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Management of hepatocellular carcinoma patients with portal vein tumor thrombosis:A narrative review

Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 134-144页

作者： Zi-Wen Tao bao-quan Cheng Tao Zhou Yan-Jing Gao Department of Gastroenterology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012China

Background: Hepatocellular carcinoma(HCC) is one of the main reasons for malignancy-related death. Portal vein tumor thrombosis(PVTT) is the most common form of macrovascular invasion related to HCC occurring in 10%-60% of patients. HCC with PVTT is usually characterized by worsening liver function, vulnerability to blood metastasis, higher incidence of complications associated with portal hypertension, and intolerance to treatment when compared with that without PVTT. If only treated with supportive care, the median survival of HCC with PVTT is about 2.7 months. In the past, sorafenib was the only recommended therapy by guidelines with limited effectiveness. This narrative review aimed to describe the current management options for HCC with PVTT. Data sources: We have reviewed literature from Pub Med on the treatment of HCC with PVTT and compiled evidence-based facts on effective therapies available for different types of PVTT. Results: Sorafenib monotherapy is not much effective, but combining it with other methods can improve survival. Each type of PVTT can beneft from the combination of transarterial chemoembolization and sorafenib than sorafenib monotherapy. The tumor downstaging can be realized possibly after transarterial chemoembolization, but tumor invasion into the main trunk of the portal vein greatly impairs efficacy. Although surgery is a curative approach, it is often not recommended for Vp4 PVTT. Some new methods can broaden the indication, but further explorations are needed. Radiotherapy can decrease the possibility of Vp3 progression to Vp4, but building a forecast model of best radiation dose and response is necessary. Systemic chemotherapy, hepatic arterial infusion chemotherapy, radiofrequency ablation, portal stenting, and traditional Chinese medicine are also benefcial in Vp3-4 PVTT. The accurate diagnosis of PVTT can be made by radiomics, and prognostic classifcation models can be used to design personalized treatments. The application of new

关键词： Hepatocellular carcinoma Portal vein tumor thrombosis Transarterial chemoembolization Radiotherapy Surgery Sorafenib

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Impact of ionospheric irregularity on SBAS integrity:spatial threat modeling and improvement

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Journal of Systems Engineering and Electronics 2018年第5期29卷 908-917页

作者： bao Junjie LI Rui LIU Pan huang Zhigang School of Electronic and Information Engineering Beihang University

The ionosphere, as the largest and least predictable error source, its behavior cannot be observed at all places simultaneously. The confidence bound, called the grid ionospheric vertical error(GIVE), can only be determined with the aid of a threat model which is used to restrict the expected ionospheric behavior. However, the spatial threat model at present widespread used, which is based on fit radius and relative centroid metric(RCM), is too conservative or the resulting GIVEs will be too large and will reduce the availability of satellite-based augmentation system(SBAS). In this paper, layered two-dimensional parameters, the vertical direction double RCMs, are introduced based on the spatial variability of the ionosphere. Comparing with the traditional threat model, the experimental results show that the user ionospheric vertical error(UIVE) average reduction rate reaches 16%. And the 95% protection level of conterminous United States(CONUS) is 28%, even under disturbed days, which reaches about 5% reduction *** results show that the system service performance has been improved better.

关键词： ionospheric delay spatial threat model relative centroid metric(RCM) user ionospheric vertical error(UIVE)

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Mechanical and magnetic hysteresis as indicators of the origin and inception of fatigue damage in steel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第8期11卷 580-586页

作者： Sheng bao Wei-liang JIN Ming-feng huang Institute of Structural Engineering Zhejiang University Hangzhou 310058 China

N2 and N3 are known as the transition points of the three principal stages of fatigue: initial accommodation, accretion of damage and terminal fatigue. Many experiments show that the ratios of N2/Nf and N3/Nf tend to be stable even though the specific N2 and N3 values may fluctuate widely. The primary goal of this research is to study the piezomagnetic field surrounding AISI 1018 steel specimen under repeated loads and to find the ratio values of N2/Nf and N3/Nf by analyzing 11 sets of low-cycle fatigue data. An MTS-810 testing system with a peak capacity of 222 kN was used to obtain the data which consisted of stress, strain, and piezomagnetic field. A computer program was constructed to track the evolution of the piezomagnetic field and re- gression analysis was carried out to determine N2 and N3 values. It was observed that there exists a consistent relationship between N2 and Nf. The apparent invariance of the ratio N2/Nf implies that N2 may be identified as an index of performance in the early loading response of a specimen that forecasts its fatigue life, Nf. It has been demonstrated that measurements of the magnetic and mechanical hysteresis can yield significant insights into the various stages of the development of a fatigue critical microstructure which culminates in complete rupture of the material.

关键词： Piezomagnetic effects. Fatigue damage. Mechanical hvsteresis. Magnetic hysteresis

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Coupling dynamic analysis of spacecraft with multiple cylindrical tanks and flexible appendages

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Acta Mechanica Sinica 2016年第1期32卷 144-155页

作者： Wen-Jun Wu bao-Zeng Yue Hua huang School of Aerospace Engineering Beijing Institute of Technology School of Automobile and Traffic Engineering Guangxi University of Science and Technology Satellite Communication Department China Academy of Space Technology

This paper is mainly concerned with the coupling dynamic analysis of a complex spacecraft consisting of one main rigid platform, multiple liquid-filled cylindrical tanks, and a number of flexible appendages. Firstly, the carrier potential function equations of liquid in the tanks are deduced according to the wall boundary conditions. Through employ- ing the Fourier-Bessel series expansion method, the dynamic boundaries conditions on a curved free-surface under a low-gravity environment are transformed to general simple differential equations and the rigid-liquid coupled sloshing dynamic state equations of liquid in tanks are obtained. The state vectors of rigid-liquid coupled equations are composed with the modal coordinates of the relative potential func- tion and the modal coordinates of wave height. Based on the B ernoulli-Euler beam theory and the D＇Alembert＇s prin- ciple, the rigid-flexible coupled dynamic state equations of flexible appendages are directly derived, and the coordi- nate transform matrixes of maneuvering flexible appendages are precisely computed as time-varying. Then, the cou- pling dynamics state equations of the overall system of the spacecraft are modularly built by means of the Lagrange＇s equations in terms of quasi-coordinates. Lastly, the cou-piing dynamic performances of a typical complex spacecraft are studied. The availability and reliability of the presented method are also confirmed.

关键词： Multiple liquid-filled cylindrical tanks TheFourier-Bessel series expansion method Low-gravityenvironment Maneuvering flexible appendages TheLagrange's equations in terms of quasi-coordinates

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Extended differential geometric guidance law for intercepting maneuvering targets

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Journal of Systems Engineering and Electronics 2018年第5期29卷 1046-1057页

作者： huang Jingshuai ZHANG Hongbo TANG Guojian bao Weimin College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China China Aerospace Science and Technology Corporation Beijing 100048China

Without assumptions made on motion states of missile and target, an extended differential geometric guidance law is derived. Through introducing a line of sight rotation coordinate system, the derivation is simplified and has more explicit physical significances. The extended law is theoretically applicable to any engagement scenarios. Then, on basis of the extended law, a modified one is designed without the requirement of target acceleration and an approach is proposed to determining the applied direction of commanded missile acceleration. Qualitative analysis is carried out to study the capture performance and a criterion for capture is given. Simulation results indicate the two laws are effective and make up the deficiency that pure proportional navigation suitable for endoatmospheric interceptions cannot deal with high-speed maneuvering targets. Furthermore, the correctness of the criterion is validated.

关键词： missile guidance maneuvering target extended differential geometric guidance law capture performance proportional navigation

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A survey on fast simulation of elastic objects

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Frontiers of Computer Science 2019年第3期13卷 443-459页

作者： Jin huang Jiong CHEN Weiwei XU Hujun bao State Key Lab of CAD&CG Zhejiang University Hangzhou 310058 China

Elastic simulation plays an important role in computer graphics and has been widely applied to film and game industries. It also has a tight relationship to virtual reality and computational fabrication applications. The balance between accuracy and performance are the most important challenge in the design of an elastic simulation algorithm. This survey will begin with the basic knowledge of elastic simulation, and then investigate two major acceleration techniques for it. From the viewpoint of deformation energy, we introduce typical linearization and reduction ideas for accelerating. We also introduce some recent progress in projective and position-based dynamics, which mainly rely on special numerical methods. Besides, optimal control for elastic objects and typical collision resolving techniques are discussed. Finally, we discuss several possible future works on integrating elastic simulation into virtual reality and 3D printing applications.

关键词： computer graphics elastic simulation reduction linearization

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A Uniformly Convergent Numerical Method for Singularly Perturbed Nonlinear Eigenvalue Problems

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Communications in Computational Physics 2008年第6期4卷 135-160页

作者： Weizhu bao Ming-huang Chai Department of Mathematics and Center for Computational Science and Engineering National University of Singapore117543Singapore Department of Mathematics National University of Singapore117543Singapore. NUS High School National University of Singapore117543Singapore.

In this paper we propose a uniformly convergent numerical method for discretizing singularly perturbed nonlinear eigenvalue problems under constraints with applications in Bose-Einstein condensation and quantum *** begin with the time-independent Gross-Pitaevskii equation and show how to reformulate it into a singularly perturbed nonlinear eigenvalue problem under a *** asymptotic approximations for the problem are presented to locate the positions and characterize the widths of boundary layers and/or interior layers in the solution.A uniformly convergent numerical method is proposed by using the normalized gradient flow and piecewise uniform mesh techniques based on the asymptotic approximations for the *** numerical results are reported to demonstrate the effectiveness of our numerical method for the ***,the method is applied to compute ground and excited states of Bose-Einstein condensation in the semiclassical regime and some conclusive findings are reported.

关键词： Nonlinear eigenvalue problem Bose-Einstein condensation ground state excited state energy chemical potential piecewise uniform mesh.

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Diagnostic role of microRNA-125b for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 395-397页

作者： Feng Li quan-Wa bao Liu-Yi-Qi Jiang Qi-Lin huang Xu Zhang Ju-Xiang Chen Department of Neurosurgery Changzheng HospitalSecond Military Medical University415 Fengyang RoadShanghai200003China State Key Laboratory of Genetic Engineering School of Life SciencesFudan University2005 Songhu RoadShanghai 200433China

It is estimated that there was 841 0 0 0 new cases of liver cancer and 782 0 0 0 associated deaths worldwide in 2018,ranking as the sixth most common cancer and the fourth leading cause of cancer-related deaths[1].With approximately 90%of total cases,hepatocellular carcinoma(HCC)is the most frequent type of primary liver cancer,and is a major public global health challenge at present[1].The majority of HCC patients are usually at advanced stages when diagnosed,which misses the optimal treatment and prognosis is ***-fetoprotein(AFP)is the most widely applied diagnostic serum biomarker to detect HCC at present;however,the diagnostic accuracy of AFP is unsatisfactory,with sensitivity of 53%and specificity of 90%for early stage HCC[2].Recently,plenty of studies reported that microRNA-125b(miR-125b)might function as potential diagnostic biomarker in HCC[3–8].miR-125 family,consisting of miR-125a,miR-125b-1,and miR-125b-2,is closely associated with differentiation,proliferation,invasion,and metastasis of cancer ***,the diagnostic accuracy of miR-125b remains inconsistent.

关键词： hepatocellular invasion specificity

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Continuous non-autonomous memristive Rulkov model with extreme multistability

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Chinese Physics B 2021年第12期30卷 121-130页

作者： quan Xu Tong Liu Cheng-Tao Feng Han bao Hua-Gan Wu Bo-Cheng bao School of Microelectronics and Control Engineering Changzhou UniversityChangzhou 213164China

Based on the two-dimensional(2D)discrete Rulkov model that is used to describe neuron dynamics,this paper presents a continuous non-autonomous memristive Rulkov *** effects of electromagnetic induction and external stimulus are simultaneously considered *** electromagnetic induction flow is imitated by the generated current from a flux-controlled memristor and the external stimulus is injected using a sinusoidal ***,the presented model possesses a line equilibrium set evolving over the *** equilibrium set and their stability distributions are numerically simulated and qualitatively ***,numerical simulations are executed to explore the dynamical behaviors associated to the electromagnetic induction,external stimulus,and initial ***,the initial conditions dependent extreme multistability is elaborately disclosed in the continuous non-autonomous memristive Rulkov ***,an analog circuit of the proposed model is implemented,upon which the hardware experiment is executed to verify the numerically simulated extreme *** extreme multistability is numerically revealed and experimentally confirmed in this paper,which can widen the future engineering employment of the Rulkov model.

关键词： extreme multistability memristor electromagnetic induction Rulkov model

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Elongational Flow-induced Crystallization of Poly(L-lactic acid)Telechelic Ionomers

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Chinese Journal of Polymer Science 2024年第12期42卷 1957-1965,I0010页

作者： Fan Liu Shao-Yong huang Jian Tang quan Chen State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China

In this study,we prepared unentangled and slightly entangled poly(L-lactic acid)telechelic ionomer samples(Mn=5 and 16 kg/mol)based on sodium sulfonate *** telechelic samples exhibit extremely slow crystallization kinetics below the melting temperature T_(m) and above the glass transition temperature T_(g),which enables us to examine the linear viscoelasticity of the ionomer melt samples *** application of either the shear flow(at 85℃)or elongational flow(between 70 and 90℃)strongly accelerates the crystallization,leading to strong strain hardening and formation of highly orientedα*** on the relative average rates of the strain-induced dissociation and strain-induced crystallization,the stress evolution can be classified into two cases,and the critical work for strain-induced crystallization is higher in case where the strain-induced dissociation occurs earlier than the strain-induced crystallization.

关键词： Polylactides telechelic ionomers Flow-induced crystallization Strain-induced dissociation

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