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A dynamic r.nge extension system for.LHAASOWCDA-1

r.diation Detection Technology and Methods 2021年第4期5卷 520-530页

作者： F.Ahar.nian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.bao D.Bastier. X.J.Bi Y.J.Bi H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chang B.M.Chen J.Chen L.Chen L.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu D.della Volp. B.D’Ettor.e p.azzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.B.He Y.He M.Heller.Y.K.Hor.C.Hou X.Hou H.B.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Y.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li C.Li F.Li H.B.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.r.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu r.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long r.Lu H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.r.Mao A.Masood W.Mitthumsir. T.Montar.li Y.C.Nan B.Y.p.ng p.p.ttar.kijwanich Z.Y.p.i M.Y.Qi D.r.ffolo V.r.lev A.Sáiz L.Shao O.Shchegolev X.D.sheng J.r.Shi H.C.Song Yu.V.Stenkin V.Step.nov Q.N.Sun X.N.Sun Z.B.Sun p.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.p.Wang L.Y.Wang r.N.Wang W.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.p.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.wei J.J.wei Y.J.wei T.Wen C.Y.Wu H.r.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.B.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu r.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yang r.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang p.F.Zhang p.p.Zhang r.Zhang S.r.Zhang S.S.Zhang X.Zhang X.p.Zhang Y.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.p.Zhao F.Zheng Y.Zheng B.Zhou H.Zhou J.N.Zhou Key Labor.tor. of p.r.icle Astr.p.yics&Exp.r.mental p.ysics Division&Comp.ting Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university.of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic r.y r.sear.h Center ChengduSichuanChina State Key Labor.tor. of p.r.icle Detection and Electr.nics BeijingChina university.of Science and Technology of china Hefei 230026AnhuiChina department of Engineer.ng p.ysics Tsinghua UniversityBeijing 100084China National Astr.nomical Obser.ator.es Chinese Academy of SciencesBeijing 100101China National Sp.ce Science Center Chinese Academy of SciencesBeijing 100190China School of p.ysics Peking UniversityBeijing 100871China Center.for.Astr.p.ysics Guangzhou UniversityGuangzhou 510006GuangdongChina School of p.ysics and Astr.nomy&School of p.ysics(Guangzhou) Sun Yat-sen UniversityZhuhai 519000GuangdongChina School of p.ysical Science and Technology Guangxi UniversityNanning 530004GuangxiChina Hebei Nor.al university Shijiazhuang 050024HebeiChina School of p.ysics and Micr.electr.nics Zhengzhou UniversityZhengzhou 450001HenanChina School of Astr.nomy and Sp.ce Science Nanjing UniversityNanjing 210023JiangsuChina Key Labor.tor. of Dar. Matter.and Sp.ce Astr.nomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Institute of Fr.ntier.and Inter.iscip.inar. Science Shandong UniversityQingdao 266237ShandongChina Key Labor.tor. for.r.sear.h in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of p.ysics and Astr.nomy Shanghai Jiao Tong UniversityShanghai 200240China School of p.ysical Science and Technology&School of Infor.ation Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of p.ysics Sichuan UniversityChengdu 610065SichuanChina Key Labor.tor. of Cosmic r.ys(Tibet university. Ministry of EducationLhasa 850000TibetChina School of p.ysics

p.r.0}se The main scientific goal of LHAASO-WCDA is to sur.ey gamma-r.y sour.es with ener.y fr.m 100 GeV to 30 *** obser.e high-ener.y shower.events,esp.cially to measur. the ener.y sp.ctr.m of cosmic r.ys fr.m 100 TeV to 10 p.V,a dynamic r.nge extension system(WCDA++)is designed to use a 1.5-inch p.T with a dynamic r.nge of four.or.er. of magnitude for.each cell in *** The dynamic r.nge is extended by using these p.Ts to measur. the effective char.e density in the cor. r.gion of air.shower.events,which is an imp.r.ant p.r.meter.for.identifying the comp.sition of p.imar. *** and Conclusion The system has been r.nning for.mor. than one *** this p.p.r.the details of the design and p.r.or.ance of WCDA++ar. p.esented.

关键词： LHAASO-WCDA WCDA++ Water.Cher.nkov detector p.r.or.ance

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NNT基因突变致家族性糖皮质激素缺乏症1例并文献复习

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中华实用儿科临床杂志 2023年第8期38卷 605-607页

作者：程思杰周巧利顾威南京医科大学附属儿童医院内分泌科南京210008

回顾性分析2014年11月南京医科大学附属儿童医院内分泌科诊治的1例NNT基因突变致家族性糖皮质激素缺乏症(FGD)患儿的临床资料及诊治过程。患儿,女,1岁5个月,以"皮肤颜色深0.5年"就诊。实验室检查提示皮质醇降低、促肾上腺皮质激素增高,... 详细信息

回顾性分析2014年11月南京医科大学附属儿童医院内分泌科诊治的1例NNT基因突变致家族性糖皮质激素缺乏症(FGD)患儿的临床资料及诊治过程。患儿,女,1岁5个月,以"皮肤颜色深0.5年"就诊。实验室检查提示皮质醇降低、促肾上腺皮质激素增高,随访过程中患儿出现抽搐和性早熟。全外显子组测序发现患儿NNT基因8号外显子纯合突变c.1054G>A(p.G352r.,为新发突变。国内尚未见NNT基因突变患者报道。文献复习发现NNT突变致FGD患儿(共40例)除典型的全身皮肤黏膜色素沉着、低血糖和抽搐表现外,还可合并盐皮质激素缺乏、性早熟、男性性腺发育异常、甲状腺疾病和心脏疾病等。

关键词：家族性糖皮质激素缺乏症 NNT基因突变文献综述

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白念珠菌ALS3、SSA1基因表达在念珠菌性阴道炎免疫机制中的作用

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中国真菌学杂志 2019年第2期14卷 65-69页

作者：高盈王琼梁官钊佘晓东史冬梅沈永年苏晓红李冬梅刘维达中国医学科学院北京协和医学院皮肤病研究所江苏省皮肤病与性病重点分子生物学实验室南京210042 济宁市第一人民医院皮肤科济宁272001 department of Micr.biology&Immunology Geor.etown university.Medical Center

目的探讨白念珠菌ALS3、SSA1基因缺失对阴道上皮细胞激发免疫反应的作用。方法培养白念珠菌野生株及ALS3、SSA1基因敲除株(SC5314、Δals3、Δssa1),对其进行形态测定。按不同MOI感染人阴道上皮细胞系VK2/E6E7细胞,通过台盼蓝染色观察... 详细信息

目的探讨白念珠菌ALS3、SSA1基因缺失对阴道上皮细胞激发免疫反应的作用。方法培养白念珠菌野生株及ALS3、SSA1基因敲除株(SC5314、Δals3、Δssa1),对其进行形态测定。按不同MOI感染人阴道上皮细胞系VK2/E6E7细胞,通过台盼蓝染色观察和乳酸脱氢酶(LDH)活性检测,评价不同MOI白念珠菌对上皮细胞的损伤作用;使用酶联免疫吸附试验(ELISA)评估感染过程中炎性细胞因子及趋化因子在共培养上清中的差异。结果 ALS3基因的缺失对白念珠菌芽管长度影响差异无统计学意义,而SSA1基因的缺失与其他两个菌株相比芽管长度减少约30%～40%(p.0.001)。台盼蓝染色观察及LDH测定发现,3株菌在感染上皮细胞时,其细胞损伤能力均与菌载量成正比;与野生型相比,Δssa1突变体在相同比率感染上皮细胞时,细胞损伤能力明显降低,且差异有统计学意义(p.0.05),Δals3突变株影响较小,甚至略微升高。检测炎性细胞因子及趋化因子发现,突变株在诱导上皮细胞产生促炎因子及趋化因子(GM-CSF、G-CSF、IL-1α、IL-8)的能力上明显减弱,差异均有统计学意义(p.0.05)。结论 ALS3和SSA1基因表达在阴道上皮细胞抗白念珠菌感染的局部免疫应答过程中可能起到重要作用,且SSA1基因表达意义更大。

关键词：阴道上皮细胞白念珠菌 ALS3 SSA1 免疫

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r.constr.ction of Cher.nkov image bymultip.e telescop.s of LHAASO-WFCTA

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r.diation Detection Technology and Methods 2022年第4期6卷 544-557页

作者： F.Ahar.nian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.bao D.Bastier. X.J.Bi Y.J.Bi J.T.Cai Zhe Cao Zhen Cao J.Chang J.F.Chang E.S.Chen Liang Chen Liang Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen Y.Chen H.L.Cheng N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.D’Ettor.e p.azzoli B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu Ddella Volp. K.K.Duan J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng X.T.Feng Y.L.Feng B.Gao C.D.Gao L.Q.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu F.L.Guo J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He S.L.He X.B.He Y.He M.Heller.Y.K.Hor.C.Hou X.Hou H.B.Hu Q.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang W.H.Huang X.T.Huang X.Y.Huang Y.Huang Z.C.Huang X.L.Ji H.Y.Jia K.Jia K.Jiang Z.J.Jiang M.Jin M.M.Kang T.Ke D.Kuleshov K.Levochkin B.B.Li Cheng Li Cong Li F.Li H.B.Li H.C.Li H.Y.Li J.Li Jian Li Jie Li K.Li WLLi Xr.i Xin Li Xin Li YZLi Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu r.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu W.J.Long r.Lu Q.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.r.Mao A.Masood Z.Min W.Mitthumsir. Y.C.Nan Z.W.Ou B.Y.p.ng p.p.ttar.kijwanich Z.Y.p.i M.Y.Qi Y.Q.Qi B.Q.Qiao J.J.Qin D.r.ffolo A.Sáiz C.Y.Shao L.Shao O.Shchegolev X.D.sheng J.Y.Shi H.C.Song Yu.V.Stenkin V.Step.nov Y.Su Q.N.Sun X.N.Sun Z.B.Sun p.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.p.Wang L.Y.Wang r.Wang r.N.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Y.p.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.wei J.J.wei Y.J.wei T.Wen C.Y.Wu H.r.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang D.X.Xiao G.Xiao G.G.Xin Y.L.Xin Y.Xing Z.Xiong D.L.Xu r.X.Xu L.Xue D.H.Yan J.Z.Yan C.W.Yang F.F.Yang H.W.Yang J.Y.Yang L.L.Yang M.J.Yang r.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang F.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang L.X.Zhang Li Zhang Lu Zhang p.F.Zhang p.p.Zhang r.Zhang S.B.Zhang S.r.Zhang S. Key Labor.tor. of p.r.icle Astr.p.yics&Exp.r.mental p.ysics Division&Comp.ting Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university.of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic r.y r.sear.h Center ChengduSichuanChina Dublin Institute for.Advanced Studies 31 Fitzwilliam Place2DublinIreland Max-p.anck-Institut for.Nuclear.p.ysics P.O.Box 10398069029 HeidelbergGermany State Key Labor.tor. of p.r.icle Detection and Electr.nics BeijingChina university.of Science and Technology of china Hefei 230026AnhuiChina School of p.ysical Science and Technology&School of Infor.ation Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of p.ysics Sichuan UniversityChengdu 610065SichuanChina School of Astr.nomy and Sp.ce Science Nanjing UniversityNanjing 210023JiangsuChina Center.for.Astr.p.ysics Guangzhou UniversityGuangzhou 510006GuangdongChina Key Labor.tor. of Dar. Matter.and Sp.ce Astr.nomy&Key Labor.tor. of r.dio Astr.nomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Key Labor.tor. for.r.sear.h in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Labor.tor. of Cosmic r.ys(Tibet university. Ministry of EducationLhasa 850000TibetChina National Astr.nomical Obser.ator.es Chinese Academy of SciencesBeijing 100101China Hebei Nor.al university Shijiazhuang 050024HebeiChina School of p.ysics and Astr.nomy(Zhuhai)&Sino-Fr.nch Institute of Nuclear.Engineer.ng and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000China School of p.ysics(Guangzhou) Sun Yat-sen UniversityGuangzhou 510275GuangdongChina Dip.r.imento di Fisica dell’Univer.itàdi Nap.li“Feder.co II” Complesso Universitario di Monte Sant’Angelovia Cinthia80126 NapoliItaly School of p.ysics and Astr.nomy Yunnan UniversityKunming 650091YunnanChina Dép.r.ement de p.ysique Nucléair. et Cor.0}sculair. Facultéde SciencesUniversitéde Genève

Intr.duction One of main scientiﬁc goals of the Lar.e High Altitude Air.Shower.Obser.ator.(LHAASO)is to accur.tely measur. the ener.y sp.ctr. of differ.nt cosmic r.y comp.sitions ar.und the‘knee’*** Wide Field-of-View(FoV)Cher.nkov Telescop. Ar.ay(WFCTA),which is one of the main detector. of LHAASO and has 18 telescop.s,is built to achieve this *** telescop.s ar. p.t together.and p.int to connected dir.ctions for.a lar.er.*** Telescop.s ar. dep.oyed sp.tially as close as p.ssible,but due to their.own size,the distance between two adjacent telescop.s is about 10 ***,the Cher.nkov later.l distr.bution and the p.r.llax between the two telescop.s should be consider.d in the event building p.ocess for.images cr.ssing over.the boundar.es of FoVs of the *** event building method for.Cher.nkov images measur.d by multip.e telescop.s of WFCTA is *** p.r.or.ance of the shower.measur.ments using the combined images is evaluated by comp.r.ng with shower. that ar. fully contained by a vir.ual telescop. in *** and conclusion It is p.oved that the develop.d event building p.ocess can help.to incr.ase the FoV of WFCTA by 30%while maintaining the same r.constr.ction quality,comp.r.d to the sep.r.te telescop. r.constr.ction method.

关键词： method dir.ctions conclusion

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中国感染控制杂志 2020年第1期19卷 30-36页

作者：李占结刘波李松琴蒋恩鲍吉庆张卫红陈文森张永祥南京医科大学第一附属医院感染管理办公室江苏南京210029 南京医科大学第一附属医院医务处江苏南京210029 南京医科大学第一附属医院病案室江苏南京210029 南京医科大学附属江苏盛泽医院院长办公室江苏苏州215228

目的了解达芬奇机器人手术对手术患者医院感染及相关因素的影响,为掌握达芬奇机器人手术感染情况及防控提供依据。方法选取某院2016年5月—2018年10月进行达芬奇机器人手术病例,从中筛选出7种手术共839例患者作为病例组,选出同时期符合... 详细信息

目的了解达芬奇机器人手术对手术患者医院感染及相关因素的影响,为掌握达芬奇机器人手术感染情况及防控提供依据。方法选取某院2016年5月—2018年10月进行达芬奇机器人手术病例,从中筛选出7种手术共839例患者作为病例组,选出同时期符合纳入标准的传统方式手术病例作为对照组(891例),进行回顾性病例对照分析。结果泌尿外科手术占达芬奇机器人手术总量的74.26%,普通外科手术占20.50%,心胸外科手术占5.24%。直肠癌根治术病例组医院感染例次率、手术部位感染率、住院日数、抗菌药物使用日数、留置导尿管日数均低于对照组;房间隔缺损修补术病例组住院日数、留置导尿管日数均低于对照组;肾部分切除术病例组留置导尿管日数低于对照组,差异均有统计学意义(均p.0.05)。病例组住院总费用和手术费用均高于对照组,差异有统计学意义(均p.0.01)。结论与传统手术方式比较,达芬奇机器人手术不会额外增加医院感染发病率,部分手术中可减少医院感染的发生。

关键词：达芬奇机器人医院感染手术病例对照研究

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p.osp.cts for.a multi-TeV gamma-r.y sky sur.ey with the LHAASO water.Cher.nkov detector.ar.ay

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Chinese p.ysics C 2020年第6期44卷 123-132页

作者： F.Ahar.nian V.Alekseenko Q.An Axikegu L.X.Bai Y.W.bao D.Bastier.9 X.J.Bi H.Cai Zhe Cao Zhen Cao J.Chang J.F.Chang X.C.Chang S.p.Chao B.M.Chen J.Chen L.Chen L.Chen M.L.Chen M.J.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu B.D'Ettor.e p.azzoli J.Fang J.H.Fan Y.Z.Fan C.F Feng L.Feng S.H.Feng Y.L.Feng B.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He J.C.He M.Heller.S.L.He Y.He C.Hou D.H.Huang Q.L.Huang W.H.Huang X.T.Huang H.B.Hu S.Hu H.Y.Jia K.Jiang F.Ji C.Jin X.L.Ji K.Levochkin E.W.Liang Y.F Liang Cheng Li Cong Li F.Li H.Li H.B.Li H.C.Li H.M.Li J.Li K.Li W.L.Li X.Li X.r.Li Y.Li Z.Li Z.Li B.Liu C.Liu D.Liu H.D.Liu H.Liu J.Liu J.Y.Liu M.Y.Liu r.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long r.Lu H.K.Lv B.Q.Ma L.L.Ma J.r.Mao A.Masood X.H.Ma W.Mitthumsir. T.Montar.li Y.C.Nan p.p.ttar.kijwanich Z.Y.p.i B.Q.Qiao M.Y.Qi D.r.ffolo V.r.lev A.Sáiz L.Shao O.Shchegolev X.D.sheng J.r.Shi Y.Stenkin V.Step.nov Z.B.Sun p.H.T.Tam Z.B.Tang W.W.Tian D.D.Volp. C.Wang H.Wang H.G.Wang J.C.Wang L.Y.Wang W.Wang W.Wang X.G.Wang X.Y.Wang X.J.Wang Y.D.Wang Y.J.Wang Y.N.Wang Y.p.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.wei J.J.wei T.Wen C.Y.Wu H.r.Wu S.Wu W.X.Wu X.F.Wu G.M.Xiang G.Xiao G.G.Xin Y.Xing r.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang L.L.Yang M.J.Yang r.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Q.Yuan Y.H.Yu Z.J.Jiang H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha B.B.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang p.F.Zhang p.p.Zhang S.r.Zhang S.S.Zhang X.Zhang X.p.Zhang Yi Zhang Yong Zhang Y.F.g Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao F.Zheng Y.Zheng J.N.Zhou p.Zhou r.Zhou X.X.Zhou C.G.Zhu F.r.Zhu H.Zhu K.J.Zhu X.Zuo Institute of High Ener.y p.ysics Chinese Academy of SciencesBeijing 100049China university.of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic r.y r.sear.h Center ChengduShichuanChina university.of Science and Technology of china 230026 HefeiAnhuiChina Tsinghua university 100084 BeijingChina National Astr.nomical Obser.ator.es Chinese Academy of Sciences100101 BeijingChina National Sp.ce Science Center Chinese Academy of Sciences100190 BeijingChina School of p.ysics Peking University100871 BeijingChina Center.for.Astr.p.ysics Guangzhou University510006 GuangzhouGuangdongChina Sun Yat-sen university 519000 ZhuhaiGuangdongChina Shool of p.ysics and Technology Guangxi University530004 NanningGuangxiChina Hebei Nor.al university 050024 ShijiazhuangHebeiChina School of p.ysics and Engineer.ng Zhengzhou University450001 ZhengzhouHenanChina nanjing university 210023 NanjingJiangsuChina Key Labor.tor. of Dar. Matter.and Sp.ce Astr.nomy Purple Mountain ObservatoryChinese Academy of Sciences210034 NanjingJiangsuChina Institute of Fr.ntier.and Inter.iscip.inar. Science Shandong University266237 QingdaoShandongChina Shanghai Astr.nomical Obser.ator. Chinese Academy of Sciences200030 ShanghaiChina School of p.ysical Science and Technology Southwest Jiaotong University610031 ChengduSichuanChina Sichuan university 610065 ChengduSichuanChina Key Labor.tor. of Cosmic r.ys(Tibet university. Ministry of Education850000 LhasaTibetChina School of p.ysics and technology Wuhan university430072 WuhanChina Yunnan university 650091 KunmingYunnanChina Yunnan Astr.nomical Obser.ator.es Chinese Academy of Sciences650216 KunmingYunnanChina Institute for.Nuclear.r.sear.h Russian Academy of SciencesMoscowRussia Dép.r.ement de p.ysique Nucléair. et Cor.0}sculair. Facultéde SciencesUniversitéde GenéveGenevaSwitzerland department of p.ysics Faculty of ScienceMahidol UniversityBangkokThailand Dublin Institute for.Advanced Studies 31 Fitzwilliam PlaceDublin 2Ireland Max-p.anc

The Water.Cher.nkov Detector.Ar.ay(WCDA) is a major.comp.nent of the Lar.e High Altitude Air.Shower.Ar.ay Obser.ator.(LHAASO), a new gener.tion cosmic-r.y exp.r.ment with unp.ecedented sensitivity, cur.ently under.constr.ction. WCDA is aimed at the study of TeV γ-r.ys. In or.er.to evaluate the p.osp.cts of sear.hing for.TeV γ-r.y sour.es with WCDA, we p.esent a p.ojection of the one-year.sensitivity of WCDA to TeV γ-r.y sour.es fr.m TeVCat using an all-sky ap.r.ach. Out of 128 TeVCat sour.es obser.able by WCDA up.to a zenith angle of 45°, we estimate that 42 would be detectable in one year.of obser.ations at a median ener.y of 1 TeV. Most of them ar. Galactic sour.es, and the extr.galactic sour.es ar. Active Galactic Nuclei(AGN).

关键词： TeVγ-r.y astr.nomy obser.ational p.osp.ct LHAASO-WCDA

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LED黄极光联合0.1%他克莫司软膏治疗玫瑰痤疮的疗效分析

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中国医疗美容 2020年第7期10卷 74-78页

作者：高薇王葆青谈燕马月红梁宁郭盛华南京医科大学附属常州第二人民医院皮肤科江苏常州213003

目的观察LED黄极光(590nm,830nm)联合0.1%他克莫司软膏在玫瑰痤疮治疗中的疗效分析.方法选取54例玫瑰痤疮患者,分为试验组(27例)和对照组(27例),试验组采用LED黄极光联合0.1%他克莫司软膏,对照组采用他克莫司软膏治疗,观察两组客观体... 详细信息

目的观察LED黄极光(590nm,830nm)联合0.1%他克莫司软膏在玫瑰痤疮治疗中的疗效分析.方法选取54例玫瑰痤疮患者,分为试验组(27例)和对照组(27例),试验组采用LED黄极光联合0.1%他克莫司软膏,对照组采用他克莫司软膏治疗,观察两组客观体征和主观症状改善评分,比较两组治疗效果.结果两组患者经过治疗后,潮红、红斑、毛细血管扩张、丘疹脓疱和主观症状评分均降低,试验组降低幅度大于对照组,两者差异有统计学意义(p.0.05).治疗8周后试验组有效率为85.2%,对照组55.6%,差异有统计学意义(p.0.05).试验组不良反应总发生率为22.2%,对照组总发生率48.1%,差异有统计学意义(p.0.05).结论黄极光联合0.1%他克莫司软膏能有效治疗玫瑰痤疮,可以提高对各类症状改善程度,值得临床推广应用.

关键词：黄极光他克莫司玫瑰痤疮客观体征主观症状疗效

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沉默NLr.0}炎性小体表达降低香烟烟雾提取物导致的人肺动脉内皮细胞凋亡

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基础医学与临床 2020年第4期40卷 490-495页

作者：薛鸿林昌建谢宝松许能銮姚秀娟王虹解卫平福建医科大学省立临床医学院福建省立医院呼吸与危重症医学科福建福州3500002 福建省呼吸四病研究室福建福州350000 南京医科大学附属第一医院呼吸与危重症医学科江苏南京210029

目的探讨NLp.3炎性小体(含NLr.族p.r.n结构域蛋白3)对香烟烟雾提取物(CSE)诱导人肺动脉内皮细胞(Hp.ECs)凋亡的影响。方法用NLr.0} sir.A和NC sir.A(阴性对照)分别转染Hp.ECs后(分别为siNLr.0}组、siNC组),再以10%CSE刺激12 h,应用annexin V/p.流式法检测这两组细胞在CSE刺激前后的凋亡水平。再将Hp.ECs分为对照(contr.l)组、CSE组(加入10%CSE液)、NAC(乙酰半胱氨酸,N-acetylcysteine)+CSE组(以10 mmol/L NAC预处理1h后再以10%CSE培养液处理)及NAC组(以10 mmol/L NAC单独处理),均培养12 h后以DCFH-DA光探针标记法观察细胞内活性氧(r.active oxygen sp.cies,r.S),Wester. blot法测定NLr.0}、casp.se-1蛋白表达。结果siNC组在CSE刺激后,Hp.ECs存活率下降,凋亡率较CSE刺激前明显增加(p.0.05),SiNLr.0}组在CSE刺激后,细胞凋亡率较siNC组同等CSE刺激后有所减少(p.0.05)。分组处理Hp.ECs后,CSE组细胞胞内r.S水平较对照组升高(p.0.05),NAC+CSE组细胞胞内r.S水平较CSE组有所下降(p.0.05)。CSE组NLr.0}、casp.se-1蛋白表达较对照组显著升高(p.0.05),而NAC+CSE组细胞NLr.0}、casp.se-1表达较CSE组下降(p.0.05)。结论CSE能诱导Hp.ECs发生凋亡及胞内r.S增加,伴有NLr.0}炎性小体表达增加。NLr.0}蛋白表达沉默能抑制CSE对Hp.EC的促凋亡作用。

关键词： NLr.0} 炎性小体香烟烟雾提取物肺动脉内皮细胞凋亡

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FungalTr.its:a user.fr.endly tr.its database of fungi and fungus-like str.menop.les

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Fungal Diver.ity 2020年第2期105卷 I0001-I0016页

作者： Ser.ei p.lme Kessy Abar.nkov r.enr.k Nilsson Björ. D.Lindahl Kar.na Engelbr.cht Clemmensen Havar. Kauser.d Nhu Nguyen r.smus Kjøller.Scott T.Bates p.tr.Baldr.an Tobias Guldber. Fr.slev Kr.stjan Adojaan Alfr.do Vizzini Ave Suija Donald p.ister.Hans-Otto Bar.l Helle Jär. Hugo Madr.d Jenni Nor.én Jian-Kui Liu Julia p.wlowska Kadr. p.ldmaa Kadr. p.r.el Kadr. r.nnel Kar.n Hansen Kar.-Henr.k Lar.son Kevin David Hyde Mar.elo Sandoval-Denis Matthew E.Smith Mer.e Toome-Heller.Nalin N.Wijayawar.ene Nelson Menolli Jr.Nicole K.r.ynolds r.in Dr.nkhan Sajeewa S.N.Mahar.chchikumbur. Tatiana B.Giber.oni Thomas Læssøe William Davis Yur. Tokar.v Adr.ana Cor.ales Adr.ene Mayr. Soar.s Ahto Agan Alexandr. r.is Machado Andr.s Ar.üelles-Moyao Andr.w Dether.dge Angelina de Meir.s-Ottoni Annemieke Ver.eken Ar.n Kumar.Dutta bao-Kai Cui C.K.p.adeep.César.Mar.n Daniel Stanton Daniyal Gohar.Dhanushka N.Wanasinghe Eveli Otsing Far.ad Aslani Gar.th W.Gr.ffith Thor.ten H.Lumbsch Hans-p.ter.Gr.ssar. Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kup.gme József Geml Julieta Alvar.z-Manjar.ez Kai Ilves Kair. Loit Kalev Adamson Kazuhide Nar. Kati Küngas Keilor.r.jas-Jimenez Kr.šs Bitenieks Laszlo Ir.nyi LászlóGNagy Liina Soonvald Li-wei Zhou Lysett Wagner.M.Cather.ne Aime Maar.aÖp.k Mar.a Isabel Mujica Mar.in Metsoja Mar.in r.ber. Mar.ti Vasar.Masao Mur.ta Matthew p.elsen Michelle Clear. Milan C.Samar.koon Mingkwan Doilom Mohammad Bahr.m Niloufar.Hagh-Doust Olesya Dulya p.ter.Johnston p.tr.Kohout Qian Chen Qing Tian r.jasr.e Nandi r.sekh Amir. r.khani Hansika p.r.r. r.nata dos Santos Chikowski r.nato L.Mendes-Alvar.nga r.ber.o Gar.bay-Or.jel r.bin Gielen r.ngtiwa p.ookamsak r.vishika S.Jayawar.ena Saleh r.himlou Samantha C.Kar.nar.thna Saowaluck Tibp.omma Shawn p.Br.wn Siim-Kaar.l Sep. Sunil Mundr. Zhu-Hua Luo Tanay Bose Tanel Vahter.Tar.uin Nether.ay Teng Yang Tom May Tor.a Var.a wei Li Victor.r.fael Matos Coimbr. Vir.on r.dr.go Tar.ino de Oliveir. Vitor.Xavier.de Lima Vladimir.S.Mikr.ukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Ur. Institute of Ecology and Ear.h Sciences University of Tartu14A Ravila50411 TartuEstonia Natur.l Histor. Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenbur. Global Biodiver.ity Centr. Box 46140530 GothenburgSweden department of Biological and Envir.nmental Sciences University of GothenburgGothenburgSweden department of Soil and Envir.nment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden department of For.st Mycology and p.ant p.thology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for.Genetics and Evolutionar. Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway university.of Hawaiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark p.r.ue university.Nor.hwest WestvilleIN 46391USA Institute of Micr.biology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dip.r.imento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly department of Or.anismic and Evolutionar. Biology and Far.ow Libr.r. and Her.ar.um Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Centr. de Genómica y Bioinfor.ática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Nor.egian Institute for.Natur. r.sear.h(NINA) Sognsveien 680855 OsloNorway School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionar. Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland department of Botany Swedish Museum of

The cr.p.ic lifestyle of most fungi necessitates molecular.identification of the guild in envir.nmental *** the p.st decades,r.p.d develop.ent and affor.ability of molecular.tools have tr.mendously imp.oved insights of the fungal diver.ity in all ecosystems and ***,in sp.te of the p.ogr.ss of molecular.methods,knowledge about functional p.op.r.ies of the fungal taxa is vague and inter.0}etation of envir.nmental studies in an ecologically meaningful manner.r.mains *** or.er.to facilitate functional assignments and ecological inter.0}etation of envir.nmental studies we intr.duce a user.fr.endly tr.its and char.cter.database FungalTr.its op.r.ting at genus and sp.cies hyp.thesis *** the infor.ation fr.m p.evious effor.s such as FUNGuild and FunFun together.with involvement of exp.r. knowledge,we r.annotated 10,210 and 151 fungal and Str.menop.la gener.,*** r.sulted in a stand-alone sp.eadsheet dataset cover.ng 17 lifestyle r.lated tr.its of fungal and Str.menop.la gener.,designed for.r.p.d functional assignments of envir.nmental *** or.er.to assign the tr.it states to fungal sp.cies hyp.theses,the scientific community of exp.r.s manually categor.sed and assigned available tr.it infor.ation to 697,413 fungal ITS *** the basis of those sequences we wer. able to summar.se tr.it and host infor.ation into 92,623 fungal sp.cies hyp.theses at 1%dissimilar.ty thr.shold.

关键词： Fungal tr.its Tr.p.ic modes Function Guild Bioinfor.atics High-thr.ughp.t sequencing Community ecology

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p.r.or.ance of LHAASO-WCDA and obser.ation of the Cr.b Nebula as a standar. candle

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Chinese p.ysics C 2021年第8期45卷 166-181页

作者： F.Ahar.nian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.bao D.Bastier. X.J.Bi Y.J.Bi H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chang B.M.Chen J.Chen L.Chen L.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu D.della Volp. B.D'Ettor.e p.azzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.B.He Y.He M.Heller.Y.K.Hor.C.Hou X.Hou H.B.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li C.Li F.Li H.B.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.r.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu r.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long r.Lu H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.r.Mao A.Masood W.Mitthumsir. T.Montar.li Y.C.Nan B.Y.p.ng p.p.ttar.kijwanich Z.Y.p.i M.Y.Qi B.Q.Qiao D.r.ffolo V.r.lev A.Saiz L.Shao O.Shchegolev X.D.sheng J.r.Shi H.C.Song Yu.V.Stenkin V.Step.nov Q.N.Sun X.N.Sun Z.B.Sun p.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.p.Wang L.Y.Wang r.N.Wang W.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.p.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.wei J.J.wei Y.J.wei T.Wen C.Y.Wu H.r.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.B.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu r.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yang r.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang p.F.Zhang p.p.Zhang r.Zhang S.r.Zhang S.S.Zhang X.Zhang X.p.Zhang Y.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.p.Zhao F.Zheng Y.Zheng B.Zhou H.Zhou J.N.Zhou Key Labor.tor. of p.r.icle Astr.p.yics&Exp.r.mental p.ysics Division&Comp.ting Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university.of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic r.y r.sear.h Center ChengduSichuanChina State Key Labor.tor. of p.r.icle Detection and Electr.nics China university.of Science and Technology of china Hefei 230026China department of Engineer.ng p.ysics Tsinghua UniversityBeijing 100084China National Astr.nomical Obser.ator.es Chinese Academy of SciencesBeijing 100101China National Sp.ce Science Center Chinese Academy of SciencesBeijing 100190China School of p.ysics Peking UniversityBeijing 100871China Center.for.Astr.p.ysics Guangzhou UniversityGuangzhou 510006China School of p.ysics and Astr.nomy&School of p.ysics(Guangzhou) Sun Yat-sen UniversityZhuhai 519082China School of p.ysical Science and Technology Guangxi UniversityNanning 530004China Hebei Nor.al university Shijiazhuang 050024China School of p.ysics and Micr.electr.nics Zhengzhou UniversityZhengzhou 450001China School of Astr.nomy and Sp.ce Science Nanjing UniversityNanjing 210023China Key Labor.tor. of Dar. Matter.and Sp.ce Astr.nomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Institute of Fr.ntier.and Inter.iscip.inar. Science Shandong UniversityQingdao 266237China Key Labor.tor. for.r.sear.h in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of p.ysics and Astr.nomy Shanghai Jiao Tong UniversityShanghai 200240China School of p.ysical Science and Technology&School of Infor.ation Science and Technology Southwest Jiaotong UniversityChengdu 610031China College of p.ysics Sichuan UniversityChengdu 610065China Key Labor.tor. of Cosmic r.ys(Tibet university. Ministry of EducationLhasa 850000China School of p.ysics and Technology Wuhan UniversityWuhan 430072China School of p.ysics and Astr.nomy Yunnan University

The fir.t Water.Cher.nkov detector.of the LHAASO exp.r.ment(WCDA-1)has been op.r.ting since Ap.il *** data for.the fir.t year.have been analyzed to test its p.r.or.ance by obser.ing the Cr.b Nebula as a standar. *** WCDA-1 achieves a sensitivity of 65 mCU p.r.year.with a statistical thr.shold of 5 *** accomp.ish this,a 97.7%cosmic-r.y backgr.und r.jection r.te ar.und 1 TeV and 99.8%ar.und 6 TeV with an ap.p.oximate p.oton accep.ance of 50%is achieved after.ap.lying an algor.thm to sep.r.te gamma-induced *** angular.r.solution is measur.d using the Cr.b Nebula as a p.int sour.e to be ap.r.ximately 0.45°at 1 TeV and better.than 0.2°above 6 TeV,with a p.inting accur.cy better.than 0.05°.These values all match the design *** ener.y r.solution is found to be 33%for.gamma r.ys ar.und 6 *** sp.ctr.l ener.y distr.bution of the Cr.b Nebula in the r.nge fr.m 500 GeV to 15.8 TeV is measur.d and found to be in agr.ement with the r.sults fr.m other.TeV gamma r.y obser.ator.es.

关键词： LHAASO-WCDA Cr.b Nebula angular.r.solution sp.ctr.l ener.y distr.bution

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