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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 37-38页

作者： baldus s. Rudolph V. Rois. M. 朱冰坡 Univers.ty Hos.ital Hamburg-Eppendorf Heart Center Department of CardiologyMartinistrasse 52 20246 Ham-burg Germany Dr.

Background -Neutrophils.and monocytes.are centrally linked to vas.ular inflammatory dis.as., and leukocyte-derived myeloperoxidas.(MPO) has.emerged as.an important mechanis.ic participant in impaired vas.motor function. MPO binds.to and trans.ytos.s.endothelial cells.in a glycos.minoglycan-dependent manner, and MPO binding to the ves.el wall is.a prerequis.te for MPO-dependent oxidation of endothelium-derived nitric oxide(NO) and impairment of endothelial function in animal models. In the pres.nt s.udy, we inves.igated whether heparin mobilizes.MPO from vas.ular compartments.in humans.and defined whether this.trans.ates.into increas.d vas.ular NO bioavailability and function. Methods.and Res.lts.-Plas.a MPO levels.before and after heparin adminis.ration were as.es.ed by ELIs. in 109 patients.undergoing coronary angiography. Whereas.bas.line plas.a MPO levels.did not differ between patients.with or without angiographically detectable coronary artery dis.as.(CAD), the increas. in MPO plas.a content on bolus.heparin adminis.ration was.higher in patients.with CAD(P=0.01). Heparin treatment als. improved endothelial NO bioavailability, as.evidenced by flow-mediated dilation(Ps.in forearm blood flow(Ps. was.correlated with improvement in endothelial function(r=0.69, Ps.s.ent with this.tenet, ex vivo heparin treatment of extracellular matrix proteins. cultured endothelial cells. and s.phenous.vein graft s.ecimens.from CAD patients.decreas.d MPO burden. Conclus.ons.-Mobilization of ves.el-as.ociated MPO may repres.nt an important mechanis. by which heparins.exert antiinflammatory effects.and increas. vas.ular NO bioavailability. Thes. data add to the growing body of evidence for a caus.l role of MPO in compromis.d vas.ular NO s.gnaling in humans.

关键词：髓过氧化物酶 NO 生物利用度冠状动脉造影血流介导细胞源性葡萄糖胺聚糖隐静脉移植物血流量

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食管黏膜下鳞状细胞癌及腺癌的高淋巴结转移率

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世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 15-16页

作者： Bolls.hweiler E. baldus s.E. s.hrder W. A.H. Hls.her 张红凯 Dept. of Vis.eral and Vas.ular s.rgery University of Cologne Medical Center Kerpener Strasse 62 50937 Cologne GermanyDr.

Background and s.udy aims. The application of endos.opic mucos.ctomy in early es.phageal cancer is.limited by the pres.nce of lymph-node metas.as.s. The aim of this.pros.ective s.udy was.to analyze the rate of lymph-node involvement relative to the depth of mucos.l or s.bmucos.l tumor penetration, comparing s.uamous.cell carcinomas.and adenocarcinomas. Patients.and methods. A total of 60 patients.with pT1 es.phageal cancer- 24 with s.uamous.cell carcinomas.(s.Cs. and 36 with adenocarcinomas. were treated with trans.horacic enbloc es.phagectomy with two-field lymphadenectomy (n = 50) or trans.iatal es.phageal res.ction (n = 10). An average of 30 lymph nodes.were examined, and the following characteris.ics.were evaluated: his.ology, mucos.l infiltration, depth of s.bmucos.l wall infiltration in three thirds.(s.1, s.2, s.3), grading, res.ction category, ratio of metas.atic to res.cted lymph nodes. and locations.of metas.atic nodes. Res.lts. The rates.of lymph-node metas.as.s.were 0% for the 16 mucos.l carcinomas.and 45% for the 44 s.bmucos.l carcinomas.(Ps.gnificant differences.in the extent of lymph-node involvement between s.bmucos.l adenocarcinomas.(41% ) and s.bmucos.l s.Cs.(50% ). s.1 carcinomas.were as.ociated with a lower rate of lymph-node metas.as.s.(s.Cs.33% , adenocarcinomas.22% ) than s.3 carcinomas.(s.Cs.69% , adenocarcinomas.78% ). Two patients.(9% ) with s.bmucos.l s.Cs.and five patients.(23% ) with s.bmucos.l adenocarcinomas.were clas.ified as.having s.age pM1 lymph. The average lymph-node ratio in patients.with pN1 was.0.13 for adenocarcinomas.and 0.1 for s.Cs.(difference not s.gnificant). In the multivariate analys.s. the parameters.mucos.l vs. s.bmucos.l (P s. G3 (P s.owed a s.gnificant impact in relation to metas.atic lymph nodes. Conclus.ons. The mos. important factor for predicting lymph-node metas.as.s.in early es.phageal cancer is.the pres.nce of s.bmucos.l infiltration. Early adenocarcinomas.and

关键词：淋巴结转移率鳞状细胞癌早期食管癌黏膜下腺癌内镜下黏膜切除术经胸食管切除术肿瘤浸润深度前瞻性研究癌患者

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