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PREPARATION AND EVALUATION OF HPLC BONDED PHASE WITH L-PROLINE LIGAND

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Chinese Chemical Letters 1992年第3期3卷 197-200页

作者： tian Bao HUANG bang Gui WU Yuan De LONG Jing Xian zhou Chengdu Institute of Organic Chemistry Academia SinicaChengdu 610015

This paper describes a simple method for the preparation of L-proline stationary phase bonded to silica gel and characterization of the bonded phase by IR spectrometry, elemental analysis and nitrogen adsorption method at low *** enantiomeric resolutions of 3-(2-pyridyl)-3-aminopropionic acid and 2,3-diaminobutanoic acid on the bonded phase were carried out.

关键词： Pro CSP PREPARATION AND EVALUATION OF HPLC BONDED PHASE WITH L-PROLINE LIGAND HPLC

CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3711-3729页

作者： Boning Niu tianyi tian Lu Wang Yinmei tian tian tian Yuanyuan Guo Hu zhou Zhiping Zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchHigh Throughput Drug Screening PlatformXiamen UniversityXiamen 361102China National Engineering Research Center for Nanomedicine Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Centre for Novel Drug Delivery System Huazhong University of Science and TechnologyWuhan 430030China

SMAD4 deficiency in colorectal cancer(CRC)is highly correlated with liver metastasis and high mortality,yet there are few effective precision therapies ***,we show that CCR1^(+)-granulocytic myeloid-derived suppressor cells(G-MDSCs)are highly infiltrated in SMAD4-deficient CRC via CCL15/CCR1 and CCL9/CCR1 axis in clinical specimens and mouse models,*** excessive TGF-β,secreted by tumor-infiltrated CCR1^(+)-G-MDSCs,suppresses the immune response of cytotoxic T lymphocytes(CTLs),thus facilitating ***,we develop engineered nanovesicles displaying CCR1 and TGFBR2 molecules(C/T-NVs)to chemotactically target the tumor driven by CCL9/CCR1 axis and trap TGF-βthrough TGF-β-TGFBR2 specific *** C/T-NVs counteract CCR1^(+)-G-MDSC infiltration through competitive responding CCL9/CCR1 axis.C/T-NVs-induced intratumoral TGF-βexhaustion alleviates the TGF-β-suppressed immune response of ***,C/T-NVs attenuate liver metastasis of SMAD4-deficient *** further exploration,high expression of programmed cell death ligand-1(PD-L1)is observed in clinical specimens of SMAD4-deficient *** C/T-NVs with anti-PD-L1 antibody(aPD-L1)induces tertiary lymphoid structure formation with sustained activation of CTLs,CXCL13^(+)-CD4^(+)T,CXCR5^(+)-CD20^(+)B cells,and enhanced secretion of cytotoxic cytokine interleukin-21 and IFN-γaround tumors,thus eradicating metastatic *** strategy elicits pleiotropic antimetastatic immunity,paving the way for nanovesicle-mediated precision immunotherapy in SMAD4-deficient CRC.

关键词： SMAD4-deficient CRC Metastasis G-MDSCs TGF-β CCR1 TGFBR2

Dopamine Switches Affective States Under Acute Sleep Deprivation

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Neuroscience Bulletin 2024年第8期40卷 1205-1208页

作者： zhou-Cai Luo tian-Ming Gao State Key Laboratory of Organ Failure Research Key Laboratory of Mental Health of the Ministry of EducationGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangdong-Hong Kong Joint Laboratory for Psychiatric DisordersGuangdong Province Key Laboratory of Psychiatric DisordersGuangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi DiseasesDepartment of NeurobiologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

The transition of affective states manifests affective regulation,wherein individuals adaptively adjust their emotional states to cope with changes in the external environment,reflecting their sensitivity and adaptability to environmental *** process of affective state transition is complex,involving both instantaneous and persistent changes influenced by environmental,behavioral,and pharmacological *** underlying neural mechanisms encompass alterations in neurotransmitter release,neural circuit activity,and the plasticity of brain structures[1].

关键词： alterations Dopamine neural

NLRP3炎性小体在脊髓损伤后小胶质细胞中的作用

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中国组织工程研究 2025年第13期29卷 2849-2860页

作者：周文洋廖烨晖田明昊何宝强钟德君西南医科大学附属医院骨科四川省泸州市646000

背景:NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor thermal protein domain associated protein 3,NLRP3)炎性小体与脊髓损伤后的神经炎症密切相关,小胶质细胞极化和焦亡在其中发挥关键作用,靶向调控NLRP3有利于诱导小胶质细胞... 详细信息

背景:NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor thermal protein domain associated protein 3,NLRP3)炎性小体与脊髓损伤后的神经炎症密切相关,小胶质细胞极化和焦亡在其中发挥关键作用,靶向调控NLRP3有利于诱导小胶质细胞从M1促炎表型向M2抗炎表型极化和调节小胶质细胞焦亡,是一个有前景的治疗策略。目的:归纳NLRP3炎性小体在脊髓损伤后小胶质细胞中作用的分子机制以及治疗策略的研究进展。方法:检索PubMed、Web of Science和中国知网数据库,英文检索词为“spinal cord injury,NLRP3,microglia,polarization,pyroptosis”,中文检索词为“脊髓损伤,NLRP3,小胶质细胞,极化,焦亡,炎症”,按纳入和排除标准共纳入79篇文献进行总结。结果与结论:①目前,关于脊髓损伤复杂的发病机制尚未有统一定论,大量研究表明脊髓损伤与炎症因子和信号通路关系密切,以NLRP3炎性小体作为其发病机制和治疗突破口的相关研究也是当前的热点。②NLRP3炎性小体在脊髓损伤后的炎症反应、氧化应激和神经元恢复等起到关键作用。③小胶质细胞是脑和脊髓中的免疫细胞,是继发性脊髓损伤最重要的调节因子,脊髓损伤后小胶质细胞对内部环境作出调整,主要表现为极化及焦亡,产生大量炎症因子,阻碍脊髓损伤的神经再生和功能恢复,通过调控小胶质细胞表型变化,是治疗脊髓损伤的另一个关键因素。④NLRP3炎性小体与小胶质细胞密切相关,脊髓损伤后NLRP3炎性小体主要在小胶质细胞中表达,其会促进小胶质细胞向M1极化和促进促裂解蛋白D的产生,进一步破坏神经稳态,从而加重脊髓损伤的进展。⑤许多分子参与NLRP3炎性小体调控小胶质细胞,其中核转录因子κB及MAPK信号通路促进NLRP3炎性小体表达,其他信号通路抑制该炎性小体表达。⑥目前有大量的外源性分子及药物调控NLRP3炎性小体,临床应用前景广泛,已有相关药物处于临床试验阶段并取得良好疗效,如NLRP3特异性抑制剂MCC950,但如何精准控制靶向递送、减少对其他组织器官影响等关键问题亟需解决,随着研究的深入,未来有望在脊髓损伤治疗方式上作出新的突破。

关键词：脊髓损伤 NLRP3 小胶质细胞极化焦亡炎症非编码RNA 中药活性成分干细胞特异性抑制剂

Congruences for finite triple harmonic sums

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第6期8卷 946-948页

作者： FU Xu-dan zhou Xia CAI tian-xin Department of Mathematics Zhejiang University Hangzhou 310028 China Hangzhou Foreign Language School Hangzhou 310023 China

Zhao （2003a） first established a congruence for any odd prime p〉3, S（1,1,1 ;p）=-2Bp-3 （mod p）, which holds when p=3 evidently. In this paper, we consider finite triple harmonic sum S（α,β, γ,ρ）（modp） is considered for all positive integers α,β, γ. We refer to w=α＋β＋ γ as the weight of the sum, and show that if w is even, S（α,β, γ,ρ）=0 （mod p） for p≥w＋3; if w is odd, S（α,β, γ,ρ）=-rBp-w （mod p） for p≥w, here r is an explicit rational number independent ofp. A congruence of Catalan number is obtained as a special case.

关键词： Finite triple harmonic sums Recursive relation Bernoulli numbers Catalan numbers

Transmitting Multiple Information Signals by a Single Chaotic Carrier

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Chinese Physics Letters 1997年第3期14卷 161-164页

作者： zhou Chang-song CHEN tian-lun Department of Physics Nankai UniversityTianjin 300071

A method for transmitting multiple digital information signals by a single transmitted chaotic signal is *** information signals are encoded by modifying some tunable parameters of a chaotic system and decoded at the receiver by following the parameter modulation in the transmitter via *** Lorenz system is used to demonstrate the validity,robastness and security of the method.

关键词： method chaotic system

Inverse scattering transforms of the inhomogeneous fifth-order nonlinear Schrodinger equation with zero/nonzero boundary conditions

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Communications in Theoretical Physics 2022年第8期74卷 56-68页

作者： Jin-Jin Mao Shou-Fu tian tian-zhou Xu Lin-Fei Shi School of Mathematics and Statistics Beijing Institute of TechnologyBeijing 100081China School of Mathematics China University of Mining and TechnologyXuzhou 221116China

The present work studies the inverse scattering transforms(IST)of the inhomogeneous fifth-order nonlinear Schrodinger(NLS)equation with zero boundary conditions(ZBCs)and nonzero boundary conditions(NZBCs).Firstly,the bound-state solitons of the inhomogeneous fifth-order NLS equation with ZBCs are derived by the residue theorem and the Laurent's series for the first ***,by combining with the robust IST,the Riemann-Hilbert(RH)problem of the inhomogeneous fifth-order NLS equation with NZBCs is ***,based on the resulting RH problem,some new rogue wave solutions of the inhomogeneous fifth-order NLS equation are found by the Darboux ***,some corresponding graphs are given by selecting appropriate parameters to further analyze the unreported dynamic characteristics of the corresponding solutions.

关键词： the inhomogeneous fifth-order nonlinear Schrodinger equation inverse scattering transforms Darboux transformation bound-state soliton rogue wave zero/nonzero boundary conditions

Isolation and Crystal Structure of 1',4'-Trans-diol of Abscisic Acid

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Chinese Journal of Structural Chemistry 2006年第9期25卷 1085-1089页

作者： WANG tian-Shan zhou Jin-Yan TAN Hong Chengdu Institute of Biology The Chinese Academy of Sciences Chengdu 610041 China Department of Chemistry Hainan Normal University Haikou 571158 China

1 ′,4′-Trans-diol of abscisic acid was isolated from botrytis cinerea as a colorless crystal. The molecular and crystal structures have been determined by X-ray diffraction analysis. It crystallizes in orthorhombic system, space group P212121 with a = 6.724（3）, b = 17.559（6）, c = 12.265（2）,A,α =β=γ= 90°, V= 1448.1（8）,A^3, Z=4, Dx = 1.222 g/cm^3, F（000） = 576 and μ（MoKa） = 0.087 mm^-1. The final R = 0.0628 and wR = 0.1604 for 2501 independent reflections with Rint - 0.0160 and 1679 observed reflections with 1 〉2σ（I）. There are three intermolecular hydrogen bonds in a unit cell.

关键词： botrytis cinerea abscisic acid 1′,4′-trans-diol of abscisic acid X-ray diffraction analysis

Metamaterials beyond negative refractive index： Applications in telecommunication and sensing

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Science China(Technological Sciences) 2016年第7期59卷 1007-1011页

作者： LIU RuoPeng ZHAO ZhiYa JI ChunLin zhou tian Kuang-Chi Institute of Advanced Technology Shenzhen 518000 China State Key Laboratory of Metamaterial Electromagnetic Modulation Technology Shenzhen 518000 China

Metamaterials have earned their name with extraordinary properties such as negative refractive index and invisibility cloaking. With over 15 years of research and development, metamaterials show their debut in real world applications, especially in the areas of telecommunication, sensing, aerospace & defense, optics and medical instrumentation. In the meanwhile, metamaterials are expanding their concept in areas beyond electromagnetics. In this paper, the authors would like to focus on the research and applications in telecommunication and sensing. Octave-bandwidth horn antennas, flat-panel satellite antennas and air-borne holographic satellite antennas are all fabulous examples of clever implementation that bring metamaterials into practical devices. We would like to discuss the features that differentiate metamaterials from conventional counterparts in case studies. With the advancement in design, manufacturing, packaging, detection and testing, more sophisticated features are expected in the telecommunication, sensing, and beyond.

关键词： metamaterial dispersion engineering field enhancement compressive sensing