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Melanotic Xp11-associated tumor of the sigmoid colon:A case report

World Journal of Clinical Cases 2019年第5期7卷 684-690页

作者： Gang Wang Gang-Gang Li Sheng-Mao Zhu bao-jia cai Peng-Jie Yu Cheng-Wu Zhang the Graduate School of Qinghai University Department of Gastrointestinal Surgery Affiliated Hospital of Qinghai University

BACKGROUND Melanotic Xp11-associated tumors are rare mesenchymal-derived tumors. So far,most primary melanotic Xp11-associated tumors have been reported in the kidney, and reports of this tumor in the gastrointestinal tract are *** SUMMARY Here we describe the case of a 25-year-old woman who presented with a melanotic Xp11-associated tumor in the sigmoid colon. Colonoscopy revealed a large mucosal bulge in the sigmoid colon, approximately 32 cm inside the *** surface was rough with local erosion. The tumor was brittle on biopsy and bled easily. Computed tomography revealed thickening of the rectal wall with edema. Postoperative pathology indicated the likelihood of a perivascular epithelioid cell tumor. Histologically, the tumor comprised plump epithelioid cells with abundant clear to lightly eosinophilic cytoplasm and round nuclei arranged in an alveolar or trabecular pattern. The tumor cells were strongly positive for HMB-45, Melan-A, Cathepsin K, and TFE3 but negative for vimentin,smooth muscle actin, S100 protein, CD10, CK20, and desmin. The tumor cells had a low Ki-67 labeling index(approximately 2%). Fluorescence in situ hybridization revealed TFE3 fracture. Based on these histologic and immunohistochemical features, a diagnosis of melanotic Xp11-associated tumor of the sigmoid colon was *** In summary, we report the clinicopathological features of a primary tumor that is extremely rare in the sigmoid colon and review the clinicopathological characteristics of melanotic Xp11-associated tumors, compatible with the very rare tumor termed "melanotic Xp11 translocation renal cancer" in all aspects.

关键词： Melanotic Xp11-associated tumor Perivascular epithelioid cell tumor Melan-A Sigmoid colon Case report

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Comparison of efficacy and safety of nab-paclitaxel and oxaliplatin+S-1 and standard S-1 and oxaliplatin chemotherapy regimens for treatment of gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3224-3238页

作者： Yi-Cong Wang Long Feng Gong-Ping Wang Peng-Jie Yu Can Guo bao-jia cai Yan Song Ting Pan Bo-Hao Lin Yuan-Dong Li Jing-Jing Xiao Department of Gastrointestinal Oncology The Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Interventional Medicine Xi’an No.3 HospitalThe Affiliated Hospital of Northwestern UniversityXi’an 710018Shaanxi ProvinceChina Department of RadiologyLuoyang No.6 People's Hospital Luoyang 471000Henan ProvinceChina Department of Gastrointestinal Surgery The Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

BACKGROUND Gastric cancer(GC)is a relatively frequent clinical phenomenon,referring to ma-lignant tumors emerging in the gastric mucosal epithelial *** has a high mor-bidity and mortality rate,posing a significant threat to the health of ***,how to diagnose and treat GC has become a heated topic in this research *** To discuss the effectiveness and safety of nab-paclitaxel in combination with oxaliplatin and S-1(P-SOX)for the treatment of GC,and to analyze the factors that may influence its *** A total of 219 eligible patients with advanced GC,who were treated at Qinghai University Affiliated Hospital Gastrointestinal Oncology between January 2018 and March 2020,were included in the *** them,149 patients received SOX regimen and 70 patients received S-1 *** patients underwent both preoperative and postoperative chemotherapy consisting of 2-4 cycles each,totaling 6-8 cycles,along with parallel D2 radical surgical *** patients were followed up for a period of three years or until reaching the event *** The short-term and long-term efficacy of the P-SOX group was significantly higher than that of the SOX group,and the safety was *** multivariate analysis revealed that progression-free survival was associated with perioperative chemotherapy efficacy,tumor diameter≤2cm,high differentiation,and early cTNM(T stands for invasion depth;N stands for node metastasis;M stands for distant invasion)*** In comparison to the SOX regimen,the P-SOX regimen demonstrates improved short-term and long-term efficacy with tolerable adverse *** is anticipated that the P-SOX regimen will emerge as a first-line chemotherapy option for *** with GC who receive effective perioperative chemotherapy(Response Evaluation Criteria in Solid Tumors 1.1,Tumor Regression Grade),have a tumor diameter≤2cm,exhibit high degree of differentiation,and are at an early cTNM stage show better prognos

关键词： Nab-paclitaxel Gastric cancer Efficacy Safety

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑Xia Su jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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顶板高抽钻孔抽放瓦斯的应用

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煤矿安全 2008年第6期39卷 39-40页

作者：贾宝财纪道荣韩玉发鸡西矿业集团正阳煤矿黑龙江鸡西158177

通过应用顶板高位钻孔抽放瓦斯的技术,在解决正阳煤矿一采37#左六工作面上隅角及回风瓦斯超限问题上取得了显著效果,为该矿积累了在此煤层开采过程中解决瓦斯超限问题的经验,同时也为矿井开采其它相邻煤层治理瓦斯时,提供了参考依据。

关键词：瓦斯抽放项板高抽钻孔应用

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顶板高抽钻孔抽放瓦斯的应用

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煤炭技术 2008年第4期27卷 72-73页

作者：宋金国贾宝财鸡西矿业集团公司正阳煤矿黑龙江鸡西158100

鸡西矿业集团正阳煤矿一采37#左六工作面应用顶板高位钻孔抽放瓦斯的技术,解决上隅角及回风瓦斯超限问题,为该矿在此煤层开采过程中解决瓦斯超限问题积累了经验,同时也为矿井开采其它相邻煤层治理瓦斯提供参考依据。

关键词：瓦斯抽放高抽钻孔抽放效果

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Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-Lin Zhang Kun-Huan Zhang jia-Qian Ju Jing-cai Liu Shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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U型通风方式采煤工作面上隅角瓦斯处理方法

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煤炭技术 2008年第5期27卷 88-89页

作者：贾宝财刘振宇鸡西矿业集团公司正阳煤矿黑龙江鸡西158100

通过对U型通风方式采煤工作面上隅角的瓦斯积聚形成原因的分析,以及对设置临时挡风帘、提高采面供风量、设置采空区风幛、U+L通风系统专用排瓦斯尾巷、高位钻孔抽放瓦斯等五种处理上隅角瓦斯超限方法效果的比较分析,总结出了较好的处理... 详细信息

通过对U型通风方式采煤工作面上隅角的瓦斯积聚形成原因的分析,以及对设置临时挡风帘、提高采面供风量、设置采空区风幛、U+L通风系统专用排瓦斯尾巷、高位钻孔抽放瓦斯等五种处理上隅角瓦斯超限方法效果的比较分析,总结出了较好的处理上隅角瓦斯超限的方法。

关键词： U型通风系统上隅角瓦斯治理

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生物信息学在生物医学与药物开发中的应用

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食品工程 2010年第2期 16-18,42页

作者：李润花贾宝财太原师范学院生物系太原030006 忻州师范学院忻州03400

生物信息学是利用计算和分析工具收集、解释生物学数据的学科,随着高通量质谱技术的出现及其在疾病基因组、蛋白质组学研究中的应用,生物信息学在解读基因组、转录组及蛋白质组学分析产生的海量数据中发挥着越来越重要的作用。

关键词：生物信息学生物医学药物开发

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Error estimates of numerical methods for the nonlinear Dirac equation in the nonrelativistic limit regime

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Science China Mathematics 2016年第8期59卷 1461-1494页

作者： bao WeiZhu cai YongYong jia XiaoWei YIN jia Department of Mathematics National University of SingaporeSingapore 119076Singapore Beijing Computational Science Research Center Beijing 100193China Department of Mathematics Purdue UniversityWest LafayetteIN 47907USA NUS Graduate School for Integrative Sciences and Engineering(NGS) National University of SingaporeSingapore 117456Singapore

We present several numerical methods and establish their error estimates for the discretization of the nonlinear Dirac equation （NLDE） in the nonrelativistic limit regime, involving a small dimensionless parameter 0 〈 ε〈〈1 which is inversely proportional to the speed of light. In this limit regime, the solution is highly oscillatory in time, i.e., there are propagating waves with wavelength O（ ε^2） and O（1） in time and space, respectively. We begin with the conservative Crank-Nicolson finite difference （CNFD） method and establish rigorously its error estimate which depends explicitly on the mesh size h and time step τ- as well as the small parameter 0 〈 ε≤1 Based on the error bound, in order to obtain ＇correct＇ numerical solutions in the nonrelativistic limit regime, i.e., 0 〈 ε≤1 , the CNFD method requests the ε-scalability： τ- = O（ε3） and h = O（√ε）. Then we propose and analyze two numerical methods for the discretization of NLDE by using the Fourier spectral discretization for spatial derivatives combined with the exponential wave integrator and time- splitting technique for temporal derivatives, respectively. Rigorous error bounds for the two numerical methods show that their ε-scalability is improved to τ = O（ε2） and h = O（1） when 0 〈 ε 〈〈 1. Extensive numerical results are reported to confirm our error estimates.

关键词： nonlinear Dirac equation nonrelativistic limit regime Crank-Nicolson finite difference method exponential wave integrator time splitting spectral method ^-scalability

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A review on single bubble gas–liquid mass transfer

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Chinese Journal of Chemical Engineering 2020年第11期28卷 2707-2722页

作者： Yuyun bao Jinting jia Shuaifei Tong Zhengming Gao Ziqi cai State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China

It is common to empirically correlate volumetric mass transfer coefficient kLa for predicting gas–liquid mass transfer in industrial applications,and the investigation of single bubble mass transfer is crucial for a detailed understanding of mass transfer *** this work,experiments,models and simulations based on the experimental results were highlighted to elucidate the mass transfer between single bubbles and ambient *** experimental setups,measurement methods,the mass transfer of single bubbles in the Newtonian and the nonNewtonian liquid,models derived from the concept of eddy diffusion,the extension of Whitman’s,Higbie’s and Danckwerts’models,or dimensionless numbers,and simulation methods on turbulence,gas–liquid partition methods and mass transfer source term determination are introduced and commented *** people have a great knowledge on mass transfer between single bubbles and ambient liquid in single conditions,it is still insufficient when facing complex liquid conditions or some phenomena such as turbulence,contamination or non-Newtonian *** studies on single bubbles are required for experiments and models in various liquid conditions in future.

关键词： Gas-liguid mass transfer Single bubbles Mass transfer models Simulation Surfactant Non-Newtonian fluid

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