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Surgical management of Zollinger-Ellison syndrome: Classical considerations and current controversies

World Journal of Gastroenterology 2019年第32期25卷 4673-4681页

作者： Qian-Qian Shao bang-bo zhao Liang-bo Dong Hong-Tao Cao Wei-Bin Wang Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences/Peking Union Medical College

Zollinger-Ellison syndrome(ZES)is characterized by gastric acid hypersecretion causing severe recurrent acid-related peptic *** secretion of gastrin can now be effectively controlled with powerful proton pump inhibitors,but surgical management to control gastrinoma itself remains *** on a thorough literature review,we design a surgical algorithm for ZES and list some significant consensus findings and recommendations:(1)For sporadic ZES,surgery should be routinely undertaken as early as possible not only for patients with a precisely localized diagnosis but also for those with negative imaging *** surgical approach for sporadic ZES depends on the lesion location(including the duodenum,pancreas,lymph nodes,hepatobiliary tract,stomach,and some extremely rare sites such as the ovaries,heart,omentum,and jejunum).Intraoperative liver exploration and lymphadenectomy should be routinely performed;(2)For multiple endocrine neoplasia type 1-related ZES(MEN1/ZES),surgery should not be performed routinely except for lesions>2 *** attempt to perform radical resection(pancreaticoduodenectomy followed by lymphadenectomy)can be *** ameliorating effect of parathyroid surgery should be considered,and parathyroidectomy should be performed first before any abdominal surgery for ZES;and(3)For hepatic metastatic disease,hepatic resection should be routinely ***,liver transplantation is still considered an investigational therapeutic approach for ***-designed prospective studies are desperately needed to further verify and modify the current considerations.

关键词： Zollinger-Ellison syndrome Sporadic gastrinomas Multiple endocrine neoplasia type 1 Hepatic metastatic disease Surgical treatment

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Impact of Startup Strategy and Buffer Tank Volume on the Compressor Inlet State for a 3-MW sCO2 Brayton Cycle

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Journal of Thermal Science 2025年第1期34卷 159-175页

作者： zhao Decai WANG bo Key Laboratory of Advanced Energy and Power Institute of Engineering Thermophysics(IET)Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences

The supercritical carbon dioxide（sCO2） Brayton cycle system has become an emerging and highly promising method of thermal power conversion due to its efficiency advantage,system compactness,and excellent adaptability of the heat *** the low carbon sCO2Brayton cycle testbed with cycle output power approaching 3 MW,a relatively detailed dynamic simulation model of the entire system is constructed to explore the dynamic response characteristics of the system with different startup strategies and different buffer tank volumes during the startup *** simulation results indicate that the smaller the volume of the buffer tank,the more rapid and obvious the parameter fluctuation in the buffer tank during the *** the allowable relative deviation limit of density is 5%,then the ratio of the buffer tank volume to the volume of the entire closed loop should not be lower than 36.80%.The strategy of simultaneous temperature and speed increase during turbine bypass start can effectively reduce the fluctuation of compressor inlet parameters and reach the steady-state more *** paper provides the recommended matching table for the opening of the turbine bypass valve（TBV） and the main regulating valve（MGV） to reduce the parameter fluctuation during the bypass *** effectiveness of the proposed turbine bypass and bypass switching startup strategy is verified by simulation,which may be used as a reference for test bench's future debugging and operation.

关键词： buffer tank dynamic characteristic dynamic model sCO2 Brayton cycle startup strategy

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： zhao-Jun Zhang Wen-Wei Wang Jing-Shui Zhen bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei Liu Yantong Li Meng-Xiang Wu Hao Kang Xiao-Li zhao Lin Xu Linlin Liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng Hai-bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction

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High sensitivity dual polarization four channels surface plasmon resonance refractive index sensor with wide detection range and high linearity based on photonic crystal fiber

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Optoelectronics Letters 2025年

作者： CUI Nan PAN Honggang ZHANG Ailing zhao Zihong CHEN Zhipan ZHANG bo Tianjin Key Laboratory of Film Electronic and Communication Devices， Engineering Research Center of Optoelectronic Devices and Communication Technology， Ministry of Education， School of Integrated Circuit Science and Engineering， Tianjin University of Technology

In this paper， we propose and numerically characterize the optical characteristics of a high sensitivity dual polarization four channels surface plasmon resonance refractive index sensor with wide detection range and high linearity based on photonic crystal fiber （PCF）. Four light transmission channels are constructed by using big air holes. The small rectangular air hole in the center of the fiber core is used to add asymmetry. We use gold plasma material to achieve better sensing performance. A thin film of TiO2is placed on the PCF surface， which assists gold in the adhesion on PCF. The maximum wavelength sensitivity of the sensor can reach 20000 nm/RIU in both x and y polarization modes. While the maximum wavelength resolution of the sensor is 5×10-6RIU. The average wavelength sensitivity reached 15900nm/RIU and 15800nm/RIU in x and y polarization mode. The sensor features R2=0.9969 / R2=0.9966 high linear performance in x and y polarization mode and the maximum FOM values 509.13 RIU-1/ 489.63 RIU-1in x and y polarization mode. Besides the sensor’s detection range is 1.26-1.36， which is a wide refractive index detection range. The sensor has a wide range of applications in biomedical and other fields.

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui Chen Peng zhao Wen-bo Deng Ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-bo Li Qi Zhang Jun-zhao Xiao Yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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低聚甘露糖增强短双歧杆菌抑制具核梭杆菌生长的机制研究

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食品工业科技 2025年第1期46卷 163-170页

作者：张旭妍刘瑞洁赵博许晓曦东北农业大学食品学院黑龙江哈尔滨150030 教育部乳品重点实验室黑龙江哈尔滨150030

为探究双歧杆菌与低聚糖协同抑制具核梭杆菌作用及机理,采用6种常见双歧杆菌(动物双歧杆菌、长双歧杆菌、婴儿双歧杆菌、短双歧杆菌、两歧双歧杆菌、青春双歧杆菌)代谢6种不同结构且应用广泛的低聚糖(低聚甘露糖、低聚半乳糖、低聚异麦... 详细信息

为探究双歧杆菌与低聚糖协同抑制具核梭杆菌作用及机理,采用6种常见双歧杆菌(动物双歧杆菌、长双歧杆菌、婴儿双歧杆菌、短双歧杆菌、两歧双歧杆菌、青春双歧杆菌)代谢6种不同结构且应用广泛的低聚糖(低聚甘露糖、低聚半乳糖、低聚异麦芽糖、低聚果糖、低聚乳果糖、阿拉伯半乳聚糖),通过硫化氢的生成与生物膜的抑制,确定最佳抑制具核梭杆菌组合,通过扫描电镜、透射电镜与流式细胞仪分析具核梭杆菌菌体细胞完整性,研究抑菌机理,并探讨其酸性代谢产物对具核梭杆菌的抑制作用影响,测定其短链脂肪酸产量,此外还挖掘了双歧杆菌潜在细菌素基因簇。结果显示,低聚甘露糖促进短双歧杆菌抑制具核梭杆菌效果最佳,其组合可显著减少硫化氢的产生与生物膜的形成,与空白对照相比,在添加量达到20%时,对具核梭杆菌的抑制率可达到63.16%±4.48%,其表观结构明显损伤,蛋白和核酸流出,细胞膜的完整性和通透性被破坏。这种抑菌效果会随着上清液pH向中性环境的靠近而下降,表明上清液中酸性代谢产物在发挥抑菌效果中起重要作用,上清液中乙酸、丙酸、丁酸、戊酸分别含量为26.112、10.829、5.106、5.232 mmol/L。此外基因预测到短双歧杆菌包含2个潜在的细菌素合成基因簇。综上,低聚甘露糖配合短双歧杆菌的合生元组合或可作为一种安全、有效的具核梭杆菌生物防控抑制剂,为预防及辅助治疗结直肠癌等肿瘤疾病提供更为安全有效的新方法。

关键词：双歧杆菌低聚糖抑菌机制短链脂肪酸具核梭杆菌

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国土空间规划背景下黄河流域水生态空间格局演变特征及其影响因素

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水土保持研究 2025年第2期32卷 178-190页

作者：薄立明赵浪尹力张翔魏伟武汉大学中国发展战略与规划研究院武汉430072 武汉大学城市设计学院武汉430072 中国地质大学(武汉)国家地理信息系统工程技术研究中心武汉430078 湖北省人居环境工程技术研究中心武汉430072

[目的]科学认知黄河流域上、中、下游水生态空间格局演化特征及影响因素,促进水资源用途管制客体向国土空间规划体系治理系统的融入,推动黄河流域生态保护和高质量发展。[方法]采用空间转移矩阵、最优地理探测器等量化模型分析黄河流域... 详细信息

[目的]科学认知黄河流域上、中、下游水生态空间格局演化特征及影响因素,促进水资源用途管制客体向国土空间规划体系治理系统的融入,推动黄河流域生态保护和高质量发展。[方法]采用空间转移矩阵、最优地理探测器等量化模型分析黄河流域上、中、下游水生态空间格局演变的区域差异,剖析了水生态空间格局演变路径并揭示其内在影响因素。[结果](1)黄河流域水生态空间规模为2.76万km^(2),仅占流域国土总面积的2.28%,上、中、下游水生态空间规模占比为22∶2∶3,研究期内规模性扩张了4 989.90 km^(2),上游地区增长规模最大,下游地区增长幅度最剧烈。(2)上游地区水生态空间主要与其他生态空间发生交叉转换,引起水生态空间大规模扩张,其次是与农业空间交互转换造成水生态空间小规模流失;中游地区水生态空间主要与农业空间发生交叉转换,其次是其他生态空间,引起水生态空间小规模扩张;下游地区农业空间向水生态空间的转换引起水生态空间大规模扩张的同时水生态空间也规模性转换为城镇空间。(3)上游地区水生态空间规模性扩张核心影响因素是水资源“液态化”的水文循环过程,流失则是主要由第一、三产业发展诉求驱动;中游地区水生态空间格局演变整体表现为政府财政所主导的适配地区自然地理条件、社会经济发展的水资源调配过程;下游地区则是水生态空间伴随城镇化进程在农业地区和城镇地区的转移。[结论]黄河流域上、中、下游水生态空间格局演变特征、路径和影响因素差异显著,需要根据各区域水资源保护利用的发展定位,建立起共同治理、协同发展的流域协作体系。

关键词：水生态空间国土空间规划用途管制时空格局黄河流域

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Establishment and verification of theoretical model for underwater light-sheet Scheimpflug LiDAR system

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Science China Technological Sciences 2025年第1期 54-61页

作者： Fei FENG Guojun WU bo LIU Xu zhao Yafeng WU Jinghan XU Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences University of Chinese Academy of Sciences

The Scheimpflug imaging in the air can increase the depth-of-view and has been well studied with an accurate Scheimpflug imaging model. However, there is no corresponding underwater light-sheet Scheimpflug(ULSS) imaging *** a result, imaging accuracy cannot be ensured in the design phase, which mainly relies on the post-calibration. In this paper,the ULSS imaging model is firstly established, which gives the relationship between the pixel number and target distance, as well as that between the target distance and range resolution. A new experimental bracket and an underwater Scheimflug imaging lens were designed and developed. Based on this new device, several experiments were carried out in a pool to study the range resolution of this ULSS LiDAR, by which the correctness of the imaging model was verified. It also shows that the newly designed ULSS LiDAR can achieve a millimeter-level resolution within 8 m.

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