检索结果-南通市图书馆

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

Mechanism of action of Linggui zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-bao Liao Wei-bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Existence of Mild Solutions for a Class of Fractional Non-autonomous Evolution Equations with Delay

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2020年第4期36卷 870-878页

作者： bo zhu bao-yan HAN Wen-guang YU School of Mathematics and Quantitative Economics Shandong University of Finance and EconomicsJinan 250014China Common Course Teaching Department Shandong University of Art and DesignJinan 250014China School of Insurance Shandong University of Finance and EconomicsJinan 250014China

In this paper,we consider the existence and uniqueness of the mild solutions for a class of fractional non-autonomous evolution equations with delay and Caputo's fractional *** using the measure of noncompactness,β-resolvent family,fixed point theorems and Banach contraction mapping principle,we improve and generalizes some related results on this *** last,we give an example to illustrate the application of the main results of this paper.

关键词： Fractional non-autonomous evolution equations β-resolvent family Mild solution Measure of noncompactness.

A Variational ODE and its Application to an Elliptic Problem

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2007年第4期23卷 685-696页

作者： Huan-song Zhou Hong-bo zhu Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences P.O. Box 71010 Wuhan 430071 China

In this paper, we consider the following ODE problem { （-u＂（τ）＋（N-1）（N-3）/4τ^2 ）u（τ）＋λu（τ）=f（τ,τ（1-N）/2 u）u（τ）,τ〉0, u∈H, N≥3. （P）,where f ∈ C（（0,＋∞） ×R,R）, f（τ,s） goes t... 详细信息

In this paper, we consider the following ODE problem { （-u＂（τ）＋（N-1）（N-3）/4τ^2 ）u（τ）＋λu（τ）=f（τ,τ（1-N）/2 u）u（τ）,τ〉0, u∈H, N≥3. （P）,where f ∈ C（（0,＋∞） ×R,R）, f（τ,s） goes to p（τ） and q（τ） uniformly in τ 〉 0 as s→ 0 and s→＋∞ respectively, 0≤ p（τ） ≤ q（τ） ∈L^∞（0,∞）. Moreover, for τ 〉 0, f（τ, s） is nondecreasing in s≥ 0. Some existence and non-existence of positive solutions to problem （P） are proved without assuming that p（τ） = 0 and q（τ） has a limit at infinity. Based on these results, we get the existence of positive solutions for an elliptic problem.

关键词： Elliptic equation asymptotically linear mountain pass theorem

Update on Mayer—Rokitansky—Küster—Hauser syndrome

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2022年第6期16卷 859-872页

作者： Na Chen Shuang song Xinmiao bao Lan zhu National Clinical Research Center for Obstetric and Gynecologic Diseases Department of Obstetrics and GynecologyState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing100730China Peking Union Medical College M.D.ProgramBeijing100730China

This review presents an update of Mayer—Rokitansky—Küster—Hauser(MRKH)syndrome on its etiologic,clinical,diagnostic,psychological,therapeutic,and reproductive *** etiology of MRKH syndrome remains unclear due to its intrinsic *** and genetic causes that may interact during the embryonic development have been proposed with no definitive etiopathogenesis *** proportion of concomitant extragenital malformations varies in different studies,and the discrepancies may be explained by ethnic *** addition to physical examination and pelvic ultrasound,the performance of pelvic magnetic resonance imaging is crucial in detecting the presence of rudimentary uterine *** syndrome has long-lasting psychological effects on patients,resulting in low esteem,poor coping strategies,depression,and anxiety *** psychological counseling and peer support to diagnosed patients is *** and timely psychological intervention could significantly improve a patient’s *** nonsurgical and surgical methods have been suggested for treatment of MRKH *** to the high success rate and minimal risk of complications,vaginal dilation has been proven to be the first-line *** is the second-line option for patients experiencing dilation *** transplantation and gestational surrogacy are options for women with MRKH syndrome to achieve biological motherhood.

关键词： MRKH(Mayer-Rokitansky-Küster-Hauser)syndrome etiology clinical characteristic diagnosis treatment psychological effect

Primary parenchymal squamous cell carcinoma of the kidney:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng bo Shao Chao-Min Xu Ke Wang Jia-zhu Wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Postural effect on manual laterality during grooming in northern white-cheeked gibbons(Nomascus leucogenys)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2019年第5期40卷 449-455页

作者： Da-Peng Zhao bo-song Li bao-Guo Li Tianjin Key Laboratory of Animal and Plant Resistance College of Life Sciences Tianjin Normal University Tianjin 300387 China Shaanxi Key Laboratory for Animal Conservation College of Life Sciences Northwest University Xi’an Shaanxi 710069 China Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming Yunnan 650223 China

Investigations on manual laterality in non-human primates can help clarify human evolutionary origins of hand preference and cerebral cognition. Although body posture can influence primate hand preference, investigations on how posture affects hylobatid manual laterality are still in their infancy. This study focused on how spontaneous bipedal behavioral tasks affect hand preference in Hylobatidae. Ten captive northern white-cheeked gibbons (Nomascus leucogenys) were chosen as focal subjects. Unimanual grooming during sitting posture and supported bipedal posture were applied as behavioral tasks. The gibbons displayed a modest tendency on left-hand preference during sitting posture and right-hand preference during supported bipedal posture, although no group-level hand preference was detected for either posture. From the sitting to supported bipedal posture, 70% of individuals displayed different degrees of right-side deviation trends. The strength of manual laterality in the supported bipedal posture was higher than that in the sitting posture. We found significant sex differences in manual laterality during supported bipedal posture but not during sitting posture. Thus, to a certain degree, bipedal posture in N. leucogenys facilitates stronger hand preference, elicits a rightward trend in manual laterality, and produces sex-specific hand preference.

关键词： Grooming Hand preference Hylobatidae Posture

Prelithiation design for suppressing delamination in lithium-ion battery electrodes

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2021年第12期42卷 1703-1716页

作者： Yifei QIAN bo LU Yinhua bao Yanfei ZHAO Yicheng song Junqian ZHANG Department of Mechanics Shanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai UniversityShanghai 200444China Department of Civil Engineering School of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China

Prelithiation has been intensively investigated in high-capacity lithiumion batteries(LIBs).However,the optimization of prelithiation degrees for long service life of LIBs still remains a *** positive effect of prelithiation on suppressing degradation of LIBs,besides directly pursuing the high first Coulomb efficiency which has been widely reported in the literature,is revealed and discussed based on an analytical model focusing on the interfacial delamination in *** full charge-discharge cycling,well-designed prelithiation can effectively suppress the delamination and reduce the debonding size by approximately 25%,compared with the case without *** the strategy combining partial charge-discharge cycling and prelithiation,the largest reversible capacity without debonding can be significantly improved by approximately100%with well-designed *** work is expected to provide a prelithiation design principle and further improve the mechanical stability of LIB electrodes.

关键词： prelithiation delamination electrode concentration-dependent property analytical solution

Ballistic penetration damages of hybrid plain-woven laminates with carbon,Kevlar and UHMWPE fibers in different stacking sequences

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2023年第8期26卷 23-38页

作者： Zhi-yong Li You-song Xue bao-zhong Sun bo-hong Gu Shanghai Frontier Science Research Center for Modern Textiles College of TextilesDonghua UniversityShanghai201620China

Hybrid composite materials combine different fibers in preform and take advantages of different mechanical behaviors for improving ballistic impact damage *** we report ballistic impact damages of plain-woven laminates with different hybrids and stacking *** kinds of hybrid laminates,i.e.,carbon/Kevlar,carbon/ultra-high molecular weight polyethylene(UHMWPE),and UHMWPE/Kevlar,had been prepared and tested in ballistic penetration with fragment simulating projectiles(FSP).The residual velocities of the projectiles and impact damage morphologies of the laminates have been obtained to show impact energy absorptions for the different hybrid schemes.A microstructural model of the hybrid laminates had also been established to show impact damage mechanisms with finite element analysis(FEA).We found that the UHMWPE/Kevlar hybrid laminates with Kevlar layers as the front face have the highest energy absorption capacity,followed by the carbon/Kevlar hybrid laminates with carbon layers as the front *** main damage modes are fiber breakages,matrix crack and interlayer *** ballistic damage evolutions from the FEA results show that the major damage is shear failure for front layers,while tension failure for the back *** expect that the ballistic impact performance could be improved from the different hybrid schemes.

关键词： Hybrid laminates Ballistic impact damages Energy absorption Finite element analysis(FEA)