检索结果-南通市图书馆

Hybrid data-driven framework for shale gas production performance analysis via game theory, machine learning, and optimization approaches

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2023年第1期20卷 277-294页

作者： Jin Meng Yu-Jie Zhou Tian-Rui Ye Yi-Tian Xiao Ya-Qiu Lu Ai-Wei Zheng bang liang Petroleum Exploration and Production Research Institute SINOPECBeijing100083PR China Jianghan Oilfield Company Research Institute of Exploration and DevelopmentSINOPECWuhan430223HubeiPR China

A comprehensive and precise analysis of shale gas production performance is crucial for evaluating resource potential,designing a field development plan,and making investment decisions.However,quantitative analysis can be challenging because production performance is dominated by the complex interaction among a series of geological and engineering factors.In fact,each factor can be viewed as a player who makes cooperative contributions to the production payoff within the constraints of physical laws and models.Inspired by the idea,we propose a hybrid data-driven analysis framework in this study,where the contributions of dominant factors are quantitatively evaluated,the productions are precisely forecasted,and the development optimization suggestions are comprehensively generated.More specifically,game theory and machine learning models are coupled to determine the dominating geological and engineering factors.The Shapley value with definite physical meaning is employed to quantitatively measure the effects of individual factors.A multi-model-fused stacked model is trained for production forecast,which provides the basis for derivative-free optimization algorithms to optimize the development plan.The complete workflow is validated with actual production data collected from the Fuling shale gas field,Sichuan Basin,China.The validation results show that the proposed procedure can draw rigorous conclusions with quantified evidence and thereby provide specific and reliable suggestions for development plan optimization.Comparing with traditional and experience-based approaches,the hybrid data-driven procedure is advanced in terms of both efficiency and accuracy.

关键词： Shale gas Production performance Data-driven Dominant factors Game theory Machine learning Derivative-free optimization

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-bang Xu Wei-Jie Guan Yi-Lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway inflammation.The envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this process.Pathogens could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)signaling.However,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be elucidated.Here,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial barrier.In addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial cells.This elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E protein.Overall,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

考虑连续山体影响的耐张型悬索支撑输电结构风振响应分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

工程力学 2024年第S1期41卷 31-37页

作者：王涛王邦杰李正良哈尔滨工业大学交通科学与工程学院黑龙江哈尔滨150090 哈尔滨工业大学重庆研究院重庆401151 重庆大学土木工程学院重庆400045 风工程及风资源利用重庆市重点实验室(重庆大学) 重庆400045

针对适用于山区的新型输电结构——悬索支撑输电结构,为了评估连续山体数量对该结构性能的影响,该文进行了连续山体影响下边界层风洞试验;基于试验数据,分析了平均和脉动风速在不同数量连续山体影响下的演变趋势,并给出了平均风修正系... 详细信息

针对适用于山区的新型输电结构——悬索支撑输电结构,为了评估连续山体数量对该结构性能的影响,该文进行了连续山体影响下边界层风洞试验;基于试验数据,分析了平均和脉动风速在不同数量连续山体影响下的演变趋势,并给出了平均风修正系数和脉动风修正系数的建议公式;提出了连续山体影响下悬索支撑输电结构的风致非线性动力分析方法;针对位于某耐张段的悬索支撑输电结构,评估了其风致动力响应受不同数量连续山体的影响。研究结果表明:当连续山体数量增加时,在山顶处,平均风修正系数先增大后平稳,在背风面山脚处,平均风修正系数先增大后减小,而最大脉动风修正系数呈现先减小后增大的趋势;就导线、支撑导线悬索的跨中位移和跨中张力而言,其均值和标准差随着连续山体数量增加呈现先减小再增加后逐渐平稳的趋势;不同数量连续山体对导线、支撑导线悬索跨中位移均值影响较为显著,对其标准差影响较小,而对于跨中张力则恰好相反。

关键词：连续山体风洞试验悬索支撑输电结构耐张段风振

Integrated gut microbiota,plasma metabolomics and network pharmacology to reveal the anti-ischemic stroke effect of cooked rhubarb

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2024年第9期9卷 1-13页

作者： Ting Li Lan-Fang Tan Lin Shen Jie-Hui Kuang Si-Kai Zhan bang Liu Jia-Le Cai Sheng-Wang liang Ming-Hua Xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization Guangxi Institute of BotanyChinese Academy of SciencesGuilin 541006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527300China

Background:Cooked rhubarb(CR)is obtained by steaming raw rhubarb(Rheum palmatum L.,Rheum officinale Baill.,or Rheum tanguticum Maxim.ex Balf.)with millet wine.It is used as a traditional Chinese medicine for treating cerebral stroke,where patients often face severe constipation.This study explored the pharmacological effects and mechanisms of CR against ischemic stroke(IS)in rats.We used integrated analysis of gut microbiota,metabolomics,and network pharmacology.Methods:The compounds in CR were identified using LC-MS/MS.The impact of CR on rat middle cerebral artery occlusion/reperfusion(MCAO/R)-induced cerebral infarct size and brain tissue pathology was assessed through 2,3,5-triphenyl tetrazolium chloride and HE staining.Changes in hemorheology were measured by evaluating blood viscosity,and serum levels of pro-inflammatory cytokine were also determined.Gut microbiota composition was analyzed through 16S rRNA gene sequencing.Serum metabolites were examined using untargeted metabolomics and Spearman correlation analysis.The pseudo-germ-free test was used to determine whether tumour necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)improvement in IS are dependent on gut microbiota.Results:In vivo studies showed CR enhances neurobehavioral function in MCAO/R rats and reduces cerebral infarction area.CR also ameliorates brain and intestinal barrier damage caused by stroke.It also decreased inflammation and oxidative stress in IS rats.Furthermore,CR promotes the growth of Akkermansia and Verrucomicrobia,aiding in intestinal barrier repair.Notably,CR primarily influences the primary bile acid biosynthesis pathway.The pseudo-germ-free experiment and network pharmacology confirmed TNF-αand IL-1βas potential targets.CR relies on gut microbiota for its anti-inflammatory effects to improve IS.Conclusion:Cooked rhubarb offers neuroprotective benefits by enhancing beneficial bacteria abundance and regulating bile acid metabolism.It emerges as a potential therapeutic agent for IS.

关键词： cooked rhubarb ischemic stroke gut microbiota metabolomics

Gas microchannel plate-pixel detector for X-ray polarimetry

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第5期35卷 60-73页

作者： Huan-Bo Feng Hong-bang Liu Dong Wang Zi-Li Li Shu-Lin Liu Qian Liu Hang-Zhou Li Bin-Long Wang Yan-Jun Xie Zong-Wang Fan Hui Wang Ran Chen Di-Fan Yi Rui-Ting Ma Fei Xie Bo Peng Xiang-Ming Sun Jin Li En-Wei liang Present Address:Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Science Huzhou UniversityHuzhou 313000China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physical Science University of Chinese Academy of SciencesBeijing 100049China The 13th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050057China

POLAR-2 is a gamma-ray burst(GRB)polarimeter that is designed to study the polarization in GRB radiation emissions,aiming to improve our knowledge of related mechanisms.POLAR-2 is expected to utilize an on-board polarimeter that is sensitive to soft X-rays(2-10 keV),called low-energy polarization detector.We have developed a new soft X-ray polari-zation detector prototype based on gas microchannel plates(GMCPs)and pixel chips(Topmetal).The GMCPs have bulk resistance,which prevents charging-up effects and ensures gain stability during operation.The detector is composed of low outgassing materials and is gas-sealed using a laser welding technique,ensuring long-term stability.A modulation factor of 41.28%±0.64% is obtained for a 4.5 keV polarized X-ray beam.A residual modulation of 1.96%±0.58% at 5.9 keV is observed for the entire sensitive area.

关键词： X-ray polarimetry Gas microchannel plate-pixel detector Gamma-ray bursts

小天体柔性着陆任务规划的动态时间约束推理方法

在线全文

学校读者我要写书评

暂无评论

宇航学报 2024年第2期45卷 212-221页

作者：王棒徐瑞李朝玉朱圣英梁子璇北京理工大学宇航学院北京100081 深空自主导航与控制工信部重点实验室(北京理工大学) 北京100081

针对小天体柔性着陆任务规划中的复杂耦合时间约束一致性推理效率问题,建立任务规划时间约束网络,通过划分时间约束类型,设计约束动态添加策略,提出动态弧一致时间约束推理方法,限制新添加约束的传播范围,局部求解时间网络一致性,实现... 详细信息

针对小天体柔性着陆任务规划中的复杂耦合时间约束一致性推理效率问题,建立任务规划时间约束网络,通过划分时间约束类型,设计约束动态添加策略,提出动态弧一致时间约束推理方法,限制新添加约束的传播范围,局部求解时间网络一致性,实现规划过程中时间约束网络一致性的高效维护。最后,构建小天体着陆规划场景,生成着陆任务规划活动及时间约束。仿真结果表明,与现有时间约束推理方法相比,所提出方法提高了时间约束推理效率,进而可为小天体柔性着陆任务规划提供支撑。

关键词：小天体探测柔性着陆器着陆任务规划动态弧一致时间约束推理

UV油墨对凹印烟标VOCs含量影响的实验研究

在线全文

学校读者我要写书评

暂无评论

印刷与数字媒体技术研究 2024年第1期 83-91页

作者：刘静何邦贵夏家良王琪昆明理工大学机电工程学院昆明650500 云南九九彩印有限公司昆明650032

为研究UV油墨应用于烟标的凹版印刷后,能否满足生产质量要求且有效降低烟标生产中VOCs排放和残留,本研究对当前烟标的凹版印刷工艺进行分析,以UV油墨作为烟标的印刷油墨,使用凹印机组进行打样试生产,最后对凹印车间VOCs排放量以及打样... 详细信息

为研究UV油墨应用于烟标的凹版印刷后,能否满足生产质量要求且有效降低烟标生产中VOCs排放和残留,本研究对当前烟标的凹版印刷工艺进行分析,以UV油墨作为烟标的印刷油墨,使用凹印机组进行打样试生产,最后对凹印车间VOCs排放量以及打样所得到的样张进行卷烟盒包装纸安全性指标和表面印刷质量检测。实验结果表明,使用UV油墨后,烟标中VOCs溶剂残留的检测结果均低于国家烟草专卖局所给出的限量标准,其中VOCs总含量仅为0.01mg/m~2,相比于溶剂油墨样张中VOCs总含量减少了2.3mg/m~2;同时车间VOCs总排放量减少了55.31mg/m~3,且烟标表面印刷质量相较于标准样张能达到90%以上的色彩还原度。实验可说明使用UV油墨有较好的VOCs减排作用,同时也大大提升了烟标的安全性能,成功解决了溶剂型油墨在烟标凹版印刷中VOCs排放量大和有害物质残留问题。

关键词：烟标凹版印刷 UV油墨 VOCs残留印刷工艺

在线全文

学校读者我要写书评

暂无评论

磁阵列微波放电中和器的电子引出机制

物理学报 2024年第11期73卷 231-236页

作者：付瑜亮张思远孙安邦马祖福王亚楠西安交通大学电工材料电气绝缘全国重点实验室西安710049

微波放电中和器作为微波离子推力器系统的重要组成部分,在维持航天器电位平衡、中和羽流方面发挥着重要作用,其电子引出性能直接关系到电推力器系统的工作状态.在磁阵列微波放电中和器的磁场结构定型实验中,发现调转磁阵列朝向后引出电... 详细信息

微波放电中和器作为微波离子推力器系统的重要组成部分,在维持航天器电位平衡、中和羽流方面发挥着重要作用,其电子引出性能直接关系到电推力器系统的工作状态.在磁阵列微波放电中和器的磁场结构定型实验中,发现调转磁阵列朝向后引出电流的伏安特性曲线差异极大.由于磁阵列微波放电中和器的放电室直径仅10 mm,介入式探针诊断对等离子体干扰大,本文采用了一体化粒子模拟方法对中和器的工作过程进行仿真,仿真结果与实验现象相符合.通过对比不同磁场结构、工作电压下的等离子体参数分布,发现引出孔附近的电势分布决定着中和器的电子引出能力;并进一步揭示了离子在中和器电子引出过程中发挥的关键作用,阐明了磁场结构对中和器电子引出能力的影响机制.最后,本文总结了微波放电中和器有效引出电子的两个必要条件:1)磁场梯度指向引出孔,引导等离子体迁移;2)引出孔附近有足够的离子抬升电势,降低或打破电势阱.

关键词：电子回旋共振中和器电子引出

微波离子推力器中磁场发散区电子加热模式研究

在线全文

学校读者我要写书评

暂无评论

物理学报 2024年第9期73卷 199-203页

作者：付瑜亮张思远杨谨远孙安邦王亚楠西安交通大学电工材料电气绝缘全国重点实验室西安710049

在微波离子推力器的磁场结构设计中,一般认为增大磁镜区的面积能够约束更多电子,有利于提高能量利用率;减小发散区面积能够减少电子在壁面的损失,有利于降低放电损耗.随着一体化仿真研究深入,发现利用Child-Langmuir鞘层的特性可约束电... 详细信息

在微波离子推力器的磁场结构设计中,一般认为增大磁镜区的面积能够约束更多电子,有利于提高能量利用率;减小发散区面积能够减少电子在壁面的损失,有利于降低放电损耗.随着一体化仿真研究深入,发现利用Child-Langmuir鞘层的特性可约束电子,使其在鞘层与磁镜间往复运动获能.对此,本文设计了适用于1 cm磁阵列微波离子推力器的磁场结构,并对其初始放电和束流引出过程进行了一体化仿真,对比阐明了电子在磁场发散区受Child-Langmuir鞘层、天线表面鞘层和磁镜共同约束下的获能模式.该获能模式可提升磁场发散区的电子温度,促进电离,提升栅极前等离子体密度,进而提升束流密度.仿真结果表明,在氙气流量0.3 sccm(1 sccm=1 mL/min),微波功率为1 W,栅极电压φ_(sc)/φ_(ac)=300 V/–50 V条件下,磁阵列微波离子推力器的电流密度较2 cm微波离子推力器提升57.9%.本文从理论上对磁场发散区电子加热模式进行了验证,研究结果将为微波离子推力器优化设计提供理论依据,促进微波离子推力器性能提升.

关键词：电子回旋共振离子推力器电子约束电子加热