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Nano friction behaviour between magnetic materials and copper considering the inter-diffusion effect

Friction 2024年第7期12卷 1532-1547页

作者： Zilin LI Lisha DOU Shiyu YANG Huajiang OUYANG Qichen ZHU Xiaoyang CHEN Xin JIA Shuaiwei DOU Xiaolong CUI Yudong ZHANG Jingjiang QIU Guochen QI bangbang nie Pan LIU Ronghan WEI School of Mechanics and Safety Engineering Zhengzhou UniversityZhengzhou 450001China Engineering Technology Research Center of Henan Province for MEMS Manufacturing and Application Zhengzhou UniversityZhengzhou 450001China Institute of Intelligent Sensing Zhengzhou UniversityZhengzhou 450001China School of Engineering University of LiverpoolLiverpool L693GHUK School of Cyber Science and Engineering&Hanwei Institute of Internet of Things Zhengzhou UniversityZhengzhou 450001China

Copper,permalloy,cobalt,and silicon are the materials that have been widely utilised in magnetic *** the size of interest is down to the nanoscale,the inter-diffusion between certain materials becomes *** paper studies the nanoscale friction characteristics between frictional pairs with and without inter-diffusion properties through the atomic force *** distinct evolution features of nanoscale friction force when inter-diffusion is involved are discovered experimentally,which is also confirmed through theoretical ***,through the thin film deposition method,four pairs of contact materials(Cu–Ni_(81)Fe_(19),Si–Ni_(81)Fe_(19),Cu–Co,Cu–Si)are designed for friction tests,in which diffusion occurs at the interface of Cu–Ni_(81)Fe_(19)***,the effects of sliding velocity and loading force on the nano friction of each pair are *** is found that regardless of the diffusion phenomenon:(1)the adhesion force values exhibit a notable correlation to the values of the friction force;(2)the friction force in all four material pairs consistently increases with the growth of the normal loading force,although the growth rate may *** terms of the sliding velocity effect,the friction forces of immiscible materials(Si–Ni_(81)Fe_(19),Cu–Co,and Cu–Si)are found to increase with the increasing sliding ***,the friction force of Cu–Ni_(81)Fe_(19),decreases with the increasing sliding ***,a compositive friction model considering both the velocity and the normal force effect was proposed,which shows good agreement with the experimental results and explains the nano friction behaviour of both miscible and immiscible metals.

关键词： atomic force microscope friction force normal load sliding velocity

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Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

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Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu Deng Mingbo nie Hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

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基于微结构的金属薄膜柔性应变传感器

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微纳电子技术 2022年第10期59卷 1049-1057页

作者：赵东阳聂帮帮齐国臣宋慧谦李保林卫荣汉郑州大学力学与安全工程学院郑州450001 郑州大学智能传感研究院郑州450001

柔性应变传感器通常难以兼具高灵敏度和宽传感范围的性能。利用光刻工艺制备出微结构模板,将模板的微结构复制到聚二甲基硅氧烷(PDMS)表面,然后在PDMS表面沉积金属膜层得到具有微结构的金属薄膜柔性应变传感器。结果表明,金属薄膜表面... 详细信息

柔性应变传感器通常难以兼具高灵敏度和宽传感范围的性能。利用光刻工艺制备出微结构模板,将模板的微结构复制到聚二甲基硅氧烷(PDMS)表面,然后在PDMS表面沉积金属膜层得到具有微结构的金属薄膜柔性应变传感器。结果表明,金属薄膜表面的微结构有效阻碍了微裂缝的延伸,该传感器具有较大的传感范围(拉伸应变极限为25%),并保留了金属薄膜传感器的高灵敏度(应变系数为154)。此外,该传感器响应时间短(0.07 s),具有较小的迟滞系数(约8.8%),能够快速准确响应各种拉伸应变波形,其电学响应波形与拉伸应变波形具有一致性,并且能够稳定监测人体手腕关节动作。

关键词：柔性应变传感器微结构金属薄膜微裂缝高灵敏度

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A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2025年第2期20卷 503-517页

作者： Qi Liu Jianye Xie Runxue Zhou Jin Deng Weihong nie Shuwei Sun Haiping Wang Chunying Shi Department of Human Anatomy Histology and EmbryologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of General Practice The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic ***,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in ***,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic *** metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ***,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel ***-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in *** results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor *** findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.

关键词： angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 neuroprotection self-assembling nanofiber hydrogel

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Wrinkling in graded core/shell systems using symplectic formulation

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Applied Mathematics and Mechanics(English Edition) 2023年第12期44卷 2057-2070页

作者： Yaqi GUO Guohua nie School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

Wrinkles in flat graded elastic layers have been recently described as a timevarying Hamiltonian system by the energy *** core/shell structures can also undergo surface instabilities under the external *** this study,we show that by treating the radial direction as a pseudo-time variable,the graded core/shell system with radially decaying elastic properties can also be described within the symplectic *** combination with the shell buckling equation,the present paper addresses the surface wrinkling of graded core/shell structures subjected to the uniform external pressure by solving a series of ordinary differential equations with varying *** representative gradient distributions are showcased,and the predicted critical pressure and critical wave number are verified by finite element *** symplectic framework provides an efficient and accurate approach to understand the surface instability and morphological evolution in curved biological tissues and engineered structures.

关键词： wrinkling graded core/shell system symplectic analysis gradient distribution

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Unraveling the Dynamics of Antibody-Antigen Interaction by DNA Origami

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Chemical Research in Chinese Universities 2020年第5期36卷 983-984页

作者： nie Zhou State Key Laboratory of Chemo Bio-sensing and Chemometncs College of Chemistry and Chemical EngineeringHunan Provincial Key Laboratoty of Biomacromolecular Chemical BiologyHunan UniversityChangsha 410082P.R.China

To investigate the dynamic interaction between antibody and *** et *** designed a triangular DNA origami framework to spatially organize the antigenic epitopes at the naiioscale and thus to monitor the transient binding kinetics of thedynamic antigen-antibody complexes at room *** study provides a straightforward,desigiiable and programmable strategy to investigate the transition kinetics of antibody-antigen interaction at a single-molecule level and improve theunderstanding toward thedesign of the next-generation antibodies and vaccines lor various biomedical *** work has been published online in Nature Communications on June 19,2020.

关键词： temperature. kinetics interaction

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Simulation and evaluation study of atmospheric aerosol nonsphericity as a function of particle size

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Particuology 2024年第7期90卷 281-291页

作者： Qianjun Mao Xin nie School of Urban Construction Wuhan University of Science and TechnologyWuhan430065China College of New Energy and Materials Northeast Petroleum UniversityDaqing163318China

Aerosol nonsphericity causes great uncertainty in radiative forcing assessments and climate *** considerable studies have attempted to quantify this uncertainty,the relationship between aerosol nonsphericity and particle size is usually not considered,thus reducing the accuracy of the *** this study,a coupled inversion algorithm combining an improved stochastic particle swarm optimization algorithm and angular light scattering is used for the nonparametric estimation of aerosol nonsphericity variation with particle size,and the optimal sample selection method is employed to screen the *** on the verification of inversion accuracy,the variation of aerosol aspect ratio with particle size based on the ellipsoidal model in global regions has been obtained from Aerosol Robotic Network(AERONET)data,and the effect of nonsphericity on radiative forcing and dry deposition has been *** results show that the aspect ratio increases with particle size in all regions,with the maximum ranging from 1.4 to 1.8 in the desert,reflecting the differences in aerosol composition at different particle *** radiation calculations,considering aerosol nonsphericity makes the aerosol cooling effect weaker and surface radiative fluxes increase,but hardly changes the aerosol absorption,with maximum differences of 9.22%and 22.12%at the bottom and top of the atmosphere,***,the differences in radiative forcing between aspect ratios as a function of particle size and not varying with particle size are not significant,averaging less than 2%.Besides,the aspect ratio not varying with particle size underestimates the deposition velocity of small particles and overestimates that of large particles compared to that as a function of particle size,with maximum differences of 7%and 4%,respectively.

关键词： Aerosol nonsphericity Inversion Aspect ratio Radiative forcing Dry deposition velocity

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Forward-backward stochastic differential equation with subdifferential operator and associated variational inequality

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Science China Mathematics 2015年第4期58卷 729-748页

作者： nie TianYang School of Mathematics Shandong University School of Mathematics and Statistics University of Sydney

We study the existence and uniqueness of the solution to a forward-backward stochastic differential equation with subdifferential operator in the backward equation. This kind of equations includes, as a particular case, multi-dimensional forward-backward stochastic differential equation where the backward equation is reflected on the boundary of a closed convex(time-independent) domain. Moreover, we give a probabilistic interpretation for the viscosity solution of a kind of quasilinear variational inequalities.

关键词： backward stochastic differential equations variational inequalities subdifferential operators viscosity solutions

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A procedure of the method of reverberation ray matrix for the buckling analysis of a thin multi-span plate

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Applied Mathematics and Mechanics(English Edition) 2020年第7期41卷 1055-1068页

作者： Zhiwei LI Guohua nie School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China

A procedure of the method of reverberation ray matrix(MRRM)is developed to perform the buckling analysis of thin multi-span rectangular plates having internal line supports or stiffeners.A computation algorithm for the reverberation ray matrix in the MRRM is derived to determine the buckling ***,the analytical solutions are presented for the buckling of the structure having two opposite simply-supported or clamped-supported edges with spans,while the constraint condition of two remaining edges may be in any combination of free,simply-supported,and clamped boundary ***,based on the analysis of matrices relating to the unknown coefficients in the solution form for the deflection in terms of buckling modal functions,some recursive equations(REs)for the MRRM are introduced to generate a reduced reverberation ray matrix with unchanged dimension when the number of spans increases,which promotes the computation *** numerical examples are given,and the present results are compared with the known solutions to illustrate the validity and accurateness of the MRRM for the buckling analysis.

关键词： multi-span thin rectangular plate buckling method of reverberation ray matrix(MRRM) recursive equation(RE)

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