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Cytomegalovirus colitis induced segmental colonic hypoganglionosis in an immunocompetent patient: A case report

World Journal of Clinical Cases 2021年第20期9卷 5631-5636页

作者： ban seok kim Seon-Young Park Dong Hyun kim Nah Ihm kim Jae Hyun Yoon Jae Kyun Ju Chang Hwan Park Hyun Soo kim Sung Kyu Choi Department of Gastroenterology Chonnam National University HospitalGwangju 501-757South Korea Department of Pathology Chonnam National University HospitalGwangju 501-757South Korea Department of Surgery Chonnam University HospitalGwangju 501-757South Korea

BACKGROUND Cytomegalovirus(CMV)colitis is usually seen in immunocompromised patients with risk factors such as human immunodeficiency virus infection,solid organ transplant,inflammatory bowel disease,or ***,many clinicians usually do not consider the possibility of CMV colitis in immunocompetent *** reported a rare case of segmental colonic hypoganglionosis associated with CMV colitis in an immunocompetent *** SUMMARY A 48-year-old woman with no underlying disease was admitted to our hospital for severe abdominal pain and *** tomography of the abdomen showed diffuse dilatation of the small intestine and the entire *** sigmoidoscopic findings and result of polymerase chain reaction(PCR)for CMV revealed the compatible findings of CMV colitis,the patient was treated with intravenous *** treatment,sigmoidoscopic findings and CMV PCR results *** the patient continued to suffered from *** months after the initial admission,patient visited the emergency department with severe abdominal pain and imaging revealed aggravation of fecal impaction and bowel *** performed subtotal colectomy to control patient’s *** examination of the resected specimen showed significantly reduced number of mature ganglion cells in the sigmoid colon compared to that in the proximal *** Our case demonstrates that CMV colitis can develop even in patients with no other underlying disease,and that CMV colitis can be one of the causes for developing colonic hypoganglionosis.

关键词： Colonic pseudo-obstruction Colitis Cytomegalovirus Ganglia Case report

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An Empirical Study on the Effectiveness of Adversarial Examples in Malware Detection

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3535-3563页

作者： Younghoon ban Myeonghyun kim Haehyun Cho School of Software Soongsil UniversitySeoul06978Korea

Antivirus vendors and the research community employ Machine Learning(ML)or Deep Learning(DL)-based static analysis techniques for efficient identification of new threats,given the continual emergence of novel malware *** the other hand,numerous researchers have reported that Adversarial Examples(AEs),generated by manipulating previously detected malware,can successfully evade ML/DL-based *** antivirus systems,in particular,have been identified as vulnerable to such *** paper firstly focuses on conducting black-box attacks to circumvent ML/DL-based malware *** attack method utilizes seven different perturbations,including Overlay Append,Section Append,and Break Checksum,capitalizing on the ambiguities present in the PE format,as previously employed in evasion attack *** directly applying the perturbation techniques to PE binaries,our attack method eliminates the need to grapple with the problem-feature space dilemma,a persistent challenge in many evasion attack *** a black-box attack,our method can generate AEs that successfully evade both DL-based and ML-based ***,AEs generated by the attack method retain their executability and malicious behavior,eliminating the need for functionality *** thorogh evaluations,we confirmed that the attack method achieves an evasion rate of 65.6%against well-known ML-based malware detectors and can reach a remarkable 99%evasion rate against well-known DL-based malware ***,our AEs demonstrated the capability to bypass detection by 17%of vendors out of the 64 on VirusTotal(VT).In addition,we propose a defensive approach that utilizes Trend Locality Sensitive Hashing(TLSH)to construct a similarity-based defense *** several experiments on the approach,we verified that our defense model can effectively counter AEs generated by the perturbation *** conclusion,our defense model alleviates the limitation of the mos

关键词： Malware classification machine learning adversarial examples evasion attack cybersecurity

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Ultrasonographic findings of re-epithelialized skin after partial-thickness burns

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Burns & Trauma 2018年第3期6卷 219-227页

作者： Jong Dae kim Suk Joon Oh Sun Gyu kim Song Vogue Ahn Yu Jin Jang ban seok Yang Ji Yun Jeong Kwang Jo kim Department of Burn Reconstructive Surgery Bestian Seoul HospitalDogok-ro 429Gangnam-guSeoulRepublic of Korea Department of Health Convergence Ewha Womans UniversityEwhayeodae-gil 52Seodaemun-guSeoulRepublic of Korea Department of Radiology Bestian Seoul HospitalDogok-ro 429Gangnam-guSeoulRepublic of Korea.4Department of General SurgeryBestian Seoul HospitalSeoulRepublic of Korea

Background:This study aimed to investigate the difference between ultrasonographic findings of normal skin and those of re-epithelialized skin after partial-thickness burns and to evaluate the relationship between these findings and clinical outcomes. Methods:This study retrospectively analysed the ultrasound images of re-epithelialized skin after partial-thickness burns and contralateral normal skin from January 2016 to December 2016. A total of 155 lesions from 148 patients were analysed with ultrasound images, and healing time was documented. The scar status of each lesion was evaluated through medical records and photographs. We analysed the difference in ultrasonographic findings between normal skin and re-epithelialized skin after partial-thickness burns and statistically analysed the relationship between healing time, scar status and ultrasonographic findings. Results: The re-epithelialized skin after partial-thickness burns was significantly thicker than the contralateral normal skin, and the echogenicity was significantly lower. The ultrasound images of the re-epithelialized skin after partial-thickness burns showed the characteristic findings of low-echogenic bands (LEB), and the proportion of LEB thickness is strongly correlated with healing time. In the multivariate analysis of scar status, only the proportion of LEB thickness was statistical y significant. Conclusion:In this study, we found that there were ultrasonographic differences between re-epithelialized skin after partial-thickness burns and normal skin and that an LEB of varying thickness was formed after re-epithelialization. The thickness of the LEB in re-epithelialized skin after partial-thickness burns increased with healing time and was related to scar status.

关键词： Partial-thickness burn Ultrasonography Low-echogenic band Healing time Scar Re-epithelialized skin

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Synthesizing core-shell Ni-rich LiNi_(x)Co_(y)Mn_(z)O_(2) from spent Li-ion battery leachate

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Journal of Energy Chemistry 2024年第12期99卷 128-138页

作者： Seongdeock Jeong Sanghyuk Park Dongwoo kim Gyeongbin Ko Wooseok kim Sungkyu kim Sungho ban Haeun Lee Yonghoon kim Kyungjung Kwon Department of Energy and Mineral Resources Engineering Sejong UniversityGwangjin-guSeoul 05006Republic of Korea Autonomous Intelligent Unmanned Flying Vehicles Institute Sejong UniversityGwangjin-guSeoul 05006Republic of Korea Department of Nanotechnology&Advanced Materials Engineering Sejong UniversityGwangjin-guSeoul 05006Republic of Korea Battery Cell Development Team Hyundai Motor CompanyHwaseong-siGyeonggi-do 18280Republic of Korea

As the global electric vehicle market continues to grow,the recycling of Li-ion battery (LIB) becomes more important worldwide and the resynthesis of cathode materials would be the most value-added recycling approach taking into account limited metal *** resynthesized homogenous LiNi_(x)Co_(y)Mn_(z)O_(2)(NCM) from spent LIB leachate shows comparable battery performance to pristine NCM from virgin materials,there is general concern in its cycling ***,we synthesize core–shell(CS) Ni-rich NCM,which consists of Ni-rich NCM as the core and NCM derived from the original or purified leachate of spent LIBs as the *** CS Ni-rich NCM exhibits improved rate capability resulting from expanded interslab thickness in the NCM *** Ni-rich NCM from purified LIB leachate shows improvement in cycling performance and thermal *** specifically delivers a capacity retention of 86.6%at a high temperature after 80 cycles compared to that (75.0%) of pristine CS Ni-rich *** improvements are caused by a relatively high Mg content on the shell and the widespread distribution of Al through the CS *** Ni-rich NCM derived from spent LIB leachate provides a new alternative approach to conventional LIB recycling methods,which would utilize efficiently limited metal resources for the sustainable LIB production.

关键词： Li-ion battery Recycling Leachate NCM Core-shell

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A useful guide of effective mesh-size decision in predicting the ultimate strength of flat-and curved plates in compression

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Journal of Ocean Engineering and Science 2023年第4期8卷 401-417页

作者： Do Kyun kim Imjun ban Bee Yee Poh Sung-Chul Shin Department of Naval Architecture and Ocean Engineering College of EngineeringSeoul National UniversitySeoulSouth Korea Research Institute of Marine Systems Engineering Seoul National UniversitySeoulKorea Group of Marine Offshore and Subsea Technology(MOST)School of EngineeringNewcastle UniversityNewcastle upon TyneUK Department of Naval Architecture and Ocean Engineering Pusan National UniversityBusanSouth Korea Ocean and Ship Technology Research Group Department of Civil and Environmental EngineeringPETRONAS University of TechnologySeri IskandarPerakMalaysia

The present study aims to determine the appropriate size of mesh or the number of the element(NoE)for flat-and curved plates,which is suggested to assess its safety subjected to axial compression based on the ultimate limit state(ULS)design and analysis *** unstiffened panel(=plate)and stiff-ened panel,considered primary members of ships and ship-shaped offshore structures,are subjected to repeated axial compression and tension caused by continued vertical bending moments applied to the hull *** are attached with stiffeners by welding,and 6,8 or 10 elements are generally rec-ommended to allocate in flat-plate’s breadth direction in between stiffeners for finite-element(FE)mod-elling,which enables the presentation of the shape of initial deflection applied to the *** the case of the load-shorting curve for curved plate,it is reported that the nonlinear behaviour characteristics,i.e.,snap-through,snap-back,secondary buckling and others,appear in typical flank *** take this into account,we investigated the preferred number of elements(6,8 or 10)generally applied to the flat plate whether it is an appropriate or more fine-sized element(or mesh)that should be considered.A useful guide is documented based on obtained outcomes which may help structural engineers select optimised mesh-size to predict ultimate strength and understand its characteristic of the flat and curved plates.

关键词： Ultimate strength Unstiffened panel Longitudinal compression Mesh convergence Finite-element method

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Risk factors of organ failure in cholangitis with bacteriobilia

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World Journal of Gastroenterology 2015年第24期21卷 7506-7513页

作者： Jae Min Lee Sang Hyub Lee Kwang Hyun Chung Jin Myung Park ban seok Lee Woo Hyun Paik Joo Kyung Park Ji Kon Ryu Yong-Tae kim Departments of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine Gyeongsang National University College of Medicine Gyeongsang National University Hospital Department of Internal Medicine Kangwon National University School of Medicine Kangwon National University Hospital Department of Internal Medicine Inje University Ilsan Paik Hospital Department of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine

AIM: To identify the risk factors for organ failure(OF) in cholangitis with ***: This study included 182 patients with acute cholangitis who underwent percutaneous transhepatic biliary drainage between January 2005 and April 2013. We conducted a retrospective analysis of comprehensive clinical and laboratory ***: There were 24 cases(13.2%) of OF and five deaths(2.7%). Bile culture was positive for microbial growth in 130 out of 138(94.2%) patients. In multivariate analysis of 130 patients with positivebile cultures, significant predictive factors for OF were the presence of extended-spectrum beta-lactamase(ESBL) organisms in blood cultures, pre-existing renal dysfunction, and choledocholithiasis as an etiology, with odds ratios of 15.376, 6.319, and 3.573, respectively. We developed a scoring system with a regression coefficient of each significant variable. The OF score was calculated using the following equation:(2.7 × ESBL organisms in blood cultures) +(1.8 × pre-existing renal dysfunction) +(1.3 × choledocholithiasis). This scoring system for predicting OF was highly specific(99.1%) and had a positive predictive value of 86.2%.CONCLUSION: ESBL organisms in blood cultures, preexisting renal dysfunction, and choledocholithiasis are risk factors for OF in cholangitis with bacteriobilia. The OF scoring system may aid clinicians to identify a poor prognosis group.

关键词： Acute cholangitis Bacteriobilia Bile culture Organ failure

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Comparison of cytological and histological preparations in the diagnosis of pancreatic malignancies using endoscopic ultrasoundguided fine needle aspiration

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 418-423页

作者： Dong Kee Jang Sang Hyub Lee Jun Kyu Lee Woo Hyun Paik Kwang Hyun Chung ban seok Lee Jun Hyuk Son Jae Woo Lee Ji Kon Ryu Yong-Tae kim Kyoung-Bun Lee Department of Internal Medicine Dongguk University Ilsan Medical CenterGoyang-siGyeonggi-doKorea Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Internal Medicine Inje University Ilsan Paik HospitalGoyang-siGyeonggi-doKorea Department of Pathology Seoul National University College of MedicineSeoulKorea

BACKGROUND:Endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) has become a crucial diagnostic technique for pancreatic *** specimen obtained by EUS-FNA can be prepared for either cytological or histological *** study was to compare diagnostic performance of cytological and histological preparations using EUSFNA in the same lesions when pancreatic malignancies were ***:One hundred and eighteen patients who underwent EUS-FNA for suspected pancreatic malignancies were consecutively *** procedures were conducted by a single echoendoscopist under the same *** adequate preparations were obtained by 22-gauge needles with 20 to-and-fro movements for each *** 4 preparations included 2 cytological and 2 histological *** pathologic reviews of all specimens were conducted independently by a single experienced ***,specificity,and accuracy of the 2 preparations were ***:The enrolled patients consisted of 62 males(52.5%),with the mean age of 64.6±10.5 *** was performed in 23(19.5%) *** hundred and sixteen(98.3%) lesions were classified as malignant,while 2(1.7%) were *** of cytology and histology were 87.9% and 81.9%,respectively,with no significant difference(P=0.190).Accuracy was also not significantly *** preparation was more sensitive when the size of lesion was <3 cm(86.7% vs 68.9%,P=0.033).CONCLUSIONS:Our results suggested that the diagnostic performances of cytological and histological preparations are not significantly different for the diagnosis of pancreatic ***,cytological preparation might be more sensitive for pancreatic lesions <3 cm.

关键词： endoscopic ultrasound-guided fine needle aspiration pancreatic neoplasms cytology pathology histology

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Power management unit chip design for automobile active-matrix organic light-emitting diode display module

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Journal of Central South University 2009年第4期16卷 621-628页

作者： kim J H PARK J H kim J H CAO T V LEE T Y ban H J YANG K kim H G HA P B kim Y H Department of Electronic Engineering Changwon National University 9 Sarim-Dong Changwon 641-773 Korea Denso PS Electronics Corporation 47 Seongsan-Dong Changwon 641-315 Korea

A power management unit （PMU） chip supplying dual panel supply voltage, which has a low electro-magnetic interference （EMI） characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip＇s 0.25 μ high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done.

关键词： DC-DC converter AMOLED charge pumping power management unit (PMU) dual panel supply voltage

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Blood transcriptomic markers associated with immune abnormalities and sleep quality

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Genes & Diseases 2024年第6期11卷 111-114页

作者： Sang-Min Park Hyo-Jeong ban Minsung Lee Soo Yeon kim Siwoo Lee Hee-Jeong Jin College of Pharmacy Chungnam National UniversityDaejeon34134Republic of Korea Korean Medicine(KM)Data Division Korea Institute of Oriental MedicineDaejeon 34054Republicof Korea

The prevalence of sleep disorders is increasing worldwide,prompting greater efforts to understand the biological mechanisms underlying *** the growing interest in this area,a continuous transcriptome analysis for studying sleep quality is still *** study performed a regression analysis of the Pittsburgh sleep quality index(PsQ)from the blood transcriptome to identify marker genes associated with sleep quality.

关键词： sleep Blood prevalence

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Does robot-assisted laparoscopic radical prostatectomy enable to obtain adequate oncological and functional outcomes during the learning curve?From the Korean experience

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Asian Journal of Andrology 2009年第2期11卷 167-175页

作者： Young Hwii Ko Jeong Hyeon ban seok Ho Kang Hong seok Park Jeong Gu Lee Duck Ki Yoon Je Jong kim Jun Cheon Vipul RPatel Department of Urology MIS&Robotic Urologic Surgery CenterKorea University School of MedicineSeoul 136705Korea Global Robotics Institute University of Central FloridaFlorida HospitalOrlandoFL 32803USA

To estimate the short-term results of robot-assisted laparoscopic radical prostatectomy(RALRP)during the learning curve,in terms of surgical,oncological and functional outcomes,we conducted a prospective survey on *** July 2007,a single surgeon performed 63 robotic prostatectomies using the same operative *** data,including pathological and early functional results of the patient,were collected prospectively and *** with the accumulation of the cases,the total operative time,setup time,console time and blood loss were significantly *** major complication was present in any *** was needed in six patients;all of them were within the initial 15 *** positive surgical margin rate was 9.8%(5/51)in pT2 *** most frequent location of positive margin in this stage was the lateral aspect(60%),but in pT3 disease multiple margins were the most frequent(41.7%).Overall,53(84.1%)patients had totally continent status and the median time to continence was 6.56 *** 17 patients who maintained preoperative sexual activity(Sexual Health Inventory for Men≥17),stage below pT2,followed up for>6 months with minimally one side of neurovascular bundle preservation procedure,12(70.6%)were capable of intercourse postoperatively,and the mean time for sexual intercourse after operation was 5.7 *** this series,robotic prostatectomy was a feasible and reproducible technique,with a short learning curve and low perioperative complication *** during the initial phase of the learning curve,satisfactory results were obtained with regard to functional and oncological outcome.

关键词： learning curve outcomes assessment radical prostatectomy robotics

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