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RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao Wang bang liu Yang-Pu Jia Zhao-Xiong Zhang Xin liu Dao-Han Wang Yong-Jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

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Understanding and Generating Ultrasound Image Description

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Journal of Computer Science & Technology 2018年第5期33卷 1086-1100页

作者： Xian-Huu Zeng bang-Gui liu Meng Zhou School of Computer Science and Technology Chongqing University of Posts and Telecommunications Chongqing 400065 China

To understand the content of ultrasound images more conveniently and more quickly, in this paper, we propose a coarse-to-fine ultrasound image captioning ensemble model, which can automatically generate the annotation text that is composed of relevant n-grams to describe the disease information in the ultrasound images. First, the organs in the ultrasound images are detected by the coarse classification model. Second, the ultrasound images are encoded by the corresponding fine-grained classification model according to the organ labels. Finally, we input the encoding vectors to the language generation model, and the language generation model generates automatically annotation text to describe the disease information in the ultrasound images. In our experiments, the encoding model can obtain the high accuracy rate in the ultrasound image recognition. And the language generation model can automatically generate high-quality annotation text. In practical applications, the coarse-to-fine ultrasound image captioning ensemble model can help patients and doctors obtain the well understanding of the contents of ultrasound images.

关键词： ultrasound image fine-grained classification image captioning

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Preparation and properties of the Ni-Al/Fe-Al intermetallics composite coating produced by plasma cladding

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International Journal of Minerals,Metallurgy and Materials 2011年第6期18卷 725-730页

作者： Li-min Zhang bang-wu liu Dong-bai Sun National Center of Analysis and Testing for Non-ferrous Metals ＆ Electronic Materials General Research Institute for Nonferrous Metals Beijing 100088 China Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China Corrosion and Protection Center University of Science and Technology Beijing Beijing 100083 China

A novel approach to produce an intermetallic composite coating was put *** microstructure,microhardness,and dry-sliding wear behavior of the composite coating were investigated using X-ray diffraction （XRD）,scanning electron microscopy （SEM）,energy dispersive spectrum （EDS） analysis,microhardness test,and ball-on-disc wear *** results indicate that some new phases FeAl,Fe0.23Ni0.77Al,and Ni3Al exit in the composite coating with the Al2O3 *** results show that the coating is bonded with carbon steel metallurgically and exhibits typical rapid directional solidification *** Cr7C3 carbide and intermetallic compounds co-reinforced composite coating has a high average hardness and exhibits an excellent wear resistance under dry-sliding wear test compared with the Cr7C3 carbide-reinforced composite *** formation mechanism of the intermetallic compounds was also investigated.

关键词： composite coatings plasma cladding intermetallics microhardness wear resistance

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Annealing Effects on Structural,Optical Properties and Laser-Induced Damage Threshold of MgF2 Thin Films

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Acta Metallurgica Sinica(English Letters) 2017年第1期30卷 73-78页

作者： Ting-Ting Tan bang-Jie liu Zhi-Hui Wu Zheng-Tang liu State Key Lab of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China

The chemical structures, optical properties and laser-induced damage thresholds of magnesium fluoride films annealed at different temperatures were investigated. The results showed that the stoichiometry of MgF2 film changed a little with the increase in annealing temperature. Analysis of the optical properties indicated that excellent antireflection behavior of the film in the range of 200-400 nm can be obtained by the samples coated with MgF2 film. The refractive index increased and the extinction coefficient decreased with increasing annealing temperature. Compared with the asdeposited films, the laser-induced damage threshold was improved after annealing process and decreased with the increase in annealing temperature, which was probably due to the denser film and more absorption centers under higher annealing temperature.

关键词： Annealing temperature Chemical structure Optical properties Laser-induced damage threshold (LIDT) MgF2 films

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Density-functional theory investigation of energy gaps and optical properties of Hg_(1-x)Cd_x Te and In_(1-x)Ga_x As

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Chinese Physics B 2012年第1期21卷 404-408页

作者： Guo San-Dong liu bang-Gui Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

We use a modified Becke-Johnson exchange plus a local density approximation correlation potential within the density functional theory to investigate the electronic structures of Hg1-xCdxTe and In1-xGaxAs with x being 0, 0.25, 0.5, 0.75, and 1. For both of the two series, our calculated energy gaps and dielectric functions （real part 61 and imaginary part 62） are in agreement with the corresponding experimental results with x being between 0 and 1. The calculated zero-frequency refractive index varies greatly with x for Hg1-xCdxTe, but changes little with for In1-xGaxAs, which is consistent with the real parts of their dielectric functions. Therefore, this new approach is satisfactory to describe the electronic structures and the optical properties of the semiconductors.

关键词： semiconductor gap optical property

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Marine Mobile Wireless Channel Modeling Based on Improved Spatial Partitioning Ray Tracing

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China Communications 2020年第3期17卷 1-11页

作者： Zhibin Gao bang liu Zhipeng Cheng Canbin Chen Lianfen Huang Department of Communication Engineering Xiamen UniversityXiamen 361005China China Contribution Bank Fintech Xiamen 361005China

In 5G era,it is expected to achieve wireless network coverage including offshore *** of marine wireless channels is the basis of constructing a marine communication *** this paper,a communication scene between an unmanned aerial vehicle(UAV)and a boat is simulated to study the marine wireless ***,an improved spatial partitioning ray tracing algorithm is proposed to track the propagation path of electromagnetic waves at sea ***,a mobile channel is simulated and modeled based on the track ***,a loss measurement is carried out in the coastal waters based on the simple wireless channel loss measuring platform,and a path loss propagation model is *** we compare the actual measurement data with the simulation results and find that the two are have good consistency,which further verifies the reliability of the simulation.

关键词： marine wireless channel ray tracing channel modeling path loss

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Symptom experience and symptom burden of patients following first-ever stroke within 1 year： a cross-sectional study

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Neural Regeneration Research 2018年第11期13卷 1907-1912页

作者： Dan Shi Zheng Li Jian Yang bang-Zhong liu Hui Xia School of Nursing Fudan University Shanghai China Xuhui District Center Hospital of Shanghai Shanghai China Zhongshan Hospital Affiliated to Fudan University Shanghai China

Symptoms that are multidimensional and concurrent should be assessed from different dimensions and managed together. Few studies have evaluated concurrent and multidimensional symptoms in patients with stroke. Most studies of stroke focused on dysfunctions and complications. We hypothesize that patients with stroke have a heavy symptom burden within 1 year. This study aimed to describe multidimensional and concurrent symptoms within 1 year after stroke. This study recruited 230 patients with stroke from the Rehabilitation Department of Xuhui District Center Hospital of Shanghai and the Shanghai Sunshine Rehabilitation Center in China from March to September 2017. The patients＇ multidimensional symptom experience and symptom burden were analyzed using a self-made structured questionnaire and the influential factors for symptom burden were identified. The mean number of symptoms in patients with stroke was 11.7 ± 3.5. More than two thirds of the participants suffered from at least 10 co-occurring symptoms. Unilateral limb weakness had the highest prevalence and frequency. Participation restriction had the highest symptom dimensions of severity and distress. Lack of self-care ability（severity）, memory deterioration（frequency）, imbalance of body（distress）, moodiness（distress）, being unable to move limbs at will（distress）, shoulder pain（distress）, and slower response（frequency） were independent factors of the total symptom burden score. These findings can provide essential information for efficient symptom management of patients with stroke.

关键词： nerve regeneration stroke burden multidimensional unilateral limb weakness participation restriction symptom management concurrent symptoms neural regeneration

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Correlation-driven threefold topological phase transition in monolayer OsBr_(2)

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Frontiers of physics 2023年第3期18卷 121-130页

作者： San-Dong Guo Yu-Ling Tao Wen-Qi Mu bang-Gui liu School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China

Spin–orbit coupling(SOC)combined with electronic correlation can induce topological phase transition,producing novel electronic ***,we investigate the impact of SOC combined with correlation effects on physical properties of monolayer OsBr_(2),based on first-principles calculations with generalized gradient approximation plus U(GGA+U)*** intrinsic out-of-plane magnetic anisotropy,OsBr_(2)undergoes threefold topological phase transition with increasing U,and valleypolarized quantum anomalous Hall insulator(VQAHI)to half-valley-metal dxy dx2−y2 dz2¯6m2(HVM)to ferrovalley insulator(FVI)to HVM to VQAHI to HVM to FVI transitions can be *** topological phase transitions are connected with sign-reversible Berry curvature and band inversion between/and *** to symmetry,piezoelectric polarization of OsBr_(2)is confined along the in-plane armchair direction,and only one d11 is *** a given material,the correlation strength should be fixed,and OsBr_(2)may be a piezoelectric VQAHI(PVQAHI),piezoelectric HVM(PHVM)or piezoelectric FVI(PFVI).The valley polarization can be flipped by reversing the magnetization of Os atoms,and the ferrovalley(FV)and nontrivial topological properties will be suppressed by manipulating out-of-plane magnetization to in-plane *** considered reasonable U range,the estimated Curie temperatures all are higher than room *** findings provide a comprehensive understanding on possible electronic states of OsBr_(2),and confirm that strong SOC combined with electronic correlation can induce multiple quantum phase transition.

关键词： correlation SOC phase transition piezoelectricity

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Pore structure analysis of directionally solidified porous copper

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China Foundry 2020年第5期17卷 325-331页

作者： Xiao-bang liu Yan-xiang Li Hua-wei Zhang Yuan liu Xiang Chen School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Directionally solidified porous copper is considered as a potential candidate in the field of microchannel heat *** the Bridgman-type directional solidification method,a porous copper ingot was *** of the porosity,pore number density,average pore diameter and average interpore spacing at different ingot heights was *** results show that with the increase of ingot height,the porosity firstly increases and then basically remains unchanged from the ignot height of 65 mm;the pore number density rapidly decreases at first,and the decreasing speed becomes slower when the ignot height higher than 85 mm;the average pore diameter increases and then remains unchanged from the ingot height of 85 mm;the average interpore spacing increases,and the increasing speed of average interpore spacing becomes slower with the increase of height to higher than 85 *** order to study the evolution of diameter and spatial distribution of pores,the distribution ranges of pore diameter,nearest-neighbor distance and radial cumulative pore number were *** the ingot height increases,the distribution ranges of pore diameter and nearest-neighbor distance firstly increase and then tend to be *** are no pore clusters and for long distance,the spatial distribution of pores is uniform at different ingot *** structure and 3D pore morphology of porous copper were observed with the help of light illumination and X-ray *** nucleation,pore interruption,pore coalescence,diameter change of pores and lateral displacement of pores were found to exist in the pore structure.

关键词： porous metal directional solidification pore structure

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Ab initio Molecular Dynamics Study on Small Carbon Nanotubes

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Chinese Physics Letters 2001年第11期18卷 1496-1499页

作者： YE Lin-Hui liu bang-Gui WANG Ding-Sheng Institute of Physics and Center for Condensed Matter Physics Chinese Academy of Science P.O.Box 603Beijing 100080 Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100080

Ab initio molecular dynamics simulations are performed on small single wall nanotubes. By structural relaxation,the equilibrium C-C bond lengths and bond angles are determined. Our result shows that for both zigzag and armchair nanotubes there are two nonequivalent bond lengths. One bond stretches from that of the graphene sheet, while the other shrinks. Small variations on bond angles are also shown. Energy bands are calculated for the optimized structures. It is found that the intrinsic curvature of the very small nanotube greatly modifies the energy band which can no longer be well described in the tight-binding zone-folding picture. In our calculation very small nanotubes are metallic. The energy per atom fits quite well with the relation of E(R) = E0 + f/R2 even for the extreme small radius. The implications of the results on the properties of small nanotubes are discussed.

关键词： Small Molecular curvature

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