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Prevalence of osteoporosis and vertebral fractures and related factors in patients with ankylosing spondylitis

Chinese Medical Journal 2014年第15期127卷 2740-2747页

作者： Mehmet Ali Ulu ibrahim Batmaz banu dilek Remzi Cevik Batman State Hospital Faculty of Physical Medicine andRehabilitation Batman Turkey Dicle University Faculty of Medicine Physical Medicine andRehabilitation Diyarbakir Turkey Dokuz Eylul University Faculty ofMedicine Physical Medicine andRehabilitation izmir TurkeY

Background Osteoporosis and vertebral factures are well recognized features in patients with ankylosing spondylitis （AS）.The aim of this study was to investigate the prevalence and risk factors of osteoporosis and vertebral fractures in patients with *** Fifty-nine AS patients and 40 healthy controls were *** mineral density （BMD） was measured using dual-energy X-ray absorptiometry （DEXA） at posterior-anterior （PA） lumbar,lateral lumbar and hip *** and lumbar X-rays were obtained for morphometric ***,biological and radiological statuses were evaluated with Bath Ankylosing Spondylitis Disease Activity Index （BASDAI）,Bath Ankylosing Spondylitis Metrology Index （BASMI）,Bath Ankylosing Spondylitis Functional Index （BASFI）,Bath Ankylosing Spondylitis Radiology Index-total （BASRI-t）,erythrocyte sedimentation rate （ESR） and the C-reactive protein *** Osteoporosis was present in 32% of patients and 5% of controls according to lateral vertebral BMD *** was present in 31% of *** effect of some clinical and laboratory parameters on BMD status and vertebral fractures was analyzed in the patient *** in lateral lumbar DEXA was associated with higher BASMI,BASFI,BASRI-t scores and ESR *** hip BMD was associated with low BMI and high BASFI and BASRI-t *** fractures were associated with advanced age,longer disease duration,longer duration since diagnosis,higher BASMI and BASRI-t scores,higher ESR level,reduced femoral and lateral lumbar *** regression analysis revealed that only BASRI-t score was significantly associated with low lateral spinal BMD and BMI and BASFI score were independently associated with low hip *** presence of compression fractures was independently associated with BASRI-t score and low lateral lumbar *** Osteoporosis and vertebral fractures in AS seem to be related to the extent of radiological involvement.A low lateral

关键词： ankylosing spondylitis lateral lumbar dual-energy X-ray absorptiometry osteoporosis vertebral fractures

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