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Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： Xian-Rong Wu Xiao-Hong He Yong-Fang xie School of Life Health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

A CFD model for gas uniform distribution in turbulent flow for the production of titanium pigment in chloride process

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Chinese Journal of Chemical Engineering 2016年第6期24卷 749-756页

作者： Yadong Li Gang xie Ting Lei Chongjun bao lin Tian Yanqing Hou State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and Technology Kunming 650093 China Faculty of Metallurgical and Energy Engineering Kunming University of Science and Technology Kunming 650093 China Kunming Metallurgical Research Institute Kunming 650031 China Key Laboratory of Pressure Hydrometallurgy Technology Associated Non-Ferrous Metal Resources Kunming 650031 China Kunming Metallurgy College Kunrning 650-033 China

The fluid dynamic behavior of feeding gas （TiCI4） in an annular channel affects the combination of 02 and TiCI4 in an oxidation reactor, a key piece of equipment in titanium pigment production. The numerical procedure was validated by a 3-dimensional gas flow in the annular channel. Applying the validated model, the flow character- istics of TiCl4 in the oxidation reactor with a tangential inlet were simulated and characterized. The flow distribu- tion with five rectifying rings of different structure was simulated and analyzed. The results showed that the rectifying ring improved the distribution uniformity of the pressure and outlet velocity. Compared to the original case without a rectifying ring, the non-uniformity of the pressure and outlet velocity could be reduced by up to 91% and 69% respectively. The rectifying ring #5, which can be installed and adjusted easily, is more effective in realizing even distribution. In addition, installation of the rectifying ring effectively reduced the circulating flow in an annular channel as well as the total energy loss.

关键词： Oxidation reactorChloride processRectifying ringComputational fluid dynamicsDimensionless pressure

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

Lateral-profile planning:Three-dimensional-profile-based optimal trajectory generation

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Science China(Technological Sciences) 2022年第12期65卷 3057-3068页

作者： ZHANG YuanLong xie Yu bao WeiMin College of Intelligence Science and Technology National University of Defense TechnologyChangsha 410073China Science and Technology Committee of China Aerospace Science and Technology Corporation Beijing 100048China

The conventional re-entry guidance method considerably limits the maneuverability of hypersonic glide vehicles under pre-given angle-of-attack *** address this issue,based on a previous three-dimensional(3D)profile guidance method,we propose a lateral-profile-first 3D profile optimization design strategy to solve the trajectory generation problem under complex conditions involving multiple *** the traditional method,which prioritizes the design of the longitudinal drag acceleration profiles,our method first converted the re-entry flight constraints into a lateral flight corridor,generated the initial lateral profile via parameterization,and solved the 3D profile using the coupling relationship between the longitudinal and lateral *** design of the 3D profile requires simultaneous consideration of waypoints,no-fly zones,and altitude profiles;hence,a new 3D profile optimization design model was constructed,and a customized sequential quadratic programming algorithm was employed to solve *** advantages of the proposed method were demonstrated based on landing footprint results obtained using the lateral profile-first ***,simulation results based on the common aero vehicle-high-performance model verified the feasibility and effectiveness of the strategy.

关键词： hypersonic glide vehicle three-dimensional profile lateral profile-first planning optimal trajectory footprint

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Crystalline porous materials:from zeolites to metal-organic frameworks(MOFs)

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Frontiers of Chemical Science and Engineering 2020年第2期14卷 123-126页

作者： Zaiku xie bao-Lian Su State Key Laboratory of Green Chemical Engineering and Industrial Catalysis Sinopec Shanghai Research Institute of Petrochemical TechnologyShanghai 201208China Laboratory of Inorganic Materials Chemistry(CMI) University of NamurNamurBelgium State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430074China

As a class of important crystalline porous materials,zeolites which were first found in 1756 have now been widely used in chemical industries for catalysis,adsorption and separation.35232 patents with the title including Hzeolite*n are documented by Derwent Innovations Index on January 2,2020[1].Despite of spread applications of zeolites and related-materials in industry,fundamental research of zeolites and their applications are still desired in both academia and industry,as shown in Fig.1.

关键词： porous zeolites zeolite

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan Wei Yaru Qiao Jiming xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

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World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei Zhang Liang Li Hao-Yu Qu Guang-Yu Chen Meng-Zhou xie Yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

Alpha-Chain Structure of ^(12)C

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Chinese Physics Letters 1996年第7期13卷 516-519页

作者： xie Wen-fang bao Cheng-guang Department of Physics Guangdong University of TechnologyGuangzhou 510090 CCAST(World Laboratory)P.O.Box 8730Beijing 100080 Department of Physics Zhongshan UniversityGuangzhou 510275

Alpha-chain states in ^(12)C are studied via an analysis of underlying quantum mechanical *** is pointed out that the linear chain band exists undoubting in ^(12)***,the pure linear chain structure does not exist in ^... 详细信息

关键词： symmetry triangle

Optimized strength and conductivity of multi-scale copper alloy/metallic glass composites tuned by a one-step spark plasma sintering(SPS)process

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Journal of Materials Science & Technology 2022年第33期128卷 22-30页

作者： Weizong bao Jie Chen Guoqiang xie School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

A superiority in interfacial bonding is favorable to fabricate high-strength conductive composites for electrical contact *** the present work,high strength and high conductivity multi-scale metallic glass composites(including micron-scale Cu Zr Al metallic glass reinforcement,hundred-nanometer-scale Cu Cr Zr crystalline grain matrix,and nano-scale precipitated phase)were fabricated by a one-step spark plasma sintering(SPS).The strength and conductivity of the bulk copper matrix metallic glass composites(BCMGCs)were enhanced simultaneously with the increase in the sintering pressure of the *** excellent performance is attributed to the improved interfacial bonding between the metallic glass reinforcement and the copper alloy matrix due to the high pressure assisted by temperature and pulsed *** particular,the precipitation of nanoprecipitates at the interface further reduces the interfacial resistance and improves the mechanical properties of the *** work broadens the horizon for the selection and optimization of reinforcements and manufacturing processes for high-performance electrical contact materials(ECMs).

关键词： CuZrAl metallic glass Spark plasma sintering Mechanical properties Electrical performance