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Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation

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当代医学科学(英文) 2023年第4期43卷 749-758页

作者： Xin QUAN Teng MA Kai GUO Huan WANG Cai-yong YU Chu-chu QI bao-qiang song Department of Plastic Surgery Xijing Hospitalthe Fourth Military Medical UniversityXi'an 710032China Department of Orthopedics Xijing Hospitalthe Fourth Military Medical UniversityXi'an 710032China Department of Burns and Cutaneous Surgery Xijing Hospitalthe Fourth Military Medical UniversityXi'an 710032China Department of Respiratory Medicine Xi'an Hospital of Traditional MedicineXi'an 710000China Department of Neurobiology School of Basic Medicinethe Fourth Military Medical UniversityXi'an 710032China

Objective:This study aims to investigate the effects of hydralazine on inflammation induced by spinal cord injury(SCI)in the central nervous system(CNS)and its mechanism in promoting the structural and functional recovery of the injured ***:A compressive SCI mouse model was utilized for this *** and quantitative real-time polymerase chain reaction were employed to examine the levels of acrolein,acrolein-induced inflammation-related factors,and macrophages at the injury site and within the *** blotting was used to evaluate the activity of the phosphoinositide 3-kinase(PI3K)/AKT pathway to study macrophage *** neuropathic pain and motor function recovery were evaluated by glutamic acid decarboxylase 65/67(GAD65/67),vesicular glutamate transporter 1(VGLUT1),paw withdrawal response,and Basso Mouse Scale *** staining and Luxol Fast Blue(LFB)staining were performed to investigate the structural recovery of the injured ***:Hydralazine downregulated the levels of acrolein,IL-1β,and TNF-αin the spinal *** downregulation of acrolein induced by hydralazine promoted the activation of the PI3K/AKT pathway,leading to M2 macrophage polarization,which protected neurons against SCI-induced ***,hydralazine promoted the structural recovery of the injured spinal cord *** inflammation and oxidative stress by hydralazine in the animal model alleviated neuropathic pain and altered neurotransmitter ***,hydralazine facilitated motor function recovery following *** staining and LFB staining indicated that hydralazine promoted the structural recovery of the injured ***:Hydralazine,an acrolein scavenger,significantly mitigated SCI-induced inflammation and oxidative stress in vivo,modulated macrophage activation,and consequently promoted the structural and functional recovery of the injured CNS.

关键词： spinal cord injury proinflammation oxidative stress macrophage acrolein scavenger

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Tracking Control of Autonomous Underwater Vehicles with Internal Moving Mass

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自动化学报 2008年第10期34卷 1319-1323页

作者： LI Jia-Wang song bao-Wei SHAO Cheng College of Marine Northwestern Polytechnical University Xi＇an710072 P. R. China

追踪轨道的控制问题被调查为一自治在水下作为致动器用一个内部点团和一个后面的推进器搬到垂直飞机的车辆(AUV ) 。与点团的动力学结合了， AUV 作为一个 underactuated 系统被建模。一个基于 Lyapunov 的追踪控制器被使用 backsteppi... 详细信息

追踪轨道的控制问题被调查为一自治在水下作为致动器用一个内部点团和一个后面的推进器搬到垂直飞机的车辆(AUV ) 。与点团的动力学结合了， AUV 作为一个 underactuated 系统被建模。一个基于 Lyapunov 的追踪控制器被使用 backstepping 途径稳定错误动力学并且强迫位置错误到起源的一位小邻居建议。模拟结果验证建议追踪的途径。

关键词：轨迹控制自动化系统水下交通工具动力系统

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Effects of LY294002 on the invasiveness of human gastric cancer in vivo in nude mice

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World Journal of Gastroenterology 2009年第40期15卷 5044-5052页

作者： Chun-Gen Xing bao-song Zhu Xiao-Qing Fan Hui-Hui Liu Xun Hou Kui Zhao Zheng-Hong Qin Department of General Surgery The Second Affiliated Hospital Soochow University Suzhou 215006 Jiangsu Province China Department of General Surgery The Second Hospital of Jiaxing City Jiaxing 314000 Jiangsu Province China Department of Neurology The Second Affiliated Hospital Soochow University Suzhou 215006 Jiangsu Province China Laboratory of Aging and Nervous Diseases Soochow University School of Medicine Suzhou 215123 Jiangsu Province China

AIM: To investigate the effects of class phosphatidy-linositol 3-kinase (PI3K) inhibitor LY294002 on the invasiveness and related mechanisms of implanted tumors of SGC7901 human gastric carcinoma cells in nude mice. METHODS: Nude mice were randomly divided into model control groups and LY294002 treatment groups. On days 5, 10 and 15 after treatment, the inhibitory rate of tumor growth, pathological changes in tumor specimens, expression levels of matrix metalloproteinase (MMP)-2, MMP-9, CD34 [representing microvessel density (MVD)] and vascular endothelial growth factor (VEGF), as well as apoptosis indexes in tumor samples were ***: In this study, we showed that treatingthe tumors with LY294002 could significantly inhibit carcinoma growth by 11.3%, 29.4% and 36.7%, after 5, 10 and 15 d, respectively, compared to the control group. Hematoxylin & eosin staining indicated that the rate of inhibition increased progressively (23.51% ± 3.11%, 43.20% ± 3.27% and 63.28% ± 2.10% at 5, 10 and 15 d, respectively) along with apoptosis. The expression of MMP-2 was also downregulated (from 71.4% ± 1.6% to 47.9% ± 0.7%, 31.9% ± 0.9% and 7.9% ± 0.7%). The same effects were observed in MMP-9 protein expression (from 49.4% ± 1.5% to 36.9% ± 0.4%, 23.5% ± 0.9% and 7.7% ± 0.6%), the mean MVD (from 51.2% ± 3.1% to 41.9% ± 1.5%, 30.9% ± 1.7% and 14.9% ± 0.8%), and the expression of VEGF (from 47.2% ± 3.1% to 25.9% ± 0.5%, 18.6% ± 1.2% and 5.1% ± 0.9%) by immunohistochemical ***: The classPI3K inhibitor LY294002could inhibit the invasiveness of gastric cancer cells by downregulating the expression of MMP-2, MMP-9, and VEGF, and reducing MVD.

关键词： Phosphatidylinositol 3-kinase LY294002 Gastric cancer Neoplasm invasiveness

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Lysosomal cholesterol accumulation is commonly found in most peroxisomal disorders and reversed by 2-hydroxypropyl-β-cyclodextrin

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Science China(Life Sciences) 2023年第8期66卷 1786-1799页

作者： Lewei Dong Jian Xiao Shuai Liu Gang Deng Yacheng Liao Beibei Chu Xiaolu Zhao bao-Liang song Jie Luo College of Life Sciences Taikang Center for Life and Medical SciencesHubei Key Laboratory of Cell HomeostasisWuhan UniversityWuhan 430072China College of Veterinary Medicine Henan Agricultural UniversityZhengzhou 450046China

Peroxisomal disorders(PDs)are a heterogenous group of diseases caused by defects in peroxisome biogenesis or *** adrenoleukodystrophy is the most prevalent form of PDs and results from mutations in the ABCD1 gene,which encodes a transporter mediating the uptake of very long-chain fatty acids(VLCFAs).The curative approaches for PDs are very ***,we investigated whether cholesterol accumulation in the lysosomes is a biochemical feature shared by a broad spectrum of *** individually knocked down fifteen PD-associated genes in cultured cells and found ten induced cholesterol accumulation in the lysosome.2-Hydroxypropyl-β-cyclodextrin(HPCD)effectively alleviated the cholesterol accumulation phenotype in PD-mimicking cells through reducing intracellular cholesterol content as well as promoting cholesterol redistribution to other cellular *** ABCD1 knockdown cells,HPCD treatment lowered reactive oxygen species and VLCFA to normal *** Abcd1 knockout mice,HPCD injections reduced cholesterol and VLCFA sequestration in the brain and adrenal *** plasma levels of adrenocortical hormones were increased and the behavioral abnormalities were greatly ameliorated upon HPCD ***,our results suggest that defective cholesterol transport underlies most,if not all,PDs,and that HPCD can serve as a novel and effective strategy for the treatment of PDs.

关键词： cholesterol peroxisome lysosome peroxisomal disorders X-ALD cyclodextrin ABCD1 VLCFA

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Mapping of quantitative trait loci for fiber and lignin contents from an interspecific cross Oryza sativa×Oryza rufipogon

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第7期12卷 518-526页

作者： Jian-kun XIE Xiang-li KONG Jie CHEN Biao-lin HU Piao WEN Jie-yun ZHUANG Jin-song bao Institute of Nuclear Agricultural Sciences College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China College of Life Sciences Jiangxi Normal University Nanchang 330022 China China National Rice Research Institute Hangzhou 310006 China

Rice straw is always regarded as a by-product of rice production,but it could be a significant energy source for ruminant *** of the genetic variation and genetic architecture of cell wall traits will facilitate rice breeders by improving relevant traits through selective breeding and genetic *** common wild rice,Oryza rufipogon Griff.,which is considered to be the progenitor of Oryza sativa,has been widely utilized for the identification of genes of agronomic importance for rice genetic *** the present study,the mapping of quantitative trait loci (QTLs) for acid detergent fiber (ADF),neutral detergent fiber (NDF),acid detergent lignin (ADL),and ADL/NDF ratio was carried out in two environments using a backcrossed inbred line (BIL) population derived from a cross between the recurrent parent Xieqingzao B (XB) and an accession of Dongxiang wild rice (DWR).The results indicated that all four traits tested were continuously distributed among the BILs,but many BILs showed transgressive segregation.A total of 16 QTLs were identified for the four traits,but no QTLs were in common in two environments,suggesting that environment has dramatic effects on fiber and lignin *** to the QTL positions for grain yield-related traits,there were no unfavorable correlations between grain yield components and cell wall traits in this *** QTLs identified in this study are useful for the development of dual-purpose rice varieties that are high in grain yield and are also high in straw quality.

关键词： Rice straw Acid detergent fiber Lignin Quantitative trait loci

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Sesquiterpenes and polyphenols with glucose-uptake stimulatory and antioxidant activities from the medicinal mushroom Sanghuangporus sanghuang

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Chinese Journal of Natural Medicines 2021年第9期19卷 693-699页

作者： ZHANG Jin-Jin CHEN bao-song DAI Huan-Qin REN Jin-Wei ZHOU Li-Wei WU Sheng-Hua LIU Hong-Wei State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Department of Biology National Museum of Natural ScienceTaichung 40453TaiwanChina

A chemical investigation on the fermentation products of Sanghuangporus sanghuang led to the isolation and identification of fourteen secondary metabolites(1-14)including eight sesquiterpenoids(1-8)and six polyphenols(9-14).Compounds1-3 were sesquiterpenes with new structures which were elucidated based on NMR spectroscopy,high resolution mass spectrometry(HRMS)and electronic circular dichroism(ECD)*** the isolates were tested for their stimulation effects on glucose uptake in insulin-resistant HepG2 cells,and cellular antioxidant *** 9-12 were subjected to molecular docking experiment to primarily evaluate their anti-coronavirus(SARS-CoV-2)*** a result,compounds 9-12 were found to increase the glucose uptake of insulin-resistant HepG2 cells by 18.1%,62.7%,33.7%and 21.4%at the dose of 50μmol·L^(-1),*** 9-12 also showed good cellular antioxidant activities with CAA_(50)values of 12.23,23.11,5.31 and 16.04μmol·L^(-1),*** docking between COVID-19 M^(pro)and compounds 9-12 indicated potential SARS-CoV-2 inhibitory activity of these four *** work provides new insights for the potential role of the medicinal mushroom *** as drugs and functional foods.

关键词： Sanghuangporus sanghuang Sesquiterpenoids Polyphenols Glucose-uptake stimulation Cellular antioxidant activity Anti-coronavirus activity

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A new application of capsulorhexis forceps in phacoemulsification: capsulorhexis forceps-assisted prechop technique

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 337-339页

作者： Jian-Cen Tang Hong-Ping Cui Hao Chu Ji Xu bao-song Liu Department of Ophthalmology Shanghai East Hospital Tongji University School of Medicine The Cataract Service Wuhan Eyegood Ophthalmic Hospital

Dear Editor,I am ***-Cen Tang,from the Department of Ophthalmology,Shanghai East Hospital,Tongji University School of Medicine,Shanghai.I write to present a new application of capsulorhexis forceps in phacoemulsificat... 详细信息

关键词： capsulorhexis forceps-assisted prechop technique Figure

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Cu-catalyzed regioselective diborylation of 1,3-enynes for the efficient synthesis of 1,4-diborylated allenes

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Chinese Chemical Letters 2024年第5期35卷 141-144页

作者： Wujun Jian Mong-Feng Chiou Yajun Li Hongli bao song Yang National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyang 550025China Strait Institute of Flexible Electronics(SIFE Future Technologies)Fujian Normal UniversityFuzhou 350117China Key Laboratory of Coal to Ethylene Glycol and Its Related Technology State Key Laboratory of Structural ChemistryFujian Institute of Research on the Structure of MatterUniversity of Chinese Academy of SciencesFuzhou 350002China

Borylation of 1,3-enynes with bis(boronate)compounds often ends up with the formation of hydroborylated products,leaving the diborylation of 1,3-enynes for the formation of 1,4-diborylated allenes to be ***,a copper-catalyzed chemo-,regio-,and stereo-selective diborylation of 1,3-enynes for the efficient construction of 1,4-diborylated allenes under base-free conditions was reported.A wide range of 1,3-enynes bearing various functional groups can participant in the reaction and afforded the corresponding 1,4-diborylated allenes in good to excellent yields,which was enabled by the protocol of Bpin to BF3K *** borylcopper species was supposed to selectively attack the C-C triple bond of the 1,3-enynes.

关键词： Copper catalysis Regioselective 1,3-Enynes Borylation Allenes

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Metal-Organic Framework Enabling Poly(Vinylidene Fluoride)-Based Polymer Electrolyte for Dendrite-Free and Long-Lifespan Sodium Metal Batteries

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Energy & Environmental Materials 2024年第1期7卷 68-76页

作者： Yusi Lei Liang Yue Yuruo Qi Yubin Niu Shujuan bao Jie song Maowen Xu Faculty of Materials and Energy Institute for Clean Energy&Advanced MaterialsSouthwest UniversityChongqing 400715China Shandong Zero-One-Four Advanced Materials Co. Ltd.Feicheng 271099China

Sodium dentrite formed by uneven plating/stripping can reduce the utilization of active sodium with poor cyclic stability and,more importantly,cause internal short circuit and lead to thermal runaway and ***,sodium dendrites and their related problems seriously hinder the practical application of sodium metal batteries(SMBs).Herein,a design concept for the incorporation of metal-organic framework(MOF)in polymer matrix(polyvinylidene fluoride-hexafluoropropylene)is practiced to prepare a novel gel polymer electrolyte(PH@MOF polymer-based electrolyte[GPE])and thus to achieve high-performance *** addition of the MOF particles can not only reduce the movement hindrance of polymer chains to promote the transfer of Na^(+)but also anchor anions by virtue of their negative charge to reduce polarization during electrochemical reaction.A stable cycling performance with tiny overpotential for over 800 h at a current density of 5 mA cm^(-2)with areal capacity of 5 mA h cm^(-2)is achieved by symmetric cells based on the resulted GPE while the Na_(3)V_(2)O_(2)(PO_(4))_(2)F@rGO(NVOPF)|PH@MOF|Nacell also displays impressive specific cycling capacity(113.3 mA h g^(-1)at 1 C)and rate capability with considerable capacity retention.

关键词： dendrite-free gel polymer electrolyte metal organic framework sodium batteries

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New meroterpenoid compounds from the culture of mushroom Panus lecomtei

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Chinese Journal of Natural Medicines 2020年第4期18卷 268-272页

作者： WANG Si-Xian ZHAO Rui-Lin GUO Cui CHEN bao-song DAI Huan-Qin LIU Gao-Qiang LIU Hong-Wei Hunan Provincial Key Laboratory of Forestry Biotechnology&International Cooperation Base of Science and Technology Innovation on Forest Resource Biotechnology Central South University of Forestry&TechnologyChangsha 410004China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medicine School University of Chinese Academy of SciencesBeijing 100049China

Two new meroterpenoid compounds(1 and 2) together with five known meroterpenoid derivatives(3–7) were isolated from solid culture of mushroom Panus lecomtei. The structures of new compounds were confirmed by the analysis of NMR and HRESI-MS spectroscopic data. The biosynthetic pathway of 1–7 was postulated. All isolated compounds were evaluated for antibacterial activities against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Bacillus Calmette–Gué*** 3 exhibited weak antibacterial activity against Bacillus Calmette–Guérin with the inhibition rate of 83.6% at 100 μmol·*** compounds showed no antibacterial activities against all tested pathogens at 100 μmol·L-1.

关键词： Panus lecomtei Meroterpenoid Antibacterial Biosynthetic pathway

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