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Effect of lanthanum on microstructure of a nickel-based single crystal superalloy

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China Foundry 2025年第1期22卷 55-64页

作者： Hong Gao Kai Guan Ren-jie Cui Jian-chao qin Zi-han Zhao Zhao-hui huang Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical MaterialsBeijing 100095China

To enhance the high-temperature oxidation resistance and mechanical properties of a secondgeneration nickel-based superalloy,various concentrations of lanthanum(La)ranging from 5.0×10^(-5)wt.%to 3.4×10^(-4)wt.%are added to the *** microstructure of the nickel-based single crystal superalloy with trace of La was examined by means of SEM,EDS and *** show the addition of La decreases the segregation of elements and increases the amount ofγ/γ′eutectics of the as-cast alloy,and in the interdendritic region,the growth of eutectics is accompanied by the growth of strip clusters composed of Ni_(5)La and Ni_(3)*** the La content in the alloy increases,the proportion of Ni_(5)La in the cluster *** heat treatment,incipient melting occurs in the cluster regions,leading to an increase in microporosity compared to the original as-cast ***,the heat treatment alters the shape of the clusters from a strip morphology to an elliptical one,and it changes their composition from Ni_(5)La and Ni_(3)Ta to a combination of Ni_(5)La,Ni_(3)Ta,and MC carbides.

关键词： single crystal superalloy lanthanum microstructure heat-treatment precipitate phase

Isothermal reduction kinetics and reduction prediction for iron ore pellets

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Journal of Iron and Steel Research International 2025年第1期32卷 64-72页

作者： Fei Meng Hao Liu Yue-lin qin huang-jie Hua Yin Deng Ze-zheng Sun Long-hai Liu School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing401331China CISDI Group Co. Ltd.Chongqing401122China College of Materials Science and Engineering Chongqing UniversityChongqing400044China Sichuan Desheng Group Vanadium&Titanium Co. Ltd.Leshan614000SichuanChina

Iron ore pellets,as one of the main charges of blast furnaces,have a greater impact on the CO_(2)emission reduction and stable operation of blast *** isothermal reduction behavior of the pellets obtained from a Chinese steel plant was studied in the gas mixtures of CO and N_(2).The results showed the reduction process is divided into two *** reduction in the initial stage(time t≤40 min)is cooperatively controlled by internal diffusion and interface chemical reactions with the activation energy of 30.19 and 16.67 kJ/mol,*** controlling step of the reduction in the final stage(t>40 min)is internal diffusion with the activation energy of 34.60 kJ/*** reduction process can be described by two equations obtained from kinetic *** reduction degree can be predicted under different temperatures and time,and the predicted results showed an excellent correlation with the experimental *** reduction mechanisms were confirmed by the analysis of the scanning electron microscope equipped with an energy dispersive spectrometer and optical microscope.

关键词： Pellet Reduction behavior Kinetics Mechanism Reduction prediction

Kinesin family member 14 expression and its clinical implications in colorectal cancer

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 299-321页

作者： Kai qin Jia-Yuan Luo Da-Tong Zeng Wan-Ying huang Bin Li Qi Li Yan-Ting Zhan Rong-Quan He Wei-Jian huang Gang Chen Zu-Yuan Chen bang-Teng Chi Yu-Xing Tang Rui-Xue Tang Hui Li Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinan 250000Shandong ProvinceChina Department of Colorectal and Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer globally,causing over 900000 deaths *** factors include aging,diet,obesity,sedentary lifestyle,tobacco use,genetic predisposition,and inflammatory bowel *** current treatments,survival rates for advanced CRC remain low,highlighting the need for better therapeutic *** To evaluate both the clinical significance and the pathological implications of the Kinesin family member 14(KIF14)expression within CRC ***,this study aims to investigate the interaction between nitidine chloride(NC)and KIF14,considering their potential as therapeutic *** The expression of the KIF14 protein in CRC was analyzed using immunohistochemical *** integration of multicenter high-throughput data facilitated the calculation of the standardized mean difference(SMD)for KIF14 mRNA *** assessment of clinical and pathological impact was enhanced by analyzing combined receiver operating characteristic curves,along with measures of sensitivity,specificity,and likelihood ***,clustered regularly interspaced short palindromic repeats knockout screening for cell growth and single-cell sequencing were employed to validate the significance of KIF14 expression in *** analysis established the prognostic value of KIF14 in *** molecular mechanism of NC against CRC was elucidated through whole-genome sequencing and enrichment analysis,and molecular docking was utilized to explore the targeting affinity between NC and *** KIF14 was highly expressed in 208 CRC *** from 17 platforms involving 2436 CRC samples and 1320 noncancerous colorectal tissue controls indicated that KIF14 expression was significantly higher in CRC samples,with an SMD of 1.92(95%CI:1.49-2.35).The area under the curve was 0.94(95%CI:0.92-0.96),with a sensitivity of 0.85(95%CI:0.78-0.90)and a specificity of 0.90(95%CI:0.85-0.93).The positive and negative l

关键词： Colorectal cancer Kinesin family member 14 Nitidine chloride Molecular docking Standardized mean difference

Hierarchically Porous Polypyrrole Foams Contained Ordered Polypyrrole Nanowire Arrays for Multifunctional Electromagnetic Interference Shielding and Dynamic Infrared Stealth

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Nano-Micro Letters 2025年第4期17卷 399-418页

作者： Yu-long Liu Ting-yu Zhu qin Wang Zi-jie huang De-xiang Sun Jing-hui Yang Xiao-dong Qi Yong Wang School of Chemistry Key Laboratory of Advanced Technologies of Materials(Ministry of Education)Southwest Jiaotong UniversityChengdu 610031People’s Republic of China

As modern communication and detection technologies advance at a swift pace,multifunctional electromagnetic interference(EMI)shielding materials with active/positive infrared stealth,hydrophobicity,and electric-thermal conversion ability have received extensive *** the aforesaid requirements simultaneously remains a huge *** this research,the melamine foam(MF)/polypyrrole(PPy)nanowire arrays(MF@PPy)were fabricated via one-step electrochemical *** hierarchical MF@PPy foam was composed of three-dimensional PPy micro-skeleton and ordered PPy nanowire *** to the upwardly grown PPy nanowire arrays,the MF@PPy foam possessed good hydrophobicity ability with a water contact angle of 142.00°and outstanding stability under various harsh ***,the MF@PPy foam showed excellent thermal insulation property on account of the low thermal conductivity and elongated ligament characteristic of PPy nanowire ***,taking advantage of the high conductivity(128.2 S m^(-1)),the MF@PPy foam exhibited rapid Joule heating under 3 V,resulting in dynamic infrared stealth and thermal camouflage *** importantly,the MF@PPy foam exhibited remarkable EMI shielding effectiveness values of 55.77 dB and 19,928.57 dB cm^(2)g^(-1).Strong EMI shielding was put down to the hierarchically porous PPy structure,which offered outstanding impedance matching,conduction loss,and multiple *** innovative approach provides significant insights to the development of advanced multifunctional EMI shielding foams by constructing PPy nanowire arrays,showing great applications in both military and civilian fields.

关键词： Polypyrrole nanowire arrays Hierarchical foam Hydrophobicity Infrared stealth Electromagnetic interference shielding

Exosome technology:A novel and effective drug delivery system in the field of cancer therapy

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 464-469页

作者： Jia-Xin Geng Yao-Fan Lu Jing-Nan Zhou Biao huang Yuan qin College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018Zhejiang ProvinceChina Zhejiang Cancer Hospital Hangzhou 310018Zhejiang ProvinceChina

In this article,we revisit an article,which specifically focuses on the utilization of exosomes derived from human bone marrow mesenchymal stem cells(MSCs)for targeted delivery of gemcitabine in pancreatic cancer *** experimental results demonstrated that the exosome-based drug delivery system derived from MSCs significantly augmented apoptosis in pancreatic cancer *** biocompatibility,targeting specificity,and low immunogenicity of exosomes render them as optimal carriers for drug delivery,enabling precise administration of therapeutics to diseased tissues while mitigating adverse effects,thereby achieving targeted treatment of cancer cells and significantly enhancing anti-tumor ***,the clinical application of exosome drug delivery platforms in oncology still presents challenges,necessitating further optimization to ensure their stability and *** study focuses on elucidating the advantages of exosomes as a drug delivery platform,exploring the utilization of MSC-derived exosomes in oncology therapy,and discussing their potential and future directions in cancer treatment.

关键词： Exosomes Drug delivery Mesenchymal stem cells Tumor therapy Gemcitabine

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia qin Lingyan Liang Yichen Wei qingping Zhang Xiaocheng Li Haixia qin Yinqi Lai Yian Lu Yan Zhang Jiazhu huang Jinli huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

Effects of postoperative quantitative assessment strategy-based nursing in patients with colorectal cancer

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 349-356页

作者： Xiao-qin Tan Xiao-Lu huang Department of Colorectal and Anal Surgery The Central Hospital of Enshi Tujia and Miao Autonomous PrefectureEnshi 445000Hubei ProvinceChina

BACKGROUND Scientifically sound and reasonable care strategies in surgical nursing play a crucial role in facilitating postoperative recovery and preventing *** study focused on the application of quantitative assessment strategies to postoperative *** quantitatively analyzing the effects of nursing interventions,we explored their feasibility and effectiveness at improving postoperative recovery quality and reducing the incidence of *** study provides a scientific basis for nursing practice and offers new insights into nursing management with significant clinical *** To analyze the efficacy of postoperative quantitative assessment strategy-based nursing care for patients with colorectal cancer(CRC).METHODS This randomized controlled trial evaluated the ability of nursing interventions using a quantitative assessment strategy to prevent postoperative complications and enhance patient *** with CRC were randomly divided into routine nursing(RN)and quantitative assessment strategy nursing(QASN)*** RN group received standard care,while the QASN group also underwent screenings for visual analog scale for pain,Barthel Index for functional recovery,and self-rating anxiety scale and self-rating depression scale for psychological ***-ups were conducted on postoperative days 1,7,14,28,and *** The participants’baseline characteristics did not significantly differ between study groups,thereby ensuring the reliability of the *** QASN vs RN group showed significant improvements in pain management(visual analog scale scores)and psychological status(self-rating anxiety scale and self-rating depression scale scores)and a reduced incidence of postoperative complications(P<0.05).The follow-up evaluations at specified intervals confirmed these findings,indicating that quantitative assessment strategies significantly enhanced patients’postoperative pain management and psychological ***

关键词： Postoperative Colorectal cancer Quantitative assessment strategy-based nursing Patient recovery Pain management Nursing evaluation

A real-time multi-head mixed attention mechanism-based prediction method for tunnel boring machine disc cutter wear

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Science China(Technological Sciences) 2025年第1期68卷 286-307页

作者： Haodi WANG Chengjin qin Honggan YU Zhinan ZHANG Guoqiang huang Zhengyang LIU Chengliang LIU State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

In the process of hard rock tunnel excavation,workers often need to enter the tunnel boring machine(TBM)cutterhead at regular intervals to measure cutter ***,this method is time-consuming and *** cutter prediction models primarily rely on geological parameters to predict overall cutter wear before construction,making it challenging to monitor real-time wear at different locations of the cutter and obtain accurate geological *** address these challenges,this paper proposes a multi-head mixed attention mechanism-based method for real-time wear prediction of TBM disc ***,a method of cutter wear normalization to eliminate measurement noise is ***,considering the complex correlation of TBM operating parameters in feature and time dimensions,a new multi-head mixed attention mechanism model is designed to establish the dependency between different features and different moments,to better establish the mapping model between operating parameters and cutter ***,the current cutter wear state can be calculated by accumulating the wear amount of all previous small excavation *** effectiveness of the method is verified by using field data from the Mumbai *** results demonstrate that the method is capable of real-time prediction of front cutter and edge cutter wear on the test set,achieving an average accuracy rate of 95.75%.Moreover,the method can update the cutter wear status after every meter of excavation,which has good real-time *** addition,the average accuracy of cutter wear prediction of the proposed method is 11.75%,10.375%,3.875%,3.625%,1.375%,3.125%,2.25%,and 0.75%higher than that of LSTM,CNN,LSTM-CNN,CACNN,SACNN,MMADNN,MTACNN,and *** summary,this approach offers an accurate prediction of cutter wear state while reducing inspection time and costs and has high application value.

关键词： tunnel boring machine cutter wear estimation multi-head mixed attention mechanism real time

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NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS

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Chinese Chemical Letters 2025年第2期36卷 337-343页

作者： Xiaoshuai Wu Bailei Wang Yichen Li Xiaoxuan Guan Mingjing Yin Wenquan Lv Yin Chen Fei Lu Tao qin Huyang Gao Weiqian Jin Yifu huang Cuiping Li Ming Gao Junyu Lu Intensive Care Unit The Second Affiliated Hospital of Guangxi Medical University Department of Critical Care Medicine The Ninth Affiliated Hospital of Guangxi Medical University Life Sciences Institute Guangxi Medical University Department of Emergency The First Affiliated Hospital of Guangxi Medical University College & Hospital of Stomatology Guangxi Medical University Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical University

Acute lung injury(ALI) was characterized by excessive reactive oxygen species(ROS) levels and inflammatory response in the lung. Scavenging ROS could inhibit the excessive inflammatory response, further treating ALI. Herein, we designed a novel nanozyme(P@Co) comprised of polydopamine(PDA) nanoparticles(NPs) loading with ultra-small Co, combining with near infrared(NIR) irradiation, which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI. For lipopolysaccharide(LPS) induced macrophages, P@Co + NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels, decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α) as well as inducing macrophage M2 directional polarization. Significantly, it displayed the outstanding activities of lowering acute lung inflammation, relieving diffuse alveolar damage, and up-regulating heat shock protein 70(HSP70) expression, resulting in synergistic enhanced ALI therapy effect. It offers a novel strategy for the clinical treatment of ROS related diseases.

关键词： Acute lung injury M2 directional polarization Nanozyme NIR driven ROS scavenging