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Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence

World Journal of Clinical Cases 2022年第31期10卷 11226-11239页

作者： Niyazi Emre Kurşunoğlu banu pinar sarer yurekli School of Medicine Ege Universityİzmir 35100Turkey Department of Endocrinology Ege University School of Medicineİzmir 35100Turkey

Obesity is becoming an inevitable pandemic all over the *** World Obesity Federation predicts in the 2022 World Obesity Atlas that one billion people worldwide,including 1 in 5 women and 1 in 7 men,will be living with obesity by ***,the prevalence of diabetes is increasing worldwide,and diabetes is becoming more of a public health *** insulin resistance due to obesity and deficiency in insulin secretion are the two main causes of type 2 diabetes mellitus(T2DM).An exogenous chemical or mixture of chemicals that interferes with any aspect of hormone action was defined as endocrine-disrupting chemicals(EDCs).Bisphenol A(BPA),the first known EDC,was synthesized and was considered to be *** production of BPA has increased progressively from 5 to 8 million tons(MT)between 2010 and ***,researchers estimated that the production should reach 10.2 MT by *** human population is exposed to EDCs in daily life in such forms as pesticides/herbicides,industrial and household products,plastics,detergents,and personal care *** term obesogen was used for chemicals that promote weight gain and obesity by increasing the number of adipocytes and fat storage in existing adipocytes,changing the energy balance,and finally regulating appetite and *** the obesogenic effect,EDCs can cause T2DM through alteration inßcell function and morphology and insulin *** this review,we provide clinical and mechanistic evidence regarding EDCs as obesogen and ***,those studies are not enough methodologically to indicate *** this respect,randomized clinical trials are needed to investigate the association between obesogen,diabetogen and the related metabolic clinical picture.

关键词： Endocrine disruptors Adipogenesis Obesity Diabetes mellitus

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