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Properties and microstructure of copper–titanium alloys with magnesium additions

Rare Metals 2024年第5期43卷 2290-2299页

作者： Lue huang Li-Jun Peng Jiang Li Xu-Jun Mi Gang Zhao Guo-Jie huang Hao-Feng Xie Yi-cheng Cao Wen-Jing Zhang Zhen Yang State Key Laboratory of Nonferrous Metals and Processes GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. LtdBejing 101407China School of Materials Science and Engineering Northeastern UniversityShenyang110000China General Research Institute for Nonferrous Metals Beijing 100088China China Academy of Space Technology Beijing 100094China China Nonferrous Metals Mining Group(Tianjin)Co.Ltd Tianjin 3001llChina

The volume fractions and morphology of precipitates in precipitation-strengthened Cu-Ti alloys,which precipitate mainly as continuous and discontinuous precipitates,are important for the application of the *** study employed hardness and electrical conductivity tests transmission electron microscopy(TEM),atom probe tomography(APT),and first-principles calculations to demonstrate that the addition of Mg is effective for accelerating nanosized continuousβ'-Cu_(4)Ti precipitation as well as for suppressing the precipitation of coarse lamellar discontinuousβ-Cu_(4)Ti precipitates along the grain boundaries,resulting in Cu-Ti alloys with high yield strength and good electrical *** results showed that the continuous precipitation ofβ'-Cu_(4)Ti was accelerated by the Mg additions,which reduced the supersaturation of the matrix,thereby reducing the chemical driving force for the discontinuous *** the other hand,Mg additions increased the mismatch between the discontinuousβ-Cu_(4)Ti precipitates and matrix decreased the nucleation rate of the discontinuous precipitates,and increased the spacing of the discontinuous precipitation layer,resulting in a lower growth rate of the discontinuous ***,the addition of Mg to Cu-Ti alloys enhances the strength and improves the resistance to over-ageing.

关键词： Cu-Ti-Mg alloy Precipitation hardening Discontinuous precipitation Continuous precipitation Microstructure formation mechanism

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Brain-inspired artificial intelligence research: A review

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Science China(Technological Sciences) 2024年第8期67卷 2282-2296页

作者： WANG GuoYin bao HuaNan LIU Qun ZHOU TianGang WU Si huang TieJun YU ZhaoFei LU CeWu GONG YiHong ZHANG ZhaoXiang HE Sheng Chongqing Key Laboratory of Computational Intelligence Chongqing University of Posts and TelecommunicationsChongqing 400065China Key Laboratory of Cyberspace Big Data Intelligent Security Chongqing University of Posts and TelecommunicationsChongqing 400065China College of Computer and Information Science Chongqing Normal UniversityChongqing 401331China State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Psychological and Cognitive Sciences Peking UniversityBeijing 100871China State Key Laboratory of Multimedia Information Processing School of Computer SciencePeking UniversityBeijing 100871China Department of Computer Science School of ElectronicsInformation and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Faculty of Electronic and Information Engineering Xi’an Jiaotong UniversityXi’an 710049China The Center for Research on Intelligent Perception and Computing Institute of AutomationChinese Academy of SciencesBeijing 100190China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China

Artificial intelligence(AI) systems surpass certain human intelligence abilities in a statistical sense as a whole, but are not yet the true realization of these human intelligence abilities and behaviors. There are differences, and even contradictions, between the cognition and behavior of AI systems and humans. With the goal of achieving general AI, this study contains a review of the role of cognitive science in inspiring the development of the three mainstream academic branches of AI based on the three-layer framework proposed by David Marr, and the limitations of the current development of AI are explored and analyzed. The differences and inconsistencies between the cognition mechanisms of the human brain and the computation mechanisms of AI systems are analyzed. They are found to be the cause of the differences and contradictions between the cognition and behavior of AI systems and humans. Additionally, eight important research directions and their scientific issues that need to focus on braininspired AI research are proposed: highly imitated bionic information processing, a large-scale deep learning model that balances structure and function, multi-granularity joint problem solving bidirectionally driven by data and knowledge, AI models that simulate specific brain structures, a collaborative processing mechanism with the physical separation of perceptual processing and interpretive analysis, embodied intelligence that integrates the brain cognitive mechanism and AI computation mechanisms,intelligence simulation from individual intelligence to group intelligence(social intelligence), and AI-assisted brain cognitive intelligence.

关键词： artificial intelligence cognitive science brain science intelligence science large language model

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Detecting somatisation disorder via speech:introducing the Shenzhen Somatisation Speech Corpus

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Intelligent Medicine 2024年第2期4卷 96-103页

作者： Kun Qian Ruolan huang Zhihao bao Yang Tan Zhonghao Zhao Mengkai Sun Bin Hu Björn W.Schuller Yoshiharu Yamamoto Key Laboratory of Brain Health Intelligent Evaluation and Intervention Ministry of EducationBeijing Institute of TechnologyBeijing 100081China School of Medical Technology Beijing Institute of TechnologyBeijing 100081China The First School of Clinical Medicine Southern Medical UniversityGuangzhouGuangdong 510515China Department of Neurology Shenzhen University General HospitalShenzhenGuangdong 518055China Group on Language Audio&MusicImperial College LondonLondon SW72AZUK Embedded Intelligence for Health Care and Wellbeing University of AugsburgAugsburg 86159Germany Educational Physiology Laboratory Graduate School of EducationThe University of TokyoTokyo 113-0033Japan

Objective Speech recognition technology is widely used as a mature technical approach in many *** the study of depression recognition,speech signals are commonly used due to their convenience and ease of *** speech recognition is popular in the research field of depression recognition,it has been little studied in somatisation disorder *** reason for this is the lack of a publicly accessible database of relevant speech and benchmark *** this end,we introduced our somatisation disorder speech database and gave benchmark *** By collecting speech samples of somatisation disorder patients,in cooperation with the Shenzhen University General Hospital,we introduced our somatisation disorder speech database,the Shenzhen Somatisation Speech Corpus(SSSC).Moreover,a benchmark for SSSC using classic acoustic features and a machine learning model was proposed in our *** To obtain a more scientific benchmark,we compared and analysed the performance of different acoustic features,i.e.,the full ComPare feature set,or only Mel frequency cepstral coefficients(MFCCs),fundamental frequency(F0),and frequency and bandwidth of the formants(F1-F3).By comparison,the best result of our benchmark was the 76.0%unweighted average recall achieved by a support vector machine with formants F1–*** The proposal of SSSC may bridge a research gap in somatisation disorder,providing researchers with a publicly accessible speech *** addition,the results of the benchmark could show the scientific validity and feasibility of computer audition for speech recognition in somatization disorders.

关键词： Somatisation disorder Machine learning Healthcare Computer audition

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Towards a new avenue for rapid synthesis of electrocatalytic electrodes via laser-induced hydrothermal reaction for water splitting

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International Journal of Extreme Manufacturing 2024年第1期6卷 340-351页

作者： Yang Sha Menghui Zhu Kun huang Yang Zhang Francis Moissinac Zhizhou Zhang Dongxu cheng Paul Mativenga Zhu Liu Department of Materials School of Natural SciencesThe University of ManchesterOxford RoadManchester M139PLUnited Kingdom Laser Processing Research Centre Department of MechanicalAerospace and Civil EngineeringSchool of EngineeringThe University of ManchesterOxford RoadManchester M139PLUnited Kingdom National Graphene Institute The University of ManchesterOxford RoadManchester M139PLUnited Kingdom Department of Chemical Engineering and Analytical Science School of EngineeringThe University of ManchesterOxford RoadManchester M139PLUnited Kingdom Research Centre for Laser Extreme Manufacturing Ningbo Institute of Materials Engineering and TechnologyChinese Academy of SciencesNingboPeople’s Republic of China

Electrochemical production of hydrogen from water requires the development ofelectrocatalysts that are active,stable,and low-cost for water *** address these challenges,researchers are increasingly exploring binder-free electrocatalytic integratedelectrodes (IEs) as an alternative to conventional powder-based electrode preparation methods,for the former is highly desirable to improve the catalytic activity and long-term stability for large-scale applications of ***,we demonstrate a laser-inducedhydrothermal reaction (LIHR) technique to grow NiMoO4nanosheets on nickel foam,which is then calcined under H2/Ar mixed gases to prepare the IE *** electrode exhibits superior hydrogen evolution reaction performance,requiring overpotentials of 59,116 and143 mV to achieve current densities of 100,500 and 1000 mA·*** the 350 h chronopotentiometry test at current densities of 100 and 500 m A·cm-2,the overpotentialremains essentially *** addition,NiFe-layered double hydroxide grown on Ni foam is also fabricated with the same LIHR method and coupled with IE-NiMo-IR to achieve water *** combination exhibits excellent durability under industrial current *** energy consumption and production efficiency of the LIHR method are systematicallycompared with the conventional hydrothermal *** LIHR method significantly improves the production rate by over 19 times,while consuming only 27.78%of the total energy required by conventional hydrothermal methods to achieve the same production.

关键词： electrocatalytic electrode laser-induced hydrothermal reaction NiFe layered double hydroxides hydrogen evolution reaction water splitting energy consumption production rate

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A proteomic landscape of pharmacologic perturbations for functional relevance

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Journal of Pharmaceutical Analysis 2024年第1期14卷 128-139页

作者： Zhiwei Liu Shangwen Jiang Bingbing Hao Shuyu Xie Yingluo Liu Yuqi huang Heng Xu cheng Luo Min huang Minjia Tan Jun-Yu Xu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210023China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdong528400China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing210023China

Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds. The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine.

关键词： Proteomics Drug Perturbation Drug target Drug combination

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Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia

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Genes & Diseases 2024年第5期11卷 105-108页

作者： Liang Zhou Youyou Li Jiaren Li Hanyu Yao Jin huang cheng Li Long Wang Department of Urology The Third Xiangya Hospital of Central South UniversityChangshaHunan 410013China

In aging males,benign prostatic hyperplasia(BPH)is a chronic pathological process that primarily causes lower urinary tract *** to histopathology,BPH is caused by an imbalance between cell death and proliferation.1 However,the exact pathophysiology remains *** is a newly discovered form of programmed cell *** cell morphology is characterized primarily by the reduction or disappearance of mitochondrial cristae and mitochondrial shrinkage.2,3 Competing endogenous RNAs(ceRNAs)are important regulators of many biological processes and have been involved in various diseases.

关键词： prostatic endogenous BPH

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ERβ-activated LINC01018 promotes endometriosis development by regulating the CDC25C/CDK1/CyclinB1 pathway

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Journal of Genetics and Genomics 2024年第6期51卷 617-629页

作者： Ruihui Lu Jingwen Zhu Xin Li cheng Zeng Yan huang Chao Peng Yingfang Zhou Qing Xue Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China

Endometriosis refers to as an estrogen-dependent *** receptorβ(ERB),the main estrogen receptor subtype which is encoded by the estrogen receptor 2(ESR2)gene,can mediate the action of estrogen in *** selective estrogen receptor modulators can target the ERβ,they are not specific due to the wide distribution of ERβ.Recently,long noncoding RNAs have been implicated in ***,we aim to explore and validate the downstream regulatory mechanism of ERβ,and to investigate the potential role of long intergenic noncoding RNA 1018(LINC01018)as a nonhormonal treatment for *** study demonstrates that the expression levels of ESR2 and LINCo1018 are increased in ectopic endometrial tissues and reveals a significant positive correlation between the ESR2 and LINCo1018 ***,ERβdirectly binds to an estrogen response element located in the LINCO1018 promoter region and activates LINC01018 ***,ERβcan regulate the CDC25C/CDK1/CyclinB1 pathway and promote ectopic endometrial stromal cell proliferation via LINC01018 in *** with these findings,the knockdown of LINC01018 inhibits endometriotic lesion proliferation in *** summary,our study demonstrates that the ERβ/LINC01018/CDC25C/CDK1/CyclinB1 signaling axis regulates endometriosis progression.

关键词： Estrogen receptorβ Long intergenic noncoding RNA 1018 (LINC01018) Endometriosis Cell cycle Proliferation

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Macroscopic on-site magnifier-based evaluation to estimate visible tissue core cut-off lengths using EUS-FNA with 22-gauge needles

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Chinese Medical Journal 2024年第4期137卷 493-495页

作者： Jialiang huang Guilian cheng Wei Wu Liming Xu Longjiang Xu Duanmin Hu Department of Gastroenterology Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Pathology Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China

To the Editor:Endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)has replaced other high-risk invasive methods and has become the primary method of tissue collection around the gastrointestinal tract.^([1])To further improve the effectiveness and safety of EUS-FNA,pathologists may perform rapid on-site cytology evaluation(ROSE),but this process requires the presence of *** on-site evaluation(MOSE)has gained attention as it resolve the shortage of pathologist resources.^([2])Endoscopists can inspect the tissue core in real time and assess the adequacy of the punctured *** this study,we conducted a single-center and single-arm exploratory study to explore the value of MOSE in assessing specimen quality during magnifier-based EUS-FNA and to confirm the cut-off length of visible tissue core(VTC)for EUS-FNA to help endosonographers independently predict the adequacy of punctured *** VTC was defined as a white or incarnadine tissue core obtained from focal lesions with a relatively complete histological structure.

关键词： EUS needle visible

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An ecological perspective on Joseph Rock’s(1884-1962)plant collection activities in China

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Journal of Plant Ecology 2024年第4期17卷 100-113页

作者： Jifan Luo Ruozhi huang Hai Yan Renwu Wu Shuai Liao Zhoubing Xiang Yongxi Zou Liangchen Shi Ke Wang Zhiyi bao College of Landscape Architecture Zhejiang Agriculture and Forestry UniversityHangzhou 311300China Zhejiang Agriculture and Forestry University Landscape Architecture Institute Hangzhou 311300China South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China

In the early 20th century,numerous western botanists,often referred to as‘plant hunters’,embarked on ambitious expeditions to China,playing a crucial role in the study of botany and botanical *** their contributions,comprehensive assessments of their explorations are *** bridge this gap,this article focuses on the work of Joseph Charles Francis Rock,a notable figure in that *** work revisits Rock’s botanical expeditions within the broader context of botanical diversity *** outlines his historical experiences in collecting plants in China and enumerates the species composition and phenotypic traits of the plants he ***,it also analyzes the spatial distribution of the species,the completeness of his collection and the α-and β-diversity of the plants he *** findings reveal that Rock led four major botanical expeditions in China between 1922 and 1933,amassing a total of 28184 sheets and 16608 numbers across 204 families,1081 genera and 4231 *** focus was predominantly on ornamental species,which exhibit a variety of flower colors and *** collection work spanned 5 provinces,35 cities and 72 counties,with a notable concentration in the Hengduan Mountains,a current biodiversity *** study not only reconstructs Rock’s botanical legacy but also offers valuable historical data and fresh analytical insights for understanding contemporary plant *** contributes to the ongoing discourse on the importance of preserving plant diversity as a cornerstone of environmental sustainability.

关键词： Joseph Charles Francis Rock plant specimen collection history plant diversity plant collector

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Addressable structured light system using metasurface optics and an individually addressable VCSEL array

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Photonics Research 2024年第6期12卷 1129-1137页

作者： CHENYANG WU XUANLUN huang YIPENG JI TINGYU cheng JIAXING WANG NAN CHI SHAOHUA YU CONNIE J.CHANG-HASNAIN School of Information Science and Technology Fudan UniversityShanghai 200433China Berxel Photonics Co. Ltd.Shenzhen 518071China Peng cheng Laboratory Shenzhen 518055China Chinese University of Hong Kong Shenzhen 518172China

Structured-light(SL)based 3D sensors have been widely used in many *** SL is the most widely deployed among all SL sensors due to its light weight,compact size,fast video rate,and low *** transmitter(known as the dot projector)consists of a randomly patterned vertical-cavity surface-emitting laser(VCSEL)array multiplicated by a diffractive optical element(DOE)with a fixed repeated *** that the separation of any two speckles is only one known and fixed number(albeit random),there are no other known scales to cal-ibrate or ***,typical SL sensors require extensive in-factory calibrations,and the depth resolution is limited to 1 mm at-60 cm *** this paper,to the best of our knowledge,we propose a novel dot projector and a new addressable SL(ASL)3D sensor by using a regularly spaced,individually addressable VCSEL array,multiplicated by a metasurface-DOE(MDOE)into a random pattern of the *** turning on or off the VCSELs in the array provides multiple known distances between neighboring speckles,which is used as a“built-in caliper”to achieve higher accuracy of *** as a precise“vernier caliper,”the addressable VCSEL array enables fine control over speckle positions and high detection *** experimentally dem-onstrated that the proposed method can result in sub-hundred-micron level *** new concept opens new possibilities for applications such as 3D computation,facial recognition,and wearable devices.

关键词： speckle light surface

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