北京大学学报（自然科学版） 2024年第2期60卷 239-248页

作者：顾书纶江大勇周敏造山带与地壳演化教育部重点实验室北京大学地球与空间科学学院北京100871

对产自安徽省巢湖市马家山剖面下三叠统奥伦尼克阶斯帕斯亚阶南陵湖组上段的短腿巢湖龙标本(GMPKU-P-3086)进行研究,根据CT扫描数据重建牙齿及前颌骨、上颌骨和齿骨的三维模型。通过对模型进行观察和度量,并与实际标本进行对比,发现以... 详细信息

对产自安徽省巢湖市马家山剖面下三叠统奥伦尼克阶斯帕斯亚阶南陵湖组上段的短腿巢湖龙标本(GMPKU-P-3086)进行研究,根据CT扫描数据重建牙齿及前颌骨、上颌骨和齿骨的三维模型。通过对模型进行观察和度量,并与实际标本进行对比,发现以下短腿巢湖龙牙齿新的特征:1)颌骨上存在连续的牙槽沟,且内具浅的牙槽窝,牙齿为亚槽生齿;2)牙齿的大小和形状呈周期性变化,显示奇偶相间的交替模式;3)口腔前部发育单牙列,替换齿位于功能齿的远中位置;4)口腔后部发育双牙列,替换齿列位于功能齿的舌侧-远中位置。短腿巢湖龙的牙齿特征与早三叠世基干鱼龙类短尾鱼龙和歌津鱼龙具有一致性,可能代表鱼龙类牙齿的原始特征,并反映捕压式食性群团地理分布的广泛性。

关键词：短腿巢湖龙早三叠世牙齿替换 CT扫描

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Glutamine transporters as effective targets in digestive system malignant tumor treatment

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Oncology Research 2024年第10期32卷 1661-1671页

作者： FEI CHU KAI TONG XIANG gu MEI bao YANFEN CHEN BIN WANG YANHUA SHAO LING WEI School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou510006China Department of Pharmacy Tianjin Medical University General HospitalTianjin300070China

Glutamine is one of the most abundant non-essential amino acids in human plasma and plays a crucial role in many biological processes of the human *** cells take up a large amount of glutamine to meet their rapid proliferation requirements,which is supported by the upregulation of glutamine *** inhibition of glutamine transporters effectively inhibits cell growth and proliferation in *** all cancers,digestive system malignant tumors(DSMTs)have the highest incidence and mortality rates,and the current therapeutic strategies for DSMTs are mainly surgical resection and *** to the relatively low survival rate and severe side effects associated with DSMTs treatment,new treatment strategies are urgently *** article summarizes the glutamine transporters involved in DSMTs and describes their role in ***,glutamine transportertarget drugs are discussed,providing theoretical guidance for the further development of drugs DSMTs treatment.

关键词： Glutamine transporter Targeted therapy Inhibitors Cancer

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Mechanism analysis of regulating Turing instability and Hopf bifurcation of malware propagation in mobile wireless sensor networks

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Chinese Physics B 2024年第6期33卷 125-140页

作者：黄习习肖敏 Leszek Rutkowski 包海波黄霞曹进德 College of Automation&College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China Systems Research Institute of the Polish Academy of Sciences 01-447 WarsawPoland College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China School of Mathematics Southeast UniversityNanjing 210096China

A dynamical model is constructed to depict the spatial-temporal evolution of malware in mobile wireless sensor networks(MWSNs). Based on such a model, we design a hybrid control scheme combining parameter perturbation and state feedback to effectively manipulate the spatiotemporal dynamics of malware propagation. The hybrid control can not only suppress the Turing instability caused by diffusion factor but can also adjust the occurrence of Hopf bifurcation induced by time delay. Numerical simulation results show that the hybrid control strategy can efficiently manipulate the transmission dynamics to achieve our expected desired properties, thus reducing the harm of malware propagation to MWSNs.

关键词： mobile wireless sensor networks reaction-diffusion Hopf bifurcation hybrid control

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压电微电机之综述

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微特电机 1998年第5期26卷 40-43页

作者：包定华闻敏顾豪爽邝安祥湖北大学压电陶瓷技术研究所

利用压电薄膜的低温沉积工艺与微机械加工技术结合可以制作出压电微电机。这种压电微电机在医用微型器械，自聚焦系统，精密微定位、微型机器人等领域有着重要应用。本文介绍了几种压电微电机的制作过程、结构、工作原理及有关结果，并... 详细信息

利用压电薄膜的低温沉积工艺与微机械加工技术结合可以制作出压电微电机。这种压电微电机在医用微型器械，自聚焦系统，精密微定位、微型机器人等领域有着重要应用。本文介绍了几种压电微电机的制作过程、结构、工作原理及有关结果，并指出了目前存在的问题和下一步研究发展的方向。

关键词：压电薄膜压电微电机压电材料微电机电机

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选区激光熔融制备FeCoCrNiMn-(N,Si)高熵合金在冷轧变形及500℃长时间退火后的析出行为

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中南大学学报（自然科学版） 2024年第8期55卷 3014-3021页

作者：张忠伦顾及宋旼中南大学粉末冶金国家重点实验室湖南长沙410083 中国建材集团科技创新研究院山东枣庄277100

对选区激光熔融制备的FeCoCrNiMn-(N,Si)高熵合金先进行冷轧变形,然后在500℃进行长时间退火处理,研究长时间退火对其相稳定性及微观组织演变的影响。研究结果表明,在退火温度为500℃,退火时间为10~40 d时,合金基体内形成了3种类型的沉... 详细信息

对选区激光熔融制备的FeCoCrNiMn-(N,Si)高熵合金先进行冷轧变形,然后在500℃进行长时间退火处理,研究长时间退火对其相稳定性及微观组织演变的影响。研究结果表明,在退火温度为500℃,退火时间为10~40 d时,合金基体内形成了3种类型的沉淀析出物(Cr_(2)N相、BCC-Cr相和L1_(0)-NiMn相),且氮原子的添加抑制了富FeCo相的形成;当退火时间从10 d增加到20 d时,沉淀物的尺寸显著增加。然而,当退火时间进一步增加到40 d时,沉淀物颗粒不长大,其尺寸保持不变。

关键词：高熵合金氮掺杂析出相选区激光熔融冷轧退火处理

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运动界面的电磁波相位匹配

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物理学报 2024年第13期73卷 121-125页

作者：袁金健顾民黄润生南京大学物理学院南京210093

电磁波在运动物体表面的折射反射和内部的传播研究中,运动界面的电磁场相位匹配作为一个重要问题,只有用Galileo变换的讨论,但运动边界对电磁波传播的相对论效应是不应被忽略的.本文从空间曲面方程的定义和相对性原理出发导出了运动曲... 详细信息

电磁波在运动物体表面的折射反射和内部的传播研究中,运动界面的电磁场相位匹配作为一个重要问题,只有用Galileo变换的讨论,但运动边界对电磁波传播的相对论效应是不应被忽略的.本文从空间曲面方程的定义和相对性原理出发导出了运动曲面单位法向量的变换式,基于该变换式导出了运动边界的电磁场边界条件.同时基于单位法向量的变换式导出考虑相对论效应时电磁波在运动边界的相位匹配.虽然该工作不涉及量子效应的影响,但可以为电磁波通讯和电磁遥感遥测的理论分析提供一些参考.

关键词：电磁波运动界面相位匹配相对性原理

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