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基于根因分析法的预见性护理对降低阴道分娩产妇产时出血的品管圈实践

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中国临床研究 2024年第8期37卷 1299-1303页

作者：梁晓涵包苏婉魏素花南京大学医学院附属鼓楼医院产科江苏南京210000

目的探讨基于根因分析法的预见性护理品管圈活动对降低阴道分娩产妇产时出血量的应用效果。方法建立品管圈,将活动主题确定为“降低产妇产时出血”,选取南京大学医学院附属鼓楼医院2022年3月14日至24日阴道分娩的43例产妇作为对照组,202... 详细信息

目的探讨基于根因分析法的预见性护理品管圈活动对降低阴道分娩产妇产时出血量的应用效果。方法建立品管圈,将活动主题确定为“降低产妇产时出血”,选取南京大学医学院附属鼓楼医院2022年3月14日至24日阴道分娩的43例产妇作为对照组,2022年9月5日至15日阴道分娩的43例产妇作为观察组。对照组采用常规护理方法,观察组采用基于根因分析法的预见性护理。比较两组产时出血发生率、出血量、会阴侧切率比及助产士的综合能力评分。结果对照组9例发生产时出血,观察组6例发生产时出血,两组产时出血发生率差异无统计学意义(20.93%vs 13.95%,χ^(2)=0.727,p.0.394)。观察组出血量较对照组显著降低[(532.3±138.9)mL vs(678.6±214.5)mL,t=3.754,p.0.05]。观察组会阴侧切率低于对照组,但差异无统计学意义(16.28%vs 25.58%,χ^(2)=1.124,p.0.289)。结论基于根因分析法的预见性护理的品管圈活动能够降低阴道分娩产妇产时出血量,同时减少子宫收缩乏力、会阴侧切引起的产时出血风险,提高助产士的综合能力。

关键词：品管圈阴道分娩产时出血根因分析法预见性护理

Fr.ntier. in high entr.p. alloys and high entr.p. functional mater.als

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r.r. Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen Huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao Jiang Xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian Wang bao-Long shen Zhe Jia Feng-Qi Zhang wei Wang Qi Liu Yang r.n Xun-Li Wang Xiao-Ya Cui Xiao-Yang Wang Ya-Nan Chen Bing-Bing Fan Meng-r. Li Qi-Long Gao Jia-Ming Guo Zeng-bao Jiao Zhi-Min Guo Yu-p.ng Zhao Qian Yu r.i Huang Ling-Kun Zhang Yi-p.ng Lu Xu-Bo Li Huai-Jun Lin Yan Ma wei-Ming Yang Zhi-Hua shen Hai-Yan He Yong-Gang Sun Yong-Jiang Huang De-Zhuang Wang Qing-Feng Liu Fei-Yang Wang Hui Liu Hong-Hui Wu Li-Qiang Wang Yang Lu Nan Wang Tian-Li Wang wei-Bing Liao Yi-Han Wang Yuan Wu Yu-Zhen Yin Jie p.n Yi Zhang Qing Wang Jian-Yang Zhang Tao Yang Yasir.Sohail Jin-Yu Zhang Hua Ji Qiang Li wei-Di Liu Zhi-Gang Chen Xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo Wu School of Mater.als Science and Engineer.ng Nanjing University of Science and Technology Jiangsu Key Labor.tor. for.Advanced Metallic Mater.als School of Materials Science and Engineering Southeast University department of p.ysics City University of Hong Kong School of Mater.als Science and Engineer.ng Tianjin University School of p.ysics and Micr.electr.nics Zhengzhou University department of Mechanical Engineer.ng Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center.of Electr.n Micr.scop. and State Key Labor.tor. of Silicon Mater.als School of Materials Science and Engineering Zhejiang University Key Labor.tor. of Solidification Contr.l and Digital p.ep.r.tion Technology (Liaoning p.ovince) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear.& Cor.osion r.sistance and Functional Mater.als Jinan University School of Mechanics and Civil Engineer.ng China University of Mining and Technology School of p.ysical Sciences Great Bay University School of Mater.als Science andEngineer.ng Harbin Institute of Technology State Key Labor.tor. of Mater.als-Or.ented Chemical Engineer.ng College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center.for.Mater.als Genome Engineer.ng Research Institute for Carbon Neutrality University of Science and Technology Beijing department of Mechanical Engineer.ng The University of Hong Kong School of Comp.ting Macquarie University Key Labor.tor. of Op.oelectr.nic Devices and Systems of Ministr. of Education and Guangdong p.ovince College of Physics and Optoelectronic Engineering Shenzhen University State Key Labor.tor. for.Advanced Metals and Mater.als University of Science and Technology Beijing State Key Labor.tor. of Mater.als p.ocessing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of mater.als Shanghai University department of Mater.als Science and Engineer.ng C

Owing to their.excep.ional p.op.r.ies, high-entr.p. alloys(HEAs) and high-entr.p. mater.als have emer.ed as p.omising r.sear.h ar.as and shown diver.e ap.lications. Her.,the r.cent advances in the field ar. comp.ehensively r.viewed,or.anized into five sections. The fir.t section intr.duces the backgr.und of HEAs, cover.ng their.definition, significance,ap.lication p.osp.cts, basic p.op.r.ies, design p.incip.es, and micr.str.ctur.. The subsequent section focuses on cutting-edge high-entr.p. str.ctur.l mater.als, highlighting develop.ents such as nanostr.ctur.d alloys, gr.in boundar. engineer.ng,eutectic systems, cr.ogenic alloys, thin films, micr.-nano-lattice str.ctur.s, additive manufactur.ng, high entr.p. metallic glasses, nano-p.ecip.tate str.ngthened alloys, comp.sition modulation, alloy fiber., and r.fr.ctor. systems. In the following section, the emp.asis shifts to functional mater.als, exp.or.ng HEAs as catalysts, magneto-calor.c mater.als, cor.osion-r.sistant alloys, r.diation-r.sistant alloys, hydr.gen stor.ge systems, and mater.als for.biomedicine. Additionally, the r.view encomp.sses functional high-entr.p. mater.als outside the r.alm of alloys, including ther.oelectr.c, quantum dots, nanooxide catalysts, ener.y stor.ge mater.als, negative ther.al exp.nsion cer.mics,and high-entr.p. wave absor.0}ion mater.als. The p.p.r.concludes with an outlook, discussing futur. dir.ctions and p.tential gr.wth ar.as in the field. Thr.ugh this comp.ehensive r.view,r.sear.her., engineer., and scientists may gain valuable insights into the r.cent p.ogr.ss and op.or.unities for.fur.her.exp.or.tion in the exciting domains of high-entr.p. alloys and functional mater.als.

关键词： Cutting-edge str.ctur.l mater.als Cutting-edgefunctional mater.als High entr.p. alloys

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for.the diagnosis and tr.atment of gastr.c cancer. 2023

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Cancer.Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang Xiao-Tian Zhang Lei Tang Qi Wu Mu-Yan Cai Yuan-Fang Li Xiu-Juan Qu Hong Qiu Yu-Jing Zhang Jie-Er.Ying Jun Zhang Ling-Yu Sun r.ng-Bo Lin Chang Wang Hao Liu Miao-Zhen Qiu Wen-Long Guan sheng-Xiang r.o Jia-Fu Ji Yan Xin wei-Qi sheng Hui-Mian Xu Zhi-wei Zhou Ai-p.ng Zhou Jing Jin Xiang-Lin Yuan Feng Bi Tian-Shu Liu Han Liang Yan-Qiao Zhang Guo-Xin Li Jun Liang bao-r.i Liu Lin shen Jin Li r.i-Hua Xu department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of Gastr.intestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China department of r.diology Peking University Cancer HospitalBeijingP.R.China department of Endoscop. Center Peking University Cancer HospitalBeijingP.R.China department of p.thology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China department of Gastr.c Sur.er. Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China department of r.diother.p. Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China department of Sur.ical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor.Center The First Hospital of Jilin UniversityChangchunJilinP.R.China department of Gener.l Sur.er. Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China department of r.diology Zhongshan HospitalFudan UniversityShanghaiP.R.China department of

The 2023 up.ate of the Chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for.Gastr.c Cancer.focuses on standar.izing cancer.diagnosis and tr.atment in china,r.flecting the latest advancements in evidence-based medicine,healthcar. r.sour.e availability,and p.ecision *** up.ates addr.ss the differ.nces in ep.demiological char.cter.stics,clinicop.tho-logical featur.s,tumor.biology,tr.atment p.tter.s,and dr.g selections between Easter. and Wester. gastr.c cancer.*** r.visions include a str.ctur.d temp.ate for.imaging diagnosis r.p.r.s,up.ated standar.s for.molecular.mar.er.testing in p.thological diagnosis,and an elevated r.commendation for.neoadju-vant chemother.p. in stage III gastr.c *** advanced metastatic gastr.c cancer.the guidelines intr.duce new r.commendations for.immunother.p.,anti-angiogenic ther.p. and tar.eted dr.gs,along with up.ated management str.tegies for.human ep.der.al gr.wth factor.r.cep.or.2(HEr.)-p.sitive and deficient DNA mismatch r.p.ir.dMMr./micr.satellite instability-high(MSI-H)***,the guidelines offer.detailed scr.ening r.commendations for.her.ditar. gastr.c cancer.and an ap.endix listing dr.g tr.atment r.gimens for.var.ous stages of gastr.c *** 2023 CSCO Clinical Guidelines for.Gastr.c Cancer.up.ates ar. based on both Chinese and inter.ational clinical r.sear.h and exp.r. consensus to enhance their.ap.licability and r.levance in clinical p.actice,p.r.icular.y in the heter.geneous healthcar. landscap. of china,while maintaining a commitment to scientific r.gor.imp.r.iality,and timely r.visions.

关键词： Chinese Society of Clinical Oncology(CSCO) gastr.c cancer diagnosis sur.er. neoadjuvant adjuvant r.diother.p. chemother.p. tar.eted ther.p. immunother.p.

江苏省2016—2021年临床分离铜绿假单胞菌耐药及基因组特征分析

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中国感染控制杂志 2024年第4期23卷 467-474页

作者：聂俊伟周璐瞿志鹏洪捷鲍倡俊谈忠鸣南京诺唯赞生物科技股份有限公司生命科学事业部江苏南京210038 东南大学生命科学与技术学院江苏南京210096 国家卫生健康委员会肠道病原微生物重点实验室江苏省疾病预防控制中心江苏南京210009

目的了解江苏地区临床分离的铜绿假单胞菌耐药情况及基因特征。方法收集2016—2021年江苏地区各哨点医院临床分离的铜绿假单胞菌,采用肉汤稀释法对分离株进行10类19种抗菌药物的敏感性测定,对分离株行全基因组测序并多位点序列分型,综... 详细信息

目的了解江苏地区临床分离的铜绿假单胞菌耐药情况及基因特征。方法收集2016—2021年江苏地区各哨点医院临床分离的铜绿假单胞菌,采用肉汤稀释法对分离株进行10类19种抗菌药物的敏感性测定,对分离株行全基因组测序并多位点序列分型,综合抗菌药物耐药性数据库(CAr.)扫描分析耐药基因。结果2016—2021年通过致病菌识别网12个市的哨点医院收集患者分离的铜绿假单胞菌101株。药敏试验结果显示,全部菌株对共计6类8种抗菌药物全部耐药,包括酰胺醇类抗生素氯霉素、磺胺类的复方磺胺甲口恶唑、头孢菌素类的头孢噻肟和头孢唑林、四环素类的四环素、青霉素类的氨苄西林及氨苄西林/舒巴坦以及β-内酰胺类的阿莫西林/克拉维酸;45.54%的分离株为碳青霉烯类耐药菌株,对亚胺培南、美罗培南两种碳青霉烯类抗生素的耐药率已分别达45.54%、39.60%;耐10种以上抗生素的菌株达63.36%;共发现35种耐药表型,其中1株菌对19种抗菌药物广泛耐药,耐药谱为AMC-AM-SAM-CZ-CTX-C-TE-SXT的菌株最多(31.69%,32株)。多位点序列分析发现75个ST型,聚类发现ST 262处于中心点,并遗传进化出11个亚型或分支。全基因组扫描发现6类18种抗菌药物耐药基因,cr.0}p.因的携带情况与表型完全一致。结论2016—2021年江苏地区临床分离的铜绿假单胞菌耐药情况严重,两种碳青霉烯类抗生素的耐药率、耐10种以上抗生素的菌株比例高于国内其他省份,应引起高度重视。

关键词：铜绿假单胞菌耐药性全基因组测序耐药基因多位点序列分型

Univer.ality of slip.avalanches in a ductile Fe-based bulk metallic glass

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Jour.al of Ir.n and Steel r.sear.h Inter.ational 2017年第4期24卷 366-371页

作者： Jiao-jiao Li Jun-wei Qiao Kar.n A.Dahmen wei-ming Yang bao-long shen Ming-wei Chen Labor.tor. of Ap.lied p.ysics and Mechanics of Advanced Mater.als College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024ShanxiChina Key Labor.tor. of Inter.ace Science and Engineer.ng in Advanced Mater.als Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024ShanxiChina department of p.ysics University of Illinois at Urbana-ChampaignIllinois 61801USA State Key Labor.tor. for.Geomechanics and Deep.Under.r.und Engineer.ng School of Mechanics and Civil EngineeringChina University of Mining and TechnologyXuzhou 221116JiangsuChina School of Mater.als Science and Engineer.ng Southeast UniversityNanjing 211189JiangsuChina Advanced Institute for.Mater.als r.sear.h Tohoku UniversitySendal 980-8577Japan

Inter.ittent ser.ated flows of a novel ductile Fe60Ni20p.3C7 bulk metallic glass（BMG）at var.ant str.in r.tes wer. investigated by statistics *** and clutter.distr.bution of slip.avalanche magnitudes ar. disp.ayed dur.ng stable p.astic flows at str.in r.tes of 2×10-4 s-1 and 5×10-5 s-1,r.sp.ctively,which means that ser.ation behavior.dep.nds on the str.in ***,the r.mar.able agr.ement between measur.d slip.avalanche magnitudes and the scaling behavior.i.e.a univer.al comp.ementar. cumulative distr.bution function（CCDF）p.edicted by mean-field theor.（MFT）model,indicates that the p.asticity of the p.esent Fe-based BMGs can be tuned by imp.sed str.in r.tes：Smax^6）ε-λ.This tuned p.asticity is elucidated with exp.nded fr.e-volume ***,the scaling behavior.of ser.ated flows for.other.str.in r.tes can be p.edicted as well.

关键词： Bulk metallic glass Slip.avalanche p.asticity Mean-field theor. model Str.in r.te

Solute car.ier.r.lated signatur. for.assessing p.ognosis and immunity in p.tients with clear.cell r.nal cell car.inoma

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Oncology r.sear.h 2023年第2期31卷 181-192页

作者： wei bao QIANGUANG HAN XIAO GUAN ZIJIE WANG MIN GU department of Ur.logy The Second Affiliated Hospital of Nanjing Medical UniversityNanjingChina department of Ur.logy The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina department of Gener.l Sur.er. The Second Affiliated Hospital of Nanjing Medical UniversityNanjingChina

Backgr.und:Clear.cell r.nal cell car.inoma(ccr.C)is the most common malignant kidney ***,the tumor.micr.envir.nment and cr.sstalk involved in metabolic r.p.ogr.mming in ccr.C ar. not ***:We used The Cancer.Genome Atlas to obtain ccr.C tr.nscr.p.ome data and clinical *** EMTAB-1980 cohor. was used for.exter.al *** GENECAr.S database contains the fir.t 100 solute car.ier.SLC)-r.lated *** p.edictive value of SLC-r.lated genes for.ccr.C p.ognosis and tr.atment was assessed using univar.ate Cox r.gr.ssion *** SLC-r.lated p.edictive signatur. was develop.d thr.ugh Lasso r.gr.ssion analysis and used to deter.ine the r.sk p.ofiles of p.tients with *** in each cohor. wer. sep.r.ted into high-and low-r.sk gr.up. based on their.r.sk *** clinical imp.r.ance of the signatur. was assessed thr.ugh sur.ival,immune micr.envir.nment,dr.g sensitivity,and nomogr.m analyses using r.***:SLC25A23,SLC25A42,SLC5A1,SLC3A1,SLC25A37,SLC5A6,SLCO5A1,and SCp. comp.ised the signatur.s of the eight SLCr.lated *** with ccr.C wer. sep.r.ted into high-and low-r.sk gr.up. based on the r.sk value in the tr.ining and validation cohor.s;the high-r.sk gr.up.had a significantly wor.e p.ognosis(p.0.001).The r.sk scor. was an indep.ndent p.edictive indicator.of ccr.C in the two cohor.s accor.ing to univar.ate and multivar.ate Cox r.gr.ssion(p.0.05).Analysis of the immune micr.envir.nment showed that immune cell infiltr.tion and immune checkp.int gene exp.ession differ.d between the two gr.up.(p.0.05).Dr.g sensitivity analysis showed that comp.r.d to the low-r.sk gr.up.the high-r.sk gr.up.was mor. sensitive to sunitinib,nilotinib,JNK-inhibitor.VIII,dasatinib,bosutinib,and bor.ezomib(p.0.001).Sur.ival analysis and r.ceiver.op.r.ting char.cter.stic cur.es wer. validated using the E-MTAB-1980 ***:SLC-r.lated genes have p.edictive r.levance in ccr.C and p.ay r.les in the immunological milieu

关键词： Clear.cell r.nal cell car.inoma Solute car.ier Bioinfor.atics Metabolic r.p.ogr.mming Immune micr.envir.nment

比较不同分子量羟乙基淀粉对血流动力学、凝血功能及肾功能的影响

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现代生物医学进展 2011年第S2期11卷 5053-5056页

作者：高玉洁韩流张勇史宏伟鲍红光南京医科大学附属南京第一医院麻醉科江苏南京210006

目的:对比进口6%羟乙基淀粉200/0.5(6%HES200/0.5,贺斯)和6%羟乙基淀粉130/0.4(6%HES130/0.4,万汶)对术中血流动力学、凝血功能及肾功能的影响。方法:84例择期手术的患者随机分为6%HES200/0.5组(H组,n=42)和6%HES130/0.4组(V组,n=42),分别在手术开始后输注6%HES200/0.5或6%HES130/0.41000mL。监测麻醉前(T0)、输注开始时(T1)、开始后30min(T2)、1h(T3)和输注结束时(T4)血流动力学参数;在T0、T4和输注结束后24h(T5)抽取静脉血及留取尿液标本,检测凝血功能和肾功能指标。结果:和T0相比,T1、T2时两组SBp.DBp.低,Hr.高(p.0.05);T3、T4时,SBp.DBp.Hr.差异(p.0.05);T4时p.和Ap.T升高,FIB和p.t计数下降(p.0.05);而在T5时,各项凝血功能指标均无差异(p.0.05)。在各个时间点,两组的血流动力学参数和凝血功能指标均在正常值范围之内,组间两两比较均无统计学差异(p.0.05)。在T0、T4和T5时,两组各项肾功能指标组内和组间两两比较均无差异(p.0.05)。结论:两种羟乙基淀粉均能有效维持术中血流动力学稳定,对凝血功能和肾功能影响很小,都是在手术中耐受性佳、安全性较高的扩容药物。

关键词：羟乙基淀粉血流动力学凝血功能肾功能

p.ep.r.tion of magnetic r.sonance p.obes using one-p.t method for.detection of hep.tocellular.car.inoma

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Wor.d Jour.al of Gastr.enter.logy 2015年第14期21卷 4275-4283页

作者： You-wei Li Zheng-Guang Chen Zhou-she Zhao Hong-Li Li Ji-Chen Wang Zong-Ming Zhang department of r.diology Beijing Chuiyangliu Hospital Affiliated to School of MedicineTsinghua University department of r.diology Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine GE Healthcar. china Beijing Economic and Technology Development Area department of r.diology Nanjing Ben Q Hospital department of Gener.l Sur.er. Beijing Electric Power HospitalCapital Medical University

AIM: To p.ep.r. the sp.cific magnetic r.sonance(Mr. p.obes for.detection of hep.tocellular.car.inoma(HCC) using one-p.t ***: The car.oxylated dextr.n-coated nanop.r.icles wer. conjugated with anti-α-fetop.otein(anti-AFp. or.anti-glyp.can 3(anti-Gp.3) antibodies thr.ugh 1-(3-dimethylaminop.op.l)-3-ethylcar.odiimide hydr.chlor.de/N-hydr.xysuccinimide(EDC/NHS)-mediated r.action to synthesize the *** p.ysical and chemical p.op.r.ies of the p.obes wer. deter.ined by tr.nsmission electr.n micr.scop.(TEM) and dynamic light scatter.ng, and the r.laxivity was comp.r.d to uncombined ultr.small sup.r.0}r.magnetic ir.n oxide nanop.r.icles(USp.ONs) using a 1.5T clinical Mr.*** binding efficiency of the antibodies to nanop.r.icles was measur.d with an ultr.violetvisible *** addition, the p.obes wer. incubated with tar.etable cells in ***: The sup.r.0}r.magnetic Mr.p.obes(antiGp.3-USp.ON p.obe and anti-AFp.USp.ON p.obe) wer. synthesized using one-p.t *** mean hydr.dynamic diameter.was 47 nm with a br.ader.slight size *** coup.ing efficiency of car.oxylated dextr.n-coated ultr.small sup.r.0}r.magnetic ir.n oxide(USp.O) with anti-Gp.3 or.anti-AFp.antibody was 15.9% and 88.8%, *** of the USp.O nanop.r.icles may bind 3 Gp.3 antibodies or.12 AFp.*** statistical analysis showed no significance(p.> 0.05) in shor.ening the T1 and T2 values when comp.r.ng the USp.O-AFp.or.USp.OGp.3 to *** of TEM images r.vealed that anti-Gp.3-USp.ON p.obes and anti-AFp.USp.ON p.obes could sp.cifically enter.into the Hep.G2 cell by combining with the Gp.3 r.cep.or. or.AFp.r.cep.or., wher.as the Hep.G2 cell samp.e incubated with USp.ONs showed no or.few nanop.r.icles in the ***: The synthesized p.obes using one-p.t method can be used for.in vitr. exp.r.mental study and have p.tential clinical ap.lication in Mr.imaging for.detection of hep.tocellular.car.inomas.

关键词： Hep.tocellular car.inoma Ultr.small sup.r.0}r.magne

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深低温停循环对大脑皮层神经细胞凋亡的影响

现代医学 2004年第3期32卷 187-189页

作者：陶运明莫绪明彭卫戚继荣钱龙宝顾海涛南京医科大学附属南京儿童医院心胸外科江苏南京210008

目的　观察深低温停循环对大脑皮层神经细胞凋亡的影响。方法　取SD大鼠 3 0只 ,随机分为 3组 :深低温对照 (DHC)组、常温对照 (NTC)组和深低温停循环组 (DHCA)组 ,采用大鼠深低温双侧颈总动脉阻断后再灌注模型 ,在2 1℃时将双侧颈总动... 详细信息

目的　观察深低温停循环对大脑皮层神经细胞凋亡的影响。方法　取SD大鼠 3 0只 ,随机分为 3组 :深低温对照 (DHC)组、常温对照 (NTC)组和深低温停循环组 (DHCA)组 ,采用大鼠深低温双侧颈总动脉阻断后再灌注模型 ,在2 1℃时将双侧颈总动脉阻断 60min ,再灌注 2 4h后取大脑皮层细胞制成细胞悬液 ,流式细胞仪分析细胞凋亡改变 ,电镜观察细胞超微结构的变化 ,对实验数据进行统计分析。结果　NTC组有 5只死亡。DHC组、NTC组和DHCA组的大脑皮层细胞凋亡率分别为 ( 2 .2 0± 0 .43 ) %、( 19.2 3± 1.0 1) %和 ( 4 .72± 1.0 2 ) % ,差异有显著意义 (p.<0 .0 0 1)。结论　深低温停循环能增强大脑细胞对缺氧的耐受性。

关键词：深低温停循环大脑皮层神经细胞双侧颈总动脉 DHCA 凋亡对照结论实验数据目的