检索结果-南通市图书馆

Saudi Consensus for Oral Semaglutide, the Recent Innovation in GLP-1 RAs Era;Consensus Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Diabetes Mellitus 2023年第2期13卷 222-238页

作者： Ali Alromaih Abdullah Alshamrani bandar alharbi Ibtissam alharbi Turki alharbi Samia Bokhari Hussein Elbadawi Mohammed Almehthel Abdulghani Alsaeed Khalid Alyahia Fatimah Alhowyan Marc Evans Roopa Mehta Emad Issak Saud Alsifri Medical Services Ministry of Defense Riyadh Saudi Arabia Khamis Mushait Military Hospotal Khamis Mushait Saudi Arabia Prince Sultan Military Hospital Riyadh Saudi Arabia King Fahad Armed Forces Hospital Jeddah Saudi Arabia My Clinic Medical Center Jeddah Saudi Arabia King Fahad Medical City Riyadh Saudi Arabia South Region Armed Forces Hospital Khamis Mushait Saudi Arabia University Hospital Llandough Cardiff United Kingdom Department of Endocrinology and Metabolism INCMNSZ Mexico City Mexico Asalam Medical Center Cairo Egypt Al Hada Armed Forces Hospital Taif Saudi Arabia

GLP-1 receptor agonists (GLP-1 RAs) are among the most successful medications for treating people with type 2 diabetes mellitus (T2DM), giving reasonable glycemic control with a low risk of hypoglycemia in those who have failed to control their condition with other oral anti-diabetic drugs (OADs). However, GLP-1RAs are underutilized—as time patients remained on their last oral treatment regimen with inadequate glycemic control prior to GLP-1RA initiation is on average of 19 month—despite evidence supporting their effectiveness, safety, and possible CV outcome advantages. With the new advances in GLP-1 RAs, the first oral form for the semaglutide molecule was developed with proven efficacy, safety, and patient preferences that may help pave the road for more utilization of this class. Therefore, we, a Saudi task force, gathered to develop an explicit, evidence-based consensus on oral semaglutide use in Saudi patients with diabetes. The panel recommends a GLP-1RA in those T2DM patients with or without or at high risk for ASCVD, HF, and/or CKD when there is a need to minimize weight gain or promote weight loss, or when there is a need to minimize hypoglycemia. Ensure that people with T2DM and ASCVD, HF, or CKD are treated appropriately with an SGLT-2i or GLP-1 RA. This approach should be initiated independent of background therapy, glycaemic control, or individualized treatment goals. Healthcare professionals should do their best to prevent clinical inertia in T2DM to help people with T2DM achieve better glycemic control and prevent or delay diabetes-related complications. The availability of oral forms of GLP-1RA medications could help combat this problem of clinical inertia to start GLP-1RA at the right time, as patients prefer oral to injectable forms. The availability of oral GLP-1RA can help in starting this class early and encourage healthcare professionals in prescribing it at the right time. Moreover, it can help those patients who fear of the injections. The p

关键词： Glucagon-Like Peptide-1 Receptor Agonists T2DM Glycemic Control Semaglutide Oral Semaglutide Injectable Semaglutide

Exploring Multi-Task Learning for Forecasting Energy-Cost Resource Allocation in IoT-Cloud Systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第6期79卷 4603-4620页

作者： Mohammad Aldossary Hatem A.alharbi Nasir Ayub Department of Computer Engineering and Information College of EngineeringPrince Sattam Bin Abdulaziz UniversityWadi Al-Dawasir11991Saudi Arabia Department of Computer Engineering College of Computer Science and EngineeringTaibah UniversityMadinah42353Saudi Arabia Department of Creative Technologies Air University IslamabadIslamabad44000Pakistan

Cloud computing has become increasingly popular due to its capacity to perform computations without relying on physical infrastructure,thereby revolutionizing computer ***,the rising energy consumption in cloud centers poses a significant challenge,especially with the escalating energy *** paper tackles this issue by introducing efficient solutions for data placement and node management,with a clear emphasis on the crucial role of the Internet of Things(IoT)throughout the research *** IoT assumes a pivotal role in this study by actively collecting real-time data from various sensors strategically positioned in and around data *** sensors continuously monitor vital parameters such as energy usage and temperature,thereby providing a comprehensive dataset for *** data generated by the IoT is seamlessly integrated into the Hybrid TCN-GRU-NBeat(NGT)model,enabling a dynamic and accurate representation of the current state of the data center *** the incorporation of the Seagull Optimization Algorithm(SOA),the NGT model optimizes storage migration strategies based on the latest information provided by IoT *** model is trained using 80%of the available dataset and subsequently tested on the remaining 20%.The results demonstrate the effectiveness of the proposed approach,with a Mean Squared Error(MSE)of 5.33%and a Mean Absolute Error(MAE)of 2.83%,accurately estimating power prices and leading to an average reduction of 23.88%in power ***,the integration of IoT data significantly enhances the accuracy of the NGT model,outperforming benchmark algorithms such as DenseNet,Support Vector Machine(SVM),Decision Trees,and *** NGT model achieves an impressive accuracy rate of 97.9%,surpassing the rates of 87%,83%,80%,and 79%,respectively,for the benchmark *** findings underscore the effectiveness of the proposed method in optimizing energy efficiency and enhancing the predictive

关键词： Cloud computing energy efficiency data center optimization internet of things(IoT) hybrid models

Mitigating Blackhole and Greyhole Routing Attacks in Vehicular Ad Hoc Networks Using Blockchain Based Smart Contracts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第2期138卷 2005-2021页

作者： Abdulatif Alabdulatif Mada alharbi Abir Mchergui Tarek Moulahi Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Computer Science Higher Institute of Management of GabesGabes UniversityGabes6029Tunisia Information Technology College of ComputerQassim UniversityBuraydahSaudi Arabia Faculty of Science and Technology of Sidi Bouzid Kairouan UniversityKairouan3131Tunisia

The rapid increase in vehicle traffic volume in modern societies has raised the need to develop innovative solutions to reduce traffic congestion and enhance traffic management *** advanced technology,such as Intelligent Transportation Systems(ITS),enables improved traffic management,helps eliminate congestion,and supports a safer *** provides real-time information on vehicle traffic and transportation systems that can improve decision-making for road ***,ITS suffers from routing issues at the network layer when utilising Vehicular Ad Hoc Networks(VANETs).This is because each vehicle plays the role of a router in this network,which leads to a complex vehicle communication network,causing issues such as repeated link breakages between vehicles resulting from the mobility of the network and rapid topological *** may lead to loss or delay in packet transmissions;this weakness can be exploited in routing attacks,such as black-hole and gray-hole attacks,that threaten the availability of ITS *** this paper,a Blockchain-based smart contracts model is proposed to offer convenient and comprehensive security mechanisms,enhancing the trustworthiness between ***-Classification Blockchain-Based Contracts(SCBC)and Voting-Classification Blockchain-Based Contracts(VCBC)are utilised in the proposed *** results show that VCBC succeeds in attaining better results in PDR and TP performance even in the presence of Blackhole and Grayhole attacks.

关键词： Blockchain data privacy machine learning routing attacks smart contract VANET

Video Summarization Approach Based on Binary Robust Invariant Scalable Keypoints and Bisecting K-Means

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第3期78卷 3565-3583页

作者： Sameh Zarif Eman Morad Khalid Amin Abdullah alharbi Wail S.Elkilani Shouze Tang Department of Information Technology Faculty of Computers and InformationMenoufia UniversityMenoufia32511Egypt Department of Artificial Intelligence Faculty of Artificial IntelligenceEgyptian Russian UniversityBader11829Egypt Department of Computer Science Community CollegeKing Saud UniversityRiyadh11362Saudi Arabia College of Applied Computer Science King Saud UniversityAl-Muzahmiya19676Saudi Arabia School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing400065China

Due to the exponential growth of video data,aided by rapid advancements in multimedia *** became difficult for the user to obtain information from a large video *** process of providing an abstract of the entire video that includes the most representative frames is known as static video *** method resulted in rapid exploration,indexing,and retrieval of massive video *** propose a framework for static video summary based on a Binary Robust Invariant Scalable Keypoint(BRISK)and bisecting K-means clustering *** current method effectively recognizes relevant frames using BRISK by extracting keypoints and the descriptors from video *** video frames’BRISK features are clustered using a bisecting K-means,and the keyframe is determined by selecting the frame that is most near the cluster *** applying any clustering parameters,the appropriate clusters number is determined using the silhouette *** were carried out on a publicly available open video project(OVP)dataset that contained videos of different *** proposed method’s effectiveness is compared to existing methods using a variety of evaluation metrics,and the proposed method achieves a trade-off between computational cost and quality.

关键词： BRISK bisecting K-mean video summarization keyframe extraction shot detection

Single nucleotide polymorphism within chromosome 8q24 is associated with prostate cancer development in Saudi Arabia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Urology 2024年第1期11卷 26-32页

作者： Awad Elsid Osman Sahar alharbi Atif Ali Ahmed Asim Ali Elbagir Pathology and Clinical Laboratory Management Department(PCLM) King Fahad Medical CityRiyadhSaudi Arabia Department of Pathology and Laboratory Medicine University of Missouri at Children's Mercy HospitalKansas CityMOUSA

Objective: Genome-wide association studies have demonstrated that single nucleotide polymorphisms (SNPs) are important risk factors for the development of prostate cancer (PCa). Preliminary studies have suggested that the incidence of PCa in Saudi males is low but is probably familial or genetically ***: To identify any possible association of SNP with PCa development in Saudi patients, we investigated a group of SNPs in Saudi PCa patients (n=85) and compared the outcomes to healthy normal controls (n=115) and nodular hyperplasia patients (n=120). DNA was extracted from paraffin-embedded formalin fixed tissue or whole blood from both patients’ groups and healthy control group. A total of thirteen SNPs were genotyped using TaqMan® minor groove binder polymerase chain reaction ***: The rs16901979A, s629242T and rs1447295A alleles were found at significantly higher frequency in PCa patients than controls (p< 0.05). The rs16901979 CA genotype was found at significantly greater frequency in PCa patients than in healthy controls (43% vs. 14%, odds ratio=4.6, p=0.0001) and benign hyperplasia group (43% vs. 25%, odds ratio=2.2, p=0.009).Conclusion: Our study has highlighted the association of rs16901979 SNP with PCa in Saudi males. Such findings have important implications in the PCa diagnosis and in screening unaffected family members of Saudi patients.

关键词： Prostatecancer Saudi Singlenucleotide polymorphism Allele

Development of Non-ABO Red Blood Cell Alloantibodies in Patient Undergoing Allogeneic Haematopoietic Stem Cell Transplant

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2024年第5期13卷 162-170页

作者： Ahmed Alsuhaibani Khalid Batarfi Ahmed alharbi Haya Alwasel Abdullah Alenazi Abdulmohsen Alotaibi Jalal Hassan Rayyan Alotaibi Hajer Aziz Nourah Alharethi Sara Alobaidi Maram Alonayzan Sanad Alharthi Majd Alanazi Sarah Alotaibi Ahmed Shareefi bandar Alqahtani Department of Laboratory and Pathology King Abdulaziz Medical City of National Guard Riyadh Saudi Arabia

Alloantibodies that are non ABO Alloimmunization to protein antigens happens only after exposure, in contrast to ABO isohaemagglutinins, which are present naturally, even in the absence of prior exposure. It is recognized that while non-ABO RBC antibodies are less common than ABO antibodies, they generate essentially the same issues that lead to unfavorable clinical results. If non-ABO alloantibodies are identified early on, these issues related complications may be avoided This call for an in-depth understanding of the recipient and donor’s ABO-Rh grouping, antibody screening, and the phenotype of certain antigens. Equally important, the temporal association time between transplantation and hemolysis can help identify the underlying mechanism of hemolysis and direct appropriate management. Therefore, for that, it is crucial to identify the etiology of post-HSCT anemia for prevention and therapy, in addition to a thorough grasp of the mechanism of anemia in non-ABO-incompatible HSCT and the temporal link between HSCT and anemia. Finding the cause of post-HSCT anemia is essential for prevention and therapy, in addition to a thorough grasp of the mechanism of anemia in non-ABO-incompatible HSCT and the temporal link between HSCT and anemia. Therefore, for that, it is crucial to identify the etiology of post-HSCT anemia. In this case report review, we would like to highlight the vital role of transfusion medicine services and stem cell clinical teams in paying particular attention to the clinical significance of non-ABO alloantibodies involved to avoid causing overt hemolysis of incompatible donor RBCs or delayed erythropoiesis. Considering the fact that some of the Haematopoietic stem cell transplant centers do not give an attention to the other non-ABO RBC antigens.

关键词： Haematopoietic Stem Cell Transplant (HSCT) Non-ABO Red Blood Cell Antibodies Alloantibodies

Exploring the Prevalence and Contributing Factors of Depression among Sickle Cell Anemia Patients in Saudi Arabia’s Jazan Region

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mental Health Promotion 2024年第5期26卷 351-359页

作者： Abdullah A.alharbi Ahmad Y.Alqassim Mohammed A.Muaddi Najat H.Aldubayyan Rana I.Abuhadi Futon A.Akoor Sarah J.Mobarki Imtenan A.Oberi Ghaidaa H.alharbi Yara Ajeebi Adnan M.Alkhayat Hafiz Malhan Mohammed Bakkar Anwar M.Makeen Family and Community Medicine Department Faculty of MedicineJazan UniversityJazan45142Saudi Arabia Laboratory Department King Fahd Central HospitalMinistry of HealthJazan45142Saudi Arabia Internal Medicine Department Prince Mohammad bin Nasser HospitalMinistry of HealthJazan45142Saudi Arabia Hematology Department King AbdulAziz Medical City for National GuardRiyadh11426Saudi Arabia

Sickle Cell Anemia(SCA)is a prevalent genetic condition in Saudi Arabia,particularly in the Jazan *** study’s purpose was to assess the prevalence of de-pression among individuals with SCA in this area and to identify the factors associated with this *** study involved 391 adult participants,all patients in the hematology center of Prince Mohammed bin Nasser Hospital(PMNH).Data was collected through an anonymous interview questionnaire–the Arabic version of the Patient Health Questionnaire-9(PHQ-9)–between March–May *** questionnaire covered socio-demographic information and variables related to the participant’s SCA history,such as pain levels,frequency of pain,hospitalization duration,and frequency of blood *** variables underwent Chi-square and One-way ANOVA testing,followed by multivariate *** study found a 42%prevalence of depression among the SCA *** significantly linked with heightened depression levels included being widowed or divorced,experiencing frequent and severe pain,and longer duration of hospital *** educational level of at least a bachelor’s degree was also a significant *** study reveals a high prevalence of depression among SCA patients in the Jazan *** underscores the need for policymakers to educate both physicians and patients about the importance of mental health in SCA *** study also highlights the need for more research into the specific causes and effects of depressive symptoms in SCA patients to inform the creation of effective management plans.

关键词： Sickle cell anemia prevalence depression public health policy Jazan region Saudi Arabia

Non-target lung embolization during portal vein embolization due to an unrecognized portosystemic venous fistula:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第15期11卷 3625-3630页

作者： Sultan R alharbi Mohammed Bin Nasif Haifa bandar Alwaily Interventional Radiology Unit Department of RadiologyCollege of MedicineKing Saud UniversityKing Khalid University HospitalRiyadh 11362Saudi Arabia Department of Radiology College of MedicineKing Saud UniversityRiyadh 11362Saudi Arabia

BACKGROUND Portal vein embolization(PVE)is an effective and relatively safe procedure performed prior to major hepatic resection to enhance future liver *** embolization during PVE is rare,and if it occurs,it usually affects the future liver *** portosystemic venous fistulas are extremely rare in non-cirrhotic *** report a case of non-targeted lung embolization during PVE due to an unrecognized intrahepatic portosystemic *** SUMMARY A 60-year-old male presented with metastatic colon cancer of the *** patient underwent preoperative right *** the embolization procedure,a small amount of glue and lipiodol emulsion was embolized to the heart and lungs through an unrecognized intrahepatic portosystemic *** patient remained clinically stable and underwent the planned hepatic resection after 4 wk,with an uneventful postoperative *** Conventional portograms and careful evaluation prior to PVE are advisable to avoid such complications.

关键词： Portal vein embolization Non-target embolization Portosystemic venous fistula Case report

Practical guide:Glucagon-like peptide-1 and dual glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists in diabetes mellitus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第3期15卷 331-347页

作者： Saleh Fahad Alqifari Omar Alkomi Abdullah Esmail Khadijeh Alkhawami Shahd Yousri Mohamad Ayham Muqresh Nawwarah alharbi Abdullah A Khojah Ahmed Aljabri Abdulrahman Allahham Kousalya Prabahar Hanan Alshareef Mohammed Aldhaeefi Tariq Alrasheed Ali Alrabiah Laila A AlBishi Department of Pharmacy Practice Faculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Department of Clinical Sciences Sulaiman Alrajhi University-College of MedicineAl Bukayriyah 52726Saudi Arabia Department of Family Medicine Dr.Soliman Fakeeh Hospital DSFHJeddah 21461Saudi Arabia Department of Pharmacy Practice Faculty of PharmacyKing Abdulaziz UniversityJeddah 22252Saudi Arabia Clinical and Administrative Pharmacy Sciences College of PharmacyHoward UniversityWashingtonDC 20059United States Department of Internal Medicine Faculty of MedicineUniversity of TabukTabuk 71491Saudi Arabia Department of Pharmacy Practice Raabe College of PharmacyOhio Northern UniversityOhioOH 45810United States Department of Pediatric Faculty of MedicineUniversity of TabukTabuk 71491Saudi Arabia

Practical guide:Glucagon-like peptide-1 and dual glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists in diabetes mellitus common second-line choice after metformin for treating *** considerations can make selecting and switching between different GLP-1 RAs *** study aims to provide a comprehensive guide for the usage of GLP-1 RAs and dual GIP and GLP-1 RAs for the management of T2DM.

关键词： Glucagon-like peptide-1 receptor agonist Diabetes mellitus Metabolic syndrome Dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist Clinical practice Endocrinology