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Expression of HIF-1α in hepatocellular carcinoma and its relationship with vasculogenic mimicry and clinical pathology

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The Chinese-German Journal of Clinical Oncology 2013年第11期12卷 528-531页

作者： Xiaojie Ma Jie Li bangxian tan Department of Oncology The Affiliated Hospital of North Sichuan Medical College Department of Oncology Mianyang Central Hospital

Objective： The aim of this study was to discuss HIF-la expression and vasculogenic mimicry （VM） in hepatocel- lular carcinoma （HCC） and their relationship with the clinical pathological features and clinical significance. Methods： Two hundred and seven specimens from patients in The Affiliated Hospital of North Sichuan Medical College who received hepatic cell carcinoma resection were tested by immunohistochemistry and double staining of CD31 and PSA. Then detected the expression of HIF-la, VM, and analysed the relationship between clinical pathology. Results： The HIF-la positive rate was 71.01% and its expression was associated with liver cirrhosis, tumor size and TNM stage （P 〈 0.05）. HIF-la protein expres- sion was positively associated with the VM （y = 0.1988, P = 0.0041）. Conclusion： Hypoxia may be the reason for VM in high invasive HCC, regulating the tumor microenvironment may have great significance in inhibiting invasion and metastasis of HCC.

关键词： hepatocellular carcinoma (HCC) HIF-la vasculogenic mimicry (VM)

Condylar invasion after postoperative chemotherapy for primary intraosseous squamous cell carcinoma of the mandible: a case report

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Oncology and Translational Medicine 2019年第4期5卷 192-194页

作者： Long Cheng Qinyun Li Guobo Du Daiyuan Ma bangxian tan Department of Oncology Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China Department of Nephrology Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant tumor that occurs predominantly in the jaw. Pathological evidence shows that PIOSCC originates from the residual odontogenic epithelium and a preexisting odontogenic cyst or tumor. Here, we report the case of a 63-year-old man with central squamous cell carcinoma of the mandible. On the basis of imaging and histopathology reports, the patient was diagnosed with PIOSCC of the jaw. Subsequently, he was treated with postoperative adjuvant chemotherapy. During a postoperative follow-up visit in the ninth month, mandibular computed tomography (CT) scanning and bone imaging revealed local recurrence and condylar invasion. Therefore, radiation along with chemotherapy was administered. This case study adds to the literature on PIOSCC and widens the understanding of its diagnosis, treatment, and prognosis.

关键词： PIOSCC condyle invasion postoperative chemotherapy

Ewing sarcoma/primitive neuroectodermal tumor of the ureter:A case report and literature review

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Oncology and Translational Medicine 2021年第1期7卷 41-44页

作者： Qian Zhou Guobo Du Jie tang Yujia Wang Yu Xiao bangxian tan North Sichuan Medical College Nanchong 637000China Department of Oncology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000China

Ewing sarcoma/primary neuroectodermal tumors are rare,invasive,and small round blue cell *** are few reports of its occurrence in the urinary ***,we present the first middle-aged female patient whose Ewing sarcoma primary site was in the *** main clinical manifestation was intermittent *** was in good health after complete surgical resection and adjuvant *** date,there has been no recurrence or *** early diagnosis and appropriate treatment can help prolong survival.18F-fluorodeoxyglucose positron emission tomography/computed tomography is expected to be an effective means of evaluating treatment effects and detecting metastasis and *** this article,besides introducing a case of Ewing sarcoma/primitive neuroectodermal tumor of the ureter,we review the literature to discuss the current status of diagnosis and treatment.

关键词： Ewing sarcoma(ES) primitive neuroectodermal tumor(PNET) ureter positron emission tomography/computed tomography(PET/CT)

Clinical study of three dimensional conformal radiotherapy combined with intracavitary brachytherapy in the treatment of cervical cancer

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The Chinese-German Journal of Clinical Oncology 2011年第6期10卷 340-343页

作者： Yeqin Zhou Daiyuan Ma Tao Ren Xianfu Li Jing Hu bangxian tan Department of Radiotherapy Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China

Objective: The aim of our study was to evaluate the outcome and complications of cervical cancer patients undergoing conventional intracavitary brachytherapy (ICBT) treated with 3D-conformal radiotherapy (3DCRT). Methods: Sixty cervical cancer patients were divided randomly into the conformal group and the conventional group. Thirty patients treated with 3D-conformal radiotherapy in the 3DCRT group, when the whole pelvic received DT 40 Gy, a planning CT scan of each patient was obtained and the second 3DCRT therapy plan was taken. Then, continued to irradiate to 50 Gy. At last, 3DCRT was boosted at local involved volumes to the total dose of 60 Gy. When 3DCRT was combined with intracavitary brachytherapy, the dose of brachytherapy to point A was 30 Gy/5 fractions. In the conventional group, after a total tumor dose of 40 Gy was delivered by the whole pelvic irradiation, the four-field technique was used to irradiate the total pelvic and regional nodes (median dose of 10 Gy), and the involved volumes were boosted to 60 Gy and the dose of brachytherapy to point A was 30 Gy-36 Gy/5-6 fractions. Moreover, both groups were combined with intracavitary brachytherapy respectively. Results: The 1, 2, 3-year survival rates for the 3DCRT group and the conventional group were 96.7%, 93.3%, 90.0% and 86.6%, 76.7%, 70% respectively (P = 0.04, P = 0.02 and P = 0.02). There was a statistically significant difference between the two groups. Compared to the two groups each other in toxic effects, except for the I-II grade rectal and bladder reaction and pelvic fibrosis which was lower in the 3DCRT group (P = 0. 007, P = 0. 006 and P = 0. 015), the side effects were similar and well tolerated in two groups. Conclusion: The all-course 3DCRT combined with intracavitary brachytherapy can be considered as an effective and feasible approach to cervical cancer and may significantly improve the survival rate and reduce the late toxicity. This new role for 3DCRT merits need further evaluation

关键词： cervical cancer external radiotherapy three dimensional conformal radiotherapy chemotherapy intracavitary brachytherapy

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晚期非小细胞肺癌维持治疗的研究进展

中国肿瘤临床 2021年第12期48卷 631-635页

作者：周倩(综述) 谭榜宪(审校) 川北医学院附属医院肿瘤科南充市637000 重庆大学附属三峡医院肿瘤科

肺癌是全球发病率及死亡率最高的恶性肿瘤,虽然含铂双药化疗一定程度上提高了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效,但预后仍欠佳。为了进一步改善患者的生存,进行有效的维持治疗至关重要。本文就晚期NSCLC维持治... 详细信息

肺癌是全球发病率及死亡率最高的恶性肿瘤,虽然含铂双药化疗一定程度上提高了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效,但预后仍欠佳。为了进一步改善患者的生存,进行有效的维持治疗至关重要。本文就晚期NSCLC维持治疗的研究现状进行综述,探讨维持治疗的临床意义及如何选择个体化治疗方案。

关键词：非小细胞肺癌维持治疗靶向治疗免疫治疗联合治疗

Inhibition of γ-synuclein (SNCG) expression in breast cancer MDA-MB231 cell line

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The Chinese-German Journal of Clinical Oncology 2012年第3期11卷 156-159页

作者： Tao Ren bangxian tan Xiaojie Ma Yan Gui Daiyuan Ma Yeqin Zhou Department of Radiation Oncology Key Disciplines of Oncology in Sichuan ProvinceThe Affiliated HospitalNorth Sichuan Medical CollegeNanchong 637000China

Objective:The aim of the study was to evaluate the inhibition of different chemotherapy drugs on γ-synuclein (SNCG) positive expression of breast cancer cell line MDA-MB231,and the effects on cell cycle and apoptosis,and to explore the related mechanism as ***:We treated the breast cancer cell line MDA-MB231 for the inhibition of SNCG with chemotherapy drugs such as irinotecan,nedaplatin and 5-fluorouracil using RT-PCR and immunohistochemistry,and adopted flow cytometry to detect cell cycle distribution and ***:At the transcription and translation levels,the SNCG expression level in nedaplatin group and 5-fluorouracil group was lower than that of other groups and there was statistically significance (P < 0.01) compared with the control group,while there was not statistically significant between irinotecan group and the control *** drugs action,cell cycle and distribution in each experiment group changed obviously,where the cells in G0G1 phase increased,especially the cells in the nedaplatin group and 5-fluorouracil group changed most significantly,as well as the obvious change in the cells of nedaplatin group and 5-fluorouracil group in the apoptosis ***:There was a stronger inhibition of SNCG expression in nedaplatin and 5-fluorouracil groups,and can cause significant cell cycle and apoptosis *** may also be concluded that nedaplatin and 5-fluorouracil could make effects by the mechanisms of inhibiting cancer cell proliferation and inducing cell apoptosis.

关键词： γ-synuclein (SNCG) MDA-MB231 cells breast cancer RT-PCR

Radiation therapy concurrent with weekly cisplatin therapy for loco-regionally advanced nasopharyngeal carcinoma:outcomes of a clinical trial

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The Chinese-German Journal of Clinical Oncology 2011年第4期10卷 187-191页

作者： Daiyuan Ma Chunqiao Fu bangxian tan Mi Liu Xianfu Li Yeqin Zhou Department of Radiation Oncology 1st Affiliated Hospital of North Sichuan Medical College Nanchong 637000China

Objective:The purpose of this study was to define the maximum tolerated dose(MTD) by describing the doselimiting toxicity(DLT) of weekly cisplatin concurrently with conventional plus 3-dimensional conformal radiotherapy(CT + 3DCRT) in patients with loco-regionally advanced nasopharyngeal carcinoma(NPC).Methods:Patients with loco-regionally advanced NPC(III/IVa stage) were enrolled into a dose-escalating *** was graded according to Common Terminology Criteria for Adverse Events version 3.0(CTCAE v3.0).MTD was defined when 2 of 6 patients developed *** starting dose of cisplatin was 15 mg/m2/w,with a subsequent dose escalation of 5 mg/m2/w in cohorts of 3 new *** + 3DCRT was given to the nasopharynx and the upper neck;the lower neck was treated by a single anterior field *** prescription dose was 70-80 Gy by 35-40 fractions to the nasopharynx gross tumor,and 66-70 Gy by 33-35 fractions to the positive neck lymph ***:From Jun.2008 to Sep.2009,24 patients received complete chemoradiotherapy,and all of them were eligible for toxicity *** the first five dose levels of 15 mg/m2/w and 35 mg/m2/w,no patient experienced *** the next dose level of 40 mg/m2/w,1 patient experienced DLT of grade 3 myelosuppression for 1.4 weeks,and among the additional 3 patients,no one developed *** the seventh dose level of 45 mg/m2/w,all the patients developed grade 3 myelosuppression for more than 1 weeks,and the dose-escalating trial *** 23(95.8%) patients achieved clinical complete remission(CR) in the local site;22(91.7%) achieved CR in the regional site,and all patients got CR 3 months *** a median follow-up of 16.4 months,1 patient developed liver metastases 2 months later,1 patient developed bone metastases 10 months later and 22 kept disease-free ***:The MTD of cisplatin weekly with concurrent CT + 3DCRT for local advanced NPC is 40 mg/m2/w,with myelosuppression as DLT.

关键词： nasopharyngeal carcinoma(NPC) cisplatin/treatment chemotherapy radiotherapy concurrent treatment dose escalating

Three-dimensional conformal radiotherapy plus concurrent DICE chemotherapy for early-stage nasal-type natural killer/T-cell lymphoma of Waldeyer's ring: A single-institution study

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Oncology and Translational Medicine 2015年第4期1卷 181-185页

作者： Ji Zhou Daiyuan Ma Yeqin Zhou Xianfu Li bangxian tan Mi Liu Tao Ren Department of ENT The Affiliated Hospital North Sichuan Medical College Department of Oncology The Affiliated Hospital North Sichuan Medical College

Objective Nasal-type natural killer/T-cell lymphoma of Waldeyer＇s ring （WR-NK/TL） has different clinico- pathological characteristics from those of other subtypes of NK/T lymphoma; thus, the optimal treatment remains unclear. To find a more effective treatment model for WR-NK/TL, we conducted a single-center study of concurrent radiochemotherapy. Methods Forty-five patients with newly diagnosed stage IE to liE WR-NKTL were randomly divided into two groups. The 23 cases in the concurrent radiochemotherapy group were treated with three-dimensional conformal radiotherapy （48-52 Gy） and 2 courses of DICE （dexamethasone, ifosfamide, cisplatin, and etoposide） synchronous chemotherapy. The 22 cases in the radiotherapy group only received three-dimen- sional conformal radiotherapy （50-54 Gy）. The primary end points were overall survival （OS）, progression- free survival （PFS）, and toxicity. Results The 1-, 3-, and 4-year OS and PFS rates were 95.5%, 65.6%, and 45.9%, and 86.4%, 56.0%, and 46.7% in the radiotherapy group, and 100%, 88.5%, and 88.5%, and 100%, 82.0%, and 73.8% in the concurrent radiochemotherapy group, respectively. The OS （P = 0.0477） and PFS rates （P = 0.0488） were higher in the concurrent radiochemotherapy group than in the radiotherapy group. The overall re- sponse rate was 100% in both the radiotherapy group [complete response （CR）, 18 cases] and concurrent radiochemotherapy group （CR, 22 cases）. The concurrent radiochemotherapy group had more severe side effects, especially grade 3 ＋ 4 events, such as leukopenia, anorexia, and stomatitis. However, side effects benefiting from excellent oral care were endurable. Conclusion Radiotherapy plus concurrent DICE chemotherapy may be an effective and safe compre- hensive treatment for patients with WR-NKTL.

关键词： nasal cavity NK/T-cell lymphoma prognosis radiotherapy chemotherapy

Late course three-dimensional conformal radiotherapy for esophageal carcinoma

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The Chinese-German Journal of Clinical Oncology 2011年第3期10卷 147-149页

作者： Jin Hu bangxian tan Mi Liu Yeqing Zhou Daiyuan Ma Tao Ren Xianfu Li Department of Radiotherapy Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China

Objective： The aim of our study was to evaluate the clinical results and acute side effects of late course three-dimensional conformal radiotherapy （3DCRT） for esophageal carcinoma. Methods： From January 2004 to October 2006, 70 patients with esophageal carcinoma received late course 3DCRT. Their clinical data were analyzed retrospectively. The short-term clinical results, acute side effects, local control rates and survival rates were evaluated. Results： The complete response rate was 62.9%, partial response rate was 35.7%, and the overall response rate was 98.6%. The 1-, 2-and 3-year local control rates were 77.1%, 51.4% and 45.7%, respectively. The 1-, 2-and 3-year overall survival rates were 75.7%, 54.3% and 38.6%, respectively. The median survival time was 26 months. Conclusion： The technique of late course 3DCRT is an effective treatment for esophageal carcinoma and tend to improve the overall survival rate.

关键词： esophageal neoplasm three-dimensional conformal radiotherapy prognosis