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国外锡工业 1990年第2期18卷 6-11页

作者： balk.,aa 王丽静

Enhancing prognostic accuracy in predicting rectal neuroendocrine neoplasms

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World Journal of Gastroenterology 2024年第37期30卷 4087-4089页

作者： Renin Peter aa Raj Abdulqadir J Nashwan Department of Medicine Aston Medical SchoolBirmingham B47ETUnited Kingdom Department of Nursing&Midwifery Research Hamad Medical CorporationDoha 3050Qatar

The recently published retrospective study introduces the GATIS score,a new predictive model for rectal neuroendocrine *** analyzing data from a large Chinese multicenter cohort,the study shows that the GATIS score,incor-porating tumor grade,T stage,tumor size,age,and prognostic nutritional index,demonstrates superior predictive power for overall survival and progression-free survival compared to traditional World Health Organization grade and tumor,nodes and metastases staging *** editorial aims to discuss the impor-tance of the GATIS score,its potential impact on clinical practice,and the strengths and limitations of the ***,it explores the significance,methodology,and clinical implications of these findings.

关键词： Rectal neuroendocrine neoplasm Nomogram Random forest Prognosis Overall survival Progression-free survival

Graphene oxide-lithium-ion batteries:inauguration of an era in energy storage technology

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Clean Energy 2024年第3期8卷 194-205页

作者： Yachana Mishra Aditi Chattaraj Alaa aa Aljabali Mohamed El-Tanani Murtaza M.Tambuwala Vijay Mishra School of Bioengineering and Biosciences Lovely Professional UniversityPhagwara(Punjab)-144411India Department of Pharmaceutics&Pharmaceutical Technology Yarmouk UniversityIrbidJordan College of Pharmacy Ras Al Khaimah Medical and Health Sciences UniversityUAE Lincoln Medical School University of LincolnBrayford Pool CampusLincoln LN67TSEnglandUK School of Pharmaceutical Sciences Lovely Professional UniversityPhagwara(Punjab)-144411India

A significant driving force behind the brisk research on rechargeable batteries,particularly lithium-ion batteries(LiBs)in high-performance applications,is the development of portable devices and electric ***-based materials,which have finite specific capacity,make up the anodes of *** attempts are being made to produce novel nanostructured composite anode materials for LiBs that display cycle stability that is superior to that of graphite using graphene ***,using significant amounts of waste graphene oxide from used LiBs represents a fantastic opportunity to engage in waste management and circular *** review outlines recent studies,developments and the current advancement of graphene oxide-based LiBs,including preparation of graphene oxide and utilization in LiBs,particularly from the perspective of energy storage technology,which has drawn more and more attention to creating high-performance electrode systems.

关键词： lithium-ion batteries graphene oxide energy storage technology waste management clean energy

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噪声如何影响儿童?

空中英语教室（高级版．彭蒙惠英语） 2024年第6期 28-29,47,48页

作者： Sophie J.balk 不详

许多家长都知道巨大的噪声会伤害孩子的听力。诸如烟花或枪炮等非常响的声音,可能造成直接的伤害。使用个人收听设备听音乐、看视频和上课,如果声音太大,也会对听力造成损害。但是,我们也了解到,过于杂的环境可能不只会对听力造成有害... 详细信息

许多家长都知道巨大的噪声会伤害孩子的听力。诸如烟花或枪炮等非常响的声音,可能造成直接的伤害。使用个人收听设备听音乐、看视频和上课,如果声音太大,也会对听力造成损害。但是,我们也了解到,过于杂的环境可能不只会对听力造成有害影响。

关键词：噪声有害影响声音上课听力伤害

Androgen receptor functions in prostate cancer development and progression

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Asian Journal of Andrology 2014年第4期16卷 561-564页

作者： Steven P balk Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA.

The androgen receptor （AR） is critical for the normal development ofprostate and for its differentiated functions. The consistent expression of AR in prostate cancer （PCa）, and its continued activity in PCa that relapse after androgen deprivation therapy （castration-resistant prostate cancer （CRPC））, indicate that at least a subset of these genes are also critical for PCa development and progression. This review addressed AR regulated genes that may be critical for PCa, and how AR may acquire new functions during PCa development and progression.

关键词： BETA-CATENIN NUCLEAR RECEPTOR TRANSCRIPTIONAL ACTIVITY PTEN LOSS COREPRESSOR SOX9 GENE INHIBITION CELLS PROLIFERATION

Measuring and understanding global human settlements patterns and processes:innovation,progress and application

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International Journal of Digital Earth 2020年第1期13卷 2-8页

作者： Ehrlich Daniele balk.Deborah Richard Sliuzas 不详

Human settlements–the places where people live and work–are rapidly *** of the processes driving the physical changes in human settlements are population and economic growth,rural-urban migration,and in-situ urban transformation that also includes the envelopment of small settlements by larger ones and land-expansive *** some parts of the world,particularly the global South,urbanization occurs at rates that generate unprecedented city sizes(WUP 2018).

关键词： settlement development sizes

Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 667-681页

作者： Yue Zhang Jingwen Gao Na Li Peng Xu Shimeng Qu Jinqian Cheng Mingrui Wang Xueru Li Yaheng Song Fan Xiao Xinyu Yang Jihong Liu Hao Hong Ronghao Mu Xiaotian Li Youmei Wang Hui Xu Yuan Xie Tianming Gao Guangji Wang Jiye aa Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesResearch Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical SciencesChina Pharmaceutical UniversityNanjing 210009China Key Laboratory of Drug Monitoring and Control Drug Intelligence and Forensic CenterMinistry of Public SecurityBeijing 100193China School of Pharmacy China Pharmaceutical UniversityNanjing 211198China School of Foreign Languages China Pharmaceutical UniversityNanjing 211198China Department of Neurobiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Pharmacology China Pharmaceutical UniversityNanjing 211198China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China

Studies have suggested that the nucleus accumbens(NAc)is implicated in the pathophysiology of major depression;however,the regulatory strategy that targets the NAc to achieve an exclusive and outstanding anti-depression benefit has not been ***,we identified a specific reduction of cyclic adenosine monophosphate(cAMP)in the subset of dopamine D1 receptor medium spiny neurons(D1-MSNs)in the NAc that promoted stress susceptibility,while the stimulation of cAMP production in NAc D1-MSNs efficiently rescued depression-like *** treatment enhanced cAMP both in D1-MSNs and dopamine D2 receptor medium spiny neurons(D2-MSNs)of depressed mice,however,the rapid antidepressant effect of ketamine solely depended on elevating cAMP in NAc *** discovered that a higher dose of crocin markedly increased cAMP in the NAc and consistently relieved depression 24 h after oral administration,but not a lower *** fast onset property of crocin was verified through multicenter ***,crocin specifically targeted at D1-MSN cAMP signaling in the NAc to relieve depression and had no effect on *** findings characterize a new strategy to achieve an exclusive and outstanding anti-depression benefit by elevating cAMP in D1-MSNs in the NAc,and provide a potential rapid antidepressant drug candidate,crocin.

关键词： CAMP Nucleus accumbens Depression D1-MSN D2-MSN

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癌：人体的自身武器

生物科学动态 1989年第2期 25-28页

作者： balk.,F 施绮云

Exposing the urban continuum:implications and crosscomparison from an interdisciplinary perspective

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International Journal of Digital Earth 2020年第1期13卷 22-44页

作者： Johannes H.Uhl Hamidreza Zoraghein Stefan Leyk Deborah balk.Christina Corbane Vasileios Syrris Aneta JFlorczyk Department of Geography University of Colorado BoulderBoulderCOUSA National Center for Atmospheric Research(NCAR) BoulderCOUSA CUNY Institute for Demographic Research and Baruch College City University of New YorkNew York CityNYUSA European Commission Joint Research Centre(JRC)IspraItaly

There is an increasing availability of geospatial data describing patterns of human settlement and population such as various global remote-sensing based built-up land layers,fine-grained census-based population estimates,and publicly available cadastral and building footprint *** development constitutes new integrative modeling opportunities to characterize the continuum of urban,peri-urban,and rural settlements and ***,little research has been done regarding the agreement between such data products in measuring human presence which is measured by different proxy variables(*** of built-up structures derived from different remote sensors,census-derived population counts,or cadastral land parcels).In this work,we quantitatively evaluate and cross-compare the ability of such data to model the urban continuum,using a unique,integrated validation database of cadastral and building footprint data,*** data,and three different versions of the Global Human Settlement Layer(GHSL)derived from remotely sensed *** identify advantages and shortcomings of these data types across different geographic settings in the U.S.,which will inform future data users on implications of data accuracy and suitability for a given application,even in data-poor regions of the world.

关键词： Built-up surfaces Global Human Settlement Layer(GHSL) Sentinel-1 Landsat agreement assessment urban modeling cadastral parcel data U.S.census data

Local thermal conductivity of polycrystalline AlN ceramics measured by scanning thermal microscopy and complementary scanning electron microscopy techniques

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Chinese Physics B 2012年第1期21卷 374-379页

作者： Zhang Yue-Fei Wang Li R.Heiderhoff A.K.Geinzer Wei Bin Ji Yuan Han Xiao-Dong L.J.balk.Zhang Ze Institute of Microstructure and Property of Advanced Materials Beijing University of TechnologyBeijing 100124China Department of Electronics Faculty of ElectricalInformation and Media EngineeringUniversity of WuppertalWuppertal D-42119Germany Department of Materials Science Zhejiang UniversityHangzhou 300038China

The local thermal conductivity of polycrystalline aluminum nitride （A1N） ceramics is measured and imaged by using a scanning thermal microscope （SThM） and complementary scanning electron microscope （SEM） based techniques at room temperature. The quantitative thermal conductivity for the A1N sample is gained by using a SThM with a spatial resolution of sub-micrometer scale through using the 3w method. A thermal conductivity of 308 W/m-K within grains corresponding to that of high-purity single crystal A1N is obtained. The slight differences in thermal conduction between the adjacent grains are found to result from crystallographic misorientations, as demonstrated in the electron backscattered diffraction. A much lower thermal conductivity at the grain boundary is due to impurities and defects enriched in these sites, as indicated by energy dispersive X-ray spectroscopy.

关键词： thermal conductivity A1N ceramics scanning thermal microscopy scanning electronmicroscopy