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KoNA:Korean Nucleotide Archive as A New Data Repository for Nucleotide Sequence Data

Genomics, Proteomics & Bioinformatics 2024年第1期22卷 161-167页

作者： Gunhwan Ko Jae Ho lee Young Mi Sim Wangho Song Byung-Ha Yoon Iksu Byeon bang hyuck lee Sang-Ok Kim Jinhyuk Choi Insoo Jang Hyerin Kim Jin Ok Yang Kiwon Jang Sora Kim Jong-Hwan Kim Jongbum Jeon Jaeeun Jung Seungwoo Hwang Ji-Hwan Park Pan-Gyu Kim Seon-Young Kim Byungwook lee Korea Bioinformation Center Korea Research Institute of Bioscience&BiotechnologyDaejeon 34141Republic of Korea

During the last decade,the generation and accumulation of petabase-scale high-throughput sequencing data have resulted in great challenges,including access to human data,as well as transfer,storage,and sharing of enormous amounts of *** promote data-driven biological research,the Korean government announced that all biological data generated from government-funded research projects should be deposited at the Korea BioData Station(K-BDS),which consists of multiple databases for individual data ***,we introduce the Korean Nucleotide Archive(KoNA),a repository of nucleotide sequence *** of July 2022,the Korean Read Archive in KoNA has collected over 477 TB of raw next-generation sequencing data from national genome *** ensure data quality and prepare for international alignment,a standard operating procedure was adopted,which is similar to that of the International Nucleotide Sequence Database *** standard operating procedure includes quality control processes for submitted data and metadata using an automated pipeline,followed by manual *** ensure fast and stable data transfer,a high-speed transmission system called GBox is used in ***,the data uploaded to or downloaded from KoNA through GBox can be readily processed using a cloud computing service called *** seamless coupling of KoNA,GBox,and Bio-Express enhances the data experience,including submission,access,and analysis of raw nucleotide *** not only satisfies the unmet needs for a national sequence repository in Korea but also provides datasets to researchers globally and contributes to advances in *** KoNA is available at https://***/kona/.

关键词： Korea BioData Station Nucleotide sequence Next-generation sequencing repository Genomics Deposition and access of big data

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Acetylacetone-TiO_(2) Promoted Large Area Compatible Cascade Electron Transport Bilayer for Efficient Perovskite Solar Cells

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Energy & Environmental Materials 2024年第2期7卷 221-228页

作者： Hyong Joon lee Jin Kyoung Park Jin hyuck Heo Sang Hyuk Im Department of Chemical and Biological Engineering Korea University145 Anam-ro Seongbuk-guSeoul 17104Korea

In designing efficient perovskite solar cells(PSCs),the selection of suitable electron transport layers(ETLs)is critical to the final device performance as they determine the driving force for selective charge ***_(2)nanoparticles(NPs)based ETLs have been a popular choice for PSCs due to superior electron mobility,but their relatively deep-lying conduction band energy levels(ECB)result in substantial potential ***,TiO_(2)NPs establish favorable band alignment owing to shallower ECB,but their low intrinsic mobility and abundant surface trap sites impede the final *** this reason,constructing a cascaded bilayer ETL is highly desirable for efficient PSCs,as it can rearrange energy levels and exploit on advantages of an individual *** this study,we prepare SnO_(2)NPs and acetylacetone-modified TiO_(2)(Acac-TiO_(2))NPs and implement them as bilayer SnO_(2)/Acac-TiO_(2)(BST)ETL,to assemble cascaded energy band ***_(2)contributes to rapid charge carrier transport from high electron mobility while Acac-TiO_(2)minimizes band-offset and effectively suppresses interfacial ***,the optimized BST ETL generates synergistic influence and delivers power conversion efficiency(PCE)as high as 23.14%with open-circuit voltage(V_(oc))reaching 1.14 ***,the BST ETL is transferred to a large scale and the corresponding mini module demonstrates peak performance of 18.39%PCE from 25 cm^(2)aperture ***,the BST-based mini module exhibit excellent stability,maintaining 83.1%of its initial efficiency after 1000 h under simultaneous 1 Sun light-soaking and damp heat(85℃/RH 85%)environment.

关键词： acetylacetone large area perovskite solar cells TiO_(2)

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电沉积Mo和Mo-Co合金纳米线用于互联电阻的电阻率改性

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Engineering 2024年第1期32卷 127-137页

作者： Jun Hwan Moon Taesoon Kim Youngmin lee Seunghyun Kim Yanghee Kim Jae-Pyoung Ahn Jungwoo Choi hyuck Mo lee Young Keun Kim Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and EngineeringDaejeon 34141Republic of Korea Advanced Analysis Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Research Resources Division Korea Institute of Science and TechnologySeoul 02792Republic of Korea

Achieving historically anticipated improvement in the performance of integrated circuits is challenging,due to the increasing cost and complexity of the required technologies with each new *** overcome this limitation,the exploration and development of novel interconnect materials and processes are highly desirable in the microelectronics ***(Mo)is attracting attention as an advanced interconnect material due to its small resistivity size effect and high cohesive energy;however,effective processing methods for such materials have not been widely ***,we investigate the electrochemical behavior of ions in the confined nanopores that affect the electrical properties and microstructures of nanoscale Mo and Mo-Co alloys prepared via template-assisted *** in an electrolyte allow the deposition of extremely pure metal materials,due to their interac-tion with metal ions and *** this study,boric acid and tetrabutylammonium bisulfate(TBA)were added to an acetate bath to inhibit the hydrogen evolution *** accelerated the reduction of Mo at the surface by inducing surface conduction on the *** Mo nanowires with a 130 nm diameter synthesized through high-aspect-ratio nanopore engineering exhibited a resistivity of(63.0±17.9)μΩ*** also evaluated the resistivities of Mo-Co alloy nanowires at various compo-sitions toward replacing irreducible conventional barrier/liner *** intermetallic compound formed at a Mo composition of 28.6 at%,the resistivity of the Mo-Co nanowire was(58.0±10.6)μΩcm,indicat-ing its superior electrical and adhesive properties in comparison with those of conventional barriers such as TaN and ***,density functional theory and non-equilibrium Green's function calcula-tions confirmed that the vertical resistance of the via structure constructed from Mo-based materials was 21%lower than that of a conventional Cu/Ta/TaN structure.

关键词： Molybdenum Molybdenum-cobalt Interconnect Microstructure Electrodeposition Density functional theory

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Biclustering of ARMA time series

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 959-965页

作者： Jeonghwa lee Chi-hyuck JUN Department of Industrial and Management Engineering Pohang University of Science and Technology

Biclustering is a method of grouping objects and attributes simultaneously in order to find multiple hidden *** dealing with a long time series,there is a low possibility of finding meaningful clusters of whole time ***,we may find more significant clusters containing partial time sequence by applying a biclustering *** paper proposed a new biclustering algorithm for time series data following an autoregressive moving average (ARMA) *** assumed the plaid model but modified the algorithm to incorporate the sequential nature of time series *** maximum likelihood estimation (MLE) method was used to estimate coefficients of ARMA in each *** applied the proposed method to several synthetic data which were generated from different ARMA *** from the experiments showed that the proposed method compares favorably with other biclustering methods for time series data.

关键词： Biclustering Time series Autoregressive moving average (ARMA) Maximum likelihood estimation (MLE)

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Fabrication of sintering-free flexible copper nanowire/ polymer composite transparent electrodes with enhanced chemical and mechanical stability

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Nano Research 2016年第7期9卷 2162-2173页

作者： Cho Rong Chu Changsoo lee Jahyun Koo hyuck Mo lee Department of Materials Science and Engineering KAIST 291 Daehak-ro Yuseong-gu Daejeon 305-701 Republic of Korea

The thermal decomposition synthesis of long copper nanowires （CuNWs） was achieved by controlling the synthesis parameters. A detailed study was performed to determine the effect of the molar ratio of copper chloride to nickel acetylacetonate, temperature, and stirring rate on the final shape of the products. Transparent electrodes （TEs） were fabricated by wet treatment with acetic acid （AA）, without using a sintering process. The low oxidation stability and high surface roughness are the main disadvantages of the CuNW TEs, which limit their applications. In order to overcome these issues, we prepared CuNW/polymer composite TEs by partial embedding of the CuNWs into poly（methyl methacrylate）（PMMA） on poly（ethylene terephthalate）（PET） substrates. The CuNW/PMMA composite TEs exhibit excellent optoelectronic performance （91.3% at 100.7 ff2/sq）, low surface roughness （4.6 nm in height）, and good mechanical and chemical stability as compared with CuNW TEs. On the basis of these properties, we believe that CuNW-based composite TEs could serve as low-cost materials for a wide range of new optoelectronic devices.

关键词： copper nanowires nanowire/polymercomposite transparent electrode chemical stability mechanical stability

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A Continuous Current Model of Accumulation Mode(Junctionless)Cylindrical Surrounding-Gate Nanowire MOSFETs

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Chinese Physics Letters 2013年第3期30卷 190-193页

作者： JIN Xiao-Shi LIU Xi KWON hyuck-In lee Jong-Ho School of Information Science and Engineering Shenyang University of TechnologyShenyang 110023 School of Electrical and Electronics Engineering Chung-Ang UniversitySeoul 156-756Korea School of EECS Engineering and ISRC(Inter-University Semiconductor Research Center) Seoul National UniversityShinlim-DongKwanak-GuSeoul 151-742Korea

A continuous current model of accumulation mode or so-called junctionless(JL)cylindrical surrounding-gate Si Nanowire metal-oxide-silicon field effect transistors(MOSFETs)is *** model is based on an approximated solution of Poisson's equation considering both body doping and mobile charge *** is verified by comparing with three-dimensional simulation results using SILVACO Atlas TCAD which shows good *** any empirical fitting parameters,the proposed continuous current model of JL SRG MOSFETs is valid for all the operation regions.

关键词： MOSFETs TCAD cylindrical

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Intimate atomic Cu-Ag interfaces for high CO2RR selectivity towards CH4 at low over potential

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Nano Research 2021年第10期14卷 3497-3501页

作者： Chungseok Choi Jin Cai Changsoo lee hyuck Mo lee Mingjie Xu Yu Huang Department of Materials Science and Engineering University of CaliforniaLos AngelesCA 90095USA Hydrogen Energy Department Korea Institute of Energy Research152 Gajeong-roYuseong-guDaejeon 34129Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Irvine Materials Research Institute(IMRI) University of CaliforniaIrvineCA 92697USA Department of Materials Science and Engineering University of CaliforniaIrvineCA 92697USA

Developing highly efficient electrochemical catalysts for carbon dioxide reduction reaction(CO_(2)RR)provides a solution to battle global warming issues resulting from ever-increasing carbon footprint due to human ***(Cu)is known for its efficiency in CO_(2)RR towards value-added hydrocarbons;hence its unique structural properties along with various Cu alloys have been extensively explored in the past ***,we demonstrate a two-step approach to achieve intimate atomic Cu-Ag interfaces on the surface of Cu nanowires,which show greatly improved CO_(2)RR selectivity towards methane(CH4).The specially designed Cu-Ag interfaces showed an impressive maximum Faradaic efficiency(FE)of 72%towards CH4 production at-1.17 V(*** hydrogen electrode(RHE)).

关键词： electrochemical CO_(2)reduction reaction catalyst copper silver bimetallic interface

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Multicenter phase Ⅱ trial of modified FOLFIRINOX in gemcitabine-refractory pancreatic cancer

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World Journal of Gastrointestinal Oncology 2018年第12期10卷 505-515页

作者： Moon Jae Chung Huapyong Kang Ho Gak Kim Jong Jin Hyun Jun Kyu lee Kwang hyuck lee Myung Hwan Noh Dae Hwan Kang Sang Hyub lee Seungmin bang 无 Division of Gastroenterology Department of Internal Medicine Yonsei University College of Medicine Seoul 03722 South Korea Department of Internal Medicine Daegu Catholic University School of Medicine Daegu 42471 South Korea Department of Internal Medicine Korea University Ansan Hospital Korea University College of Medicine Ansan 15355 South Korea Department of Internal Medicine Dongguk University Ilsan Hospital Dongguk University College of Medicine Goyang 10326 South Korea Division of Gastroenterology Department of Internal Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 06351 South Korea Department of Internal Medicine Dong-A University College of Medicine Busan 49201 South Korea Department of Internal Medicine Medical Research Institute Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan 50612 South Korea Departments of Internal Medicine and Liver Research Institute Seoul National University Hospital Seoul National University College of Medicine Seoul 03080 South Korea Pancreatobiliary Cancer Study Group of Korean Society of Gastrointestinal Cancer

AIM To evaluate the efficacy and safety of modified FOLFIRINOX as a second-line treatment for gemcitabine(GEM)-refractory unresectable pancreatic cancer(PC).METHODS This study was a prospective, multicenter, one-arm, open-label, phase Ⅱ trial. Patients with unresectable PC, who showed disease progression during GEMbased chemotherapy were enrolled. All patients were administered FOLFIRINOX with reduced irinotecan and oxaliplatin(RIO; irinotecan 120 mg/m^2 and oxaliplatin 60 mg/m^2), which was set according to the phase Ⅰ study of FOLFIRINOX. The objective response rate(ORR), disease control rate(DCR), progressionfree survival(PFS), overall survival(OS), adverse events were evaluated. Additionally, changes in quality of life(QoL) were assessed using a questionnaire on *** Between August 2015 and May 2016, a total of 48 patients were enrolled. The median follow-up time was 259 d with a median of 8.5 cycles. The ORR and DCR were 18.8% and 62.5%, respectively, including one patient who showed complete remission. The median PFS was 5.8 mo [95% confidence interval(CI): 3.7-7.9] and median OS was 9.0 mo(95%CI: 6.4-11.6). Neutropenia(64.6%) was the most common grade 3-4 adverse event, followed by febrile neutropenia(16.7%). Although 14.6% of patients experienced grade 3 fatigue, most non-hematologic AEs were under grade 2. In the QoL analysis, the global health status score before treatment was not different from the score at the last visit after treatment(45.43 ± 22.88 vs 48.66 ± 24.14, P = 0.548).CONCLUSION FOLFIRINOX with RIO showed acceptable toxicity and promising efficacy for GEM-refractory unresectable PC. However, this treatment requires careful observation of treatment-related hematologic toxicities.

关键词： Pancreatic cancer FOLFIRINOX Clinical Trial, Phase Ⅱ Chemotherapy Gemcitabine refractory

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Potholeeye^(+): Deep-Learning Based Pavement Distress Detection System toward Smart Maintenance

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Computer Modeling in Engineering & Sciences 2021年第6期127卷 965-976页

作者： Juyoung Park Jung Hee lee Junseong bang Korea Expressway Corporation 77Hyeoksin8-roGimcheon-siKorea Electronics and Telecommunications Research Institute(ETRI) 218 Gajeong-roYuseong-guDaejun-siKorea University of Science&Technology(UST) 217 Gajeong-roYuseong-guDaejun-siKorea

We propose a mobile system,called Potholeeye+,for automatically monitoring the surface of a roadway and detecting the pavement distress in real-time through analysis of a ***+pre-processes the images,extracts features,and classifies the distress into a variety of types,while the road manager is *** day for a year,we have tested Potholeeye+on real highway involving real settings,a camera,a mini computer,a GPS receiver,and so ***,Potholeeye+detected the pavement distress with accuracy of 92%,precision of 87%and recall 74%averagely during driving at an average speed of 110 km/h on a real highway.

关键词： Pavement distress detection classification convolutional neural network deep learning video analysis

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Structurally engineered colloidal quantum dot phosphor using TiO_(2) photonic crystal backbone

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Light(Science & Applications) 2022年第11期11卷 2782-2789页

作者： Hansol lee Tae-Yun lee Yeonsang Park Kyung-Sang Cho Young-Geun Rho hyuck Choo Heonsu Jeon Department of Physics and Astronomy Seoul National UniversitySeoul 08826Republic of Korea Inter-university Semiconductor Research Center Seoul National UniversitySeoul 08826Republic of Korea Department of Physics Chungnam National UniversityDaejeon 34134Republic of Korea Institute of Quantum Systems Chungnam National UniversityDaejeon 34134Republic of Korea Samsung Advanced Institute of Technology Suwon 16678Republic of Korea Institute of Applied Physics Seoul National UniversitySeoul 08826Republic of Korea

Photonic crystal(PhC)phosphor,in which the phosphor material is periodically modulated for an enhancement in color-conversion efficiency via resonant absorption of excitation photons,is a paradigm-shifting structural phosphor ***-dimensional(2D)square-lattice PhC phosphor is currently considered the most advanced platform because of not only its high efficiency,but also its immunity to excitation *** the present study,two major modifications are made to further improve the performance of the 2D PhC phosphor:increasing the refractive index contrast and planarizing the *** index contrast is improved by replacing the PhC backbone material with TiO_(2)whereas the surface planarization is achieved by removing excessive colloidal quantum dots from the *** comparison with the reference phosphor,the upgraded PhC phosphor exhibits~59 times enhanced absorption(in simulations)and~7 times enhanced emission(in experiments),both of which are unprecedentedly *** results not only brighten the viability and applicability of the PhC phosphor but also spur the phosphor development through structural engineering of phosphor materials.

关键词： immunity phosphor backbone

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