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Clinical and epidemiological features of ulcerative colitis patients in Sardinia,Italy:Results from a multicenter study

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World Journal of Clinical Cases 2022年第30期10卷 10921-10930页

作者： Salvatore Magrì Mauro Demurtas maria Francesca Onidi Marcello Picchio Walter Elisei Manuela Marzo Federica Miculan Roberto Manca maria Pina Dore Bianca maria Quarta Colosso Antonio Cicu Luigi Cugia Monica Carta laura Binaghi Paolo Usai mariantonia Lai Fabio Chicco Massimo Claudio Fantini Alessandro Armuzzi Giammarco Mocci Department of Medical Sciences and Public Health University of CagliariMonserrato 09042Italy Endoscopy Unit Humanitas Istituto Clinico CataneseCatania 95045Italy Endoscopy Unit San Martino HospitalOristano 09170Italy Gastroenterology Unit Brotzu HospitalCagliari 09121Italy Division of General Surgery Ospedale Civile P ColomboVelletri 00049Italy Gastroenterology Unit San Camillo Forlanini HospitalRome 00152Italy Internal Medicine and Gastroenterology Department Cardinale Panico HospitalTricase 73039Italy Department of Surgery San Martino HospitalOristano 09170Italy Division of Gastroenterology Santissima TrinitàHospitalCagliari 09121Italy Dipartimento di Medicina Clinica e Sperimentale University of SassariSassari 07100Italy Department of Medical Science and Public Health University of SassariSassari 07100Italy Unit of Gastroenterology ASL SassariSassari 07100Italy Gastroenterology Unit Santissima Annunziata HospitalSassari 07100Italy Medical Science and Public Health University of CagliariCagliari 09042Italy Medical Sciences and Public health Presidio Policlinico of MonserratoCagliariMonserrato 09042CagliariItaly Department of Internal Medicine University of Rome Tor VergataRome 00133Italy IBD Unit Policlinico Universitario GemelliRome 00168Italy

BACKGROUND There are little data on the epidemiological and clinical features of adult patients with ulcerative colitis(UC) in the different Italian regions,mainly derived from the absence of a national *** prevents correct interpretation of the disease *** To assess the main clinical and epidemiological features of adult patients diagnosed with UC in Sardinia,*** We performed a multicenter,observational,cross-sectional study that included adult patients with UC enrolled in seven gastroenterology unit centers in *** were obtained from the patients’ medical records and from a questionnaire administered at the inclusion *** Four hundred and forty-two patients with UC were *** median age at diagnosis was 39years(interquartile range 28-48).After a median disease duration of 10 years,53 patients experienced proximal extension of proctitis or left-sided ***-five patients developed extraintestinal *** patients(4.3%) developed cancer:two with colorectal cancer and seventeen with extracolonic ***(5-ASA) remains the mainstay of treatment for ***,95 patients(21.5%) were treated with one or more biologic agents,whereas 15 patients(3.4%) underwent surgery,mostly *** Our results provide important insights into the clinical and epidemiological features of patients with UC,and while waiting for a national Italian registry,present eligible data on the UC population in Sardinia.

关键词： Inflammatory bowel disease-basic Inflammatory bowel disease-clinical Ulcerative colitis Epidemiology Natural history Treatment

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Morpho-Anatomy of the Echium plantagineum L. (Boraginaceae) Diaspores in Relation with Water Uptake and Germination

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Phyton-International Journal of Experimental Botany 2020年第2期89卷 345-360页

作者： maria laura Molinelli Rocio Tarifa Patricia Perisse Catedra de Botanica Morfologica Facultad de Ciencias AgropecuariasUniversidad Nacional de CordobaCordobaArgentina

Echium plantagineum(Boraginaceae)is native of the Mediterranean regions,has been introduced and become widespread within the American continent(North to South),South Africa,New Zealand and *** plant has seed dormancy,aggressively spreads to infest vast areas of predominantly agricultural land and is considered a toxic weed to *** objectives of this research were:(i)to study the morpho-anatomy of the diaspores of ***;(ii)to identify the pathway of water uptake;and(iii)to characterize the germination and the *** morpho-anatomical studies were carried out analyzing semi-permanent slides of transverse and longitudinal sections of the fruits,seeds and ***,histochemical and conventional staining techniques by using stereoscopic,optical and scanning electron microscopy were *** the diaspores,the water uptake pathway was determined by fast green staining,germination tests were performed and the morpho-anatomy of seedlings was *** diaspores showed acrescent calyx surrounding the fruit,composed by 4 rough tuberculate *** indehiscent mericarpid encloses an exalbuminous seed with a thin coat and a spatulate embryo with folded *** uptake took place through the vascular trace“protuberance”in the cicatrix of the mericarpid,which triggers the germination *** was epigeal,the cotyledons were photosynthetically active at the emergence,and a rudimentary developed gemmula was *** percentage was 66.5%.The macrosclereids of the pericarp functions as an obstacle to water uptake,which is overcome when the mericarpid is detached from the gynobase,and the protuberance that acts as a water uptake path is exposed,leading to *** morpho-anatomical characteristics of diaspore,explain the successful dispersal for this aggressive weed,and provide important information in relation to the necessary care for its control.

关键词： Echiumplantagineum fruit germination imbibition mericarpid seed

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Methane oxidation and attenuation of sulphur compounds in landfill top cover systems: Lab-scale tests

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Journal of Environmental Sciences 2018年第3期30卷 317-326页

作者： Roberto Raga Alberto Pivato maria Cristina Lavagnolo laura Megido Raffaello Cossu DII-Department of Industrial Engineering University of Padova Department of Chemical and Environmental Engineering Polytechnic School of Engineering Gijón Campus University of Oviedo

In this study,a top cover system is investigated as a control for emissions during the aftercare of new landfills and for old landfills where biogas energy production might not be *** materials were studied as landfill cover system in lab-scale columns：mechanical–biological pretreated municipal solid waste（MBP）;mechanical–biological pretreated biowaste（PB）;fine（PBSf）and coarse（PBSc）mechanical–biological pretreated mixtures of biowaste and sewage sludge,and natural soil（NS）.The effectiveness of these materials in removing methane and sulphur compounds from a gas stream was tested,even coupled with activated carbon *** of CO2,CH4,O2,N2,H2S and mercaptans were analysed at different depths along the *** degradation was assessed using mass balance and the results were expressed in terms of methane oxidation rate（MOR）.The highest maximum and mean MOR were observed for MBP（17.2 g CH4/m^2/hr and 10.3 g CH4/m^2/hr,respectively）.Similar values were obtained with PB and *** lowest values of MOR were obtained for NS（6.7 g CH4/m^2/hr）and PBSf（3.6 g CH4/m^2/hr）,which may be due to their low organic content and void index,*** membranes with high load capacity did not seem to have an influence on the methane oxidation process：MBP coupled with 220 g/m^2and 360 g/m^2membranes gave maximum MOR of 16.5 g CH4/m^2/hr and 17.4 g CH4/m^2/hr,*** carbon membranes proved to be very effective on H2S ***,carbonyl sulphide,ethyl mercaptan and isopropyl mercaptan seemed to be easily absorbed by the filling materials.

关键词： Emission reduction Greenhouse gas emissionLandfill Methane oxidation H2S Soil cover

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Postoperative apnea after pyloromyotomy for infantile hypertrophic pyloric stenosis

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World Journal of Pediatric Surgery 2022年第3期5卷 125-130页

作者： Anna Camporesi Veronica Diotto Elena Zoia Simone Rotta Federica Tarantino laura maria Giuditta Eccher Valeria Calcaterra Gloria Pelizzo Marco Gemma Pediatric Anesthesia and Intensive Care Vittore Buzzi Children's HospitalMilanoItaly Department of Pediatrics Universitàdegli Studi di PaviaPaviaItaly Department of Pediatrics Vittore Buzzi Children's HospitalMilanoItaly Department of Biomedical and Clinical Science Luigi Sacco University HospitalMilanoItaly Department of Pediatric Surgery Vittore Buzzi Children's HospitalMilanoItaly NeuroAnesthesia and NeuroIntensive Care Fondazione IRCCS Istituto Neurologico Carlo BestaMilanoItaly

Objective Infantile hypertrophic pyloric stenosis(IHPS),which causes gastric outlet obstruction and hypochloremic hypokalemic metabolic alkalosis,could pose a risk of postoperative apnea in *** aim of this study is to evaluate the incidence of postoperative apnea in babies admitted to a tertiary-level pediatric surgical center in Milano,Italy with diagnosis of IHPS in *** secondary objective is to evaluate the risk factors for postoperative *** This is a single-center,retrospective,observational cohort *** patients admitted to our institution with diagnosis of IHPS during the study period were *** and surgical variables,along with blood gas parameters,were obtained from the *** apnea was defined as a respiratory pause longer than 15 s or a respiratory pause lasting less than 15 s,but associated with either bradycardia(heart rate<120 per minute),desaturation(SatO2<90%),cyanosis,or *** was obtained from nursing charts and was recorded as a no/yes dichotomous *** Of 122 patients,12(9.84%)experienced apnea and 110(90.16%)did *** univariate analysis,we found that only postoperative hemoglobin was significantly different between the groups(p=0.03).No significant multivariable model was better than this univariate model for prediction of *** Postoperative anemia,possibly due to hemodilution,increased the risk of postoperative *** could be hypothesized that anemia can be added as another apnea-contributing factor in a population at risk due to metabolic changes.

关键词： apnea admitted sized

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Noise-induced hippocampal damage:potential mechanisms

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Neural Regeneration Research 2022年第3期17卷 563-564页

作者： Sonia Jazmín Molina laura Ruth Guelman Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasCentro de Estudios Farmacológicos y Botánicos(CEFyBOUBA-CONICET)Facultad de MedicinaBuenos AiresArgentina Universidad de Buenos Aires Facultad de Medicina1^(a) Cátedra de FarmacologíaBuenos AiresArgentina

Exposure to noise of high intensities(> 80 dB) is considered a stressful event and might produce both auditory and extra-auditory damage,including different central nervous system(CNS) *** the CNS,the hippocampus(HC),a structure related to several cognitive functions,has shown to be particularly susceptible to the effects of noise.

关键词： damage auditory injuries

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Phenotyping Key Fruit Quality Traits in Olive Using RGB Images and Back Propagation Neural Networks

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Plant Phenomics 2023年第3期5卷 484-500页

作者： Giuseppe Montanaro Angelo Petrozza laura Rustioni Francesco Cellini Vitale Nuzzo Università degli Studi della Basilicata 85100 PotenzaItaly ALSIA Agenzia Lucana Sviluppo Innovazione in AgricolturaMetapontum Agrobios Research Center75010 MetapontoItaly Department of Biological and Environmental Sciences and Technologies University of SalentoLecceItaly

To predict oil and phenol concentrations in olive fruit,the combination of back propagation neural networks(BPNNs)and contact-less plant phenotyping techniques was employed to retrieve RGB image-based digital proxies of oil and phenol *** of cultivars(×3)differing in ripening time were sampled(~10-day interval,×2 years),pictured and analyzed for phenol and oil *** to this,fruit samples were pictured and images were segmented to extract the red(R),green(G),and blue(B)mean pixel values that were rearranged in 35 RGB-based colorimetric *** BPNNs were designed using as input variables(a)the original 35 RGB indexes,(b)the scores of principal components after a principal component analysis(PCA)pre-processing of those indexes,and(c)a reduced number(28)of the RGB indexes achieved after a sparse *** results show that the predictions reached the highest mean R^(2) values ranging from 0.87 to 0.95(oil)and from 0.81 to 0.90(phenols)across the *** addition to the R^(2),other performance metrics were calculated(root mean squared error and mean absolute error)and combined into a general performance indicator(GPI).The resulting rank of the GPI suggests that a BPNN with a specific topology might be designed for cultivars grouped according to their ripening *** present study documented that an RGB-based image phenotyping can effectively predict key quality traits in olive fruit supporting the developing olive sector within a digital agriculture domain.

关键词： Image image supporting

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Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury

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Cellular & Molecular Immunology 2020年第3期17卷 218-226页

作者： laura Neglia Marco Oggioni Domenico Mercurio maria-Grazia De Simoni Stefano Fumagalli1 Istituto di Ricerche Farmacologiche Mario Negri IRCCS Department of NeuroscienceMilanItaly

Mannose-binding lectin(MBL),an initiator of the lectin pathway(LP)of complement activation,is detrimental in ischemic stroke,as shown in clinical studies and rodent *** humans have one functional MBL protein,rodents have two isoforms,MBL-A and MBL-C,whose functions relative to that of human MBL are *** permit the clinical translation of preclinical data,we aimed to define the specific contributions of MBL-A and MBL-C to brain *** subjected mice with double(MBL^(−/−))or single(MBL-A^(−/−)or MBL-C^(−/−))MBL isoform depletion to transient middle cerebral artery occlusion(tMCAo).MBL^(−/−) mice had fewer neurological deficits and smaller ischemic lesions than WT ***-A^(−/−) mice had smaller lesions than WT mice and exhibited no significant behavioral defects,whereas MBL-C^(−/−) mice did not differ from WT *** induction of Mbl1 and Mbl2(the MBL-A and MBL-C genes)expression 48 h after tMCAo was similar across *** time course of Mbl1 and Mbl2 expression in WT ischemic mice showed that Mbl1 activation occurred earlier(24 h)than Mbl2 activation(48 h).The plasma levels of MBL-A and MBL-C in MBL-C^(−/−) and MBL-A^(−/−) mice,respectively,were similar to those in WT mice both at baseline and at 48 h after *** 48 h,MBL-A^(−/−)ischemic mice showed higher MBL-C levels in the brain than WT *** and MBL-C^(−/−) ischemic mice had higher LP activity in plasma and,accordingly,higher levels of C3 deposition in the brain than MBL-A^(−/−) and MBL^(−/−) *** conclusion,mice with depletion of both MBL isoforms exhibited strong protection from ischemia/reperfusion ***-A was the main contributor to injury,likely owing to its earlier activation after ischemia and more efficient activation of the complement system than MBL-C.

关键词： injury depletion likely

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Methodology and evidence from a case study in Rome to increase pedestrian safety along home-to-school routes

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第5期7卷 715-727页

作者： maria Vittoria Corazza Daniela D'Alessandro Paola Di Mascio laura Moretti Department of Civil Building and Environmental EngineeringSapienza University of RomeRome 00185Italy

Home-to-school routes are very sensitive areas: they represent, for children, a learning tool for their everyday activities, but if poorly designed, maintained and equipped they can expose them to traffic risks. Sidewalks' inappropriate level of service and poor maintenance, especially, are main factors contributing to walking unsuitability, thus to poor comfort and safety levels for young pedestrians, and more in general for all the vulnerable non-motorized road users. This paper deals with a methodology specifically developed to highlight the quality of the urban environment where the home-to-school routes are located, according to four main criteria: wellbeing, usage, appearance, and safety and security. Each criterion is associated with a checklist including the most relevant features to assess, with a focus on maintenance as a key parameter to create safe and comfortable routes to school. An application, a case study in Rome, where the lack of regular maintenance results into a network of unsafe sidewalks, is also presented, analyzing three different areas where a number of schools are located. Detours when approaching school premises were surveyed, due to the levels of distresses and linked to the poor comfort and safety levels. As the mutual influence of built environment over road safety and maintenance requirements for home-to-school paths is not largely investigated thus far, the paper's goal is to provide advanced knowledge for studies and applications further afield.

关键词： Traffic engineering Road safety Pedestrians Home-to-school routes Sidewalks

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Second-Order Invariant Domain Preserving ALE Approximation of Euler Equations

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Communications on Applied Mathematics and Computation 2023年第2期5卷 923-945页

作者： Jean-Luc Guermond Bojan Popov laura Saavedra Department of Mathematics Texas A&M UniversityCollege StationUSA Departamento de Matemática Aplicada a la Ingeniería Aeroespacial Universidad Politécnica de MadridMadridSpain

An invariant domain preserving arbitrary Lagrangian-Eulerian method for solving non-linear hyperbolic systems is *** numerical scheme is explicit in time and the approximation in space is done with continuous finite *** method is made invar-iant domain preserving for the Euler equations using convex limiting and is tested on vari-ous benchmarks.

关键词： Conservation equations Hyperbolic systems Arbitrary Lagrangian-Eulerian Moving meshes Invariant domains High-order method Convex limiting Finite element method

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Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury

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Neural Regeneration Research 2023年第6期18卷 1257-1258页

作者： Alexandra Chovsepian laura Empl Florence M.Bareyre Institute of Clinical Neuroimmunology Biomedical Building and Clinic of the Ludwig-Maximilians Universität MünchenMunichGermany

Traumatic brain injury(TBI) represents a significant cause of disability *** creates a vast array of damaging macro-and microscopic changes in the affected brain area(s),ranging from neuronal cell death,changes in structural spine integrity and dynamics to axonal injury and ove rall neuronal circuit disruption,ultimately leading to functional and cognitive deficits in both humans and animal models(N udo,2013).

关键词： injury traumatic cortex

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